[go: up one dir, main page]

DK504183D0 - Guaninderivater og fremgangsmade til fremstilling deraf - Google Patents

Guaninderivater og fremgangsmade til fremstilling deraf

Info

Publication number
DK504183D0
DK504183D0 DK5041/83A DK504183A DK504183D0 DK 504183 D0 DK504183 D0 DK 504183D0 DK 5041/83 A DK5041/83 A DK 5041/83A DK 504183 A DK504183 A DK 504183A DK 504183 D0 DK504183 D0 DK 504183D0
Authority
DK
Denmark
Prior art keywords
procedures
preparing
guanine derivatives
guanine
derivatives
Prior art date
Application number
DK5041/83A
Other languages
English (en)
Other versions
DK504183A (da
DK149001B (da
DK149001C (da
Inventor
Julien P Verheyden
John C Martin
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23017790&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK504183(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of DK504183A publication Critical patent/DK504183A/da
Publication of DK504183D0 publication Critical patent/DK504183D0/da
Publication of DK149001B publication Critical patent/DK149001B/da
Application granted granted Critical
Publication of DK149001C publication Critical patent/DK149001C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK504183A 1981-05-21 1983-11-03 9-substituerede n2-acylguaniner eller syreadditionssalte eller uorganiske metalsalte deraf DK149001C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US26721081 1981-05-21
US06267210 US4355032B2 (en) 1981-05-21 1981-05-21 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
DK227782A DK150304C (da) 1981-05-21 1982-05-19 Analogifremgangsmaade til fremstilling af 9-(1,3-dihydroxy-2-propoxymethyl)guanin eller farmaceutisk acceptable salte deraf
DK227782 1982-05-19

Publications (4)

Publication Number Publication Date
DK504183A DK504183A (da) 1983-11-03
DK504183D0 true DK504183D0 (da) 1983-11-03
DK149001B DK149001B (da) 1985-12-16
DK149001C DK149001C (da) 1988-11-28

Family

ID=23017790

Family Applications (2)

Application Number Title Priority Date Filing Date
DK227782A DK150304C (da) 1981-05-21 1982-05-19 Analogifremgangsmaade til fremstilling af 9-(1,3-dihydroxy-2-propoxymethyl)guanin eller farmaceutisk acceptable salte deraf
DK504183A DK149001C (da) 1981-05-21 1983-11-03 9-substituerede n2-acylguaniner eller syreadditionssalte eller uorganiske metalsalte deraf

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK227782A DK150304C (da) 1981-05-21 1982-05-19 Analogifremgangsmaade til fremstilling af 9-(1,3-dihydroxy-2-propoxymethyl)guanin eller farmaceutisk acceptable salte deraf

Country Status (33)

Country Link
US (1) US4355032B2 (da)
EP (1) EP0066208B1 (da)
JP (2) JPS57203086A (da)
KR (1) KR890004663B1 (da)
AR (1) AR244227A1 (da)
AT (1) ATE15899T1 (da)
AU (1) AU572086B2 (da)
BR (1) BR8202931A (da)
CA (3) CA1305140C (da)
CS (4) CS235044B2 (da)
DD (2) DD203052A5 (da)
DE (1) DE3266644D1 (da)
DK (2) DK150304C (da)
ES (7) ES512414A0 (da)
FI (1) FI73682C (da)
GR (1) GR76459B (da)
HK (1) HK67088A (da)
HU (2) HU188000B (da)
IE (1) IE53731B1 (da)
IL (1) IL65836A (da)
IN (1) IN156469B (da)
LU (1) LU88334I2 (da)
MY (1) MY8700793A (da)
NL (2) NL930022I1 (da)
NO (2) NO161740C (da)
NZ (1) NZ200691A (da)
PH (1) PH17975A (da)
PL (4) PL136637B1 (da)
PT (1) PT74934B (da)
RO (2) RO87387B (da)
SG (1) SG81687G (da)
SU (1) SU1176841A3 (da)
ZA (1) ZA823532B (da)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5157120A (en) * 1980-09-16 1992-10-20 Syntex (U.S.A.) Inc. Guanine derivatives
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
US4508898A (en) * 1980-09-16 1985-04-02 Ogilvie Kelvin K Antiviral triazine compounds
US4423050A (en) * 1981-05-21 1983-12-27 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4507305A (en) * 1981-05-21 1985-03-26 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
AT380252B (de) * 1981-08-11 1986-05-12 Wellcome Found Verfahren zur herstellung von neuen guanin- und 2,6-diaminopurinderivaten und ihren salzen
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
ZA83626B (en) * 1982-02-01 1983-12-28 Syntex Inc Substituted 9-(1 or 3-monoacyloxy or 1, 3-diacyloxy-2-propoxy-methyl purines as antiviral agent
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4902678A (en) * 1982-02-12 1990-02-20 Syntex (U.S.A.) Inc. Anti-viral compositions
US4609662A (en) * 1982-10-14 1986-09-02 Burroughs Wellcome Co. Method for using purine derivatives
US4462986A (en) * 1982-11-04 1984-07-31 Ens Bio Logicals, Inc. Synergistic anti-herpes compositions
US4814335A (en) * 1982-12-30 1989-03-21 Biomeasure, Incorporated Antiviral compounds
US4461757A (en) * 1983-02-23 1984-07-24 Ens Bio Logicals Inc. Dimethylaminomethylenated anti-herpes compounds
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
GB8320308D0 (en) * 1983-07-28 1983-09-01 Wellcome Found Antiviral combinations
EP0138683A3 (en) * 1983-09-30 1988-01-20 Merck & Co. Inc. Purine derivatives, their application in anti-viral compositions
US4897479A (en) * 1983-09-30 1990-01-30 Merck & Co., Inc. Arylsulfonyloxy purine intermediates
IE842642L (en) * 1983-10-31 1985-04-30 Harvard College Purine Derivatives
US4806642A (en) * 1984-10-05 1989-02-21 Warner-Lambert Company Purine derivatives
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
US4621140A (en) * 1984-02-23 1986-11-04 Syntex (U.S.A.) Inc. Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives
US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
WO1986000901A1 (en) * 1984-07-20 1986-02-13 Gauntt Charles O Immunoregulatory and anti-viral compound
DK168213B1 (da) * 1984-12-12 1994-02-28 Syntex Inc Alkoxymethylether- og alkoxymethylesterderivater af glycerol og fremgangsmåde til fremstilling af 9-(1,3-dihydroxy-2-propoxymethyl)guanin og ethere og estere deraf
SE8406538D0 (sv) 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US4642346A (en) * 1985-06-24 1987-02-10 Syntex (U.S.A.) Inc. Anhydrous crystalline 9-(1,3-dihydroxy-2-propoxymethyl)guanine
US4863927A (en) * 1987-05-11 1989-09-05 Merck & Co., Inc. 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
EP0375329B1 (en) * 1988-12-19 1995-05-31 The Wellcome Foundation Limited Antiviral pyrimidine and purine compounds, process for their preparation and pharmaceutical compositions containing them
US5068119A (en) * 1990-09-28 1991-11-26 Nabisco Brands, Inc. Acid-hydrolyzable ester derivatives as low calorie fat mimetics
GB2260319B (en) 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
JP3468423B2 (ja) * 1993-06-23 2003-11-17 メレルファーマスーティカルズ インコーポレイテッド 抗ウィルス及び抗新生物剤としての炭素非環式ヌクレオシド誘導体類
US5840891A (en) * 1994-07-28 1998-11-24 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US5565565A (en) 1994-08-04 1996-10-15 Syntex (U.S.A.) Inc. Preparation of N-9 substituted guanine compounds
US5627185A (en) * 1994-11-23 1997-05-06 Gosselin; Gilles Acyclovir derivatives as antiviral agents
US5840763A (en) * 1994-12-12 1998-11-24 Smithkline Beecham Plc Treatment of a latent infection of herpes viruses
DE19536164A1 (de) * 1995-09-28 1997-04-03 Boehringer Ingelheim Kg Verbessertes Verfahren zur Herstellung von 9-[(2-Hyroxyethoxy)methyl]guanin (Acyclovir)
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US6040446A (en) 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
IN179493B (da) * 1996-02-22 1997-10-11 Lupin Laboraties Ltd
EP0806425B1 (en) * 1996-04-09 2001-08-29 Lupin Laboratories Limited An improved regiospecific process for synthesis of acyclic nucleosides
US5852208A (en) * 1996-08-30 1998-12-22 Dixie Chemical Company, Inc. Method of producing compounds containing acyloxyalkoxy groups from alcohols
CN1091445C (zh) * 1999-12-29 2002-09-25 湖北省医药工业研究院 抗病毒药物中间体、它们的制备及应用
CA2477088A1 (en) 2002-02-22 2003-10-02 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
EP1556050A1 (en) * 2002-10-22 2005-07-27 Ranbaxy Laboratories Limited Pharmaceutical compositions of ganciclovir
WO2004039808A2 (en) * 2002-10-31 2004-05-13 Ranbaxy Laboratories Limited Process for the preparation of ganciclovir
WO2004048380A1 (en) * 2002-11-22 2004-06-10 Ranbaxy Laboratories Limited Process for the synthesis of ganciclovir
EA201100293A1 (ru) 2003-01-14 2011-08-30 Джилид Сайэнс, Инк. Способ (варианты) и фармацевтическая композиция (варианты) для лечения или профилактики симптомов вич-инфекции
ITMI20031202A1 (it) * 2003-06-13 2004-12-14 Lyogen Ltd Forma di cristallina del ganciclovir
WO2005021549A1 (en) * 2003-08-28 2005-03-10 Ranbaxy Laboratories Limited Amorphous valganciclovir hydrochloride
JP4746866B2 (ja) * 2004-11-19 2011-08-10 Ｔｃｍ株式会社 キャリッジ用ガタ抑制装置
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
EP2085397A1 (en) 2008-01-21 2009-08-05 Esteve Quimica, S.A. Crystalline form of abacavir
US20110059921A1 (en) * 2008-03-27 2011-03-10 Ektar Therapeutics Oligomer-Nitrogenous Base Conjugates
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
US8716263B2 (en) 2008-12-23 2014-05-06 Gilead Pharmasset Llc Synthesis of purine nucleosides
EA201100851A1 (ru) * 2008-12-23 2012-04-30 Фармассет, Инк. Аналоги нуклеозидов
EA019341B1 (ru) * 2008-12-23 2014-02-28 Джилид Фармассет, Ллс. Фосфорамидаты нуклеозидов
CN101851239B (zh) * 2009-04-03 2012-11-28 上海益威实业有限公司 一种更昔洛韦的回收方法
MX2012011171A (es) 2010-03-31 2013-02-01 Gilead Pharmasset Llc Fosforamidatos de nucleosido.
WO2012154698A2 (en) * 2011-05-06 2012-11-15 Mckenna Charles E Method to improve antiviral activity of nucleotide analogue drugs
CN102627643B (zh) * 2012-04-10 2014-01-08 常州康丽制药有限公司 更昔洛韦的精制方法
JP2015536940A (ja) 2012-10-29 2015-12-24 シプラ・リミテッド 抗ウイルス性ホスホネート類似体及びその製造方法
JP6237779B2 (ja) * 2012-11-03 2017-11-29 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング サイトメガロウイルスの阻害薬
CN103059023B (zh) * 2012-12-31 2015-09-30 浙江车头制药股份有限公司 一种制备更昔洛韦晶型ⅱ的方法
US9486530B1 (en) 2013-08-30 2016-11-08 Exela Pharma Sciences, LLC Ganciclovir compositions and related methods
WO2021209563A1 (en) 2020-04-16 2021-10-21 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
CN113476413B (zh) * 2021-08-09 2022-06-28 海南海灵化学制药有限公司 一种注射用更昔洛韦钠冻干粉的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199574A (en) * 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4060616A (en) * 1976-03-01 1977-11-29 Burroughs Wellcome Co. Purine derivatives with repeating unit
US4221910A (en) * 1978-09-15 1980-09-09 Newport Pharmaceuticals International, Inc. 9-(Hydroxy alkyl)purines
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
AU7938482A (en) * 1980-12-22 1982-07-20 Astra Lakemedel Aktiebolag Novel derivatives of guanine
AT380252B (de) * 1981-08-11 1986-05-12 Wellcome Found Verfahren zur herstellung von neuen guanin- und 2,6-diaminopurinderivaten und ihren salzen

Also Published As

Publication number Publication date
KR830010112A (ko) 1983-12-26
ES8404355A1 (es) 1984-05-01
PL236521A1 (en) 1984-01-02
CA1305141C (en) 1992-07-14
PH17975A (en) 1985-02-22
RO84860A (ro) 1984-09-29
DK504183A (da) 1983-11-03
PT74934A (en) 1982-06-01
US4355032A (en) 1982-10-19
CS235018B2 (en) 1985-04-16
DK149001B (da) 1985-12-16
SU1176841A3 (ru) 1985-08-30
DD203052A5 (de) 1983-10-12
AU572086B2 (en) 1988-05-05
ES533821A0 (es) 1985-06-16
MY8700793A (en) 1987-12-31
CA1305139C (en) 1992-07-14
NO1994005I1 (no) 1994-07-29
ES8505681A1 (es) 1985-06-16
NL930139I2 (nl) 1997-07-01
PL136004B1 (en) 1986-01-31
IE821210L (en) 1982-11-21
RO87387A (ro) 1985-08-31
PT74934B (en) 1984-05-08
NZ200691A (en) 1986-11-12
JPS57203086A (en) 1982-12-13
DK150304C (da) 1988-01-04
DE3266644D1 (en) 1985-11-07
JPH046195B2 (da) 1992-02-05
ES8606869A1 (es) 1986-05-16
HU186514B (en) 1985-08-28
NO821676L (no) 1982-11-22
KR890004663B1 (ko) 1989-11-24
HK67088A (en) 1988-09-02
LU88334I2 (fr) 1994-09-09
EP0066208A1 (en) 1982-12-08
RO84860B (ro) 1984-10-30
CA1305140C (en) 1992-07-14
ES512414A0 (es) 1984-05-01
JPH04217983A (ja) 1992-08-07
IL65836A0 (en) 1982-08-31
ES8601204A1 (es) 1985-11-16
IE53731B1 (en) 1989-02-01
PL136637B1 (en) 1986-03-31
FI73682B (fi) 1987-07-31
CS235042B2 (en) 1985-04-16
DK150304B (da) 1987-02-02
EP0066208B1 (en) 1985-10-02
US4355032B1 (da) 1983-06-14
DD213218A5 (de) 1984-09-05
CS235044B2 (en) 1985-04-16
ES8500276A1 (es) 1984-11-01
HU188000B (en) 1986-03-28
NL930022I1 (nl) 1993-05-03
US4355032B2 (en) 1990-10-30
AU8389282A (en) 1982-11-25
SG81687G (en) 1989-07-07
FI821794A0 (fi) 1982-05-20
ES529384A0 (es) 1987-01-01
DK149001C (da) 1988-11-28
PL136332B1 (en) 1986-02-28
CS235043B2 (en) 1985-04-16
GR76459B (da) 1984-08-10
ES8507549A1 (es) 1985-09-16
ES529383A0 (es) 1986-05-16
ES524899A0 (es) 1985-09-16
PL242100A1 (en) 1984-04-24
NO161740C (no) 1989-09-20
NL930139I1 (nl) 1993-11-01
ATE15899T1 (de) 1985-10-15
ES524900A0 (es) 1985-11-16
PL136579B1 (en) 1986-02-28
PL242101A1 (en) 1984-07-16
RO87387B (ro) 1985-08-31
FI73682C (fi) 1987-11-09
AR244227A1 (es) 1993-10-29
IL65836A (en) 1991-04-15
ZA823532B (en) 1983-03-30
NO161740B (no) 1989-06-12
ES8701496A1 (es) 1987-01-01
ES520849A0 (es) 1984-11-01
JPH0529399B2 (da) 1993-04-30
PL246770A1 (en) 1984-08-27
BR8202931A (pt) 1983-05-03
DK227782A (da) 1982-11-22
IN156469B (da) 1985-08-10

Similar Documents

Publication Publication Date Title
DK504183D0 (da) Guaninderivater og fremgangsmade til fremstilling deraf
DK99382A (da) Dichlorquinolinderivater og fremgangsmaade til fremstilling heraf
DK493882A (da) Faeldningskiselsyre og fremgangsmaade til fremstilling deraf
DK224781A (da) Imidazo-rifamycin-derivater og fremgangsmaade til fremstilling deraf
DK566282A (da) Benzisothiazol- og benzisoxazolpiperazinderivater og fremgangsmaade til fremstilling deraf
DK165321C (da) Oxiranderivater og fremgangsmaade til fremstilling deraf
DK493583A (da) Azolderivater og fremgangsmaade til fremstilling deraf
NO821562L (no) Cefalosporinderivater og fremgangsmaate til deres fremstilling
DK142990D0 (da) 2-fluor-4-halogen-1-nitrobenzenderivater og en fremgangsmaade til fremstilling deraf
DK130182A (da) Antagonister for argininvasopressin og fremgangsmaade til fremstilling heraf
DK330582A (da) Herbicidt virksomme 5-amino-1-phenylpyrazol-4-carboxylsyrederivater og fremgangsmaade til fremstilling deraf
DK157683A (da) N-phosphonomethylglycinderivater og fremgangsmaade til fremstilling og anvendelse deraf
DK102182A (da) Vandfrit antitranspirationsmiddel og fremgangsmaade til fremstilling deraf
DK361982A (da) Carbostyrilderivater og fremgangsmaade til fremstilling heraf
DK401882A (da) Cyclopentadienderivater og fremgangsmaader til deres fremstilling
DK160744C (da) Oxychloreringskatalysator-praekursor til oxychlorering og fremgangsmaade til fremstilling heraf
DK63080A (da) 25-hydroxy-24-oxochlostanderivater og fremgangsmaade til fremstilling deraf
DK343684D0 (da) Phenyletherderivater og fremgangsmaade til fremstilling deraf
DK596784D0 (da) Phenylderivater og fremgangsmaade til fremstilling deraf
DK445784A (da) Fluorenylalkylimidazol-derivater og fremgangsmaade til fremstilling deraf
DK401385D0 (da) 7-oxomitosan-derivater og fremgangsmaade til fremstilling deraf
NO821206L (no) Imidazolderivater og fremgangsmaate for deres fremstilling
DK249782A (da) Piperazinderivater og fremgangsmaade til fremstilling heraf
DK372582A (da) Immunogent kompleks og fremgangsmaade til fremstilling deraf
DK135684A (da) 2-cyano-imidazopyridin-derivater og fremgangsmaade til fremstilling heraf

Legal Events

Date Code Title Description
PUP Patent expired