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DK475585D0 - METHOD OF PREPARING AROMATICALLY SUBSTITUTED L-AMINO ACIDS - Google Patents

METHOD OF PREPARING AROMATICALLY SUBSTITUTED L-AMINO ACIDS

Info

Publication number
DK475585D0
DK475585D0 DK475585A DK475585A DK475585D0 DK 475585 D0 DK475585 D0 DK 475585D0 DK 475585 A DK475585 A DK 475585A DK 475585 A DK475585 A DK 475585A DK 475585 D0 DK475585 D0 DK 475585D0
Authority
DK
Denmark
Prior art keywords
amino acids
preparing
aromatically substituted
racemate
ester
Prior art date
Application number
DK475585A
Other languages
Danish (da)
Other versions
DK475585A (en
Inventor
Reinhold Keller
Merten Schlingmann
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK475585D0 publication Critical patent/DK475585D0/en
Publication of DK475585A publication Critical patent/DK475585A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

1. A process for the preparation of aromatically substituted L-amino acids by enzymatic cleavage of the racemate of the lower alkyl esters (except tert.-butylester) using alpha-chymotrypsin in the weakly acid pH range and extraction of the ester of the D form, which comprises the reaction mixture obtained in the enzymatic cleavage being made weakly alkaline, the ester of the D-amino acid being extracted from this alkaline solution using an organic solvent, and being racemized, whereupon the racemate is returned to the process, and the extracted alkaline solution being made weakly acid, whereupon the L-amino acid is isolated from it.
DK475585A 1984-10-18 1985-10-17 METHOD OF PREPARING AROMATICALLY SUBSTITUTED L-AMINO ACIDS DK475585A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843438189 DE3438189A1 (en) 1984-10-18 1984-10-18 METHOD FOR PRODUCING AROMATICALLY SUBSTITUTED L-AMINO ACIDS

Publications (2)

Publication Number Publication Date
DK475585D0 true DK475585D0 (en) 1985-10-17
DK475585A DK475585A (en) 1986-04-19

Family

ID=6248201

Family Applications (1)

Application Number Title Priority Date Filing Date
DK475585A DK475585A (en) 1984-10-18 1985-10-17 METHOD OF PREPARING AROMATICALLY SUBSTITUTED L-AMINO ACIDS

Country Status (15)

Country Link
EP (1) EP0178553B1 (en)
JP (1) JPS61108398A (en)
AT (1) ATE56472T1 (en)
CA (1) CA1265083A (en)
CS (1) CS258132B2 (en)
DE (2) DE3438189A1 (en)
DK (1) DK475585A (en)
ES (1) ES8609186A1 (en)
FI (1) FI854025A7 (en)
GR (1) GR852491B (en)
HU (1) HUT39414A (en)
IL (1) IL76740A0 (en)
NO (1) NO854127L (en)
PT (1) PT81320B (en)
ZA (1) ZA857971B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3618465A1 (en) * 1986-06-02 1987-12-03 Hoechst Ag CARRYING OUT BIO CATALYST REACTIONS IN A FLUID BED REACTOR WITH A 2-PHASE LIQUID SYSTEM
DE3622662A1 (en) * 1986-07-05 1988-01-14 Hoechst Ag METHOD FOR CONTINUOUS BIOCATALYTIC IMPLEMENTATION OF SUBSTRATES WHICH ARE SLIGHTLY SOLUBLE IN AQUEOUS SOLUTIONS
US5002871A (en) * 1986-08-18 1991-03-26 The Coca-Cola Company Enzymatic membrane method for the synthesis and separation of peptides
DE3839379A1 (en) * 1988-11-22 1990-05-23 Hoechst Ag METHOD FOR PRODUCING TRIPEPTIDES
US5025325A (en) * 1989-10-13 1991-06-18 Hewlett-Packard Company Graphics scaling method for high resolution printers
DE19546532C2 (en) * 1995-12-13 2000-04-20 Degussa Process for obtaining optically active L-alpha-aminocarboxylic acids from corresponding racemic D, L-alpha-aminocarboxylic acids
FR2778671B1 (en) * 1998-05-14 2002-07-05 Rhone Poulenc Agrochimie NEW PROCESS FOR THE PREPARATION OF SYNTHESIS INTERMEDIATES
KR100882972B1 (en) 2001-09-25 2009-02-12 에프. 호프만-라 로슈 아게 Enzymatic Methods for Preparation of Substituted 2-Amino-3- (2-Amino-phenylsulfanyl) -propionic Acid
JP5028672B2 (en) * 2007-05-23 2012-09-19 ボイス パテント ゲーエムベーハー Waste paper cutting rotor
JP4934881B2 (en) * 2007-05-23 2012-05-23 ボイス パテント ゲーエムベーハー Waste paper cutting rotor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA947214A (en) * 1971-04-02 1974-05-14 Antoine D'iorio Resolution of racemates of ring-substituted phenylalanines
US3878043A (en) * 1973-01-02 1975-04-15 Univ Southern Illinois Method for preparing L-dopa and novels compounds useful therein

Also Published As

Publication number Publication date
EP0178553A3 (en) 1987-04-29
PT81320B (en) 1987-05-18
CS258132B2 (en) 1988-07-15
ATE56472T1 (en) 1990-09-15
FI854025A0 (en) 1985-10-16
FI854025L (en) 1986-04-19
ES547901A0 (en) 1986-09-01
ZA857971B (en) 1986-05-28
DE3438189A1 (en) 1986-04-24
NO854127L (en) 1986-04-21
HUT39414A (en) 1986-09-29
DK475585A (en) 1986-04-19
IL76740A0 (en) 1986-02-28
FI854025A7 (en) 1986-04-19
EP0178553B1 (en) 1990-09-12
GR852491B (en) 1986-02-11
EP0178553A2 (en) 1986-04-23
CS738585A2 (en) 1987-12-17
PT81320A (en) 1985-11-01
CA1265083A (en) 1990-01-30
JPS61108398A (en) 1986-05-27
ES8609186A1 (en) 1986-09-01
DE3579663D1 (en) 1990-10-18

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