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DK41590D0 - Forbedrede protein c-molekyler samt fremgangsmaade til fremstilling og aktivering af samme - Google Patents

Forbedrede protein c-molekyler samt fremgangsmaade til fremstilling og aktivering af samme

Info

Publication number
DK41590D0
DK41590D0 DK041590A DK41590A DK41590D0 DK 41590 D0 DK41590 D0 DK 41590D0 DK 041590 A DK041590 A DK 041590A DK 41590 A DK41590 A DK 41590A DK 41590 D0 DK41590 D0 DK 41590D0
Authority
DK
Denmark
Prior art keywords
molecules
activation
procedures
preparation
same
Prior art date
Application number
DK041590A
Other languages
English (en)
Other versions
DK41590A (da
Inventor
Robert M Wydro
Catherine L Oppenheimer
Debra A Barngrover
Dawn T Ferrara
William R Dackowski
Gregory M Landes
Nancy A Capalucci
Original Assignee
Integrated Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Integrated Genetics Inc filed Critical Integrated Genetics Inc
Publication of DK41590D0 publication Critical patent/DK41590D0/da
Publication of DK41590A publication Critical patent/DK41590A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/20043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
DK041590A 1987-05-18 1990-02-16 Forbedrede protein c-molekyler samt fremgangsmaade til fremstilling og aktivering af samme DK41590A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5136687A 1987-05-18 1987-05-18
PCT/US1988/002083 WO1989012685A1 (en) 1987-05-18 1988-06-17 Improved protein c molecules and method for making and activating same

Publications (2)

Publication Number Publication Date
DK41590D0 true DK41590D0 (da) 1990-02-16
DK41590A DK41590A (da) 1990-04-11

Family

ID=22208746

Family Applications (1)

Application Number Title Priority Date Filing Date
DK041590A DK41590A (da) 1987-05-18 1990-02-16 Forbedrede protein c-molekyler samt fremgangsmaade til fremstilling og aktivering af samme

Country Status (4)

Country Link
EP (1) EP0380508A4 (da)
JP (1) JPH03501921A (da)
DK (1) DK41590A (da)
WO (1) WO1989012685A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT95193A (pt) * 1989-09-05 1991-05-22 Lilly Co Eli Metodo para actividade da proteina c
AU7168591A (en) * 1989-12-29 1991-07-24 Zymogenetics Inc. Hybrid protein c
US5358932A (en) * 1989-12-29 1994-10-25 Zymogenetics, Inc. Hybrid protein C
ES2052368T3 (es) * 1990-01-26 1994-07-01 Immuno Ag Factores sanguineos producidos por recombinacion y el proceso para la expresion de dichos factores, asi como recombinacion del virus de vaccina usados en dicho proceso.
JP3043558B2 (ja) * 1993-10-29 2000-05-22 財団法人化学及血清療法研究所 ヒト活性化プロテインｃ調製物及びその製法
WO2004113385A1 (en) * 2003-06-20 2004-12-29 Maxygen Holdings Ltd. Protein c propeptide variants
CA2539434C (en) 2003-09-23 2014-03-18 University Of North Carolina At Chapel Hill Methods and compositions for the correlation of single nucleotide polymorphisms in the vitamin k epoxide reductase gene and warfarin dosage
GB0324044D0 (en) 2003-10-14 2003-11-19 Astrazeneca Ab Protein
AU2005329450A1 (en) * 2005-03-15 2006-09-28 University Of North Carolina At Chapel Hill Methods and compositions for producing active Vitamin K-dependent proteins
CA2602793C (en) * 2005-04-13 2016-11-22 Astrazeneca Ab A host cell comprising a vector for production of proteins requiring gamma-carboxylation
US8206967B2 (en) 2007-07-06 2012-06-26 Medimmune Limited Method for production of recombinant human thrombin
US9631002B2 (en) 2010-12-21 2017-04-25 The University Of North Carolina At Chapel Hill Methods and compositions for producing active vitamin K-dependent proteins
WO2014005183A1 (en) 2012-07-04 2014-01-09 The University Of Sydney Treatment of inflammatory skin disorders
ES2890675T3 (es) 2014-04-16 2022-01-21 Zz Biotech Llc APC para uso en el tratamiento de cicatrices cutáneas anormales
AU2015246656B2 (en) 2014-04-16 2020-06-18 Zz Biotech Llc Use of APC analogue for wound healing

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4189534A (en) * 1976-11-11 1980-02-19 Massachusetts Institute Of Technology Cell culture microcarriers
US4579821A (en) * 1981-11-23 1986-04-01 University Patents, Inc. Control of DNA sequence transcription
US4775624A (en) * 1985-02-08 1988-10-04 Eli Lilly And Company Vectors and compounds for expression of human protein C
GR860984B (en) * 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
US4751084A (en) * 1986-02-26 1988-06-14 Monsanto Company Tissue plasminogen activator from normal human colon cells
EP0245949B1 (en) * 1986-04-09 1997-10-29 Eli Lilly And Company A method of using eukaryotic expression vectors comprising the bk virus enhancer
IL82648A0 (en) * 1986-05-27 1987-11-30 Lilly Co Eli Human protein s,a plasma protein regulator of hemostasis
ZA889497B (en) * 1987-12-28 1990-08-29 Lilly Co Eli Vectors and compounds for expression of zymogen forms of human protein c

Also Published As

Publication number Publication date
WO1989012685A1 (en) 1989-12-28
EP0380508A4 (en) 1991-04-03
EP0380508A1 (en) 1990-08-08
DK41590A (da) 1990-04-11
JPH03501921A (ja) 1991-05-09

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