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DK3679016T3 - Faste former af 2-(5-(4-(2-morpholinethoxy)phenyl)pyridin-2-yl)-n-benzylacetamid - Google Patents

Faste former af 2-(5-(4-(2-morpholinethoxy)phenyl)pyridin-2-yl)-n-benzylacetamid

Info

Publication number
DK3679016T3
DK3679016T3 DK18854688.1T DK18854688T DK3679016T3 DK 3679016 T3 DK3679016 T3 DK 3679016T3 DK 18854688 T DK18854688 T DK 18854688T DK 3679016 T3 DK3679016 T3 DK 3679016T3
Authority
DK
Denmark
Prior art keywords
morpholinethoxy
benzylacetamide
pyridin
phenyl
solid forms
Prior art date
Application number
DK18854688.1T
Other languages
English (en)
Inventor
Michael P Smolinski
Original Assignee
Atnx Spv Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=65517772&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3679016(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Atnx Spv Llc filed Critical Atnx Spv Llc
Application granted granted Critical
Publication of DK3679016T3 publication Critical patent/DK3679016T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56Amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK18854688.1T 2017-09-07 2018-09-07 Faste former af 2-(5-(4-(2-morpholinethoxy)phenyl)pyridin-2-yl)-n-benzylacetamid DK3679016T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762555390P 2017-09-07 2017-09-07
PCT/US2018/049829 WO2019051147A1 (en) 2017-09-07 2018-09-07 SOLID FORMS OF 2- (5- (4- (2-MORPHOLINOETHOXY) PHENYL) PYRIDIN-2-YL) -N-BENZYLACETAMIDE

Publications (1)

Publication Number Publication Date
DK3679016T3 true DK3679016T3 (da) 2025-12-15

Family

ID=65517772

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18854688.1T DK3679016T3 (da) 2017-09-07 2018-09-07 Faste former af 2-(5-(4-(2-morpholinethoxy)phenyl)pyridin-2-yl)-n-benzylacetamid

Country Status (17)

Country Link
US (4) US10669236B2 (da)
EP (2) EP3679016B1 (da)
JP (3) JP2020533412A (da)
KR (2) KR20240119192A (da)
CN (2) CN118439992A (da)
AU (2) AU2018330163B2 (da)
BR (1) BR112020004419A2 (da)
CA (1) CA3074831A1 (da)
DK (1) DK3679016T3 (da)
FI (1) FI3679016T3 (da)
IL (1) IL272992A (da)
LT (1) LT3679016T (da)
MX (2) MX2020002622A (da)
PT (1) PT3679016T (da)
SG (1) SG11202001868RA (da)
TW (1) TWI815820B (da)
WO (1) WO2019051147A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7968574B2 (en) * 2004-12-28 2011-06-28 Kinex Pharmaceuticals, Llc Biaryl compositions and methods for modulating a kinase cascade
EP4186890A1 (en) 2021-11-29 2023-05-31 Moehs Ibérica, S.L. Preparation of n-benzyl-2-(5-bromo-pyridin-2-yl)-acetamide for the synthesis of tirbanibulin
CN115010655A (zh) * 2022-07-21 2022-09-06 重庆迈德凯医药有限公司 一种替尼布林的纯化方法
WO2026022219A1 (en) 2024-07-24 2026-01-29 Almirall, S.A. Injectable formulations comprising tirbanibulin

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US7141593B1 (en) * 1999-06-04 2006-11-28 Abbott Laboratories Pharmaceutical formulations
PL367091A1 (en) * 2001-05-22 2005-02-21 Pfizer Products Inc. Crystal forms of azithromycin
US6821502B2 (en) * 2002-06-12 2004-11-23 Chevron U.S.A. Inc. Method of making aluminum-containing zeolite with IFR structure
US7351833B2 (en) * 2004-07-23 2008-04-01 Abbott Laboratories (1S,5S)-3-(5,6-dichloropyridin-3-yl)-3,6-diazabicyclo[3.2.0]heptane benzenesulfonate
US7968574B2 (en) 2004-12-28 2011-06-28 Kinex Pharmaceuticals, Llc Biaryl compositions and methods for modulating a kinase cascade
BRPI0519424B8 (pt) 2004-12-28 2021-05-25 Athenex Inc compostos, composição e uso dos ditos compostos para a preparação de um medicamento para prevenção ou tratamento de um distúrbio de proliferação celular ou infecção microbiana
MY152185A (en) * 2005-06-10 2014-08-29 Novartis Ag Modified release 1-[(3-hydroxy-adamant-1-ylamino)-acetyl]-pyrrolidine-2(s)-carbonitrile formulation
US7642246B2 (en) * 2005-09-13 2010-01-05 Sicor Inc. Pure rocuronium bromide
WO2008002676A2 (en) * 2006-06-29 2008-01-03 Kinex Pharmaceuticals, Llc Biaryl compositions and methods for modulating a kinase cascade
CN101528212A (zh) * 2006-09-28 2009-09-09 默克公司 Hdac抑制剂和可螯合的金属化合物的药物组合物以及金属-hdac抑制剂螯合物
US7837978B2 (en) * 2006-10-13 2010-11-23 Chevron U.S.A. Inc. Process for preparing aluminum-containing molecular sieve SSZ-26
PE20081506A1 (es) * 2006-12-12 2008-12-09 Infinity Discovery Inc Formulaciones de ansamicina
US7935697B2 (en) * 2006-12-28 2011-05-03 Kinex Pharmaceuticals, Llc Compositions for modulating a kinase cascade and methods of use thereof
US7939529B2 (en) 2007-05-17 2011-05-10 Kinex Pharmaceuticals, Llc Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof
TWI457336B (zh) * 2006-12-28 2014-10-21 Kinex Pharmaceuticals Llc 調節激酶級聯之組成物及方法
EP2160394A1 (en) * 2007-05-22 2010-03-10 Ultimorphix Technologies B.v. Tenofovir disoproxil hemi-fumaric acid co-crystal
WO2015069217A1 (en) * 2013-11-05 2015-05-14 Baylor College Of Medicine Src kinase inhibition as treatment for lympangioleiomyomatosis and tuberous sclerosis
CN106810490A (zh) * 2017-02-06 2017-06-09 重庆泰润制药有限公司 一种二芳基化合物的晶型及其制备方法和应用
AU2018231144B2 (en) 2017-03-10 2023-12-21 Atnx Spv, Llc Methods of treating and/or preventing actinic keratosis

Also Published As

Publication number Publication date
SG11202001868RA (en) 2020-03-30
MX2020002622A (es) 2020-10-01
KR20240119192A (ko) 2024-08-06
AU2018330163A1 (en) 2020-03-26
IL272992A (en) 2020-04-30
PT3679016T (pt) 2025-12-05
CA3074831A1 (en) 2019-03-14
BR112020004419A2 (pt) 2020-09-08
AU2018330163B2 (en) 2023-02-02
EP3679016A4 (en) 2021-09-29
JP2025131661A (ja) 2025-09-09
RU2020112539A (ru) 2021-10-08
TWI815820B (zh) 2023-09-21
CN118439992A (zh) 2024-08-06
EP3679016A1 (en) 2020-07-15
US11230527B2 (en) 2022-01-25
RU2020112539A3 (da) 2022-04-19
EP4674486A2 (en) 2026-01-07
CN111278808A (zh) 2020-06-12
JP2020533412A (ja) 2020-11-19
FI3679016T3 (fi) 2025-12-12
US10669236B2 (en) 2020-06-02
LT3679016T (lt) 2026-02-10
US20200255380A1 (en) 2020-08-13
TW201920160A (zh) 2019-06-01
US20250115555A1 (en) 2025-04-10
AU2023201010B2 (en) 2024-10-03
KR20200081359A (ko) 2020-07-07
US12215083B2 (en) 2025-02-04
WO2019051147A1 (en) 2019-03-14
JP2023157909A (ja) 2023-10-26
KR102691700B1 (ko) 2024-08-02
AU2023201010A1 (en) 2023-03-23
US20190071402A1 (en) 2019-03-07
EP3679016B1 (en) 2025-11-05
MX2023001805A (es) 2023-03-13
CN111278808B (zh) 2024-04-26
US20220098152A1 (en) 2022-03-31

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