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DK300977A - Fremgangsmade til fremstilling af (3-amino-5-substitueret -6-fluorpyrazinoyl- eller pyrazamido) guanidiner og derivater deraf - Google Patents

Fremgangsmade til fremstilling af (3-amino-5-substitueret -6-fluorpyrazinoyl- eller pyrazamido) guanidiner og derivater deraf

Info

Publication number
DK300977A
DK300977A DK300977A DK300977A DK300977A DK 300977 A DK300977 A DK 300977A DK 300977 A DK300977 A DK 300977A DK 300977 A DK300977 A DK 300977A DK 300977 A DK300977 A DK 300977A
Authority
DK
Denmark
Prior art keywords
pyrazamido
guanidins
pyrazinoyl
fluoro
derivatives
Prior art date
Application number
DK300977A
Other languages
English (en)
Other versions
DK145019C (da
DK145019B (da
Inventor
E J Cragoe
O W Woltersdorf
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK300977A publication Critical patent/DK300977A/da
Publication of DK145019B publication Critical patent/DK145019B/da
Application granted granted Critical
Publication of DK145019C publication Critical patent/DK145019C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK300977A 1976-07-23 1977-07-05 Analogifremgangsmaade til fremstilling af (3,5-diamino-6-fluorpyrazinoyl)guanidin eller syreadditionssalte deraf DK145019C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/708,254 US4087526A (en) 1976-07-23 1976-07-23 (3-Amino-5-substituted-6-fluoropyrazinoyl or pyrazamido)-guanidines and their derivatives bearing substituents on the guanidino nitrogens
US70825476 1976-07-23

Publications (3)

Publication Number Publication Date
DK300977A true DK300977A (da) 1978-01-24
DK145019B DK145019B (da) 1982-08-02
DK145019C DK145019C (da) 1982-12-27

Family

ID=24845039

Family Applications (1)

Application Number Title Priority Date Filing Date
DK300977A DK145019C (da) 1976-07-23 1977-07-05 Analogifremgangsmaade til fremstilling af (3,5-diamino-6-fluorpyrazinoyl)guanidin eller syreadditionssalte deraf

Country Status (9)

Country Link
US (1) US4087526A (da)
JP (1) JPS5315389A (da)
CH (1) CH634060A5 (da)
DE (1) DE2733291A1 (da)
DK (1) DK145019C (da)
FR (1) FR2366285A1 (da)
GB (1) GB1579035A (da)
NL (1) NL7707511A (da)
SE (1) SE428687B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4224447A (en) * 1979-03-27 1980-09-23 Merck & Co., Inc. Novel pyrazinecarboxamides and processes for preparing same
US4246406A (en) * 1979-03-27 1981-01-20 Merck & Co., Inc. Heterocyclic substituted pyrazinoylguanidines
US4594349A (en) * 1982-01-04 1986-06-10 Beyer Jr Karl H Hyperuretic agents
US4604394A (en) * 1984-10-01 1986-08-05 Merck & Co., Inc. Antiarrhythmic compositions and method
US6858614B2 (en) * 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenolic guanidine sodium channel blockers
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
US20050090505A1 (en) * 2003-08-18 2005-04-28 Johnson Michael R. Methods of reducing risk of infection from pathogens
US7745442B2 (en) 2003-08-20 2010-06-29 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
MX2015007797A (es) 2012-12-17 2015-10-05 Parion Sciences Inc Compuestos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil) carbamimidoil) pirazin-2-carboxamida.
JP6392242B2 (ja) 2012-12-17 2018-09-19 パリオン・サイエンシィズ・インコーポレーテッド 粘膜への水分付与が不十分であることが好都合である疾患の治療に有用なクロロ−ピラジンカルボキサミド誘導体
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL299931A (da) * 1962-10-30
NL299929A (da) * 1962-10-30
FR1525670A (fr) * 1966-08-25 1968-05-17 Merck & Co Inc Procédé de fabrication de guanidines substituées
FR7797M (da) * 1968-10-31 1970-03-31

Also Published As

Publication number Publication date
DK145019C (da) 1982-12-27
DE2733291A1 (de) 1978-01-26
FR2366285A1 (fr) 1978-04-28
GB1579035A (en) 1980-11-12
US4087526A (en) 1978-05-02
SE7707892L (sv) 1978-01-24
JPS5315389A (en) 1978-02-13
DK145019B (da) 1982-08-02
SE428687B (sv) 1983-07-18
FR2366285B1 (da) 1980-02-01
CH634060A5 (de) 1983-01-14
NL7707511A (nl) 1978-01-25

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