DK313087D0 - Fremgangsmaade til kaedekombination til dannelse af biologisk aktivt humant relaxin eller analoge dertil samt humant-relaxin-analoge og fremgangsmaade til fremkaldelse af foedsel - Google Patents

Fremgangsmaade til kaedekombination til dannelse af biologisk aktivt humant relaxin eller analoge dertil samt humant-relaxin-analoge og fremgangsmaade til fremkaldelse af foedsel

Info

Publication number: DK313087D0
Authority: DK; Denmark
Prior art keywords: procedure; analogue; relaxin; humant; creation
Prior art date: 1986-06-23

Application number

DK313087A

Other languages

English (en)

Other versions

DK313087A (da

DK173649B1 (da

Inventor

John Perry Burnier

Paul Douglas Johnston

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-06-23

Filing date

1987-06-19

Publication date

1987-06-19

1987-06-19 Application filed by Genentech Inc filed Critical Genentech Inc

1987-06-19 Publication of DK313087D0 publication Critical patent/DK313087D0/da

1987-12-24 Publication of DK313087A publication Critical patent/DK313087A/da

2001-05-21 Application granted granted Critical

2001-05-21 Publication of DK173649B1 publication Critical patent/DK173649B1/da

Links

BJRCFZKVYNDCJE-WBSNEMHCSA-N 99489-95-9 Chemical compound C([C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@H](C(N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)NCC(=O)N2)[C@@H](C)CC)=O)CSSC[C@@H](C(NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC1=O)C(O)=O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(O)=O)[C@@H](C)CC)[C@@H](C)CC)C(C)C)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](N)CCCCN)C(C)C)[C@@H](C)CC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCNC(N)=N)C(C)C)C1=CC=C(O)C=C1 BJRCFZKVYNDCJE-WBSNEMHCSA-N 0.000 title 1
102000003743 Relaxin Human genes 0.000 title 1
108090000103 Relaxin Proteins 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/64—Relaxins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/26—Containing cys-cys disulfide bridge between nonadjacent cysteine residues

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Zoology (AREA)
Toxicology (AREA)
Bioinformatics & Cheminformatics (AREA)
Reproductive Health (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Gynecology & Obstetrics (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pregnancy & Childbirth (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

DK198703130A 1986-06-23 1987-06-19 Fremgangsmåde til kædekombination til fremstilling af biologisk aktivt humant relaxin eller analoge deraf DK173649B1 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US87781986		1986-06-23
US06/877,819 US4835251A (en)	1986-06-23	1986-06-23	Method of chain combination

Publications (3)

Publication Number	Publication Date
DK313087D0 true DK313087D0 (da)	1987-06-19
DK313087A DK313087A (da)	1987-12-24
DK173649B1 DK173649B1 (da)	2001-05-21

Family

ID=25370787

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK198703130A DK173649B1 (da)	1986-06-23	1987-06-19	Fremgangsmåde til kædekombination til fremstilling af biologisk aktivt humant relaxin eller analoge deraf

Country Status (15)

Country	Link
US (1)	US4835251A (da)
EP (1)	EP0251615B1 (da)
JP (1)	JP2529693B2 (da)
KR (1)	KR960007604B1 (da)
CN (1)	CN1029784C (da)
AU (1)	AU617291B2 (da)
CA (1)	CA1336223C (da)
DE (1)	DE3783273T2 (da)
DK (1)	DK173649B1 (da)
HU (1)	HU205948B (da)
IE (1)	IE59683B1 (da)
IL (1)	IL82921A (da)
PH (1)	PH23407A (da)
PT (1)	PT85134B (da)
ZA (1)	ZA874482B (da)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5191063A (en) *	1989-05-02	1993-03-02	University Of Medicine And Dentistry Of New Jersey	Production of biologically active polypeptides by treatment with an exogenous peptide sequence
JP2857684B2 (ja) *	1989-05-04	1999-02-17	ジェネンテク，インコーポレイテッド	ヒトリラキシンの単離のための方法および組成物
US5166191A (en) *	1991-08-19	1992-11-24	Genentech, Inc.	Use of relaxin in cardiovascular therapy
US5478807A (en) *	1991-08-19	1995-12-26	Genentech, Inc.	Use of relaxin in the treatment of bradycardia
US5911997A (en) *	1995-06-07	1999-06-15	Connetics Corporation	Relaxin-like factor and methods and uses thereof
US5612051A (en) *	1995-11-17	1997-03-18	Yue; Samuel K.	Method of treating involuntary muscle dysfunction with relaxin hormone
US6709659B1 (en) *	1996-08-02	2004-03-23	Zymogenetics, Inc.	Antibodies that bind testis-specific insulin homolog polypeptides
US5994148A (en) *	1997-06-23	1999-11-30	The Regents Of University Of California	Method of predicting and enhancing success of IVF/ET pregnancy
US6251863B1 (en)	1998-09-08	2001-06-26	Samuel K. Yue	Method of preventing and treating symptoms of aging and neurodegenerative dysfunctions with relaxin
US20050032683A1 (en) *	2000-10-04	2005-02-10	Amento Edward P.	Methods of modulating apoptosis by administration of relaxin agonists or antagonists
US20050186526A1 (en) *	2002-11-01	2005-08-25	Bas Medical, Inc.	Methods and systems for enabling and stabilizing tooth movement
AU2003903124A0 (en) *	2003-06-20	2003-07-10	Mark Del Borgo	Analogues of heteromeric proteins
AU2005247332A1 (en) *	2004-04-30	2005-12-08	Corthera, Inc.	Methods and compositions for control of fetal growth via modulation of relaxin
US20060052304A1 (en) *	2004-09-02	2006-03-09	Bas Medical, Inc.	Method for remodeling bone and related sutures
AU2007236516B2 (en) *	2006-04-11	2013-01-17	Armour Therapeutics, Inc.	Modified H2 relaxin for tumor suppression
GR1006759B (el) *	2008-12-22	2010-04-20	Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras)	Εξελιγμενη χημικη μεθοδος συνθεσης της ανθρωπινης ρηλαξινης
GR1006941B (el) *	2009-06-01	2010-08-27	Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras),	Πεπτιδικη συνθεση (peptide synthesis)
GR1007010B (el)	2009-10-08	2010-10-07	Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras),	Ινσουλινοειδη πεπτιδια
AU2011291943B2 (en)	2010-08-17	2015-01-22	Ambrx, Inc.	Modified relaxin polypeptides and their uses
WO2013177529A1 (en) *	2012-05-24	2013-11-28	Angion Biomedica Corp.	Relaxin-like compounds and uses thereof
US9381231B2 (en)	2012-10-09	2016-07-05	University Of Florida Research Foundation, Inc.	Use of relaxin to restore maternal physiology in pregnancies conceived by assisted reproductive technologies
JP6289937B2 (ja) *	2014-02-27	2018-03-07	学校法人東海大学	リラキシンの製造方法
EP2946788A1 (en)	2014-05-23	2015-11-25	Immundiagnostik AG	Method and composition for treating heart failure with preserved ejection fraction
JP2018532810A (ja)	2015-11-07	2018-11-08	マルチビアインコーポレイテッド	がんの処置のための腫瘍抑制因子遺伝子治療および免疫チェックポイント治療を含む組成物
CN110381997A (zh)	2016-12-12	2019-10-25	茂体外尔公司	用于治疗和预防癌症和感染性疾病的包含病毒基因治疗和免疫检查点抑制剂的方法和组合物
CA3094329A1 (en)	2018-03-19	2020-02-20	Multivir Inc.	Methods and compositions comprising tumor suppressor gene therapy and cd122/cd132 agonists for the treatment of cancer
TWI844709B (zh)	2019-07-31	2024-06-11	美商美國禮來大藥廠	鬆弛素(relaxin)類似物及其使用方法
WO2021113644A1 (en)	2019-12-05	2021-06-10	Multivir Inc.	Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer
US20230174610A1 (en) *	2020-05-08	2023-06-08	President And Fellows Of Harvard College	Engineered relaxins and methods of use thereof
EP4429694A4 (en)	2021-11-11	2025-10-01	Tectonic Operating Company Inc	RELAXIN-2 FUSION PROTEIN ANALOGUES AND METHODS OF USE THEREOF
WO2024238955A2 (en)	2023-05-18	2024-11-21	Tectonic Therapeutic, Inc.	Relaxin-2 fusion protein analogs and methods of using same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RO81640B (ro) *	1980-03-27	1983-04-30	Eli Lilly And Company	Procedeu de preparare a insulinei
US4421685A (en) *	1980-03-27	1983-12-20	Eli Lilly And Company	Process for producing an insulin
US4656249A (en) *	1982-06-10	1987-04-07	Howard Florey Institute Of Experimental Physiology And Medicine	Peptides with relaxin activity
IL69469A (en) *	1982-08-12	1991-06-10	Florey Howard Inst	Polypeptide having human h1-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors
AU562962B2 (en) *	1982-08-12	1987-06-25	Howard Florey Institute Of Experimental Physiology And Medicine	Molecular cloning and characterisation of the gene sequence coding for human relaxin
NZ206534A (en) *	1982-12-13	1988-05-30	Florey Howard Inst	Molecular cloning and characterisation of gene sequence coding for human relaxin
AU562713B2 (en) *	1982-12-13	1987-06-18	Howard Florey Institute Of Experimental Physiology And Medicine	Cloning for human relaxin

1986
- 1986-06-23 US US06/877,819 patent/US4835251A/en not_active Expired - Lifetime
1987
- 1987-06-19 IL IL82921A patent/IL82921A/xx not_active IP Right Cessation
- 1987-06-19 DK DK198703130A patent/DK173649B1/da not_active IP Right Cessation
- 1987-06-19 HU HU872804A patent/HU205948B/hu not_active IP Right Cessation
- 1987-06-19 PH PH35432A patent/PH23407A/en unknown
- 1987-06-22 ZA ZA874482A patent/ZA874482B/xx unknown
- 1987-06-22 PT PT85134A patent/PT85134B/pt not_active IP Right Cessation
- 1987-06-22 IE IE165587A patent/IE59683B1/en not_active IP Right Cessation
- 1987-06-22 EP EP87305508A patent/EP0251615B1/en not_active Expired - Lifetime
- 1987-06-22 DE DE8787305508T patent/DE3783273T2/de not_active Expired - Lifetime
- 1987-06-22 KR KR1019870006320A patent/KR960007604B1/ko not_active Expired - Fee Related
- 1987-06-23 JP JP62156391A patent/JP2529693B2/ja not_active Expired - Lifetime
- 1987-06-23 CN CN87104447A patent/CN1029784C/zh not_active Expired - Fee Related
- 1987-06-23 CA CA000540413A patent/CA1336223C/en not_active Expired - Lifetime
- 1987-06-23 AU AU74620/87A patent/AU617291B2/en not_active Expired

Also Published As

Publication number	Publication date
DE3783273D1 (de)	1993-02-11
JPS6366198A (ja)	1988-03-24
IE871655L (en)	1987-12-23
EP0251615B1 (en)	1992-12-30
DK313087A (da)	1987-12-24
HUT44045A (en)	1988-01-28
IL82921A (en)	1992-01-15
DE3783273T2 (de)	1993-05-27
PH23407A (en)	1989-07-26
CN87104447A (zh)	1988-02-10
PT85134A (en)	1987-07-01
ZA874482B (en)	1989-02-22
IE59683B1 (en)	1994-03-23
EP0251615A3 (en)	1989-12-13
US4835251A (en)	1989-05-30
DK173649B1 (da)	2001-05-21
AU7462087A (en)	1987-12-24
JP2529693B2 (ja)	1996-08-28
CA1336223C (en)	1995-07-04
HU205948B (en)	1992-07-28
CN1029784C (zh)	1995-09-20
AU617291B2 (en)	1991-11-28
PT85134B (pt)	1990-03-30
KR960007604B1 (ko)	1996-06-07
KR880000463A (ko)	1988-03-26
EP0251615A2 (en)	1988-01-07

Publication	Publication Date	Title
DK313087D0 (da)	1987-06-19	Fremgangsmaade til kaedekombination til dannelse af biologisk aktivt humant relaxin eller analoge dertil samt humant-relaxin-analoge og fremgangsmaade til fremkaldelse af foedsel
IT7920126A0 (it)	1979-02-12	Procedimento per la preparazione di protesi per vasi sanguigni artificiali e protesi per vasi sanguigni artificiali.
NO873695D0 (no)	1987-09-03	Dentalt implantat av skruetypen og fremgangsmaate for bruk av samme.
DK205287D0 (da)	1987-04-22	Bioklaebemidler til celle- og vaevsklaebning
NO903906D0 (no)	1990-09-07	Naeringsmiddelmateriale og fremgangsmaate for fremstilling av dette.
NO873993D0 (no)	1987-09-24	Fremgangsmaate for fremstilling av fluorid- og calsiumpreparat med langvarig frigivelse.
DK15487D0 (da)	1987-01-13	Fremgangsmaade og anlaeg til behandling af kvaegkoed eller andet dyrekoed
DK524087D0 (da)	1987-10-06	Anvendelse af garvestoffer og/eller chlorogensyre samt naerings-, nydelses- og/eller laegemidler med tilsaetning af garvestoffer og/eller chlorogensyre
DK355387A (da)	1988-01-11	Overtraekspraeparat og fremgangsmaade til anvendelse deraf
DK134990D0 (da)	1990-05-31	Praeparat til tandbehandling samt fremgangsmaade til fremstilling deraf
NO894185L (no)	1989-11-29	Fremgangsmaate for fremstilling av 1-buten- og/eller heksener.
IT1226386B (it)	1991-01-15	Procedimento di preparazione di morniflumato e analoghi.
DK158989D0 (da)	1989-03-31	Fremgangsmaade til enzymatisk afhaaring af huder eller skind
NO873197D0 (no)	1987-07-30	Bedoevelsespreparat og fremgangsmaate for anvendelse av dette.
DK362987D0 (da)	1987-07-13	Hexahydroarylquinolizin og fremgangsmaade til fremstilling deraf
IT1216742B (it)	1990-03-08	Dispositivo e procedimento per la realizzazione estemporanea di testdiagnostici quantitativi sul sangue intero.
DK157205C (da)	1990-08-06	Bjaelke samt fremgangsmaade til fremstilling heraf
NO872199D0 (no)	1987-05-26	Analogifremgangsmaate for fremstilling av alkoxyalkyl- og alkylmercaptoalkylsubstituerte benzofuroisokinoliner.
IT8619179A0 (it)	1986-01-24	Procedimento per la preparazione di alcansolfonil cloruri ed arilalcansolfonil cloruri.
NO864531D0 (no)	1986-11-13	Fremgangsmaate og anordning for behandling av brunkull eller torv.
DK511687A (da)	1988-03-31	Farmaceutisk praeparat, samt fremstilling og anvendelse heraf
NO880271D0 (no)	1988-01-22	Fremgangsmaate for fremstilling av poly-umettede n-3 fettsyrer og deres derivater.
NO874320D0 (no)	1987-10-16	Fremgangsmaate for bestemmelse av funksjonelle nivaaer av protein c i humant plasma.
DE3788424D1 (de)	1994-01-20	Testverfahren des menschlichen b-lymphotropen virus (hblv).
DK165475C (da)	1993-04-26	Fremgangsmaade og anlaeg til behandling eller undersoegelse af slagtekroppe

Legal Events

Date	Code	Title	Description
2001-05-21	B1	Patent granted (law 1993)
2005-01-31	PBP	Patent lapsed	Country of ref document: DK