DK2997033T3 - Kondenserede tricykliske heterocykliske forbindelser som hiv- integrasehæmmere - Google Patents
Kondenserede tricykliske heterocykliske forbindelser som hiv- integrasehæmmereInfo
- Publication number
- DK2997033T3 DK2997033T3 DK14798188.0T DK14798188T DK2997033T3 DK 2997033 T3 DK2997033 T3 DK 2997033T3 DK 14798188 T DK14798188 T DK 14798188T DK 2997033 T3 DK2997033 T3 DK 2997033T3
- Authority
- DK
- Denmark
- Prior art keywords
- heterocyclic compounds
- hiv integrase
- integrase inhibitors
- tricyclic heterocyclic
- condensed tricyclic
- Prior art date
Links
- 229940099797 HIV integrase inhibitor Drugs 0.000 title 1
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 239000003084 hiv integrase inhibitor Substances 0.000 title 1
- 125000000169 tricyclic heterocycle group Chemical group 0.000 abstract 3
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/16—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361824739P | 2013-05-17 | 2013-05-17 | |
| PCT/CN2014/075685 WO2014183532A1 (en) | 2013-05-17 | 2014-04-18 | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2997033T3 true DK2997033T3 (da) | 2018-01-29 |
Family
ID=51897679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14798188.0T DK2997033T3 (da) | 2013-05-17 | 2014-04-18 | Kondenserede tricykliske heterocykliske forbindelser som hiv- integrasehæmmere |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9643982B2 (da) |
| EP (2) | EP3330272B1 (da) |
| AR (1) | AR096332A1 (da) |
| AU (1) | AU2014267951A1 (da) |
| CY (1) | CY1119842T1 (da) |
| DK (1) | DK2997033T3 (da) |
| ES (1) | ES2656696T3 (da) |
| HK (1) | HK1248685A1 (da) |
| HR (1) | HRP20180081T1 (da) |
| HU (1) | HUE036384T2 (da) |
| LT (1) | LT2997033T (da) |
| ME (1) | ME02977B (da) |
| NO (1) | NO3058793T3 (da) |
| PL (1) | PL2997033T3 (da) |
| PT (1) | PT2997033T (da) |
| RS (1) | RS56701B1 (da) |
| SI (1) | SI2997033T1 (da) |
| TW (1) | TWI656122B (da) |
| WO (1) | WO2014183532A1 (da) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016027879A1 (ja) | 2014-08-22 | 2016-02-25 | 塩野義製薬株式会社 | インテグラーゼ阻害活性を有する多環性ピリドン誘導体 |
| TWI520963B (zh) * | 2014-12-24 | 2016-02-11 | 國立清華大學 | １，９－二氮萉衍生物及其製法 |
| WO2017113288A1 (en) * | 2015-12-31 | 2017-07-06 | Merck Sharp & Dohme Corp. | Fused tricyclic heterocyclic compounds as hiv integrase inhibitors |
| US10934312B2 (en) | 2016-12-02 | 2021-03-02 | Merck Sharp & Dohme Corp. | Tricyclic heterocycle compounds useful as HIV integrase inhibitors |
| JOP20190130A1 (ar) * | 2016-12-02 | 2019-06-02 | Merck Sharp & Dohme | مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv) |
| JP2021522254A (ja) * | 2018-04-27 | 2021-08-30 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | Ｈｉｖインテグラーゼ阻害剤として有用な三環式複素環化合物 |
| PE20201414A1 (es) | 2018-05-31 | 2020-12-07 | Shionogi & Co | Derivado policiclico de piridona |
| JP7328962B2 (ja) | 2018-05-31 | 2023-08-17 | 塩野義製薬株式会社 | 多環性カルバモイルピリドン誘導体 |
| EP3801543B1 (en) | 2018-06-05 | 2024-09-11 | Merck Sharp & Dohme LLC | Tricyclic heterocycle compounds useful as hiv integrase inhibitors |
| LT3810283T (lt) | 2018-06-21 | 2023-08-25 | F. Hoffmann-La Roche Ag | 3-((1r,3r)-1-(2,6-difluor-4-((1-(3-fluorpropil)azetidin-3- il)amino) fenil)-3-metil-1,3,4,9-tetrahidro-2h-pirido[3,4-b]indol-2-il)- 2,2- difluorpropan-1-olio tartrato druskos kietosios formos, jų paruošimo procesas ir jų naudojimo būdai vėžiui gydyti |
| HUE059677T2 (hu) | 2019-03-22 | 2022-12-28 | Gilead Sciences Inc | Áthidalt triciklusos karbamoilpiridon-vegyületek és ezek gyógyszerészeti alkalmazása |
| US20200398978A1 (en) | 2019-06-20 | 2020-12-24 | Bell Helicopter Textron Inc. | Low-drag rotor blade extension |
| WO2021107066A1 (ja) | 2019-11-28 | 2021-06-03 | 塩野義製薬株式会社 | インテグラーゼ阻害剤及び抗ｈｉｖ薬を組み合わせることを特徴とするｈｉｖ感染症の予防及び治療用医薬 |
| PE20221569A1 (es) * | 2020-02-24 | 2022-10-06 | Gilead Sciences Inc | Compuestos tetraciclicos para el tratamiento de infecciones por vih |
| KR20230079137A (ko) | 2020-09-30 | 2023-06-05 | 길리애드 사이언시즈, 인코포레이티드 | 가교된 트리사이클릭 카르바모일피리돈 화합물 및 이의 용도 |
| HUE064467T2 (hu) | 2021-01-19 | 2024-03-28 | Gilead Sciences Inc | Szubsztituált piridotriazin-származékok és alkalmazásuk |
| TW202446773A (zh) | 2022-04-06 | 2024-12-01 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2452769C (en) | 2001-08-10 | 2012-08-21 | Shionogi & Co., Ltd. | Antiviral agent |
| PT1441735E (pt) | 2001-10-26 | 2006-06-30 | Istituto Di Ricerche Di B Mo P | Inibidores de integrase do hiv a base de hidroxipirimidinona carboxamida n-substituida |
| US7232819B2 (en) | 2001-10-26 | 2007-06-19 | Istituto Di Ricerche Di Biologia P. Angeletti S.P.A. | Dihydroxypyrimidine carboxamide inhibitors of HIV integrase |
| DE60315796T2 (de) | 2002-01-17 | 2008-06-05 | Merck & Co., Inc. | Hydroxynaphthyridinoncarbonsäureamide, die sich als inhibitoren der hiv-integrase eignen |
| JP4733986B2 (ja) | 2002-12-27 | 2011-07-27 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー | ＨＩＶインテグラーゼ阻害薬として有用なテトラヒドロ−４Ｈ−ピリド［１，２−ａ］ピリミジン類および関連する化合物 |
| WO2004062613A2 (en) | 2003-01-13 | 2004-07-29 | Bristol-Myers Squibb Company | Hiv integrase inhibitors |
| US7037908B2 (en) | 2003-04-24 | 2006-05-02 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| TW200510425A (en) | 2003-08-13 | 2005-03-16 | Japan Tobacco Inc | Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor |
| AR046938A1 (es) | 2003-12-12 | 2006-01-04 | Merck & Co Inc | Procedimiento para preparar hexahidropirimido[1,2-a]azepin-2-carboxilatos y compuetos similares |
| TW200526635A (en) | 2003-12-22 | 2005-08-16 | Shionogi & Co | Hydroxypyrimidinone derivative having HIV integrase inhibitory activity |
| WO2005087766A1 (en) * | 2004-03-09 | 2005-09-22 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Hiv integrase inhibitors |
| CN1929737A (zh) * | 2004-03-09 | 2007-03-14 | 默克公司 | Hiv整合酶抑制剂 |
| JP2007528396A (ja) | 2004-03-09 | 2007-10-11 | メルク エンド カムパニー インコーポレーテッド | Ｈｉｖインテグラーゼ阻害薬 |
| WO2005087768A1 (en) | 2004-03-09 | 2005-09-22 | Merck & Co., Inc. | Hiv integrase inhibitors |
| US7273859B2 (en) | 2004-05-12 | 2007-09-25 | Bristol-Myers Squibb Company | HIV integrase inhibitors: cyclic pyrimidinone compounds |
| US7115601B2 (en) | 2004-05-18 | 2006-10-03 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| US7157447B2 (en) | 2004-05-28 | 2007-01-02 | Bristol-Myers Squibb Company | Bicyclic heterocycles as HIV integrase inhibitors |
| US7176196B2 (en) | 2004-05-28 | 2007-02-13 | Bristol-Myers Squibb Company | Bicyclic heterocycles as HIV integrase inhibitors |
| US7173022B2 (en) | 2004-05-28 | 2007-02-06 | Bristol-Myers Squibb Company | Bicyclic heterocycles as HIV integrase inhibitors |
| US7192948B2 (en) | 2004-05-28 | 2007-03-20 | Bristol-Myers Squibb Company | Bicyclic heterocycles as HIV integrase inhibitors |
| EP1866313A1 (en) | 2005-03-31 | 2007-12-19 | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. | Hiv integrase inhibitors |
| US7494984B2 (en) | 2005-08-31 | 2009-02-24 | Bristol-Myers Squibb Company | Substituted imidazo[1,2-a]pyrimidines as HIV viral DNA integrase inhibitors |
| US7897592B2 (en) | 2005-11-15 | 2011-03-01 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| US7902182B2 (en) | 2005-11-16 | 2011-03-08 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| US8039458B2 (en) | 2005-11-17 | 2011-10-18 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| US7897593B2 (en) | 2006-05-30 | 2011-03-01 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| US7893055B2 (en) | 2006-06-28 | 2011-02-22 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| EP2488521B1 (en) | 2009-10-13 | 2013-12-18 | Elanco Animal Health Ireland Limited | Macrocyclic integrase inhibitors |
| PE20130010A1 (es) * | 2010-02-26 | 2013-02-05 | Japan Tobacco Inc | Derivado de 1,3,4,8-tetrahidro-2h-pirido[1,2-a]pirazina como inhibidor de la integrasa del vih |
| BR112012024796A2 (pt) | 2010-04-02 | 2016-06-07 | Janssen R&D Ireland | inibidores de integrase macrocíclicos |
-
2014
- 2014-04-18 DK DK14798188.0T patent/DK2997033T3/da active
- 2014-04-18 SI SI201430563T patent/SI2997033T1/en unknown
- 2014-04-18 HR HRP20180081TT patent/HRP20180081T1/hr unknown
- 2014-04-18 ES ES14798188.0T patent/ES2656696T3/es active Active
- 2014-04-18 WO PCT/CN2014/075685 patent/WO2014183532A1/en not_active Ceased
- 2014-04-18 EP EP17201148.8A patent/EP3330272B1/en active Active
- 2014-04-18 PL PL14798188T patent/PL2997033T3/pl unknown
- 2014-04-18 PT PT147981880T patent/PT2997033T/pt unknown
- 2014-04-18 ME MEP-2018-4A patent/ME02977B/me unknown
- 2014-04-18 EP EP14798188.0A patent/EP2997033B1/en active Active
- 2014-04-18 LT LTEP14798188.0T patent/LT2997033T/lt unknown
- 2014-04-18 RS RS20180010A patent/RS56701B1/sr unknown
- 2014-04-18 HU HUE14798188A patent/HUE036384T2/hu unknown
- 2014-04-18 US US14/892,754 patent/US9643982B2/en active Active
- 2014-04-18 AU AU2014267951A patent/AU2014267951A1/en not_active Abandoned
- 2014-05-15 TW TW103117219A patent/TWI656122B/zh not_active IP Right Cessation
- 2014-05-16 AR ARP140101973A patent/AR096332A1/es not_active Application Discontinuation
-
2015
- 2015-01-28 NO NO15704618A patent/NO3058793T3/no unknown
-
2018
- 2018-01-24 CY CY20181100097T patent/CY1119842T1/el unknown
- 2018-06-26 HK HK18108172.3A patent/HK1248685A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2997033A1 (en) | 2016-03-23 |
| HK1248685A1 (en) | 2018-10-19 |
| TW201524978A (zh) | 2015-07-01 |
| HRP20180081T1 (hr) | 2018-02-23 |
| EP2997033A4 (en) | 2016-10-26 |
| PT2997033T (pt) | 2018-01-25 |
| US9643982B2 (en) | 2017-05-09 |
| EP3330272B1 (en) | 2021-02-17 |
| RS56701B1 (sr) | 2018-03-30 |
| NO3058793T3 (da) | 2018-03-17 |
| ME02977B (me) | 2018-10-20 |
| TWI656122B (zh) | 2019-04-11 |
| CY1119842T1 (el) | 2018-06-27 |
| EP3330272A1 (en) | 2018-06-06 |
| AR096332A1 (es) | 2015-12-23 |
| US20160108059A1 (en) | 2016-04-21 |
| ES2656696T3 (es) | 2018-02-28 |
| WO2014183532A1 (en) | 2014-11-20 |
| PL2997033T3 (pl) | 2018-04-30 |
| EP2997033B1 (en) | 2017-11-15 |
| LT2997033T (lt) | 2018-02-12 |
| SI2997033T1 (en) | 2018-04-30 |
| HUE036384T2 (hu) | 2018-07-30 |
| AU2014267951A1 (en) | 2015-11-19 |
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