DK351788D0 - Tetrahydroisoquinolin-2-ylderivater af carboxylsyrer som thromboxan-a2-antagonister - Google Patents

Tetrahydroisoquinolin-2-ylderivater af carboxylsyrer som thromboxan-a2-antagonister

Info

Publication number: DK351788D0
Authority: DK; Denmark
Prior art keywords: thromboxan; yld; tetrahydroisoquinolin; antagonists; derivatives
Prior art date: 1986-10-28

Application number

DK351788A

Other languages

English (en)

Other versions

DK160550B (da

DK351788A (da

DK160550C (da

Inventor

John Graham Durant

Andrew Derrick Gribble

Robert Anthony Slater

Original Assignee

Smith Kline French Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-10-28

Filing date

1988-06-24

Publication date

1988-06-24

1986-10-28 Priority claimed from GB868625739A external-priority patent/GB8625739D0/en

1987-06-30 Priority claimed from GB878715274A external-priority patent/GB8715274D0/en

1988-06-24 Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab

1988-06-24 Publication of DK351788A publication Critical patent/DK351788A/da

1988-06-24 Publication of DK351788D0 publication Critical patent/DK351788D0/da

1991-03-25 Publication of DK160550B publication Critical patent/DK160550B/da

1991-09-09 Application granted granted Critical

1991-09-09 Publication of DK160550C publication Critical patent/DK160550C/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

DK351788A 1986-10-28 1988-06-24 Tetrahydroisoquinolin-2-ylderivater af carboxylsyrer som thromboxan-a2-antagonister, deres anvendelse i et medicinsk praeparat og farmaceutisk middel indeholdende dem DK160550C (da)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
GB8625739		1986-10-28
GB868625739A GB8625739D0 (en)	1986-10-28	1986-10-28	Pharmaceutically active compounds
GB878715274A GB8715274D0 (en)	1987-06-30	1987-06-30	Pharmaceutically active compounds
GB8715274		1987-06-30
GB8700757		1987-10-26
PCT/GB1987/000757 WO1988003137A1 (en)	1986-10-28	1987-10-26	Tetrahydroisoquinolin-2-yl derivatives of carboxylic acids as thromboxane a2 antagonists

Publications (4)

Publication Number	Publication Date
DK351788A DK351788A (da)	1988-06-24
DK351788D0 true DK351788D0 (da)	1988-06-24
DK160550B DK160550B (da)	1991-03-25
DK160550C DK160550C (da)	1991-09-09

Family

ID=26291459

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK351788A DK160550C (da)	1986-10-28	1988-06-24	Tetrahydroisoquinolin-2-ylderivater af carboxylsyrer som thromboxan-a2-antagonister, deres anvendelse i et medicinsk praeparat og farmaceutisk middel indeholdende dem

Country Status (11)

Country	Link
US (1)	US4812573A (da)
EP (1)	EP0266949B1 (da)
JP (1)	JPH01503233A (da)
AU (1)	AU600992B2 (da)
CA (1)	CA1296011C (da)
DE (1)	DE3766472D1 (da)
DK (1)	DK160550C (da)
ES (1)	ES2036213T3 (da)
GR (1)	GR3001267T3 (da)
PT (1)	PT86000B (da)
WO (1)	WO1988003137A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2613222B1 (fr) *	1987-04-03	1991-06-14	Guigon Nadine	Composition pour les soins locaux de l'epiderme, notamment du cuir chevelu
GB8717374D0 (en) *	1987-07-22	1987-08-26	Smith Kline French Lab	Pharmaceutically active compounds
HU198458B (en) *	1987-12-30	1989-10-30	Chinoin Gyogyszer Es Vegyeszet	Process for producing 2-aminoisoquinoline derivatives and pharmaceutical compositions comprising these compounds
US6137002A (en) *	1993-07-22	2000-10-24	Eli Lilly And Company	Glycoprotein IIb/IIIa antagonists
TW397812B (en) *	1995-02-11	2000-07-11	Astra Ab	Bicyclic isothiourea derivatives useful in therapy
DZ2446A1 (fr) *	1997-03-18	2003-01-11	Smithkline Beecham Plc	Nouveaux composés
WO1999016752A1 (en) *	1997-09-30	1999-04-08	Molecular Designs International, Inc.	β3-ADRENORECEPTOR AGONISTS, AGONIST COMPOSITIONS AND METHODS OF USING
DE19934272A1 (de) *	1999-07-21	2001-01-25	Bayer Ag	Neue antivirale Mittel
ES2246922T3 (es) *	1999-12-28	2006-03-01	Eisai Co., Ltd.	Compuestos heterociclicos que tienen grupos de sulfonamida.
US6593341B2 (en)	2001-03-29	2003-07-15	Molecular Design International, Inc.	β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
AU2003245773A1 (en)	2002-02-15	2003-09-04	Glaxo Group Limited	Vanilloid receptor modulators
MY133587A (en)	2002-05-29	2007-11-30	Glaxo Group Ltd	Aromatic sulfones and their medical use
US6596734B1 (en)	2002-10-11	2003-07-22	Molecular Design International, Inc.	Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists
JP5331690B2 (ja) *	2006-08-07	2013-10-30	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	置換−１，２，３，４−テトラヒドロイソキノリン誘導体の製造方法
NZ591045A (en)	2008-08-22	2013-01-25	Baxter Int	Polymeric benzyl carbonate-derivatives
EP3053913B1 (en)	2009-05-01	2018-03-07	Aerie Pharmaceuticals, Inc.	Dual mechanism inhibitors for the treatment of disease
CN109640966A (zh)	2016-08-31	2019-04-16	爱瑞制药公司	眼用组合物
US9840468B1 (en) *	2016-12-30	2017-12-12	Aerie Pharmaceuticals, Inc.	Methods for the preparation of 6-aminoisoquinoline
CA3057872A1 (en)	2017-03-31	2018-10-04	Aerie Pharmaceuticals, Inc.	Aryl cyclopropyl-amino-isoquinolinyl amide compounds
AU2019337703B2 (en)	2018-09-14	2023-02-02	Aerie Pharmaceuticals, Inc.	Aryl cyclopropyl-amino-isoquinolinyl amide compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
USRE28034E (en) *	1972-12-14	1974-06-04		Alkylsulfinylalkyl- and sulfonyl- alkyl-i,z,j,x.tetrahydroisoqijinolines
DE3000377A1 (de) *	1980-01-07	1981-07-09	Boehringer Mannheim Gmbh, 6800 Mannheim	Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
US4321254A (en) *	1980-09-26	1982-03-23	Smithkline Corporation	Antiallergic imidodisulfamides
US4350698A (en) *	1981-09-25	1982-09-21	Smithkline Corporation	Antiallergic imidosulfamides
US4536510A (en) *	1983-07-22	1985-08-20	Smith Kline Beckman Corporation	Method of antagonizing the effects of thromboxane

1987
- 1987-10-26 ES ES198787309454T patent/ES2036213T3/es not_active Expired - Lifetime
- 1987-10-26 AU AU81081/87A patent/AU600992B2/en not_active Ceased
- 1987-10-26 DE DE8787309454T patent/DE3766472D1/de not_active Expired - Lifetime
- 1987-10-26 EP EP87309454A patent/EP0266949B1/en not_active Expired - Lifetime
- 1987-10-26 WO PCT/GB1987/000757 patent/WO1988003137A1/en not_active Ceased
- 1987-10-26 JP JP62501623A patent/JPH01503233A/ja active Pending
- 1987-10-27 PT PT86000A patent/PT86000B/pt not_active IP Right Cessation
- 1987-10-27 CA CA000550294A patent/CA1296011C/en not_active Expired - Fee Related
1988
- 1988-06-24 DK DK351788A patent/DK160550C/da not_active IP Right Cessation
- 1988-06-27 US US07/212,095 patent/US4812573A/en not_active Expired - Fee Related
1990
- 1990-12-31 GR GR90401225T patent/GR3001267T3/el unknown

Also Published As

Publication number	Publication date
DK160550B (da)	1991-03-25
DE3766472D1 (de)	1991-01-10
EP0266949B1 (en)	1990-11-28
DK351788A (da)	1988-06-24
JPH01503233A (ja)	1989-11-02
GR3001267T3 (en)	1992-08-25
EP0266949A1 (en)	1988-05-11
ES2036213T3 (es)	1993-05-16
CA1296011C (en)	1992-02-18
WO1988003137A1 (en)	1988-05-05
US4812573A (en)	1989-03-14
AU600992B2 (en)	1990-08-30
AU8108187A (en)	1988-05-25
PT86000A (en)	1987-11-01
DK160550C (da)	1991-09-09
PT86000B (pt)	1990-08-31

Publication	Publication Date	Title
DK351788D0 (da)	1988-06-24	Tetrahydroisoquinolin-2-ylderivater af carboxylsyrer som thromboxan-a2-antagonister
DK406686D0 (da)	1986-08-26	Carboxylsyrederivater
DK620486A (da)	1987-06-21	Fremgangsmaade til fremstilling af eddikesyrederivater
DK404187D0 (da)	1987-08-03	Fremgangsmaade til fremstilling af thiazolderivater
DK490287D0 (da)	1987-09-18	Fremgangsmaade til fremstilling af benzoesyrederivater
IT1205123B (it)	1989-03-15	Acidi bifenil-idrossamici
DK686487D0 (da)	1987-12-23	1h-imidazol-5-carboxylsyrederivater
DK101287A (da)	1987-08-28	1h-imidazol-5-carboxylsyrederivater
DK52886A (da)	1986-02-04	Karboxylsyreesterderivater af deglucoteicoplanin
DK674287A (da)	1988-06-23	Fremgangsmaade til fremstilling af optisk aktive dihydropyridinderivater
DK4687A (da)	1987-07-08	Anvendelse af esterforbindelser som temporaert mikrobicid
DK655487D0 (da)	1987-12-14	Furanuronsyrederivater
DK558985A (da)	1986-06-05	Fremgangsmaade til fremstilling af carboxylsyrer
DK30389D0 (da)	1989-01-24	Fremgangsmaade til fremstilling af carboxylsyrederivater
DK603987A (da)	1988-05-19	Fremgangsmaade til fremstilling af purin-9-ylalkylenoxymethylphosphonsyrer
DK574688D0 (da)	1988-10-14	Fremgangsmaade til fremstilling af propensyrederivater
DK53787D0 (da)	1987-02-02	Fremgangsmaade til fremstilling af carboxylsyreamider
DK314988A (da)	1988-12-12	Fremgangsmaade til fremstilling af 6-deoxyguaninderivater
DK498388D0 (da)	1988-09-07	Fremgangsmaade til fremstilling af propensyrederivater
DK670589A (da)	1990-06-30	Carboxylsyrederivater
NO171701C (no)	1993-04-28	Anvendelse av n-decyltioetylamin som mikrobiocid
DK16688D0 (da)	1988-01-14	Fremgangsmaade til fremstilling af propionsyrederivater
ES531976A0 (es)	1984-12-16	Procedimiento de preparacion de acidos aceticos sustituidos
DK191689A (da)	1989-10-30	Fremgangsmaade til rensning af 2-keto-l-gulonsyre
DK227088D0 (da)	1988-04-26	Prodrug-derivater af carboxylsyre-laegemidler

Legal Events

Date	Code	Title	Description
1995-06-26	PBP	Patent lapsed