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DK473289A - 2'-halogenmethyliden-, 2'-ethenyliden- og 2'-ethynyl-adenosin-derivater, deres fremstilling og anvendelse - Google Patents

2'-halogenmethyliden-, 2'-ethenyliden- og 2'-ethynyl-adenosin-derivater, deres fremstilling og anvendelse Download PDF

Info

Publication number
DK473289A
DK473289A DK473289A DK473289A DK473289A DK 473289 A DK473289 A DK 473289A DK 473289 A DK473289 A DK 473289A DK 473289 A DK473289 A DK 473289A DK 473289 A DK473289 A DK 473289A
Authority
DK
Denmark
Prior art keywords
halogenmethylidene
ethenylidene
ethynyl
preparation
adenosine derivatives
Prior art date
Application number
DK473289A
Other languages
English (en)
Other versions
DK171237B1 (da
DK473289D0 (da
Inventor
James R Mccarthy
Michael L Edwards
David M Stemerick
Esa T Jarvi
Nellikunja J Prakash
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of DK473289D0 publication Critical patent/DK473289D0/da
Publication of DK473289A publication Critical patent/DK473289A/da
Application granted granted Critical
Publication of DK171237B1 publication Critical patent/DK171237B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK473289A 1988-09-27 1989-09-26 Adenosinderivater, deres fremstilling, farmaceutiske midler med indhold deraf og anvendelse deraf til fremstilling af farmaceutiske midler DK171237B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24991188A 1988-09-27 1988-09-27
US24991188 1988-09-27
US38939189A 1989-08-03 1989-08-03
US38939189 1989-08-03

Publications (3)

Publication Number Publication Date
DK473289D0 DK473289D0 (da) 1989-09-26
DK473289A true DK473289A (da) 1990-03-28
DK171237B1 DK171237B1 (da) 1996-08-05

Family

ID=26940460

Family Applications (1)

Application Number Title Priority Date Filing Date
DK473289A DK171237B1 (da) 1988-09-27 1989-09-26 Adenosinderivater, deres fremstilling, farmaceutiske midler med indhold deraf og anvendelse deraf til fremstilling af farmaceutiske midler

Country Status (18)

Country Link
EP (1) EP0365849B1 (da)
JP (1) JP2968002B2 (da)
KR (1) KR0146333B1 (da)
CN (1) CN1046334A (da)
AR (1) AR248283A1 (da)
AT (1) ATE111477T1 (da)
AU (1) AU621664B2 (da)
CA (1) CA1336903C (da)
DE (1) DE68918215T2 (da)
DK (1) DK171237B1 (da)
ES (1) ES2063796T3 (da)
FI (1) FI94763C (da)
HU (1) HU204843B (da)
IE (1) IE63561B1 (da)
IL (1) IL91773A (da)
NO (1) NO171857C (da)
NZ (1) NZ230766A (da)
PT (1) PT91803B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206244A (en) * 1990-10-18 1993-04-27 E. R. Squibb & Sons, Inc. Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
US5340816A (en) * 1990-10-18 1994-08-23 E. R. Squibb & Sons, Inc. Hydroxymethyl(methylenecyclopentyl) purines and pyrimidines
FR2668153B1 (fr) * 1990-10-22 1995-03-31 Pasteur Merieux Serums Vacc Nouveaux composes ribonucleosides, leur procede de preparation et les medicaments les contenant.
CA2133961C (en) * 1992-05-12 1998-03-31 James R. Mccarthy A process for the preparation of ribonucleotide reductase inhibitors
US5589587A (en) * 1992-05-12 1996-12-31 Merrell Pharmaceuticals Inc. Process for the preparation of ribonucleotide reductase inhibitors
US5627053A (en) * 1994-03-29 1997-05-06 Ribozyme Pharmaceuticals, Inc. 2'deoxy-2'-alkylnucleotide containing nucleic acid
EP0770621A4 (en) * 1994-07-12 1998-01-28 Yamasa Corp 2'-DEOXY-2 '(SUBSTITUTED OR Unsubstituted METHYLIDENE) -4-THIONUCLEOSIDE
WO2000074686A1 (en) * 1999-06-09 2000-12-14 Anticancer, Inc. Modulators of methylation for control of bacterial virulence
US6579857B1 (en) 1999-06-11 2003-06-17 Evanston Northwestern Healthcare Research Institute Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors
JP2005522443A (ja) * 2002-02-14 2005-07-28 フアーマセツト・リミテツド 改変フッ素化ヌクレオシド類似体
GEP20166496B (en) 2011-12-22 2016-06-27 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL84414A0 (en) * 1986-11-14 1988-04-29 Ciba Geigy Ag N9-cyclopentyl-substituted adenine derivatives
WO1988007049A1 (fr) * 1987-03-19 1988-09-22 Yamasa Shoyu Kabushiki Kaisha Derives de nucleosides de 2'-alkylidene pyrimidine, procede de preparation et utilisation de ces composes
NZ225906A (en) * 1987-08-26 1990-10-26 Merrell Dow Pharma Aristeromycin/adenosine derivatives and pharmaceutical compositions
ZA894534B (en) * 1988-06-20 1990-03-28 Merrell Dow Pharma Novel neplanocin derivatives

Also Published As

Publication number Publication date
NZ230766A (en) 1992-07-28
FI894546A0 (fi) 1989-09-26
DE68918215D1 (de) 1994-10-20
EP0365849A3 (en) 1990-12-27
AR248283A1 (es) 1995-07-12
JP2968002B2 (ja) 1999-10-25
PT91803A (pt) 1990-03-30
ATE111477T1 (de) 1994-09-15
IL91773A0 (en) 1990-06-10
AU621664B2 (en) 1992-03-19
FI894546A7 (fi) 1990-03-28
CN1046334A (zh) 1990-10-24
NO893826L (no) 1990-03-28
EP0365849A2 (en) 1990-05-02
DE68918215T2 (de) 1995-02-02
NO171857B (no) 1993-02-01
DK171237B1 (da) 1996-08-05
ES2063796T3 (es) 1995-01-16
IE63561B1 (en) 1995-05-17
FI94763C (fi) 1995-10-25
IL91773A (en) 1994-02-27
FI94763B (fi) 1995-07-14
IE893080L (en) 1990-03-27
NO171857C (no) 1993-05-12
HU204843B (en) 1992-02-28
JPH02160769A (ja) 1990-06-20
DK473289D0 (da) 1989-09-26
HUT50844A (en) 1990-03-28
EP0365849B1 (en) 1994-09-14
AU4176089A (en) 1990-04-05
NO893826D0 (no) 1989-09-26
KR0146333B1 (ko) 1998-08-01
KR900004736A (ko) 1990-04-12
PT91803B (pt) 1995-05-31
CA1336903C (en) 1995-09-05

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed

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