DK358284D0 - Insulin-derivater, fremgangsmaade til fremstilling deraf samt deres anvendelse til behandling af diabetes mellitus - Google Patents

Insulin-derivater, fremgangsmaade til fremstilling deraf samt deres anvendelse til behandling af diabetes mellitus

Info

Publication number: DK358284D0
Authority: DK; Denmark
Prior art keywords: procedures; preparing; treatment; diabetes mellitus; insulin derivatives
Prior art date: 1983-07-22

Application number

DK358284A

Other languages

English (en)

Other versions

DK358284A (da

DK172211B1 (da

Inventor

Ulrich Grau

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-07-22

Filing date

1984-07-20

Publication date

1984-07-20

1984-07-20 Application filed by Hoechst Ag filed Critical Hoechst Ag

1984-07-20 Publication of DK358284D0 publication Critical patent/DK358284D0/da

1985-01-23 Publication of DK358284A publication Critical patent/DK358284A/da

1998-01-05 Application granted granted Critical

1998-01-05 Publication of DK172211B1 publication Critical patent/DK172211B1/da

Links

206010012601 diabetes mellitus Diseases 0.000 title 1
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 1
238000000034 method Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C07K14/622—Insulins at least 1 amino acid in D-form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Diabetes (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Toxicology (AREA)
Hematology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK358284A 1983-07-22 1984-07-20 Basisk modificeret insulin-derivat DK172211B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19833326472 DE3326472A1 (de)	1983-07-22	1983-07-22	Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE3326472		1983-07-22

Publications (3)

Publication Number	Publication Date
DK358284D0 true DK358284D0 (da)	1984-07-20
DK358284A DK358284A (da)	1985-01-23
DK172211B1 DK172211B1 (da)	1998-01-05

Family

ID=6204660

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK358284A DK172211B1 (da)	1983-07-22	1984-07-20	Basisk modificeret insulin-derivat
DK001790A DK172209B1 (da)	1983-07-22	1990-01-04	Lægemidler indeholdende basisk modificerede insulinderivater

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK001790A DK172209B1 (da)	1983-07-22	1990-01-04	Lægemidler indeholdende basisk modificerede insulinderivater

Country Status (20)

Country	Link
US (1)	US4701440A (da)
EP (1)	EP0132770B1 (da)
JP (2)	JPS6042397A (da)
AR (1)	AR241864A1 (da)
AT (1)	ATE29729T1 (da)
AU (1)	AU569097B2 (da)
CA (1)	CA1246548A (da)
DE (2)	DE3326472A1 (da)
DK (2)	DK172211B1 (da)
ES (2)	ES8504678A1 (da)
FI (1)	FI79854C (da)
GR (1)	GR81551B (da)
HU (1)	HUT37805A (da)
IE (1)	IE57709B1 (da)
IL (1)	IL72469A (da)
NO (1)	NO167810C (da)
NZ (1)	NZ208959A (da)
PH (1)	PH23014A (da)
PT (1)	PT78940A (da)
ZA (1)	ZA845620B (da)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3327928A1 (de) *	1983-08-03	1985-02-21	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von insulin-derivaten
DE3333640A1 (de) *	1983-09-17	1985-04-25	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DE3501641A1 (de) *	1985-01-19	1986-07-24	Hoechst Ag, 6230 Frankfurt	Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
DK113585D0 (da) *	1985-03-12	1985-03-12	Novo Industri As	Nye peptider
US4946828A (en) *	1985-03-12	1990-08-07	Novo Nordisk A/S	Novel insulin peptides
US4764592A (en) *	1987-04-23	1988-08-16	Eli Lilly And Company	Crystalline human proinsulin and process for its production
DE3717370A1 (de) *	1987-05-22	1988-12-01	Hoechst Ag	Mischkristalle aus insulin und insulinderivaten, verfahren zur herstellung dieser mischkristalle, diese mischkristalle enthaltende pharmazeutische mittel und ihre verwendung zur behandlung von diabetes mellitus
US4789660A (en) *	1987-09-10	1988-12-06	American Home Products Corporation	Insulin administration using methyl and propyl paraben
DE3827533A1 (de) *	1988-08-13	1990-02-15	Hoechst Ag	Pharmazeutische zubereitung zur behandlung des diabetes mellitus
DE3837825A1 (de) *	1988-11-08	1990-05-10	Hoechst Ag	Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
JPH04502465A (ja) *	1988-12-23	1992-05-07	ノボ　ノルディスク　アクティーゼルスカブ	ヒトインシュリン類似物質
US5716927A (en) *	1988-12-23	1998-02-10	Novo Nordisk A/S	Insulin analogs having a modified B-chain
DK134189D0 (da) *	1989-03-20	1989-03-20	Nordisk Gentofte	Insulinforbindelser
DE3936876A1 (de) *	1989-11-06	1991-05-23	Hoechst Ag	Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
AU9172991A (en)	1990-12-07	1992-07-08	Cnc Development, Inc.	Catalytic chemical reactor
YU66892A (sh) *	1991-08-20	1995-10-24	Hoechst Ag.	Fosfoinositolglikan - peptid sa delovanjem kao insulin
NZ245170A (en) *	1991-11-26	1994-07-26	Lilly Co Eli	Insulin and proinsulin analogues with arg at b31, b32 and ao and pharmaceutical compositions
ES2137937T3 (es) *	1991-11-29	2000-01-01	Hoechst Ag	Peptidos con efecto del tipo de insulina.
US5504188A (en) *	1994-06-16	1996-04-02	Eli Lilly And Company	Preparation of stable zinc insulin analog crystals
ATE264871T1 (de)	1996-07-26	2004-05-15	Aventis Pharma Gmbh	Insulinderivate mit erhöhter zinkbindung
DE19649350A1 (de) *	1996-11-28	1998-06-04	Hoechst Ag	Inositolglykane mit insulinartiger Wirkung
US6444641B1 (en)	1997-10-24	2002-09-03	Eli Lilly Company	Fatty acid-acylated insulin analogs
DE19825447A1 (de)	1998-06-06	1999-12-09	Hoechst Marion Roussel De Gmbh	Neue Insulinanaloga mit erhöhter Zinkbildung
EP1190249A2 (en)	1999-06-08	2002-03-27	University Of Iowa Research Foundation	Compounds and methods to enhance raav transduction
JP3647843B2 (ja) *	2001-02-21	2005-05-18	株式会社セイワ・プロ	チタン材に付着したスケールの除去剤
AU2002248464A1 (en)	2001-02-21	2002-09-12	Medtronic Minimed, Inc.	Stabilized insulin formulations
DE10114178A1 (de)	2001-03-23	2002-10-10	Aventis Pharma Gmbh	Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
DE10227232A1 (de) *	2002-06-18	2004-01-15	Aventis Pharma Deutschland Gmbh	Saure Insulinzubereitungen mit verbesserter Stabilität
US7749491B2 (en)	2003-03-31	2010-07-06	University Of Iowa Research Foundation	Compounds and methods to enhance rAAV transduction
EP2316844A3 (en) *	2003-05-21	2011-07-20	Biotech Tools S.A.	Peptide complex
US7833513B2 (en)	2004-12-03	2010-11-16	Rhode Island Hospital	Treatment of Alzheimer's Disease
PT2349324T (pt)	2008-10-17	2017-12-06	Sanofi Aventis Deutschland	Combinação de uma insulina e de um agonista do glp-1
WO2011058083A1 (de)	2009-11-13	2011-05-19	Sanofi-Aventis Deutschland Gmbh	Pharmazeutische zusammensetzung umfassend einen glp-1-agonisten, ein insulin und methionin
SG10201500871TA (en)	2009-11-13	2015-04-29	Sanofi Aventis Deutschland	Pharmaceutical composition comprising a glp-1 agonist and methionine
RS55378B1 (sr)	2010-08-30	2017-03-31	Sanofi Aventis Deutschland	Upotreba ave0010 za proizvodnju leka za tretman diabetes mellitus tipa 2
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
HRP20151068T1 (hr)	2011-08-29	2016-01-01	Sanofi-Aventis Deutschland Gmbh	Farmaceutska kombinacija za upotrebu za glikemijsku kontrolu kod pacijenata s dijabetesom tipa 2
AR087744A1 (es)	2011-09-01	2014-04-16	Sanofi Aventis Deutschland	Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
TWI758239B (zh)	2014-12-12	2022-03-21	德商賽諾菲阿凡提斯德意志有限公司	甘精胰島素/利司那肽固定比率配製劑
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
US11702672B2 (en)	2016-02-08	2023-07-18	University Of Iowa Research Foundation	Methods to produce chimeric adeno-associated virus/bocavirus parvovirus
MX2018010842A (es)	2016-03-07	2019-07-04	Univ Iowa Res Found	Expresion mediada por el virus adeno-asociado (aav) usando un promotor y pontenciador sintetico.
WO2017205739A1 (en)	2016-05-26	2017-11-30	University Of Iowa Research Foundation	cis AND trans REQUIREMENTS FOR TERMINAL RESOLUTION OF HUMAN BOCAVIRUS 1
US11142775B2 (en)	2017-01-13	2021-10-12	University Of Iowa Research Foundation	Bocaparvovirus small noncoding RNA and uses thereof
JP7439062B2 (ja)	2018-09-19	2024-02-27	ノヴォ・ノルディスク・リサーチ・センター・オックスフォード・リミテッド	グルコース感受性インスリンおよびその使用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2256215C3 (de) *	1972-11-16	1981-01-08	Hoechst Ag, 6000 Frankfurt	Insulin-Zubereitung mit einem Gehalt an kristallinem Insulin und amorphem Desphenylalanin8' -insulin
DE2460753A1 (de) *	1974-12-21	1976-06-24	Hoechst Ag	Verfahren zur herstellung von humaninsulin
DK146482C (da) *	1979-04-13	1986-10-06	Shionogi & Co	Fremgangsmaade til fremstilling af et b30-threonin-insulin
DK319780A (da) *	1980-07-24	1982-01-25	Forenede Bryggerier As	Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner
DE3209184A1 (de) *	1982-03-13	1983-09-15	Hoechst Ag, 6230 Frankfurt	Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
NL8201650A (nl) *	1982-04-21	1983-11-16	Akzo Nv	Semisynthetische bereiding van humane insuline.
DE3327928A1 (de) *	1983-08-03	1985-02-21	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von insulin-derivaten
DE3333640A1 (de) *	1983-09-17	1985-04-25	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DE3334407A1 (de) *	1983-09-23	1985-04-04	Hoechst Ag, 6230 Frankfurt	In position b 30 modifizierte insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
JPH118546A (ja) *	1997-04-24	1999-01-12	Hitachi Ltd	Ｃｍｏｓ回路

1983
- 1983-07-22 DE DE19833326472 patent/DE3326472A1/de not_active Withdrawn
1984
- 1984-07-16 HU HU842766A patent/HUT37805A/hu unknown
- 1984-07-17 AR AR84297267A patent/AR241864A1/es active
- 1984-07-18 EP EP84108442A patent/EP0132770B1/de not_active Expired
- 1984-07-18 GR GR75343A patent/GR81551B/el unknown
- 1984-07-18 AT AT84108442T patent/ATE29729T1/de not_active IP Right Cessation
- 1984-07-18 DE DE8484108442T patent/DE3466227D1/de not_active Expired
- 1984-07-19 FI FI842914A patent/FI79854C/fi not_active IP Right Cessation
- 1984-07-19 PT PT78940A patent/PT78940A/pt not_active IP Right Cessation
- 1984-07-20 PH PH31009A patent/PH23014A/en unknown
- 1984-07-20 IE IE1889/84A patent/IE57709B1/en not_active IP Right Cessation
- 1984-07-20 ZA ZA845620A patent/ZA845620B/xx unknown
- 1984-07-20 CA CA000459386A patent/CA1246548A/en not_active Expired
- 1984-07-20 NZ NZ208959A patent/NZ208959A/xx unknown
- 1984-07-20 DK DK358284A patent/DK172211B1/da not_active IP Right Cessation
- 1984-07-20 IL IL72469A patent/IL72469A/xx not_active IP Right Cessation
- 1984-07-20 ES ES534487A patent/ES8504678A1/es not_active Expired
- 1984-07-20 AU AU30922/84A patent/AU569097B2/en not_active Ceased
- 1984-07-20 NO NO842977A patent/NO167810C/no not_active IP Right Cessation
- 1984-07-20 JP JP59149784A patent/JPS6042397A/ja active Granted
- 1984-09-06 ES ES535706A patent/ES8505646A1/es not_active Expired
1986
- 1986-06-06 US US06/873,456 patent/US4701440A/en not_active Expired - Lifetime
1989
- 1989-02-22 JP JP1040427A patent/JPH01294634A/ja active Granted
1990
- 1990-01-04 DK DK001790A patent/DK172209B1/da not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES534487A0 (es)	1985-04-16
IL72469A (en)	1989-07-31
ATE29729T1 (de)	1987-10-15
CA1246548A (en)	1988-12-13
FI842914A0 (fi)	1984-07-19
DE3466227D1 (en)	1987-10-22
FI842914L (fi)	1985-01-23
PT78940A (de)	1984-08-01
US4701440A (en)	1987-10-20
IE841889L (en)	1985-01-22
GR81551B (da)	1984-12-11
EP0132770A1 (de)	1985-02-13
ZA845620B (en)	1985-02-27
ES535706A0 (es)	1985-06-01
FI79854C (fi)	1990-03-12
NO167810B (no)	1991-09-02
JPH01294634A (ja)	1989-11-28
FI79854B (fi)	1989-11-30
JPH052654B2 (da)	1993-01-13
AU3092284A (en)	1985-01-24
AU569097B2 (en)	1988-01-21
ES8505646A1 (es)	1985-06-01
PH23014A (en)	1989-03-03
NO167810C (no)	1991-12-18
DK1790D0 (da)	1990-01-04
ES8504678A1 (es)	1985-04-16
JPH0357119B2 (da)	1991-08-30
DE3326472A1 (de)	1985-02-14
AR241864A1 (es)	1993-01-29
NO842977L (no)	1985-01-23
HUT37805A (en)	1986-02-28
DK1790A (da)	1990-01-04
DK358284A (da)	1985-01-23
JPS6042397A (ja)	1985-03-06
IE57709B1 (en)	1993-03-10
DK172211B1 (da)	1998-01-05
EP0132770B1 (de)	1987-09-16
IL72469A0 (en)	1984-11-30
NZ208959A (en)	1989-02-24
DK172209B1 (da)	1998-01-05

Publication	Publication Date	Title
DK358284A (da)	1985-01-23	Insulin-derivater, fremgangsmaade til fremstilling deraf samt deres anvendelse til behandling af diabetes mellitus
NO874347D0 (no)	1987-10-19	Fremgangsmaate for fremstilling av insulin.
DE3871935D1 (de)	1992-07-16	Spritze zum einmaligen gebrauch.
DK164595C (da)	1992-12-07	3-methoxy-2-pyridyl-methylacrylater, fremgangsmaade til fremstilling deraf, middel indeholdende forbindelserne og disses eller midlets anvendelse til bekaempelse af svampe
DK143284D0 (da)	1984-02-29	Thiazolinderivater,deres fremstilling og anvendelse som laegemiddel
DK349387A (da)	1988-01-09	Nitrofuranderivater samt fremgangsmaade til fremstilling deraf og anvendelse af forbindelserne som laegemiddel
DK57480A (da)	1981-08-12	Fremgangsmaade til fremstilling af insulinderivater
DK166479C (da)	1993-10-18	Anvendelse af fluoxetin, norfluoxetin eller et farmaceutisk acceptabelt salt af fluoxetin eller norfluoxetin til fremstilling af et laegemiddel med anxiolytisk virkning
DK19887D0 (da)	1987-01-15	Peptider med vasorelaxerende, natriuretisk og diuretisk virkning, fremgangsmaade til deres fremstiling, midler indeholdende forbindelserne og deres anvendelse
DK106989D0 (da)	1989-03-06	Isoindolinonderivat, fremgangsmaade til fremstilling af dette, og laegemiddel indeholdende dette
DK353781A (da)	1983-02-11	Fremgangsmaade til fremstilling af insulinderivater
DK673988D0 (da)	1988-12-02	Manumycinderivater, fremgangsaader til deres fremstilling samt deres anvendelse
DK440288A (da)	1989-02-08	Anvendelse af eicosapentaensyre og/eller docosahexaensyre til fremstilling af midler til behandling af diabetes mellitus
DK530689D0 (da)	1989-10-25	Adenylcyclasederivater, fremgangsmaade til fremstilling deraf og deres anvendelse
DK76587A (da)	1987-08-20	Thioforbindelser med fungicid aktivitet, fremgangsmaade til deres fremstilling og deres anvendelse
DK73287A (da)	1987-08-16	Insulinderivater, deres fremstilling og anvendelse
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