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DK332888D0 - FACTOR VIII: C-DERIVATIVE, ITS MANUFACTURING AND USE - Google Patents

FACTOR VIII: C-DERIVATIVE, ITS MANUFACTURING AND USE

Info

Publication number
DK332888D0
DK332888D0 DK332888A DK332888A DK332888D0 DK 332888 D0 DK332888 D0 DK 332888D0 DK 332888 A DK332888 A DK 332888A DK 332888 A DK332888 A DK 332888A DK 332888 D0 DK332888 D0 DK 332888D0
Authority
DK
Denmark
Prior art keywords
derivative
manufacturing
factor viii
viii
factor
Prior art date
Application number
DK332888A
Other languages
Danish (da)
Other versions
DK332888A (en
Inventor
Klaus-Dieter Langner
Egon Amann
Hans Kuepper
Gerd Zettlmeissl
Bernard Huber
Original Assignee
Behringwerke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke Ag filed Critical Behringwerke Ag
Publication of DK332888D0 publication Critical patent/DK332888D0/en
Publication of DK332888A publication Critical patent/DK332888A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK332888A 1987-06-19 1988-06-17 FACTOR VIII: C-DERIVATIVE, ITS MANUFACTURING AND USE DK332888A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873720246 DE3720246A1 (en) 1987-06-19 1987-06-19 FACTOR VIII: C-LIKE MOLECULE WITH COAGULATION ACTIVITY

Publications (2)

Publication Number Publication Date
DK332888D0 true DK332888D0 (en) 1988-06-17
DK332888A DK332888A (en) 1988-12-20

Family

ID=6329877

Family Applications (1)

Application Number Title Priority Date Filing Date
DK332888A DK332888A (en) 1987-06-19 1988-06-17 FACTOR VIII: C-DERIVATIVE, ITS MANUFACTURING AND USE

Country Status (8)

Country Link
EP (1) EP0295597A3 (en)
JP (1) JPS6425799A (en)
KR (1) KR890000666A (en)
AU (1) AU609829B2 (en)
DE (1) DE3720246A1 (en)
DK (1) DK332888A (en)
FI (1) FI882890A7 (en)
PT (1) PT87752B (en)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
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US5661008A (en) * 1991-03-15 1997-08-26 Kabi Pharmacia Ab Recombinant human factor VIII derivatives
SE468050C (en) * 1991-03-15 1998-04-27 Pharmacia & Upjohn Ab Recombinant human factor VIII derivative
AU6456096A (en) * 1995-07-11 1997-02-10 Chiron Corporation Lysine 1689 factor viii:c polypeptide analogs
CA2252896C (en) 1996-04-24 2009-03-10 The Regents Of The University Of Michigan Inactivation resistant factor viii
US8183344B2 (en) 1996-04-24 2012-05-22 University Of Michigan Inactivation resistant factor VIII
EP1038959A1 (en) 1999-03-17 2000-09-27 Aventis Behring Gesellschaft mit beschränkter Haftung Factor VIII without B-domain, comprising one or more insertions of a truncated intron I of factor IX
EP1233064A1 (en) 2001-02-09 2002-08-21 Aventis Behring Gesellschaft mit beschränkter Haftung Modified factor VIII cDNA and its use for the production of factor VIII
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
US7855279B2 (en) 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
CN108530543B (en) 2009-02-03 2023-06-23 阿穆尼克斯制药公司 Extended recombinant polypeptides and compositions comprising the extended recombinant polypeptides
US9062299B2 (en) 2009-08-24 2015-06-23 Amunix Operating Inc. Coagulation factor IX compositions and methods of making and using same
WO2011041770A1 (en) 2009-10-02 2011-04-07 The Children's Hospital Of Philadelphia Compositions and methods for enhancing coagulation factor viii function
HRP20180135T1 (en) 2009-12-06 2018-04-06 Bioverativ Therapeutics Inc. CHEMICAL AND HYBRID POLYPEPTIDES OF THE VIII-FC FACTORS, AND THE METHODS OF THEIR USE
AU2011274423B2 (en) 2010-07-09 2016-02-11 Bioverativ Therapeutics Inc. Chimeric clotting factors
EP3508573A1 (en) 2010-07-09 2019-07-10 Bioverativ Therapeutics Inc. Systems for factor viii processing and methods thereof
DK2717898T3 (en) 2011-06-10 2019-03-25 Bioverativ Therapeutics Inc COAGULATING COMPOUNDS AND PROCEDURES FOR USE THEREOF
CN107261122A (en) 2011-07-08 2017-10-20 比奥贝拉蒂治疗公司 Factor IX is fitted together to and hybrid polypeptide and its application method
US10656167B2 (en) 2011-07-25 2020-05-19 Bioverativ Therapeutics Inc. Assays to monitor bleeding disorders
US9394353B2 (en) 2011-10-18 2016-07-19 Csl Limited Method for improving the stability of purified factor VIII after reconstitution
EA038705B1 (en) 2012-01-12 2021-10-07 Биовератив Терапьютикс Инк. Methods of reducing immunogenicity against blood coagulation factor viii in patients undergoing factor viii therapy
CN109111526A (en) 2012-01-12 2019-01-01 比奥贝拉蒂治疗公司 Chimeric factor VIII polypeptide and application thereof
EP3564260B1 (en) 2012-02-15 2022-10-19 Bioverativ Therapeutics Inc. Factor viii compositions and methods of making and using same
BR112014019901A8 (en) 2012-02-15 2018-01-02 Biogen Idec Inc RECOMBINANT FACTOR VIII PROTEINS
CN104519897A (en) 2012-06-08 2015-04-15 比奥根艾迪克Ma公司 Procoagulant compounds
US10202595B2 (en) 2012-06-08 2019-02-12 Bioverativ Therapeutics Inc. Chimeric clotting factors
EP3404105A1 (en) 2012-07-06 2018-11-21 Bioverativ Therapeutics Inc. Cell line expressing single chain factor viii polypeptides and uses thereof
HUE047088T2 (en) 2012-07-11 2020-04-28 Bioverativ Therapeutics Inc Factor viii complex with xten and von willebrand factor protein, and uses thereof
EP2877202A4 (en) 2012-07-25 2016-06-01 Biogen Ma Inc BLOOD FACTOR MONITORING TEST AND USES THEREOF
CA2888806A1 (en) 2012-10-18 2014-04-24 Biogen Idec Ma Inc. Methods of using a fixed dose of a clotting factor
EP3943102A1 (en) 2012-10-30 2022-01-26 Bioverativ Therapeutics Inc. Methods of using fviii polypeptide
EP4223772A3 (en) 2013-02-15 2023-10-18 Bioverativ Therapeutics Inc. Optimized factor viii gene
HUE047933T2 (en) 2013-03-15 2020-05-28 Bioverativ Therapeutics Inc Factor viii polypeptide formulations
CN105392495A (en) 2013-06-28 2016-03-09 比奥根Ma公司 Thrombin cleavable linkers with XTEN and uses thereof
US10947269B2 (en) 2013-08-08 2021-03-16 Bioverativ Therapeutics Inc. Purification of chimeric FVIII molecules
TWI667255B (en) 2013-08-14 2019-08-01 美商生物化學醫療公司 Factor viii-xten fusions and uses thereof
US10584147B2 (en) 2013-11-08 2020-03-10 Biovertiv Therapeutics Inc. Procoagulant fusion compound
EP4332839A3 (en) 2013-12-06 2024-06-05 Bioverativ Therapeutics Inc. Population pharmacokinetics tools and uses thereof
HUE059820T2 (en) 2014-01-10 2022-12-28 Bioverativ Therapeutics Inc Factor viii chimeric proteins and uses thereof
WO2015120056A1 (en) 2014-02-04 2015-08-13 Biogen Ma Inc. Use of cation-exchange chromatography in the flow-through mode to enrich post-translational modifications
WO2016004113A1 (en) 2014-06-30 2016-01-07 Biogen Ma Inc. Optimized factor ix gene
MA40864A (en) 2014-10-31 2017-09-05 Biogen Ma Inc HYPOTAURINE, GABA, BETA-ALANINE AND CHOLINE FOR THE REGULATION OF THE ACCUMULATION OF RESIDUAL BY-PRODUCTS IN MAMMAL CELL CULTURE PROCESSES
IL257231B (en) 2015-08-03 2022-09-01 Bioverativ Therapeutics Inc Factor ix fusion proteins and methods for their preparation and use
SG10201913278PA (en) 2016-02-01 2020-02-27 Bioverativ Therapeutics Inc Optimized factor viii genes
US12257288B2 (en) 2016-12-02 2025-03-25 Bioverativ Therapeutics Inc. Methods of inducing immune tolerance to clotting factors
EP3548066A1 (en) 2016-12-02 2019-10-09 Bioverativ Therapeutics Inc. Methods of treating hemophilic arthropathy using chimeric clotting factors
IL322212A (en) 2017-08-09 2025-09-01 Bioverativ Therapeutics Inc Nucleic acid molecules and uses thereof
JP2020534837A (en) 2017-09-27 2020-12-03 シギロン セラピューティクス， インコーポレイテッドＳｉｇｉｌｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Methods, compositions, and implantable elements that include active cells
SG11202007114VA (en) 2018-02-01 2020-08-28 Bioverativ Therapeutics Inc Use of lentiviral vectors expressing factor viii
US20210145889A1 (en) 2018-04-04 2021-05-20 Sigilon Therapeutics, Inc. Methods, compositions, and implantable elements comprising stem cells
US12161760B2 (en) 2018-04-04 2024-12-10 Sigilon Therapeutics, Inc. Implantable particles and related methods
HRP20250709T1 (en) 2018-05-18 2025-08-15 Bioverativ Therapeutics Inc. TREATMENT PROCEDURES FOR HEMOPHILIA A
BR112021002017A2 (en) 2018-08-09 2021-05-11 Bioverativ Therapeutics Inc. nucleic acid molecules and their uses for non-viral gene therapy
UY38389A (en) 2018-09-27 2020-04-30 Sigilon Therapeutics Inc IMPLANTABLE DEVICES FOR CELLULAR THERAPY AND RELATED METHODS
WO2020257462A1 (en) 2019-06-19 2020-12-24 Bioverativ Therapeutics Inc. Recombinant factor viii-fc for treating hemophilia and low bone mineral density
KR20220097891A (en) 2019-09-30 2022-07-08 바이오버라티브 테라퓨틱스 인크. Lentiviral vector formulation
BR112022026127A2 (en) 2020-06-24 2023-01-17 Bioverativ Therapeutics Inc METHODS FOR REMOVING FREE FACTOR VIII FROM LENTIVIRAL VECTOR PREPARATIONS MODIFIED TO EXPRESS SUCH PROTEIN
IL310997A (en) 2021-08-23 2024-04-01 Bioverativ Therapeutics Inc Optimized factor viii genes
IL311725A (en) 2021-09-30 2024-05-01 Bioverativ Therapeutics Inc Nucleic acids encoding factor viii polypeptides with reduced immunogenicity
CN120035657A (en) 2022-10-11 2025-05-23 西吉隆医疗股份有限公司 Engineered cells and implantable devices for treating disease
WO2024081310A1 (en) 2022-10-11 2024-04-18 Sigilon Therapeutics, Inc. Engineered cells and implantable elements for treatment of disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR910006424B1 (en) * 1985-08-21 1991-08-24 인코텍스 비.브이 Manufacturing method of knitted briefs
US5451521A (en) * 1986-05-29 1995-09-19 Genetics Institute, Inc. Procoagulant proteins
IL83192A (en) * 1986-07-18 1992-11-15 Gist Brocades Nv Method for the preparation of proteins with factor viii activity by microbial host cells;expression vectors,host cells,antibodies
WO1988005825A1 (en) * 1987-01-30 1988-08-11 Biogen N.V. A method for producing factor viii in high yield
EP0294910B1 (en) * 1987-06-12 1996-09-11 Immuno Ag Novel proteins with factor VIII activity, process for their preparation using genetically engineered cells and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
PT87752B (en) 1992-10-30
AU1810388A (en) 1988-12-22
KR890000666A (en) 1989-03-16
EP0295597A2 (en) 1988-12-21
FI882890L (en) 1988-12-20
EP0295597A3 (en) 1990-05-02
FI882890A7 (en) 1988-12-20
DK332888A (en) 1988-12-20
DE3720246A1 (en) 1988-12-29
AU609829B2 (en) 1991-05-09
FI882890A0 (en) 1988-06-16
JPS6425799A (en) 1989-01-27
PT87752A (en) 1988-07-01

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