DK359387D0 - Oploesninger af oxazaphosphoriner med forbedret stabilitet og fremgangsmaade til deres fremstilling - Google Patents

Oploesninger af oxazaphosphoriner med forbedret stabilitet og fremgangsmaade til deres fremstilling

Info

Publication number: DK359387D0
Authority: DK; Denmark
Prior art keywords: solutions; preparation; oxazaphosphorines; procedure; improved stability
Prior art date: 1986-07-11

Application number

DK359387A

Other languages

English (en)

Other versions

DK168322B1 (da

DK359387A (da

Inventor

Dieter Sauerbier

Klaus Molge

Werner Weigert

Otto Isaac

Original Assignee

Asta Werke Ag Chem Fab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-07-11

Filing date

1987-07-10

Publication date

1987-07-10

1987-07-10 Application filed by Asta Werke Ag Chem Fab filed Critical Asta Werke Ag Chem Fab

1987-07-10 Publication of DK359387D0 publication Critical patent/DK359387D0/da

1988-01-12 Publication of DK359387A publication Critical patent/DK359387A/da

1994-03-14 Application granted granted Critical

1994-03-14 Publication of DK168322B1 publication Critical patent/DK168322B1/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oil, Petroleum & Natural Gas (AREA)
Dermatology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicinal Preparation (AREA)
Detergent Compositions (AREA)
Cosmetics (AREA)
Carbon And Carbon Compounds (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Paper (AREA)
Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Inks, Pencil-Leads, Or Crayons (AREA)

DK359387A 1986-07-11 1987-07-10 Ethanoliske opløsninger af oxazaphosphoriner med forbedret stabilitet DK168322B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3623369		1986-07-11
DE3623369		1986-07-11

Publications (3)

Publication Number	Publication Date
DK359387D0 true DK359387D0 (da)	1987-07-10
DK359387A DK359387A (da)	1988-01-12
DK168322B1 DK168322B1 (da)	1994-03-14

Family

ID=6304930

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK359387A DK168322B1 (da)	1986-07-11	1987-07-10	Ethanoliske opløsninger af oxazaphosphoriner med forbedret stabilitet

Country Status (16)

Country	Link
US (1)	US4952575A (da)
EP (1)	EP0254902B1 (da)
JP (1)	JPS6323888A (da)
KR (1)	KR880001282A (da)
AT (1)	ATE66609T1 (da)
AU (1)	AU598282B2 (da)
CA (1)	CA1289886C (da)
DE (2)	DE3772482D1 (da)
DK (1)	DK168322B1 (da)
ES (1)	ES2038623T3 (da)
FI (1)	FI86690C (da)
GR (1)	GR3002618T3 (da)
IE (1)	IE59897B1 (da)
IL (1)	IL83141A (da)
PT (1)	PT85293B (da)
ZA (1)	ZA875059B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5051257A (en) *	1989-05-09	1991-09-24	Pietronigro Dennis D	Antineoplastic solution and method for treating neoplasms
RO113611B1 (ro) *	1990-08-03	1998-09-30	Asta Pharma Ag	Preparate solide de ifosfamida, administrate oral si procedeu de obtinere
US5227373A (en) *	1991-10-23	1993-07-13	Bristol-Myers Squibb Co.	Lyophilized ifosfamide compositions
DE59813853D1 (de) *	1997-10-13	2007-02-01	Stada Arzneimittel Ag	Flüssige darreichungsformen oxazaphosphorinhaltiger pharmazeutischer produkte
US7205404B1 (en)	1999-03-05	2007-04-17	Metabasis Therapeutics, Inc.	Phosphorus-containing prodrugs
AUPQ849900A0 (en) *	2000-06-30	2000-07-27	Dbl Australia Pty Ltd.	Injectable composition
US6613927B1 (en)	2002-02-08	2003-09-02	American Pharmaceutical Partners, Inc.	Sterile lyophilized ifosfamide and associated methods
BR0314068A (pt) *	2002-09-05	2005-07-05	Bharat Serums & Vaccines Ltd	Processo para a preparação de uma composição estável com baixo nìvel de toxicidade; composição estável que contém oxazafosforina; uso de uma composição estável que contém oxazafosforina; e método de tratamento de uma doença maligna
US7199111B2 (en) *	2002-12-02	2007-04-03	Bharat Serums & Vaccines Ltd.	Aqueous ifosfamide compositions for parenteral administration and a process for their preparations
MX2007002941A (es) *	2004-09-13	2007-05-24	Bharat Serums & Vaccines Ltd	Composiciones de emulsion estables para administracion intravenosa que tienen eficacia libre de conservadores.
WO2015123352A1 (en)	2014-02-13	2015-08-20	Ligand Pharmaceuticals, Inc.	Prodrug compounds and their uses
BR112016026140A2 (pt) *	2014-05-09	2018-08-07	AuroMedics Pharma LLC	formulações de concentrado líquido de ciclofosfamida.
CN106687118A (zh)	2014-07-02	2017-05-17	配体药物公司	前药化合物及其用途
US10849916B2 (en)	2014-07-11	2020-12-01	Dr. Reddys Laboratories Limited	Stable liquid formulations of cyclophosphamide and its impurities
WO2016005962A2 (en)	2014-07-11	2016-01-14	Dr. Reddy’S Laboratories Limited	Stable liquid formulations of cyclophosphamide and processes
WO2016132270A1 (en)	2015-02-16	2016-08-25	Leiutis Pharmaceuticals Pvt Ltd	Stable ready to use cyclophosphamide liquid formulations
CN111788196A (zh)	2018-01-09	2020-10-16	配体药物公司	缩醛化合物及其治疗用途
WO2022038072A1 (en) *	2020-08-17	2022-02-24	Sandoz Ag	Parenteral pharmaceutical composition comprising cyclophosphamide and a mixture of liquids

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3530147A1 (de) *	1985-08-23	1987-02-26	Bayer Ag	Verwendung von diazaphosphorinen zur bekaempfung von endoparasiten

1987
- 1987-07-03 DE DE8787109559T patent/DE3772482D1/de not_active Expired - Lifetime
- 1987-07-03 ES ES198787109559T patent/ES2038623T3/es not_active Expired - Lifetime
- 1987-07-03 AT AT87109559T patent/ATE66609T1/de not_active IP Right Cessation
- 1987-07-03 EP EP87109559A patent/EP0254902B1/de not_active Expired - Lifetime
- 1987-07-03 DE DE19873722043 patent/DE3722043A1/de not_active Withdrawn
- 1987-07-07 JP JP62167976A patent/JPS6323888A/ja active Granted
- 1987-07-09 PT PT85293A patent/PT85293B/pt unknown
- 1987-07-09 IL IL83141A patent/IL83141A/xx not_active IP Right Cessation
- 1987-07-10 IE IE186787A patent/IE59897B1/en not_active IP Right Cessation
- 1987-07-10 AU AU75549/87A patent/AU598282B2/en not_active Expired
- 1987-07-10 ZA ZA875059A patent/ZA875059B/xx unknown
- 1987-07-10 CA CA000541835A patent/CA1289886C/en not_active Expired - Lifetime
- 1987-07-10 FI FI873064A patent/FI86690C/fi not_active IP Right Cessation
- 1987-07-10 DK DK359387A patent/DK168322B1/da not_active IP Right Cessation
- 1987-07-11 KR KR1019870007481A patent/KR880001282A/ko not_active Ceased
1989
- 1989-02-06 US US07/307,230 patent/US4952575A/en not_active Expired - Lifetime
1991
- 1991-08-29 GR GR91401184T patent/GR3002618T3/el unknown

Also Published As

Publication number	Publication date
AU7554987A (en)	1988-01-14
IL83141A (en)	1992-11-15
IE871867L (en)	1988-01-11
DE3722043A1 (de)	1988-01-14
DK168322B1 (da)	1994-03-14
GR3002618T3 (en)	1993-01-25
ZA875059B (en)	1988-02-24
EP0254902B1 (de)	1991-08-28
DE3772482D1 (de)	1991-10-02
FI873064A0 (fi)	1987-07-10
JPH0543711B2 (da)	1993-07-02
FI873064L (fi)	1988-01-12
FI86690B (fi)	1992-06-30
PT85293A (de)	1987-08-01
DK359387A (da)	1988-01-12
FI86690C (fi)	1992-10-12
PT85293B (pt)	1990-03-30
EP0254902A3 (en)	1988-08-03
US4952575A (en)	1990-08-28
IE59897B1 (en)	1994-04-20
KR880001282A (ko)	1988-04-22
ES2038623T3 (es)	1993-08-01
IL83141A0 (en)	1987-12-31
JPS6323888A (ja)	1988-02-01
EP0254902A2 (de)	1988-02-03
ATE66609T1 (de)	1991-09-15
CA1289886C (en)	1991-10-01
AU598282B2 (en)	1990-06-21

Publication	Publication Date	Title
DK359387A (da)	1988-01-12	Oploesninger af oxazaphosphoriner med forbedret stabilitet og fremgangsmaade til deres fremstilling
DK499088D0 (da)	1988-09-08	1-oe(2-pyrimidinyl)-aminoalkylaapiperidinderivater, fremgangsmaade til fremstilling deraf og laegemiddel indeholdende saadanne derivater
NO172437C (no)	1993-07-21	Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidindionforbindelser
DK283487D0 (da)	1987-06-03	Thiazolyl-2-yl-imidazo(1,2-a)pyrimidiner, deres fremstilling og brug
NO895002L (no)	1990-06-15	Enzymhemmende aminosyrederivater.
DK400781A (da)	1982-03-11	Fremgangsmaade til fremstilling af 2-(1,4-benzodioxan-2-ylalkyl) imidazoler
DK640687A (da)	1988-06-25	Allylmercaptoacetylsydnoniminer, deres fremstilling og anvendelse
DK440987A (da)	1988-02-26	Thyroninderivater, deres fremstilling og anvendelse
ATE139441T1 (de)	1996-07-15	Verwendung von 2-iminothiazolidin-4-onderivaten als neuartige arzneimittelwirkstoffe
NO164352C (no)	1990-09-26	Analogifremgangsmaate for fremstilling av farmasoeytisk aktive, antivirale, substituerte isoksazolderivater.
ATE70838T1 (de)	1992-01-15	Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung.
ATE22284T1 (de)	1986-10-15	2-aminomethyl-6-sulfamoylphenolderivate, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen.
ATE61341T1 (de)	1991-03-15	N-substituierte, estergruppen enthaltende acrylamide.
SE8302452D0 (sv)	1983-04-29	Method for treatment of senile dementia
ES2058542T3 (es)	1994-11-01	Imidas biciclicas puenteadas de 4-(4-(3-benzoisotiazolil)-1-piperazinil)butilo antipsicoticas.
DK148058C (da)	1985-08-12	Analogifremgangsmaade til fremstilling af thiazolderivater eller syreadditionssalte deraf
AU573062B2 (en)	1988-05-26	Dihydrodithiazine derivatives
DK469381A (da)	1983-04-24	Piperidinderivater og fremgangsmaade til deres fremstilling
EP0200145A3 (en)	1988-06-01	Process for the preparation of optically active azole derivatives
SE7905862L (sv)	1980-01-06	Substituerade 4-aryl-2,5-dihydro-furan-2-oner och 4-aryl-1,5-dihydro-2h-pyrrol-2-oner och sett for deras framstellning

Legal Events

Date	Code	Title	Description
1994-03-14	B1	Patent granted (law 1993)
2007-07-30	PUP	Patent expired