DK420789A - Neuropeptid agonister - Google Patents

Neuropeptid agonister

Info

Publication number: DK420789A
Authority: DK; Denmark
Prior art keywords: agonists; neuropeptid; npy; derivatives; agonism
Prior art date: 1988-08-26

Application number

DK420789A

Other languages

English (en)

Other versions

DK420789D0 (da

Inventor

John L Krstenansky

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-08-26

Filing date

1989-08-25

Publication date

1990-02-27

1989-08-25 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1989-08-25 Publication of DK420789D0 publication Critical patent/DK420789D0/da

1990-02-27 Publication of DK420789A publication Critical patent/DK420789A/da

Links

239000000556 agonist Substances 0.000 title abstract 2
101710151321 Melanostatin Proteins 0.000 abstract 3
102400000064 Neuropeptide Y Human genes 0.000 abstract 3
URPYMXQQVHTUDU-OFGSCBOVSA-N nucleopeptide y Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=C(O)C=C1 URPYMXQQVHTUDU-OFGSCBOVSA-N 0.000 abstract 3
230000008484 agonism Effects 0.000 abstract 1
238000010256 biochemical assay Methods 0.000 abstract 1
238000012875 competitive assay Methods 0.000 abstract 1
230000009137 competitive binding Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57545—Neuropeptide Y
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Biophysics (AREA)
Chemical Kinetics & Catalysis (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Endocrinology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK420789A 1988-08-26 1989-08-25 Neuropeptid agonister DK420789A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US23759188A	1988-08-26	1988-08-26

Publications (2)

Publication Number	Publication Date
DK420789D0 DK420789D0 (da)	1989-08-25
DK420789A true DK420789A (da)	1990-02-27

Family

ID=22894367

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK420789A DK420789A (da)	1988-08-26	1989-08-25	Neuropeptid agonister

Country Status (17)

Country	Link
EP (1)	EP0355793B1 (da)
JP (1)	JP2791955B2 (da)
KR (1)	KR0149160B1 (da)
CN (1)	CN1042155A (da)
AT (1)	ATE140235T1 (da)
AU (1)	AU618118B2 (da)
CA (1)	CA1341336C (da)
DE (1)	DE68926804T2 (da)
DK (1)	DK420789A (da)
ES (1)	ES2091757T3 (da)
FI (1)	FI894006A7 (da)
HU (1)	HU204852B (da)
IL (1)	IL91395A0 (da)
NO (1)	NO893430L (da)
NZ (1)	NZ230384A (da)
PT (1)	PT91538B (da)
ZA (1)	ZA896376B (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993009227A1 (en) *	1991-11-06	1993-05-13	Garvan Institute Of Medical Research	Human neuropeptide y-y1 receptor
AU662032B2 (en) *	1991-12-19	1995-08-17	Garvan Institute Of Medical Research	A novel molecule which inhibits neuropeptide tyrosine biological function
CA2126212A1 (en) *	1991-12-19	1993-07-08	Albert Tseng	A novel molecule which inhibits neuropeptide tyrosine biological function
GB9213215D0 (en) *	1992-06-20	1992-08-05	Wellcome Found	Peptides
CA2165200A1 (en) *	1993-06-18	1995-01-05	Ambikaipakan Balasubramaniam	Neuropeptide y antagonists and agonists
US5516653A (en)	1993-12-28	1996-05-14	Synaptic Pharmaceutical Corporation	DNA encoding a human neuropeptide Y/peptide YY/pancreatic polypeptide receptor (Y4) and uses thereof
US5545549A (en) *	1994-02-03	1996-08-13	Synaptic Pharmaceutical Corporation	DNA encoding a human neuropeptide Y/peptide YY (Y2) receptor and uses thereof
US5989920A (en) *	1994-12-02	1999-11-23	Synaptic Pharmaceutical Corporation	Methods of modifying feeding behavior compounds useful in such methods and DNA encoding a hypothalmic atypical neuropeptide Y/peptide YY receptor Y5
US5602024A (en)	1994-12-02	1997-02-11	Synaptic Pharmaceutical Corporation	DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5) and uses thereof
AUPN646795A0 (en)	1995-11-09	1995-11-30	Garvan Institute Of Medical Research	Neuropeptide Y-Y5 receptor
DE19652033A1 (de) *	1996-12-13	1998-06-18	Irmgard Dr Med Guertner	Neuropeptid (CGRP) als Modulator zur Zelldifferenzierung und Proliferation
US6713265B1 (en)	1997-06-04	2004-03-30	Synaptic Pharmaceutical Corporation	Methods of modifying feeding behavior, compounds useful in such methods, and DNA encoding a hypothalamic atypical neuropeptide Y/peptide YY receptor (Y5)
ZA200508439B (en)	2003-05-05	2007-03-28	Probiodrug Ag	Medical use of inhibitors of glutaminyl and glutamate cyclases
EP1680120A2 (en)	2003-11-03	2006-07-19	Probiodrug AG	Combinations useful for the treatment of neuronal disorders
CA2554809C (en)	2004-02-05	2014-04-29	Probiodrug Ag	Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase
JP5379692B2 (ja)	2006-11-09	2013-12-25	プロビオドルグエージー	潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
US9126987B2 (en)	2006-11-30	2015-09-08	Probiodrug Ag	Inhibitors of glutaminyl cyclase
AU2008220785B2 (en)	2007-03-01	2013-02-21	Vivoryon Therapeutics N.V.	New use of glutaminyl cyclase inhibitors
JP5667440B2 (ja)	2007-04-18	2015-02-12	プロビオドルグエージー	グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
NZ598685A (en)	2009-09-11	2013-05-31	Probiodrug Ag	Heterocylcic derivatives as inhibitors of glutaminyl cyclase
JP6026284B2 (ja)	2010-03-03	2016-11-16	プロビオドルグエージー	グルタミニルシクラーゼの阻害剤
DK2545047T3 (da)	2010-03-10	2014-07-28	Probiodrug Ag	Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5)
EP2560953B1 (en)	2010-04-21	2016-01-06	Probiodrug AG	Inhibitors of glutaminyl cyclase
US8530670B2 (en)	2011-03-16	2013-09-10	Probiodrug Ag	Inhibitors
EP3461819B1 (en)	2017-09-29	2020-05-27	Probiodrug AG	Inhibitors of glutaminyl cyclase
CN111494606B (zh) *	2020-04-24	2021-12-14	广州医科大学	神经肽y的新应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3811193A1 (de) *	1988-04-01	1989-10-19	Boehringer Ingelheim Kg	Neue peptide, verfahren zu ihrer herstellung und diese peptide enthaltende pharmazeutische zusammensetzungen

1989
- 1989-08-21 ZA ZA896376A patent/ZA896376B/xx unknown
- 1989-08-22 NZ NZ230384A patent/NZ230384A/en unknown
- 1989-08-22 JP JP1214292A patent/JP2791955B2/ja not_active Expired - Lifetime
- 1989-08-22 AT AT89115469T patent/ATE140235T1/de not_active IP Right Cessation
- 1989-08-22 DE DE68926804T patent/DE68926804T2/de not_active Expired - Lifetime
- 1989-08-22 ES ES89115469T patent/ES2091757T3/es not_active Expired - Lifetime
- 1989-08-22 EP EP89115469A patent/EP0355793B1/en not_active Expired - Lifetime
- 1989-08-23 IL IL91395A patent/IL91395A0/xx unknown
- 1989-08-23 CA CA000609198A patent/CA1341336C/en not_active Expired - Lifetime
- 1989-08-24 PT PT91538A patent/PT91538B/pt not_active IP Right Cessation
- 1989-08-24 KR KR1019890012042A patent/KR0149160B1/ko not_active Expired - Lifetime
- 1989-08-25 HU HU894419A patent/HU204852B/hu not_active IP Right Cessation
- 1989-08-25 CN CN89106524A patent/CN1042155A/zh active Pending
- 1989-08-25 DK DK420789A patent/DK420789A/da not_active Application Discontinuation
- 1989-08-25 FI FI894006A patent/FI894006A7/fi not_active Application Discontinuation
- 1989-08-25 NO NO89893430A patent/NO893430L/no unknown
- 1989-08-28 AU AU40828/89A patent/AU618118B2/en not_active Expired

Also Published As

Publication number	Publication date
ES2091757T3 (es)	1996-11-16
KR900002799A (ko)	1990-03-23
EP0355793B1 (en)	1996-07-10
EP0355793A3 (en)	1992-04-22
HU204852B (en)	1992-02-28
IL91395A0 (en)	1990-04-29
CN1042155A (zh)	1990-05-16
AU4082889A (en)	1990-03-01
DE68926804D1 (de)	1996-08-14
FI894006A0 (fi)	1989-08-25
NZ230384A (en)	1996-03-26
PT91538A (pt)	1990-03-08
EP0355793A2 (en)	1990-02-28
JPH02111794A (ja)	1990-04-24
NO893430D0 (no)	1989-08-25
FI894006L (fi)	1990-02-27
ATE140235T1 (de)	1996-07-15
HUT50849A (en)	1990-03-28
KR0149160B1 (ko)	1998-10-15
AU618118B2 (en)	1991-12-12
ZA896376B (en)	1990-05-30
FI894006A7 (fi)	1990-02-27
DE68926804T2 (de)	1996-12-12
PT91538B (pt)	1995-05-04
NO893430L (no)	1990-02-27
DK420789D0 (da)	1989-08-25
JP2791955B2 (ja)	1998-08-27
CA1341336C (en)	2002-01-29

Publication	Publication Date	Title
DK420789D0 (da)	1989-08-25	Neuropeptid agonister
FI894007A0 (fi)	1989-08-25	Neuropeptid y-antagonister.
DE69024364D1 (de)	1996-02-01	Verstärkter chemilumineszenzassay
DE68906894D1 (de)	1993-07-08	Erfassung von verbrauchswerten.
FI904414A7 (fi)	1990-09-07	Tiatsolidiinidioni-hypoglykeemisesti vaikuttavat aineet
DE69025233D1 (de)	1996-03-21	Vorlade-Architektur von integrierten Speichern
DE69020436D1 (de)	1995-08-03	Feststellung der Registermarken.
TR23354A (tr)	1989-12-19	Bazi suebstituee edilmis karboksamidotioazaller ile fungisid olarak etkili bir veya daha fazla bilesikten olusan sinerjist etkili bir fungisid terkibi ve bunun bitki korumasinda kullanimi
IT1182425B (it)	1987-10-05	Materiali di rinforzo particolarmente per cuoio e relativo procedimento di fabbricazione
DE68925335D1 (de)	1996-02-15	Harzzusammensetzung und ihre Verwendung
DK519388D0 (da)	1988-09-16	Agglutinationsanalyse
DK163540C (da)	1992-08-03	Optisk integreret boelgelederkomponent
TR23016A (tr)	1989-01-16	Hamam boeceklerinin oenlenmesinde kullanilan,yenilik arzeden bilesimler ve yoentemler
KR890006511U (ko)	1989-05-13	보조척이 부설된 척
KR900008107U (ko)	1990-05-01	당구대의 포인트 눈금자
KR890000450U (ko)	1989-03-10	수동드릴의 작업대
SE8801759D0 (sv)	1988-05-10	Deck och innerslangs monteringsverktyg
KR860008427U (ko)	1986-07-24	키이 보오드 덱의 다각 경사장치
KR900012985U (ko)	1990-07-04	다용도게시판용 이동구
IT8722913A0 (it)	1987-12-09	Mescolatore pneumatico di materiali aridi.
BR6700486U (pt)	1988-10-04	Kit de perfuracao
BR6700535U (pt)	1988-10-25	Kit de perfuracao
SE8403509D0 (sv)	1984-07-03	Verktyg med hyvel och rivfunktion forsett med skaft
SE8506127D0 (sv)	1985-12-23	Femurfrakturortos med inbyggt streck

Legal Events

Date	Code	Title	Description
1993-09-13	ATS	Application withdrawn