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DK314487D0 - Benzoxepinderivat - Google Patents

Benzoxepinderivat

Info

Publication number
DK314487D0
DK314487D0 DK314487A DK314487A DK314487D0 DK 314487 D0 DK314487 D0 DK 314487D0 DK 314487 A DK314487 A DK 314487A DK 314487 A DK314487 A DK 314487A DK 314487 D0 DK314487 D0 DK 314487D0
Authority
DK
Denmark
Prior art keywords
derivatives
activity
benzoxepin
phenylbenzoxepin
plateles
Prior art date
Application number
DK314487A
Other languages
English (en)
Other versions
DK166676B1 (da
DK314487A (da
Inventor
Toshio Tatsuoka
Kayoko Nomura
Fumio Satoh
Takafumi Ishihara
Seiji Miyano
Kunihiro Sumoto
Original Assignee
Suntory Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suntory Ltd filed Critical Suntory Ltd
Publication of DK314487D0 publication Critical patent/DK314487D0/da
Publication of DK314487A publication Critical patent/DK314487A/da
Application granted granted Critical
Publication of DK166676B1 publication Critical patent/DK166676B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
DK314487A 1986-06-20 1987-06-19 2-phenoxybenzoxepinderivater, farmaceutisk praeparat indeholdende et saadant derivat, samt en fremgangsmaade til fremstilling af derivaterne DK166676B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14289886 1986-06-20
JP14289886 1986-06-20

Publications (3)

Publication Number Publication Date
DK314487D0 true DK314487D0 (da) 1987-06-19
DK314487A DK314487A (da) 1987-12-21
DK166676B1 DK166676B1 (da) 1993-06-28

Family

ID=15326163

Family Applications (1)

Application Number Title Priority Date Filing Date
DK314487A DK166676B1 (da) 1986-06-20 1987-06-19 2-phenoxybenzoxepinderivater, farmaceutisk praeparat indeholdende et saadant derivat, samt en fremgangsmaade til fremstilling af derivaterne

Country Status (10)

Country Link
US (1) US4845094A (da)
EP (1) EP0250265B1 (da)
JP (1) JPH0813807B2 (da)
AT (1) ATE56211T1 (da)
AU (1) AU597671B2 (da)
CA (1) CA1277320C (da)
DE (1) DE3764724D1 (da)
DK (1) DK166676B1 (da)
ES (1) ES2017498B3 (da)
HU (1) HU206108B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4997836A (en) * 1988-11-11 1991-03-05 Takeda Chemical Industries, Ltd. Trisubstituted piperazine compounds, their production and use
JP2851054B2 (ja) * 1989-03-15 1999-01-27 サントリー株式会社 ベンズオキセピン誘導体
FR2698873B1 (fr) * 1992-12-07 1995-02-24 Lipha Benzocycloheptènes, benzoxépines et benzothiépines activateurs des canaux potassiques, procédé de préparation, composition pharmaceutique les contenant.
ES2207652T3 (es) * 1994-08-05 2004-06-01 BAUSCH & LOMB INCORPORATED Dispositivo para la insercion de una lente intraocular flexible.
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6221897B1 (en) 1998-06-10 2001-04-24 Aventis Pharma Deutschland Gmbh Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
EP1340510A1 (en) 1998-12-23 2003-09-03 G.D. Searle LLC. Combinations of cholesteryl ester transfer protein inhibitors and bile acid sequestering agents for cardiovascular indications
EA005815B1 (ru) 1998-12-23 2005-06-30 Джи.Ди.Сирл Ллс Комбинация ингибиторов транспорта желчных кислот в подвздошной кишке и ингибиторов белка, переносящего эфиры холестерина, для сердечно-сосудистых показаний
ATE228012T1 (de) 1998-12-23 2002-12-15 Searle Llc Kombinationen von ileumgallensäuretransports inhibitoren und gallensäure sequestriermitteln für kardiovaskuläre indikationen
US6462091B1 (en) 1998-12-23 2002-10-08 G.D. Searle & Co. Combinations of cholesteryl ester transfer protein inhibitors and HMG coA reductase inhibitors for cardiovascular indications
KR20010099937A (ko) 1998-12-23 2001-11-09 윌리암스 로저 에이 심혈관 징후용 콜레스테릴 에스테르 전달 단백질 억제제및 피브르산 유도체의 조합물
DE69908643T2 (de) 1998-12-23 2004-05-13 G.D. Searle Llc, Chicago Kombinationen von cholesteryl ester transfer protein inhibitoren und nicotinsäure derivaten für kardiovaskuläre indikationen
KR20010102964A (ko) 1998-12-23 2001-11-17 윌리암스 로저 에이 심장혈관 징후를 위한 회장 담즙산 수송 억제인자 및피브린산 유도체의 조합물
US6586434B2 (en) 2000-03-10 2003-07-01 G.D. Searle, Llc Method for the preparation of tetrahydrobenzothiepines
EP1448546A4 (en) 2001-11-02 2005-02-02 Searle Llc MONO- AND DI-FLUORINATED BENZOTHIEPINE COMPOUNDS AS INHIBITORS OF TRANSPORT OF ACIDICALLY DEPENDENT SODIUM ACILIC (ASBT) BILIARY ACIDS AND TAUROCHOLATE RECOVERY
JP2005521653A (ja) 2002-01-17 2005-07-21 ファルマシア コーポレイション 先端ナトリウム同時依存性胆汁酸輸送（ａｓｂｔ）およびタウロコール酸塩取込みの阻害剤としての新規アルキル／アリールヒドロキシまたはケトチエピン化合物
PT2771003T (pt) 2011-10-28 2017-07-26 Lumena Pharmaceuticals Llc Inibidores da reciclagem de ácidos biliares para tratamento de doenças hepáticas colestáticas pediátricas
EP2770990A4 (en) 2011-10-28 2015-03-11 Lumena Pharmaceuticals Inc Gallic acid refluxing agent for the treatment of hypertension and chronic liver disease
WO2016019587A1 (en) 2014-08-08 2016-02-11 Merck Sharp & Dohme Corp. [7, 6]-fused bicyclic antidiabetic compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1593760A1 (de) * 1967-02-01 1972-06-08 Boehringer Sohn Ingelheim Verfahren zur Herstellung neuer Benz-epinderivate
DE2931399A1 (de) * 1979-08-02 1981-02-26 Kali Chemie Pharma Gmbh Neue 3-amino-1-benzoxepin-derivate und ihre salze, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
DE3440295A1 (de) * 1984-11-05 1986-05-15 Kali-Chemie Pharma Gmbh, 3000 Hannover Verfahren zur diastereoselektiven reduktion von 3-amino-1-benzoxepin-5(2h)-onen
US4736031A (en) * 1985-06-10 1988-04-05 Takeda Chemical Industries, Ltd. 2-(piperazinylalkyl)-1-benzothiepin, 1-benzoxepin, and 1,5-benzodioxepin derivatives

Also Published As

Publication number Publication date
AU7424587A (en) 1987-12-24
ES2017498B3 (es) 1991-02-16
US4845094A (en) 1989-07-04
DK166676B1 (da) 1993-06-28
HUT48231A (en) 1989-05-29
EP0250265B1 (en) 1990-09-05
DE3764724D1 (de) 1990-10-11
ATE56211T1 (de) 1990-09-15
CA1277320C (en) 1990-12-04
EP0250265A1 (en) 1987-12-23
JPH0813807B2 (ja) 1996-02-14
AU597671B2 (en) 1990-06-07
JPS63107972A (ja) 1988-05-12
DK314487A (da) 1987-12-21
HU206108B (en) 1992-08-28

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