[go: up one dir, main page]

DK375989A - Purinderivater - Google Patents

Purinderivater Download PDF

Info

Publication number
DK375989A
DK375989A DK375989A DK375989A DK375989A DK 375989 A DK375989 A DK 375989A DK 375989 A DK375989 A DK 375989A DK 375989 A DK375989 A DK 375989A DK 375989 A DK375989 A DK 375989A
Authority
DK
Denmark
Prior art keywords
purine derivatives
purine
derivatives
Prior art date
Application number
DK375989A
Other languages
English (en)
Other versions
DK375989D0 (da
Inventor
Stuart Bailey
Michael Raymond Harnden
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB888818375A external-priority patent/GB8818375D0/en
Priority claimed from GB888827724A external-priority patent/GB8827724D0/en
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of DK375989D0 publication Critical patent/DK375989D0/da
Publication of DK375989A publication Critical patent/DK375989A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D473/00Heterocyclic compounds containing purine ring systems
    • C07D473/02Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006Esters of acyclic acids which can have further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503Five-membered rings
    • C07F9/6506Five-membered rings having the nitrogen atoms in positions 1 and 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509Six-membered rings
    • C07F9/6512Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK375989A 1988-08-02 1989-07-31 Purinderivater DK375989A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888818375A GB8818375D0 (en) 1988-08-02 1988-08-02 Novel compounds
GB888827724A GB8827724D0 (en) 1988-11-28 1988-11-28 Novel compounds

Publications (2)

Publication Number Publication Date
DK375989D0 DK375989D0 (da) 1989-07-31
DK375989A true DK375989A (da) 1990-02-03

Family

ID=26294230

Family Applications (1)

Application Number Title Priority Date Filing Date
DK375989A DK375989A (da) 1988-08-02 1989-07-31 Purinderivater

Country Status (8)

Country Link
US (1) US5055458A (da)
EP (1) EP0353955A3 (da)
JP (1) JPH0288591A (da)
KR (1) KR900003170A (da)
AU (1) AU614863B2 (da)
DK (1) DK375989A (da)
NZ (1) NZ230144A (da)
PT (1) PT91330A (da)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5247085A (en) * 1987-11-30 1993-09-21 Beecham Group P.L.C. Antiviral purine compounds
GB8907173D0 (en) * 1989-03-30 1989-05-10 Beecham Group Plc Novel compounds
GB8912043D0 (en) * 1989-05-25 1989-07-12 Beecham Group Plc Novel compounds
FI930192A7 (fi) * 1990-07-19 1993-01-18 Beecham Group Plc Puriinien virusvastaiset fosfonoalkeenijohdannaiset
EP0481214B1 (en) * 1990-09-14 1998-06-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates
US5208221A (en) * 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
GB9026164D0 (en) * 1990-12-01 1991-01-16 Beecham Group Plc Pharmaceuticals
GB9107896D0 (en) * 1991-04-13 1991-05-29 Smithkline Beecham Plc Pharmaceuticals
EP0531597A1 (en) * 1991-09-12 1993-03-17 Merrell Dow Pharmaceuticals Inc. Novel unsaturated acyclic phosphonate derivatives of purine and pyrimidine
GB9205917D0 (en) * 1992-03-18 1992-04-29 Smithkline Beecham Plc Pharmaceuticals
CA2159631A1 (en) * 1993-03-30 1994-10-13 Sanofi Acyclic nucleoside analogs and oligonucleotide sequences containing them
US5817647A (en) * 1993-04-01 1998-10-06 Merrell Pharmaceuticals Inc. Unsaturated acetylene phosphonate derivatives of purines
US5798340A (en) 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
AU690587B2 (en) * 1993-09-17 1998-04-30 Gilead Sciences, Inc. Method for dosing therapeutic compounds
US5789589A (en) * 1996-04-22 1998-08-04 Drug Innovation & Design, Inc. Guanine analog phosphates
EP0981532B1 (en) * 1997-05-15 2002-08-28 Drug Innovation & Design, Inc. Acyclovir diester derivatives
US6180790B1 (en) 1997-05-15 2001-01-30 Drug Innovation And Design, Inc. Methods of preparing acyclovir prodrugs
US6653318B1 (en) 1999-07-21 2003-11-25 Yale University 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
CN100526315C (zh) 2005-06-16 2009-08-12 浙江医药股份有限公司新昌制药厂 N2-喹啉或异喹啉取代的嘌呤衍生物及其制备方法和其用途
CN101289449A (zh) 2007-04-20 2008-10-22 浙江医药股份有限公司新昌制药厂 2,6-二含氮取代的嘌呤衍生物及其制备方法和应用
CN104666315A (zh) 2010-12-10 2015-06-03 西格玛制药实验有限责任公司 口服活性核苷酸类似物或口服活性核苷酸类似物前药的高度稳定组合物
WO2014056138A1 (en) * 2012-10-08 2014-04-17 Dow Global Technologies Llc Organophosphorus compounds for flame retardant polyurethane foams
US9528269B2 (en) 2014-06-09 2016-12-27 Johns Manville Roofing systems and roofing boards with non-halogenated fire retardant
US9815256B2 (en) 2014-06-09 2017-11-14 Johns Manville Foam boards including non-halogenated fire retardants
US9523195B2 (en) 2014-06-09 2016-12-20 Johns Manville Wall insulation boards with non-halogenated fire retardant and insulated wall systems
US9815966B2 (en) 2014-07-18 2017-11-14 Johns Manville Spray foams containing non-halogenated fire retardants

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0138683A3 (en) * 1983-09-30 1988-01-20 Merck & Co. Inc. Purine derivatives, their application in anti-viral compositions
CS263952B1 (en) * 1985-04-25 1989-05-12 Holy Antonin Remedy with antiviral effect
CS263951B1 (en) * 1985-04-25 1989-05-12 Antonin Holy 9-(phosponylmethoxyalkyl)adenines and method of their preparation
MY101126A (en) * 1985-12-13 1991-07-31 Beecham Group Plc Novel compounds
GB8713695D0 (en) * 1987-06-11 1987-07-15 Beecham Group Plc Process
GB8712744D0 (en) * 1987-05-30 1987-07-01 Beecham Group Plc Active compounds
GB8724765D0 (en) * 1987-10-22 1987-11-25 Beecham Group Plc Process
NZ227104A (en) * 1987-11-30 1991-11-26 Beecham Group Plc Phosphorus-substituted purine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
AU614863B2 (en) 1991-09-12
US5055458A (en) 1991-10-08
DK375989D0 (da) 1989-07-31
EP0353955A3 (en) 1991-08-14
JPH0288591A (ja) 1990-03-28
EP0353955A2 (en) 1990-02-07
PT91330A (pt) 1990-03-08
AU3913989A (en) 1990-02-08
KR900003170A (ko) 1990-03-23
NZ230144A (en) 1991-09-25

Similar Documents

Publication Publication Date Title
DK375989A (da) Purinderivater
DE3856154D1 (de) Adenosin-Derivate
DE68927948D1 (de) Trehalosderivate
DE68925161D1 (de) Alkylavermectin-Derivate
DK23489A (da) Nucleosidderivater
DK491389D0 (da) Substituerede 9h-purinderivater
FI940167A7 (fi) Puriinijohdannaisia
DK19789D0 (da) Dehydrocholcalciferolderivater
TR24894A (tr) N-FENILPIRAZOL TüREVLERI
DK507188A (da) Cholecalciferolderivater
DE68927657D1 (de) Butynylaminderivate
FI953127A0 (fi) Puriinijohdannaisia
DK486089D0 (da) Pyranobenzoxadiazolderivater
DK378088D0 (da) Alkenderivater
FI922014A7 (fi) Nukleosidijohdannaiset
DK49688D0 (da) Propiolophenonderivater
DK71187A (da) Purinderivater
DK626989A (da) Adenosinderivater
FI895871A7 (fi) Uusia bentsopyranyylipyrrolinonijohdannaisia
DK339189A (da) Purinderivater
DK271088D0 (da) Tienopyridinderivater
DK160389A (da) Aryldionderivater
ATA155589A (de) Mitomycinphosphat-derivate
DK695788D0 (da) Naphtalenderivater
DK324489D0 (da) Substituerede azacyclohexylderivater

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment