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DK491487A - Dna-sekvens til ekspressionering af biologisk aktivt faktor xiii og anvendelse af samme - Google Patents

Dna-sekvens til ekspressionering af biologisk aktivt faktor xiii og anvendelse af samme

Info

Publication number
DK491487A
DK491487A DK491487A DK491487A DK491487A DK 491487 A DK491487 A DK 491487A DK 491487 A DK491487 A DK 491487A DK 491487 A DK491487 A DK 491487A DK 491487 A DK491487 A DK 491487A
Authority
DK
Denmark
Prior art keywords
proteins
biological activity
factor xiii
same biological
dna sequence
Prior art date
Application number
DK491487A
Other languages
English (en)
Other versions
DK175919B1 (da
DK491487D0 (da
Inventor
Earl W Davie
Ronald L Seale
Akitada Ichinose
Julie Ann Holly
Gary E Parker
Original Assignee
Zymogenetics Inc
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc, Univ Washington filed Critical Zymogenetics Inc
Publication of DK491487D0 publication Critical patent/DK491487D0/da
Publication of DK491487A publication Critical patent/DK491487A/da
Application granted granted Critical
Publication of DK175919B1 publication Critical patent/DK175919B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/104—Aminoacyltransferases (2.3.2)
    • C12N9/1044—Protein-glutamine gamma-glutamyltransferase (2.3.2.13), i.e. transglutaminase or factor XIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK198704914A 1986-09-19 1987-09-18 Ekspression af biologisk aktiv faktor XIII DK175919B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90951286A 1986-09-19 1986-09-19
US90951286 1986-09-19

Publications (3)

Publication Number Publication Date
DK491487D0 DK491487D0 (da) 1987-09-18
DK491487A true DK491487A (da) 1988-03-20
DK175919B1 DK175919B1 (da) 2005-06-27

Family

ID=25427353

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198704914A DK175919B1 (da) 1986-09-19 1987-09-18 Ekspression af biologisk aktiv faktor XIII

Country Status (7)

Country Link
EP (1) EP0268772B1 (da)
JP (4) JP2667405B2 (da)
AT (1) ATE121776T1 (da)
AU (1) AU615634B2 (da)
CA (1) CA1341577C (da)
DE (1) DE3751269T2 (da)
DK (1) DK175919B1 (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6869790B1 (en) 1986-03-12 2005-03-22 Aventis Behring Gmbh Preparation of DNA encoding factor XIIIA
DE3621371A1 (de) * 1986-03-12 1987-09-17 Behringwerke Ag Gentechnische herstellung von faktor xiiia
US6746866B1 (en) 1986-03-12 2004-06-08 Aventis Behring Gmbh Preparation of factor XIIIa by gene manipulation
JPH01216939A (ja) * 1988-02-24 1989-08-30 Hoechst Japan Kk 末熟児頭蓋内出血阻止剤
US5612456A (en) * 1988-11-14 1997-03-18 Zymogenetics, Inc. Factor XIII compositions
US5204447A (en) * 1988-11-14 1993-04-20 Zymogenetics, Inc. Purification of factor xiii
DE3906540A1 (de) * 1989-03-02 1990-09-13 Behringwerke Ag Expressionsvektoren zur synthese von proteinen in der spalthefe schizosaccharomyces pombe
DE3940651A1 (de) * 1989-12-08 1991-06-13 Behringwerke Ag Verfahren zur expression von fremdgenen in hefen
AU7586991A (en) * 1990-03-21 1991-10-21 Board Of Regents, The University Of Texas System Yeast expression vectors
JPH0478519U (da) * 1990-11-16 1992-07-08
WO1992012238A1 (en) * 1991-01-04 1992-07-23 The Board Of Regents, University Of Texas System Cloning and expression of tissue transglutaminases
ATE171071T1 (de) * 1991-12-31 1998-10-15 Zymogenetics Inc Verfahren und zusammensetzungen zur verminderung von blutverlust
AU5590394A (en) * 1992-11-03 1994-05-24 Oklahoma Medical Research Foundation Transglutaminase gene
ATE224727T1 (de) * 1993-03-30 2002-10-15 Hoechst Japan Faktor xiii zur behandlung von hautwunden
AU4648096A (en) * 1994-12-30 1996-07-24 Zymogenetics Inc. Bovine factor xiii
JP2002514433A (ja) * 1998-05-14 2002-05-21 バッテル メモリアル インスティテュート トランスジェニック植物由来ヒト凝血因子
AU2002225994A1 (en) * 2000-11-03 2002-05-15 Zymogenetics Inc. Use of blood coagulation factor xiii for treating haemophilia
DE10101962B4 (de) * 2001-01-17 2006-07-27 Tad Pharma Gmbh DNA-Sequenz mit regulatorischen Bereichen zur Expression von Proteinen
ES2303561T3 (es) 2001-10-09 2008-08-16 Zymogenetics, Inc. Metodo para inhibir la formacion de seromas utilizando el factor xiii.
JP2008510476A (ja) 2004-08-27 2008-04-10 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 生物学的材料からのｘｉｉｉ因子ポリペプチドの精製
ES2378777T3 (es) 2004-11-23 2012-04-17 Zymogenetics, Inc. Purificación del factor XIII humano recombinante
WO2010131249A2 (en) 2009-05-12 2010-11-18 Hadasit Medical Research Services And Development Ltd. Prosthetic devices coated with heated cross-linked fibrin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6029687B2 (ja) * 1978-11-07 1985-07-12 株式会社ミドリ十字 ヒト胎盤由来血液凝固第１０３因子の濃縮液の製造方法
ATE102250T1 (de) * 1984-05-11 1994-03-15 Chiron Corp Erhoehte hefetranskription unter verwendung einer hybridkonstruktion der promotorregion.
DK27885A (da) * 1985-01-22 1986-07-23 Novo Industri As Fremstilling af peptider
DE3621371A1 (de) * 1986-03-12 1987-09-17 Behringwerke Ag Gentechnische herstellung von faktor xiiia

Also Published As

Publication number Publication date
JPS63164890A (ja) 1988-07-08
DE3751269D1 (de) 1995-06-01
EP0268772A2 (en) 1988-06-01
JP3299192B2 (ja) 2002-07-08
DE3751269T2 (de) 1995-09-14
ATE121776T1 (de) 1995-05-15
JP2667405B2 (ja) 1997-10-27
EP0268772B1 (en) 1995-04-26
JPH11127873A (ja) 1999-05-18
JP3077121B2 (ja) 2000-08-14
EP0268772A3 (en) 1988-10-26
CA1341577C (en) 2008-07-22
DK175919B1 (da) 2005-06-27
JPH09327296A (ja) 1997-12-22
AU7869487A (en) 1988-03-31
AU615634B2 (en) 1991-10-10
DK491487D0 (da) 1987-09-18
JP3450844B2 (ja) 2003-09-29
JP2002223756A (ja) 2002-08-13

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