DK3250575T3 - Tosylatsalt af n-[3-[(4ar,7as)-2-amino-6-(5-fluorpyrimidin-2-yl)-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a-yl]-4-fluor-phenyl]-5-methoxy-pyrazin-2-carboxamid - Google Patents

Tosylatsalt af n-[3-[(4ar,7as)-2-amino-6-(5-fluorpyrimidin-2-yl)-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a-yl]-4-fluor-phenyl]-5-methoxy-pyrazin-2-carboxamid Download PDF

Info

Publication number: DK3250575T3
Authority: DK; Denmark
Prior art keywords: fluorpyrimidin; tetrahydropyrrolo; thiazin; pyrazin; carboxamide
Prior art date: 2015-01-30

Application number

DK16702654.1T

Other languages

Danish (da)

English (en)

Inventor

David Andrew Coates

Craig Daniel Wolfangel

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2015-01-30

Filing date

2016-01-22

Publication date

2020-01-20

2016-01-22 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2020-01-20 Application granted granted Critical

2020-01-20 Publication of DK3250575T3 publication Critical patent/DK3250575T3/da

Links

VQSRKMNBWMHJKY-YTEVENLXSA-N n-[3-[(4ar,7as)-2-amino-6-(5-fluoropyrimidin-2-yl)-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a-yl]-4-fluorophenyl]-5-methoxypyrazine-2-carboxamide Chemical compound C1=NC(OC)=CN=C1C(=O)NC1=CC=C(F)C([C@@]23[C@@H](CN(C2)C=2N=CC(F)=CN=2)CSC(N)=N3)=C1 VQSRKMNBWMHJKY-YTEVENLXSA-N 0.000 title 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical class CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK16702654.1T 2015-01-30 2016-01-22 Tosylatsalt af n-[3-[(4ar,7as)-2-amino-6-(5-fluorpyrimidin-2-yl)-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a-yl]-4-fluor-phenyl]-5-methoxy-pyrazin-2-carboxamid DK3250575T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201562109733P	2015-01-30	2015-01-30
PCT/US2016/014423 WO2016122968A1 (en)	2015-01-30	2016-01-22	Tosylate salt of n-[3-[(4ar,7as)-2-amino-6-(5-fluoropyrimidin-2-yl)-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a-yl]-4-fluoro-phenyl]-5-methoxy-pyrazine-2-carboxamide

Publications (1)

Publication Number	Publication Date
DK3250575T3 true DK3250575T3 (da)	2020-01-20

Family

ID=55275232

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK16702654.1T DK3250575T3 (da)	2015-01-30	2016-01-22	Tosylatsalt af n-[3-[(4ar,7as)-2-amino-6-(5-fluorpyrimidin-2-yl)-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a-yl]-4-fluor-phenyl]-5-methoxy-pyrazin-2-carboxamid

Country Status (41)

Country	Link
US (1)	US10080758B2 (lt)
EP (1)	EP3250575B1 (lt)
JP (2)	JP6723250B2 (lt)
KR (1)	KR101950129B1 (lt)
CN (1)	CN107108657B (lt)
AR (1)	AR103406A1 (lt)
AU (1)	AU2016211827B2 (lt)
BR (1)	BR112017012149A2 (lt)
CA (1)	CA2969475C (lt)
CL (1)	CL2017001899A1 (lt)
CO (1)	CO2017007810A2 (lt)
CR (1)	CR20170287A (lt)
CY (1)	CY1122548T1 (lt)
DK (1)	DK3250575T3 (lt)
DO (1)	DOP2017000159A (lt)
EA (1)	EA031330B1 (lt)
EC (1)	ECSP17048768A (lt)
ES (1)	ES2768782T3 (lt)
GT (1)	GT201700166A (lt)
HR (1)	HRP20192240T1 (lt)
HU (1)	HUE048029T2 (lt)
IL (1)	IL252754A0 (lt)
LT (1)	LT3250575T (lt)
MA (1)	MA41420B1 (lt)
MD (1)	MD3250575T2 (lt)
ME (1)	ME03581B (lt)
MX (1)	MX2017009713A (lt)
NZ (1)	NZ732381A (lt)
PE (1)	PE20171333A1 (lt)
PH (1)	PH12017501356A1 (lt)
PL (1)	PL3250575T3 (lt)
PT (1)	PT3250575T (lt)
RS (1)	RS59730B1 (lt)
SG (1)	SG11201706038PA (lt)
SI (1)	SI3250575T1 (lt)
SV (1)	SV2017005478A (lt)
TN (1)	TN2017000332A1 (lt)
TW (1)	TWI574969B (lt)
UA (1)	UA119581C2 (lt)
WO (1)	WO2016122968A1 (lt)
ZA (1)	ZA201703937B (lt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR103406A1 (es) *	2015-01-30	2017-05-10	Lilly Co Eli	Sal de tosilato
WO2019094608A1 (en)	2017-11-08	2019-05-16	Denali Therapeutics Inc.	Anti-bace1 antibodies and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT401651B (de) *	1994-06-14	1996-11-25	Biochemie Gmbh	7-(2-(2-aminothiazol-4-yl)-2-(z)- hydroximinoacetamido)-3-n,n- dimethylcarbamoyloxymethyl-3-cephem-4-
CA2708043C (en) *	2007-12-07	2012-11-13	Pfizer Inc.	Tosylate salt of trans-n-isobutyl-3-fluoro-3- [3-fluoro-4- (pyrrolidin-1-yl-methyl) -phenyl] cyclobut anecarboxamide
PE20091438A1 (es) *	2008-01-18	2009-09-26	Eisai Randd Man Co Ltd	Derivados fusionados de aminodihidrotiazina
TWI593692B (zh) *	2013-03-12	2017-08-01	美國禮來大藥廠	四氫吡咯并噻嗪化合物
TWI570127B (zh) *	2014-09-15	2017-02-11	美國禮來大藥廠	結晶型N-[3-[(4aR,7aS)-2-胺基-6-(5-氟嘧啶-2-基)-4,4a,5,7-四氫吡咯并[3,4-d][1,3]噻嗪-7a-基]-4-氟-苯基]-5-甲氧基-吡嗪-2-甲醯胺、其用途及醫藥組合物
AR103406A1 (es) *	2015-01-30	2017-05-10	Lilly Co Eli	Sal de tosilato

2016
- 2016-01-13 AR ARP160100076A patent/AR103406A1/es unknown
- 2016-01-13 TW TW105100973A patent/TWI574969B/zh not_active IP Right Cessation
- 2016-01-22 CA CA2969475A patent/CA2969475C/en not_active Expired - Fee Related
- 2016-01-22 BR BR112017012149-2A patent/BR112017012149A2/pt not_active Application Discontinuation
- 2016-01-22 NZ NZ732381A patent/NZ732381A/en not_active IP Right Cessation
- 2016-01-22 ES ES16702654T patent/ES2768782T3/es active Active
- 2016-01-22 AU AU2016211827A patent/AU2016211827B2/en not_active Ceased
- 2016-01-22 DK DK16702654.1T patent/DK3250575T3/da active
- 2016-01-22 RS RS20191663A patent/RS59730B1/sr unknown
- 2016-01-22 MD MDE20170309T patent/MD3250575T2/ro unknown
- 2016-01-22 WO PCT/US2016/014423 patent/WO2016122968A1/en not_active Ceased
- 2016-01-22 KR KR1020177020943A patent/KR101950129B1/ko not_active Expired - Fee Related
- 2016-01-22 SI SI201630517T patent/SI3250575T1/sl unknown
- 2016-01-22 MX MX2017009713A patent/MX2017009713A/es unknown
- 2016-01-22 EP EP16702654.1A patent/EP3250575B1/en active Active
- 2016-01-22 HU HUE16702654A patent/HUE048029T2/hu unknown
- 2016-01-22 LT LTEP16702654.1T patent/LT3250575T/lt unknown
- 2016-01-22 UA UAA201707108A patent/UA119581C2/uk unknown
- 2016-01-22 SG SG11201706038PA patent/SG11201706038PA/en unknown
- 2016-01-22 US US15/535,523 patent/US10080758B2/en active Active
- 2016-01-22 PE PE2017001211A patent/PE20171333A1/es unknown
- 2016-01-22 CN CN201680005234.2A patent/CN107108657B/zh active Active
- 2016-01-22 JP JP2017540253A patent/JP6723250B2/ja active Active
- 2016-01-22 MA MA41420A patent/MA41420B1/fr unknown
- 2016-01-22 TN TNP/2017/000332A patent/TN2017000332A1/en unknown
- 2016-01-22 HR HRP20192240TT patent/HRP20192240T1/hr unknown
- 2016-01-22 ME MEP-2019-347A patent/ME03581B/me unknown
- 2016-01-22 PL PL16702654T patent/PL3250575T3/pl unknown
- 2016-01-22 PT PT167026541T patent/PT3250575T/pt unknown
- 2016-01-22 EA EA201791229A patent/EA031330B1/ru not_active IP Right Cessation
- 2016-01-22 CR CR20170287A patent/CR20170287A/es unknown
2017
- 2017-06-07 IL IL252754A patent/IL252754A0/en unknown
- 2017-06-08 ZA ZA2017/03937A patent/ZA201703937B/en unknown
- 2017-07-03 DO DO2017000159A patent/DOP2017000159A/es unknown
- 2017-07-06 SV SV2017005478A patent/SV2017005478A/es unknown
- 2017-07-25 CL CL2017001899A patent/CL2017001899A1/es unknown
- 2017-07-27 GT GT201700166A patent/GT201700166A/es unknown
- 2017-07-28 EC ECIEPI201748768A patent/ECSP17048768A/es unknown
- 2017-07-28 PH PH12017501356A patent/PH12017501356A1/en unknown
- 2017-08-01 CO CONC2017/0007810A patent/CO2017007810A2/es unknown
2019
- 2019-04-10 JP JP2019074951A patent/JP2019142902A/ja not_active Ceased
2020
- 2020-01-15 CY CY20201100033T patent/CY1122548T1/el unknown

Also Published As

Publication number	Publication date
UA119581C2 (uk)	2019-07-10
WO2016122968A1 (en)	2016-08-04
US20170368071A1 (en)	2017-12-28
PH12017501356A1 (en)	2017-12-11
ME03581B (me)	2020-07-20
EP3250575A1 (en)	2017-12-06
PT3250575T (pt)	2020-01-16
LT3250575T (lt)	2020-02-10
US10080758B2 (en)	2018-09-25
AU2016211827B2 (en)	2018-04-26
MX2017009713A (es)	2017-11-17
CA2969475A1 (en)	2016-08-04
TN2017000332A1 (en)	2019-01-16
ZA201703937B (en)	2019-01-30
KR101950129B1 (ko)	2019-02-19
AR103406A1 (es)	2017-05-10
CO2017007810A2 (es)	2017-10-20
GT201700166A (es)	2018-11-23
SG11201706038PA (en)	2017-08-30
CN107108657B (zh)	2021-10-08
HRP20192240T1 (hr)	2020-03-06
BR112017012149A2 (pt)	2018-01-02
MD3250575T2 (ro)	2020-03-31
MA41420B1 (fr)	2020-02-28
TW201636354A (zh)	2016-10-16
RS59730B1 (sr)	2020-02-28
PE20171333A1 (es)	2017-09-13
CY1122548T1 (el)	2021-01-27
ECSP17048768A (es)	2017-11-30
SI3250575T1 (sl)	2019-12-31
KR20170097782A (ko)	2017-08-28
SV2017005478A (es)	2018-02-09
JP2019142902A (ja)	2019-08-29
CA2969475C (en)	2019-06-18
HUE048029T2 (hu)	2020-05-28
EP3250575B1 (en)	2019-11-20
IL252754A0 (en)	2017-08-31
EA031330B1 (ru)	2018-12-28
JP2018503666A (ja)	2018-02-08
AU2016211827A1 (en)	2017-06-22
EA201791229A1 (ru)	2017-11-30
PL3250575T3 (pl)	2020-06-01
NZ732381A (en)	2018-05-25
JP6723250B2 (ja)	2020-07-15
DOP2017000159A (es)	2017-07-31
ES2768782T3 (es)	2020-06-23
TWI574969B (zh)	2017-03-21
CR20170287A (es)	2017-07-20
CL2017001899A1 (es)	2018-03-23
CN107108657A (zh)	2017-08-29

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