DK364285D0 - Immunogene konjugater af e. coli ltb-enterotoxinunderenhed og kapsulaere polymere - Google Patents
Immunogene konjugater af e. coli ltb-enterotoxinunderenhed og kapsulaere polymereInfo
- Publication number
- DK364285D0 DK364285D0 DK364285A DK364285A DK364285D0 DK 364285 D0 DK364285 D0 DK 364285D0 DK 364285 A DK364285 A DK 364285A DK 364285 A DK364285 A DK 364285A DK 364285 D0 DK364285 D0 DK 364285D0
- Authority
- DK
- Denmark
- Prior art keywords
- enterotoxin
- conjugates
- unit
- immunogenic conjugates
- capsular
- Prior art date
Links
- 230000002163 immunogen Effects 0.000 title abstract 3
- 229920000642 polymer Polymers 0.000 title abstract 3
- 101710146739 Enterotoxin Proteins 0.000 title abstract 2
- 239000000147 enterotoxin Substances 0.000 title abstract 2
- 231100000655 enterotoxin Toxicity 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000001727 anti-capsular Effects 0.000 abstract 1
- 244000052616 bacterial pathogen Species 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1239—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Vibrionaceae (G)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G01N33/56916—Enterobacteria, e.g. shigella, salmonella, klebsiella, serratia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/831—Drug, bio-affecting and body treating compositions involving capsular polysaccharide of bacterium, e.g. polyribosyl ribitol phosphate
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/807—Hapten conjugated with peptide or protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
- Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Mycology (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/639,293 US4808700A (en) | 1984-07-09 | 1984-08-10 | Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers |
| US63929384 | 1984-08-10 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK364285D0 true DK364285D0 (da) | 1985-08-09 |
| DK364285A DK364285A (da) | 1986-02-11 |
| DK167879B1 DK167879B1 (da) | 1993-12-27 |
Family
ID=24563526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK364285A DK167879B1 (da) | 1984-08-10 | 1985-08-09 | Immunogent konjugat, fremgangsmaade til fremstilling deraf samt vaccine omfattende et saadant konjugat og kapsulaert polymerfragment til fremstilling af konjugatet |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4808700A (da) |
| EP (1) | EP0172107B1 (da) |
| JP (1) | JPH0811737B2 (da) |
| AT (1) | ATE71533T1 (da) |
| AU (1) | AU599570B2 (da) |
| CA (1) | CA1316474C (da) |
| DE (1) | DE3585185D1 (da) |
| DK (1) | DK167879B1 (da) |
| ES (1) | ES8707861A1 (da) |
| IE (1) | IE57784B1 (da) |
| WO (1) | WO1986001228A1 (da) |
Families Citing this family (131)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5137721A (en) * | 1981-03-09 | 1992-08-11 | Cetus Corporation | Employing strains of E. coli expressing non-indigenous adhesins and toxoids of E. coli |
| US5360897A (en) * | 1981-08-31 | 1994-11-01 | The University Of Rochester | Immunogenic conjugates of streptococcus pneumonial capsular polymer and toxin or in toxiad |
| US4902506A (en) * | 1983-07-05 | 1990-02-20 | The University Of Rochester | Immunogenic conjugates |
| CA1340372C (en) * | 1984-07-09 | 1999-02-02 | John D. Clements | Production of e. coli lt-b enterotoxin subunit |
| IL78775A (en) * | 1985-05-15 | 1992-06-21 | Biotech Australia Pty Ltd | Oral vaccines |
| US5374426A (en) * | 1986-09-03 | 1994-12-20 | University Of Saskatchewan | Rotavirus nucleocapsid protein VP6 in vaccine compositions |
| US5112749A (en) * | 1987-10-02 | 1992-05-12 | Praxis Biologics, Inc. | Vaccines for the malaria circumsporozoite protein |
| US5785973A (en) * | 1988-02-01 | 1998-07-28 | Praxis Biologics, Inc. | Synthetic peptides representing a T-cell epitope as a carrier molecule for conjugate vaccines |
| AU634153B2 (en) * | 1988-02-01 | 1993-02-18 | Wyeth Holdings Corporation | T-cell epitope as carriers molecule for conjugate vaccines |
| US6043057A (en) * | 1988-09-16 | 2000-03-28 | Vitec Aktiebolag | Recombinant systems for expression of the cholera B-sub-unit with the aid of foreign promoters and/or leader peptides |
| US6413523B1 (en) | 1989-06-02 | 2002-07-02 | The United States Of America As Represented By The Secretary Of The Navy | Pharmaceutical composition of escherichia coli heat-labile enterotoxin adjuvant and methods of use |
| ATE168272T1 (de) * | 1989-10-27 | 1998-08-15 | Arch Dev Corp | Zusammensetzungen und deren verwendung zur förderung der immunopotentiation |
| GB9021671D0 (en) * | 1990-10-05 | 1990-11-21 | Unilever Plc | Delivery of agents |
| NO175188C (no) * | 1990-06-27 | 1994-09-14 | Sjur Olsnes | Fremgangsmåte for fremstilling av et peptidkonjugat med evne til å trenge inn i cellecytosol |
| US5153312A (en) * | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
| US5843463A (en) * | 1990-12-21 | 1998-12-01 | Antexbiologics, Inc. | Adhesin-oligosaccharide conjugate vaccine for Haemophilus influenzae |
| FR2682388B1 (fr) * | 1991-10-10 | 1995-06-09 | Pasteur Merieux Serums Vacc | Procede de preparation d'un oligoside par depolymerisation d'un polyoside issu d'un agent pathogene, oligoside ainsi obtenu et son utilisation notamment comme agent vaccinal. |
| ATE198991T1 (de) * | 1991-10-18 | 2001-02-15 | Synsorb Biotech Inc | Behandlung bakterieller dysenterie |
| WO1995011701A1 (en) * | 1993-10-26 | 1995-05-04 | Syntello, Inc. | Inhibition of hiv mucosal infection |
| US5681570A (en) * | 1995-01-12 | 1997-10-28 | Connaught Laboratories Limited | Immunogenic conjugate molecules |
| US6248334B1 (en) * | 1997-01-08 | 2001-06-19 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process |
| AU758764B2 (en) * | 1998-03-02 | 2003-03-27 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Epitope peptides immunogenic against (streptococcus pneumoniae) |
| US6903184B1 (en) * | 1998-03-02 | 2005-06-07 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Multiple antigenic peptides immunogenic against Streptococcus pneumonia |
| WO1999047164A1 (en) * | 1998-03-18 | 1999-09-23 | The Administrators Of The Tulane Educational Fund | Use of mutant enterotoxin with excess b-subunit as an adjuvant |
| JP2002518343A (ja) | 1998-06-19 | 2002-06-25 | メリウクス オラバクス | ヘリコバクター感染に対する非経口的免疫処置法におけるltおよびct |
| EP1096952B1 (en) | 1998-07-15 | 2008-05-21 | The Brigham And Women's Hospital, Inc. | Polysaccharide vaccine for staphylococcal infections |
| WO2000010599A2 (en) * | 1998-08-19 | 2000-03-02 | North American Vaccine, Inc. | IMMUNOGENIC β-PROPIONAMIDO-LINKED POLYSACCHARIDE PROTEIN CONJUGATE USEFUL AS A VACCINE PRODUCED USING AN N-ACRYLOYLATED POLYSACCHARIDE |
| DZ3399A1 (fr) * | 2000-06-29 | 2002-01-03 | Smithkline Beecham Biolog | Composition de vaccin polyvalent |
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| EP2351579B1 (en) | 2002-10-11 | 2016-09-21 | Novartis Vaccines and Diagnostics S.r.l. | Polypeptide vaccines for broad protection against hypervirulent meningococcal lineages |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| CN101926988B (zh) | 2003-01-30 | 2014-06-04 | 诺华疫苗和诊断有限公司 | 抗多种脑膜炎球菌血清组的可注射性疫苗 |
| JP4738339B2 (ja) | 2003-10-02 | 2011-08-03 | ノバルティス ヴァクシンズ アンド ダイアグノスティクス エスアールエル | 複数の髄膜炎菌血清群についての液体ワクチン |
| GB0323103D0 (en) | 2003-10-02 | 2003-11-05 | Chiron Srl | De-acetylated saccharides |
| GB0406013D0 (en) | 2004-03-17 | 2004-04-21 | Chiron Srl | Analysis of saccharide vaccines without interference |
| GB0408977D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| GB0500787D0 (en) | 2005-01-14 | 2005-02-23 | Chiron Srl | Integration of meningococcal conjugate vaccination |
| NZ550533A (en) | 2004-04-30 | 2010-02-26 | Novartis Vaccines & Diagnostic | Meningococcal conjugate vaccination comprising N. meningitidis and diphtheria toxin |
| GB0409745D0 (en) | 2004-04-30 | 2004-06-09 | Chiron Srl | Compositions including unconjugated carrier proteins |
| GB0411387D0 (en) | 2004-05-21 | 2004-06-23 | Chiron Srl | Analysis of saccharide length |
| GB0413868D0 (en) | 2004-06-21 | 2004-07-21 | Chiron Srl | Dimensional anlaysis of saccharide conjugates |
| ATE479695T1 (de) * | 2004-06-24 | 2010-09-15 | Toyo Suisan Kaisha | Sulfopyranosylacylglycerol-derivate zur anwendung in kombination mit bestrahlung in einer tumor- radiotherapie |
| CN104815327A (zh) * | 2005-04-08 | 2015-08-05 | 惠氏有限责任公司 | 多价肺炎球菌多糖-蛋白质缀合物组合物 |
| UA95237C2 (uk) | 2005-06-27 | 2011-07-25 | Ґлаксосмітклайн Байолоджікалз С.А. | Імуногенна композиція |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
| PT1973564T (pt) | 2005-12-22 | 2017-01-24 | Glaxosmithkline Biologicals Sa | Vacina compreendendo conjugados polissacarídicos capsulares de streptococcus pneumoniae |
| DK2004225T3 (da) | 2006-03-22 | 2012-08-06 | Novartis Ag | Programmer for vaccination med meningocockonjugater |
| GB0605757D0 (en) | 2006-03-22 | 2006-05-03 | Chiron Srl | Separation of conjugated and unconjugated components |
| GB0612854D0 (en) | 2006-06-28 | 2006-08-09 | Novartis Ag | Saccharide analysis |
| US8956625B2 (en) | 2006-09-07 | 2015-02-17 | Glaxosmithkline Biologicals, S.A. | Inactivated polio vaccines |
| GB0700562D0 (en) | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
| CA2685506A1 (en) | 2007-05-02 | 2008-11-13 | Glaxosmithkline Biologicals S.A. | Vaccine |
| AU2008267208B2 (en) | 2007-06-26 | 2012-01-19 | Glaxosmithkline Biologicals S.A. | Vaccine comprising streptococcus pneumoniae capsular polysaccharide conjugates |
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| SI2349520T1 (sl) | 2008-10-27 | 2016-08-31 | Glaxosmithkline Biologicals S.A. | Postopek čiščenja za ogljikohidrat iz Streptococcus skupine A |
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| GB201003922D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
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| GB201005625D0 (en) | 2010-04-01 | 2010-05-19 | Novartis Ag | Immunogenic proteins and compositions |
| TW201406389A (zh) * | 2010-05-03 | 2014-02-16 | Dev Center Biotechnology | 多醣體與大腸桿菌熱不穩定腸毒素之共軛物,其用途及製法 |
| US10478483B2 (en) | 2010-06-25 | 2019-11-19 | Glaxosmithkline Biologicals Sa | Combinations of meningococcal factor H binding proteins |
| WO2012072769A1 (en) | 2010-12-01 | 2012-06-07 | Novartis Ag | Pneumococcal rrgb epitopes and clade combinations |
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| US4237224A (en) * | 1974-11-04 | 1980-12-02 | Board Of Trustees Of The Leland Stanford Jr. University | Process for producing biologically functional molecular chimeras |
| FR2407262A1 (fr) * | 1977-10-27 | 1979-05-25 | Cassenne Lab Sa | Nouveaux polysaccharides extraits de corps microbiens d'haemophilus influenzae, procede de preparation et application a titre de medicaments de ces nouveaux produits |
| US4196192A (en) * | 1977-10-28 | 1980-04-01 | American Cyanamid Company | Combined Haemophilus influenzae type b and pertussis vaccine |
| US4220717A (en) * | 1977-12-22 | 1980-09-02 | American Cyanamid Company | Isolation and purification of polyribosyl ribitol phosphate from Haemophilus influenzae type b. |
| DE2814039C3 (de) * | 1978-03-31 | 1981-02-19 | Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf), 3300 Braunschweig | Verfahren zur Herstellung von Hybrid-Bakterien |
| US4361550A (en) * | 1979-12-04 | 1982-11-30 | Ortho Pharmaceutical Corporation | Complement-fixing monoclonal antibody to human suppressor T cells and methods of preparing same |
| NL8000527A (nl) * | 1980-01-29 | 1981-08-17 | Stichting Vrienden Van De Stic | Werkwijze voor het bevorderen van hybridisatie van cellen in vitro en van de produktie en uitscheiding van stoffen, gevormd door dergelijke celhybriden, werkwijze voor het bevorderen van de produktie van monoclonale antilichamen in vitro door toepassing van een hybridomatechniek, alsmede endotheelcellen en/of supernatant van endotheelcellen. |
| US4427653A (en) * | 1981-01-26 | 1984-01-24 | President And Fellows Of Harvard College | Method of making monoclonal antibodies |
| WO1982003088A1 (en) * | 1981-03-09 | 1982-09-16 | Corp Cetus | Vaccines |
| US4356170A (en) * | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| AU551370B2 (en) * | 1981-06-22 | 1986-04-24 | University Of Rochester | Composition of a novel immunogen for protection against diarrheal disease caused by enterotoxigenic escherichia coli |
| US4411888A (en) * | 1981-06-22 | 1983-10-25 | The University Of Rochester | Composition of a novel immunogen for protection against diarrheal disease caused by enterotoxigenic Escherichia coli |
| US4451446A (en) * | 1982-03-04 | 1984-05-29 | Smithkline-Rit | Process for the preparation of polysaccharide-protein complexes from bacterial capsules, obtained products and immunogenic compositions containing them |
| US4666837A (en) * | 1982-05-24 | 1987-05-19 | Smithkline-Rit | DNA sequences, recombinant DNA molecules and processes for producing the A and B subunits of cholera toxin and preparations containing so-obtained subunit or subunits |
| NL8202527A (nl) * | 1982-06-22 | 1984-01-16 | Univ Utrecht | Vaccins tegen door bacterien met kapsel-polysacchariden verwekte ziekten en werkwijze voor het bereiden daarvan. |
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| EP0109688A3 (en) * | 1982-11-23 | 1986-12-03 | The Wellcome Foundation Limited | Improved complexes, processes for obtaining them and formulations containing such complexes |
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| US4882278A (en) * | 1983-04-29 | 1989-11-21 | President And Fellows Of Harvard College | Non-toxinogenic vibrio cholerae mutants |
| CA1340372C (en) * | 1984-07-09 | 1999-02-02 | John D. Clements | Production of e. coli lt-b enterotoxin subunit |
-
1984
- 1984-08-10 US US06/639,293 patent/US4808700A/en not_active Expired - Lifetime
-
1985
- 1985-06-28 CA CA000486073A patent/CA1316474C/en not_active Expired - Fee Related
- 1985-07-03 WO PCT/US1985/001251 patent/WO1986001228A1/en not_active Ceased
- 1985-07-03 JP JP60503270A patent/JPH0811737B2/ja not_active Expired - Fee Related
- 1985-07-04 AU AU44588/85A patent/AU599570B2/en not_active Ceased
- 1985-08-06 DE DE8585401604T patent/DE3585185D1/de not_active Expired - Lifetime
- 1985-08-06 AT AT85401604T patent/ATE71533T1/de not_active IP Right Cessation
- 1985-08-06 EP EP85401604A patent/EP0172107B1/en not_active Expired - Lifetime
- 1985-08-09 ES ES546038A patent/ES8707861A1/es not_active Expired
- 1985-08-09 IE IE1971/85A patent/IE57784B1/en not_active IP Right Cessation
- 1985-08-09 DK DK364285A patent/DK167879B1/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ATE71533T1 (de) | 1992-02-15 |
| DE3585185D1 (de) | 1992-02-27 |
| IE851971L (en) | 1986-02-10 |
| EP0172107A1 (en) | 1986-02-19 |
| IE57784B1 (en) | 1993-04-07 |
| ES8707861A1 (es) | 1987-09-01 |
| JPS61502957A (ja) | 1986-12-18 |
| US4808700A (en) | 1989-02-28 |
| DK364285A (da) | 1986-02-11 |
| ES546038A0 (es) | 1987-09-01 |
| AU4458885A (en) | 1986-02-13 |
| EP0172107B1 (en) | 1992-01-15 |
| WO1986001228A1 (en) | 1986-02-27 |
| AU599570B2 (en) | 1990-07-26 |
| JPH0811737B2 (ja) | 1996-02-07 |
| CA1316474C (en) | 1993-04-20 |
| DK167879B1 (da) | 1993-12-27 |
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