[go: up one dir, main page]

DK310383D0 - 14-fluormorphinaner, fremgangsmade til fremstilling deraf samt deres anvendelse som laegemidler - Google Patents

14-fluormorphinaner, fremgangsmade til fremstilling deraf samt deres anvendelse som laegemidler

Info

Publication number
DK310383D0
DK310383D0 DK3103/83A DK310383A DK310383D0 DK 310383 D0 DK310383 D0 DK 310383D0 DK 3103/83 A DK3103/83 A DK 3103/83A DK 310383 A DK310383 A DK 310383A DK 310383 D0 DK310383 D0 DK 310383D0
Authority
DK
Denmark
Prior art keywords
fluormorphinanes
medicines
procedures
preparing
Prior art date
Application number
DK3103/83A
Other languages
English (en)
Other versions
DK310383A (da
Inventor
Venkat Rao Ganti
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of DK310383D0 publication Critical patent/DK310383D0/da
Publication of DK310383A publication Critical patent/DK310383A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK310383A 1982-07-06 1983-07-05 14-fluormorphinaner, fremgangsmaade til fremstilling deraf samt deres anvendelse som laegemidler DK310383A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/395,597 US4451470A (en) 1982-07-06 1982-07-06 Analgesic, antagonist, and/or anorectic 14-fluoromorphinans

Publications (2)

Publication Number Publication Date
DK310383D0 true DK310383D0 (da) 1983-07-05
DK310383A DK310383A (da) 1984-01-07

Family

ID=23563694

Family Applications (1)

Application Number Title Priority Date Filing Date
DK310383A DK310383A (da) 1982-07-06 1983-07-05 14-fluormorphinaner, fremgangsmaade til fremstilling deraf samt deres anvendelse som laegemidler

Country Status (9)

Country Link
US (1) US4451470A (da)
EP (1) EP0098583A2 (da)
JP (1) JPS5921690A (da)
AU (1) AU1659483A (da)
DK (1) DK310383A (da)
ES (1) ES523863A0 (da)
GR (1) GR79339B (da)
IL (1) IL69157A0 (da)
ZA (1) ZA834900B (da)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
US4775759A (en) * 1984-11-27 1988-10-04 The United States Of America As Represented By The Department Of Health And Human Services Synthesis and utilization of 17-methyl and 17-cyclopropylmethyl-3,14-dihydroxy-4,5α-epoxy 6β-fluoromorphinans (foxy and cyclofoxy) as (18F)-labeled opioid ligands for position emission transaxial tomography (PETT)
US5208338A (en) * 1991-06-14 1993-05-04 The United States Of America As Represented By The Department Of Health & Human Services. Radiolabeled N-substituted-6-iodo-3,14-dihydroxy-4,5α-epoxymorphinans
US5878750A (en) * 1996-11-14 1999-03-09 Clemens; Anton H. Method of treating the syndrome of coronary heart disease risk factors in humans
PL341309A1 (en) * 1997-12-22 2001-04-09 Euro Celtique Method of preventing overdosage of opioidic preparations
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
NZ505193A (en) * 1997-12-22 2003-03-28 Euro Celtique S Opioid agonist/antagonist combinations
RU2138502C1 (ru) * 1999-03-29 1999-09-27 Закрытое акционерное общество "РМА-Фарм" Способ получения 17-циклопропилметил-6,14-эндо-этано-7-(2-гидрокси-3,3-диметилбут-2-ил)тетр агидро-17-норорипавина
US6716449B2 (en) 2000-02-08 2004-04-06 Euro-Celtique S.A. Controlled-release compositions containing opioid agonist and antagonist
DK2517710T3 (da) 2000-02-08 2015-05-26 Euro Celtique Sa Orale opioid-agonist-formuleringer sikret mod forfalskning
US6528520B2 (en) * 2000-08-15 2003-03-04 Cpd, Llc Method of treating the syndrome of coronary heart disease risk factors in humans
US6846831B2 (en) 2000-08-15 2005-01-25 Cpd, Llc Method of treating the syndrome of lipodystrophy
US6262062B1 (en) * 2000-08-15 2001-07-17 Cpd, Llc Method of treating the syndrome of coronary heart disease risk factors in humans
ES2361148T3 (es) 2001-05-11 2011-06-14 Endo Pharmaceuticals Inc. Forma de dosificación de opioides de liberación controlada resistente al abuso.
WO2003007802A2 (en) * 2001-07-18 2003-01-30 Euro-Celtique, S.A. Pharmaceutical combinations of oxycodone and naloxone
AU2002324624A1 (en) * 2001-08-06 2003-02-24 Euro-Celtique S.A. Sequestered antagonist formulations
US20030044458A1 (en) * 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
WO2003013525A1 (en) 2001-08-06 2003-02-20 Euro-Celtique S.A. Opioid agonist formulations with releasable and sequestered antagonist
PT1492505E (pt) 2002-04-05 2015-10-06 Euro Celtique Sa Preparação farmacêutica contendo oxicodona e naloxona
EP2422772A3 (en) 2002-09-20 2012-04-18 Alpharma, Inc. Sequestering subunit and related compositions and methods
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
TWI347201B (en) 2003-04-21 2011-08-21 Euro Celtique Sa Pharmaceutical products,uses thereof and methods for preparing the same
EP1604666A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
US20070191411A1 (en) * 2004-10-07 2007-08-16 Smith Richard A Enhancement of impaired motor and mental functions, using dextromethorphan and oxidase enzyme inhibitor
EP1702558A1 (en) * 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
ES2629766T3 (es) * 2006-04-21 2017-08-14 Nektar Therapeutics Reducción estereoselectiva de una morfinona
NZ573757A (en) 2006-06-19 2011-11-25 Alpharma Inc Coated multilayer oral dosage forms of naltrexone hydrochloride
BRPI0718420A2 (pt) * 2006-10-20 2013-11-12 Cpd Llc Método de restabelecimento do efeito da incretina
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
US20100151014A1 (en) * 2008-12-16 2010-06-17 Alpharma Pharmaceuticals, Llc Pharmaceutical composition
WO2009111162A1 (en) * 2008-02-29 2009-09-11 Mallinckrodt Inc. Process for the preparation of 3-hydroxymorphinan derivatives
CN102143740A (zh) * 2008-07-07 2011-08-03 欧洲凯尔特公司 阿片类拮抗剂治疗尿潴留的用途
AU2010223323B2 (en) 2009-03-10 2013-07-04 Euro-Celtique S.A. Immediate release pharmaceutical compositions comprising oxycodone and naloxone
ES2729679T3 (es) 2009-12-04 2019-11-05 Alkermes Pharma Ireland Ltd Derivados de morfinano para el tratamiento de la sobredosis de fármacos
KR101181000B1 (ko) * 2009-12-29 2012-09-07 엘지이노텍 주식회사 발광소자, 발광소자의 제조방법 및 발광소자 패키지
ES2705726T3 (es) 2010-08-23 2019-03-26 Alkermes Pharma Ireland Ltd Métodos para tratar el aumento de peso inducido por antipsicóticos
US9211293B2 (en) 2011-12-15 2015-12-15 Alkermes Pharma Ireland Limited Opioid agonist antagonist combinations
EP3003311A2 (en) 2013-05-24 2016-04-13 Alkermes Pharma Ireland Limited Methods for treating depressive symptoms
JP2016519161A (ja) 2013-05-24 2016-06-30 アルカームス ファーマ アイルランド リミテッド モルファン及びモルフィナン類似物及び使用の方法
EP3024461B1 (en) 2013-07-23 2020-05-13 Euro-Celtique S.A. A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
ES2787223T3 (es) 2014-11-07 2020-10-15 Univ Minnesota Sales y composiciones útiles para tratar enfermedades
EP4243768A1 (en) 2020-11-12 2023-09-20 Alkermes Pharma Ireland Limited Immediate release multilayer tablet

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA913077A (en) * 1972-10-24 J. Pachter Irwin Process of preparing n-substituted 14-hydroxydihydronormorphines
US2797223A (en) * 1957-06-25 Preparation of ix-bromocodeinone
US3137701A (en) * 1962-04-19 1964-06-16 Upjohn Co Process for the preparation of 6-deoxy-6-fluoromorphines, 6-deoxy-6-fluorocodeines, and related compounds
US3332950A (en) * 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
US3914265A (en) * 1972-12-11 1975-10-21 Du Pont Dialkylaminosulfur trifluorides as fluorinating agents
US4236008A (en) * 1978-09-19 1980-11-25 E. I. Du Pont De Nemours And Company Fluorination of precursors for fluorine analogs of hydrocodone and oxycodone
US4241065A (en) * 1979-07-02 1980-12-23 E. I. Du Pont De Nemours And Company Fluoro analogs of hydrocodone and oxycodone useful as analgesics, narcotic antagonists or both

Also Published As

Publication number Publication date
AU1659483A (en) 1984-01-12
ES8505519A1 (es) 1984-11-01
GR79339B (da) 1984-10-22
DK310383A (da) 1984-01-07
IL69157A0 (en) 1983-11-30
JPS5921690A (ja) 1984-02-03
ES523863A0 (es) 1984-11-01
US4451470A (en) 1984-05-29
EP0098583A2 (en) 1984-01-18
ZA834900B (en) 1985-02-27

Similar Documents

Publication Publication Date Title
DK310383D0 (da) 14-fluormorphinaner, fremgangsmade til fremstilling deraf samt deres anvendelse som laegemidler
DK49283D0 (da) Pyrazoloxaziner, -thiaziner og - quinoliner, fremgangsmade til fremstilling deraf samt deres anvendelse som laegemidler
DK675787A (da) 8-substituerede 2-aminotetraliner, fremgangsmaader til deres fremstilling samt deres anvendelse som laegemidler
NO812933L (no) Aminosyrederivater, fremgangsmaate til deres fremstilling, midler som inneholder forbindelsene samt deres anvendelse
DK647087A (da) Substituerede basiske tetraliner, fremgangsmaade til deres fremstilling samt deres anvendelse som laegemidler
DK398583A (da) Spergualin-beslaegtede forbindelser, fremgangsmaader til fremstilling deraf samt deres anvendelse som laegemidler
DK426083A (da) Pteriner, fremgangsmaader til deres fremstilling samt deres anvendelse
DK539087D0 (da) 4,5-dihydro- og 4,5,6,7-tetrahydro-pyrazolooe1,5-aaapyrimidiner, fremgangsmaader til deres fremstilling samt deres anvendelse som laegemidler
DK55188A (da) Alkylsubstituerede n-benzopyranyllactamer, fremgangsmaader til deres fremstilling samt deres anvendelse som laegemidler
DK303688D0 (da) Polyoxygenerede labdanderivater, fremgangsmaade til deres fremstilling samt deres anvendelse som laegemidler
DK382283D0 (da) Thiazol-derivater, fremgangsmade til fremstilling deraf samt deres anvendelse som laegemidler
DK166210C (da) Krystallinske cephalosporin-hydrohalogenidsalte, fremgangsmaade til fremstilling deraf samt deres anvendelse som laegemidler
DK544383D0 (da) Svovlholdige benzylidenderivater, fremgangsmade til deres fremstilling samt deres anvendelse
DK442183D0 (da) Thiatriazin-derivater, fremgangsmader til fremstilling deraf og deres anvendelse som laegemidler
DK259088A (da) Diarylalkyl-substituerede alkylaminer, fremgangsmaader til deres fremstilling samt deres anvendelse som laegemidler
DK586284D0 (da) Quinoloncarboxylsyre-derivater, fremgangsmaade til fremstilling deraf samt anvendelse af saadanne derivater som laegemiddel
DK231089A (da) Substituerede azolthioethere, fremgangsmaade til fremstilling deraf samt deres anvendelse som skadedyrsbekaempelsesmiddel
DK176183D0 (da) Beta-lactam-antibiotika, fremgangsmade til fremstilling deraf samt deres anvendelse som laegemiddel
DK329882A (da) Oxothienobenzoxepiner,fremgangsmaade til fremstilling deraf samt deres anvendelse som laegemidler
DK260884D0 (da) 7-oxo-4-thia-1-azabicyclo(3.2.0)-hept-2-en-derivater,fremgangsmaade til fremstilling deraf samt deres anvendelse som laegemidler
DK134083D0 (da) 7-alfa-aminoacyl-3-chlorcephalosporiner, fremgangsmade til deres fremstilling samt deres anvendelse som laegemidler
DK401883D0 (da) Kemiske forbindelser, fremgangsmade til fremstilling deraf samt deres anvendelse som skadedyrsbekaempelsesmidler med forlaenget virketid
DK162049C (da) N-substituerede tetrahydrothiaziner, fremgangsmaader til disses fremstilling samt deres anvendelse som pesticider
DK225189A (da) Hydrazinocarbonyloxylabdaner, fremgangsmaade til deres fremstilling samt deres anvendelse som laegemidler
DK280683D0 (da) Azolsubstituerede oximino-cyan-acetamid-derivater, fremgangsmader til fremstilling deraf samt deres anvendelse som fungicider

Legal Events

Date Code Title Description
ATS Application withdrawn