DK2699698T4 - Oscillerende amplifikations-reaktion for nukleinsyrer - Google Patents
Oscillerende amplifikations-reaktion for nukleinsyrer Download PDFInfo
- Publication number
- DK2699698T4 DK2699698T4 DK12773717.9T DK12773717T DK2699698T4 DK 2699698 T4 DK2699698 T4 DK 2699698T4 DK 12773717 T DK12773717 T DK 12773717T DK 2699698 T4 DK2699698 T4 DK 2699698T4
- Authority
- DK
- Denmark
- Prior art keywords
- oscilling
- nucleic acids
- amplification reaction
- amplification
- reaction
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502723—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by venting arrangements
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2522/00—Reaction characterised by the use of non-enzymatic proteins
- C12Q2522/10—Nucleic acid binding proteins
- C12Q2522/101—Single or double stranded nucleic acid binding proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2527/00—Reactions demanding special reaction conditions
- C12Q2527/101—Temperature
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Dispersion Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161477357P | 2011-04-20 | 2011-04-20 | |
| US201161477437P | 2011-04-20 | 2011-04-20 | |
| PCT/US2012/034589 WO2012145725A2 (en) | 2011-04-20 | 2012-04-20 | Oscillating amplification reaction for nucleic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK2699698T3 DK2699698T3 (da) | 2017-04-10 |
| DK2699698T4 true DK2699698T4 (da) | 2020-04-14 |
Family
ID=47042196
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12773717.9T DK2699698T4 (da) | 2011-04-20 | 2012-04-20 | Oscillerende amplifikations-reaktion for nukleinsyrer |
| DK12774413.4T DK2699700T3 (da) | 2011-04-20 | 2012-04-20 | Integreret indretning til nukleinsyreregistrering og -identifikation |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12774413.4T DK2699700T3 (da) | 2011-04-20 | 2012-04-20 | Integreret indretning til nukleinsyreregistrering og -identifikation |
Country Status (10)
| Country | Link |
|---|---|
| US (9) | US10519492B2 (da) |
| EP (2) | EP2699700B8 (da) |
| JP (3) | JP5879667B2 (da) |
| KR (3) | KR20140044323A (da) |
| CN (2) | CN103608467B (da) |
| CA (2) | CA2853615C (da) |
| DK (2) | DK2699698T4 (da) |
| ES (2) | ES2621390T5 (da) |
| PT (1) | PT2699698T (da) |
| WO (2) | WO2012145725A2 (da) |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090047673A1 (en) | 2006-08-22 | 2009-02-19 | Cary Robert B | Miniaturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids |
| ES2582602T3 (es) | 2007-03-28 | 2016-09-14 | Signal Diagnostics | Sistema y método de análisis de alta resolución de ácidos nucleicos para detectar variaciones de secuencia |
| US10669574B2 (en) | 2008-11-18 | 2020-06-02 | XCR Diagnostics, Inc. | DNA amplification technology |
| US8837159B1 (en) * | 2009-10-28 | 2014-09-16 | Amazon Technologies, Inc. | Low-profile circuit board assembly |
| DK2699698T4 (da) | 2011-04-20 | 2020-04-14 | Mesa Biotech Inc | Oscillerende amplifikations-reaktion for nukleinsyrer |
| US9758837B2 (en) * | 2011-08-02 | 2017-09-12 | The United States Of America, As Represented By The Secretary Of Agriculture | Sensitive and rapid method for Candidatus Liberibacter species detection |
| US9121046B2 (en) * | 2011-11-16 | 2015-09-01 | New England Biolabs, Inc. | Reducing template independent primer extension and threshold time for loop mediated isothermal amplification |
| US20160187239A1 (en) * | 2013-07-29 | 2016-06-30 | Mbio Diagnostics, Inc. | Assay cartridge processing systems and methods and associated assay cartridges |
| US10370707B2 (en) | 2013-10-09 | 2019-08-06 | Fluoresentric, Inc. | Multiplex probes |
| WO2015138343A1 (en) | 2014-03-10 | 2015-09-17 | Click Diagnostics, Inc. | Cartridge-based thermocycler |
| KR101809645B1 (ko) | 2014-05-30 | 2017-12-15 | 주식회사 이지다이아텍 | 자동 면역분석 수행장치 |
| BR112016029490B1 (pt) | 2014-06-18 | 2021-06-15 | Scandinavian Micro Biodevices Aps | Sistema de detecção microfluídica |
| US11098347B2 (en) | 2014-07-08 | 2021-08-24 | National Institute Of Advanced Industrial Science And Technology | Nucleic acid amplification device, nucleic acid amplification method, and chip for nucleic acid amplification |
| DE102014015586B3 (de) * | 2014-10-21 | 2016-03-31 | Webasto SE | Heizgerät |
| US9623415B2 (en) | 2014-12-31 | 2017-04-18 | Click Diagnostics, Inc. | Devices and methods for molecular diagnostic testing |
| US9671303B2 (en) * | 2015-03-10 | 2017-06-06 | Ford Global Technologies, Llc | Method and system for laser pressure transducer |
| TWI824991B (zh) * | 2015-04-24 | 2023-12-11 | 美商梅薩生物科技股份有限公司 | 用於檢測目標核酸的卡匣及控制通過在用於檢測目標核酸的卡匣中之腔室的流體之垂直流的方法 |
| DE102015110092B4 (de) * | 2015-06-23 | 2017-08-10 | Endress + Hauser Gmbh + Co. Kg | Feldgerät zum Einsatz in hygienischen Anwendungen in der Prozess- und Automatisierungstechnik und Verfahren zu dessen Herstellung |
| US10775370B2 (en) * | 2015-07-17 | 2020-09-15 | Stat-Diagnostica & Innovation, S.L. | Fluidic system for performing assays |
| US10040069B2 (en) | 2015-07-23 | 2018-08-07 | General Electric Company | Amplification and detection of nucleic acids |
| EP3430378B1 (en) * | 2016-03-14 | 2022-08-10 | Lucira Health, Inc. | Devices and methods for modifying optical properties |
| US10987674B2 (en) | 2016-04-22 | 2021-04-27 | Visby Medical, Inc. | Printed circuit board heater for an amplification module |
| WO2017197040A1 (en) | 2016-05-11 | 2017-11-16 | Click Diagnostics, Inc. | Devices and methods for nucleic acid extraction |
| WO2018005710A1 (en) | 2016-06-29 | 2018-01-04 | Click Diagnostics, Inc. | Devices and methods for the detection of molecules using a flow cell |
| USD800331S1 (en) | 2016-06-29 | 2017-10-17 | Click Diagnostics, Inc. | Molecular diagnostic device |
| CN109661273B (zh) * | 2016-06-30 | 2022-11-04 | 维斯比医学公司 | 用于核酸提取的装置和方法 |
| USD800914S1 (en) | 2016-06-30 | 2017-10-24 | Click Diagnostics, Inc. | Status indicator for molecular diagnostic device |
| GB201611469D0 (en) | 2016-06-30 | 2016-08-17 | Lumiradx Tech Ltd | Improvements in or relating to nucleic acid amplification processes |
| USD800913S1 (en) | 2016-06-30 | 2017-10-24 | Click Diagnostics, Inc. | Detection window for molecular diagnostic device |
| JP2018023360A (ja) * | 2016-07-29 | 2018-02-15 | セイコーエプソン株式会社 | 核酸増幅反応方法、試薬、および試薬の使用方法 |
| WO2018125271A1 (en) | 2016-12-28 | 2018-07-05 | Neogen Corporation | Fluid retainer cartridge assembly and method for utilizing the same |
| KR101997097B1 (ko) | 2016-12-30 | 2019-07-05 | 주식회사 이지다이아텍 | 거대 자성입자 복합체를 이용한 자동 면역분석장치 및 방법 |
| USD834721S1 (en) | 2017-03-03 | 2018-11-27 | Neogen Corporation | Assay cartridge |
| JP7111706B2 (ja) | 2017-06-07 | 2022-08-02 | タカラバイオ株式会社 | オリゴヌクレオチドの保存方法 |
| KR20190032810A (ko) | 2017-09-20 | 2019-03-28 | 주식회사 이지다이아텍 | 자성 면역분석장치 및 방법 |
| EP3459632A1 (en) * | 2017-09-26 | 2019-03-27 | Lunaphore Technologies SA | Microfluidic cartrige with built-in sampling device |
| US11162130B2 (en) | 2017-11-09 | 2021-11-02 | Visby Medical, Inc. | Portable molecular diagnostic device and methods for the detection of target viruses |
| GB2569965A (en) * | 2018-01-04 | 2019-07-10 | Lumiradx Uk Ltd | Improvements in or relating to amplification of nucleic acids |
| CN110240999B (zh) * | 2018-03-09 | 2022-09-06 | 浙江品级基因科技有限公司 | 一种提高循环肿瘤dna检出率的检测装置及方法 |
| GB201812192D0 (en) | 2018-07-26 | 2018-09-12 | Ttp Plc | Variable temperature reactor, heater and control circuit for the same |
| GB201813429D0 (en) * | 2018-08-17 | 2018-10-03 | Touchlight Ip Ltd | Synthesis of DNA with improved yield |
| JP2021534804A (ja) | 2018-09-03 | 2021-12-16 | ビスビュー メディカル,インコーポレイテッド | 抗生物質感受性検査のための装置および方法 |
| WO2020079274A1 (en) * | 2018-10-19 | 2020-04-23 | Univercells S.A. | Method for decontaminating a biomolecule production system and a system suitable for decontamination |
| WO2020132279A1 (en) | 2018-12-19 | 2020-06-25 | Nuclein, Llc | Apparatus and methods for molecular diagnostics |
| KR20220005009A (ko) | 2019-04-28 | 2022-01-12 | 비스비 메디컬, 인코포레이티드 | 디지털 검출 능력 및 무선 연결성을 갖는 분자 진단 디바이스 |
| WO2021138544A1 (en) | 2020-01-03 | 2021-07-08 | Visby Medical, Inc. | Devices and methods for antibiotic susceptibility testing |
| CN113215224A (zh) * | 2020-01-21 | 2021-08-06 | 青岛大学 | 扩增和检测核酸的方法及试剂盒 |
| WO2021147910A1 (en) * | 2020-01-21 | 2021-07-29 | Qingdao Navid Biotechnology Co., Ltd. | Methods and kits for amplification and detection of nucleic acids |
| CN113528624B (zh) * | 2020-04-17 | 2025-12-02 | 青岛简码基因科技有限公司 | 扩增和检测核酸的方法及试剂盒 |
| WO2021257576A1 (en) * | 2020-06-15 | 2021-12-23 | Arizona Board Of Regents On Behalf Of Arizona State University | Point of need diagnostic with thermal control |
| JP2023539299A (ja) * | 2020-08-26 | 2023-09-13 | センス バイオディテクション リミテッド | デバイス |
| US20230257834A1 (en) * | 2020-08-26 | 2023-08-17 | Sense Biodetection Limited | Devices |
| USD1064314S1 (en) | 2021-08-13 | 2025-02-25 | Visby Medical, Inc. | Molecular diagnostic device |
| EP4388134A4 (en) | 2021-08-20 | 2025-10-29 | Singular Genomics Systems Inc | CHEMICALLY AND THERMALLY ASSISTED NUCLEIC ACID AMPLIFICATION PROCESSES |
| US20250171864A1 (en) * | 2021-11-24 | 2025-05-29 | D-Nome | Rapid method for room temperature reverse transcription loop-mediated isothermal amplification (rt-lamp) and reagent kit |
| AU2023222749A1 (en) * | 2022-02-15 | 2024-08-29 | Cepheid | Exponential base-greater-than-base 2 nucleic acid amplification using high- and low-tm primers |
| EP4479550A1 (en) * | 2022-02-17 | 2024-12-25 | One Lambda, Inc. | Systems and methods for protein detection |
| WO2023196973A1 (en) * | 2022-04-08 | 2023-10-12 | The Broad Institute, Inc. | Amplification assays using crispr-cas based detection |
| KR20250006970A (ko) | 2022-04-29 | 2025-01-13 | 세페이드 | 열에 불안정한 실란 및 화학적으로 변형된 고체 지지체를 사용한 핵산 추출 및 단리 |
| EP4526479A1 (en) | 2022-05-19 | 2025-03-26 | Cepheid | Mvp cartridge and methods of use and manufacture |
| CN114934044B (zh) * | 2022-05-27 | 2023-11-10 | 国网电力科学研究院武汉南瑞有限责任公司 | 一种重组大肠杆菌在养护铅酸蓄电池中的应用 |
| CN115290606A (zh) * | 2022-08-22 | 2022-11-04 | 凤凰医学诊断科技有限公司 | 一种检测装置 |
| DE102022211087A1 (de) * | 2022-10-19 | 2024-04-25 | Robert Bosch Gesellschaft mit beschränkter Haftung | Verfahren und Vorrichtung zur Voramplifikation eines Nukleinsäuregemisches |
| CN115678764B (zh) * | 2022-11-07 | 2023-09-08 | 苏州思迈德生物科技有限公司 | 一种快速分子诊断的微流控芯片 |
| WO2024129998A2 (en) | 2022-12-16 | 2024-06-20 | Cepheid | Mpox clade ii biomarker panel |
| CN116121349B (zh) * | 2022-12-20 | 2024-04-09 | 南京诺唯赞生物科技股份有限公司 | 一种扩增含乙醇的核酸样本的方法 |
| CN121001822A (zh) | 2023-01-30 | 2025-11-21 | 塞弗德公司 | 呼吸道生物标志物组合 |
| WO2024216275A2 (en) * | 2023-04-13 | 2024-10-17 | 5Prime Biosciences, Inc. | Compositions and methods for upregulation of reverse transcription and reduction of sequence bias in rna sequencing |
| WO2025006633A1 (en) | 2023-06-27 | 2025-01-02 | Cepheid | Pancoronavirus biomarker panel |
| US20250073701A1 (en) | 2023-08-29 | 2025-03-06 | Cepheid | Integrated valve body and syringe tube component for assay cartridges |
| US20250171840A1 (en) | 2023-09-18 | 2025-05-29 | Cepheid | Three-phase nested amplification and multi-phasic detection |
| WO2025165828A1 (en) | 2024-01-29 | 2025-08-07 | Cepheid | Universal assay cartridge with integrated valve body and syringe tube use |
| WO2025175133A1 (en) | 2024-02-14 | 2025-08-21 | Cepheid | Melt shape genotyping |
| WO2025179142A1 (en) | 2024-02-22 | 2025-08-28 | Cepheid | Maximizing optical channel capabilities for target detection |
| WO2025199454A1 (en) | 2024-03-21 | 2025-09-25 | Cepheid | Compositions and methods for selective extraction of oligonucleotides from complex matrices |
| WO2025207561A1 (en) | 2024-03-27 | 2025-10-02 | Cepheid | Isothermal amplification using novel synthetic oligonucleotides |
Family Cites Families (145)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3667607A (en) | 1970-11-27 | 1972-06-06 | Baker Chem Co J T | Chromatographic material |
| US4235601A (en) | 1979-01-12 | 1980-11-25 | Thyroid Diagnostics, Inc. | Test device and method for its use |
| US4663277A (en) | 1983-05-20 | 1987-05-05 | Profile Diagnostic Sciences Inc. | Virus detection method and materials |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683105A (en) | 1985-10-31 | 1987-07-28 | Westinghouse Electric Corp. | Testable, fault-tolerant power interface circuit for normally de-energized loads |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US4960691A (en) | 1986-09-29 | 1990-10-02 | Abbott Laboratories | Chromatographic test strip for determining ligands or receptors |
| IE69047B1 (en) | 1989-03-23 | 1996-08-07 | Gary Harold Gregory Hen Thorpe | Liquid transfer devices |
| US5541099A (en) | 1989-08-10 | 1996-07-30 | Life Technologies, Inc. | Cloning and expression of T5 DNA polymerase reduced in 3'-to-5' exonuclease activity |
| US5225163A (en) | 1989-08-18 | 1993-07-06 | Angenics, Inc. | Reaction apparatus employing gravitational flow |
| EP0455905B1 (en) | 1990-05-11 | 1998-06-17 | Microprobe Corporation | Dipsticks for nucleic acid hybridization assays and methods for covalently immobilizing oligonucleotides |
| US6007999A (en) | 1991-07-31 | 1999-12-28 | Idexx Laboratories, Inc. | Reversible flow chromatographic binding assay |
| GB9123922D0 (en) | 1991-11-11 | 1992-01-02 | Bunce Roger A | Liquid transfer devices |
| JP2832117B2 (ja) | 1991-11-29 | 1998-12-02 | キヤノン株式会社 | サンプル測定デバイス及びサンプル測定システム |
| WO1993014217A1 (en) | 1992-01-10 | 1993-07-22 | Life Technologies, Inc. | Use of predetermined nucleotides having altered base pairing characteristics in the amplification of nucleic acid molecules |
| US6555349B1 (en) | 1993-01-22 | 2003-04-29 | Cornell Research Foundation, Inc. | Methods for amplifying and sequencing nucleic acid molecules using a three component polymerase |
| US5516664A (en) | 1992-12-23 | 1996-05-14 | Hyman; Edward D. | Enzymatic synthesis of repeat regions of oligonucleotides |
| US5432065A (en) | 1993-03-30 | 1995-07-11 | United States Biochemical Corporation | Cycle sequencing with non-thermostable DNA polymerases |
| GB9307319D0 (en) | 1993-04-07 | 1993-06-02 | British Tech Group | Liquid transfer devices |
| JPH09510351A (ja) | 1994-03-16 | 1997-10-21 | ジェン−プローブ・インコーポレイテッド | 等温鎖置換核酸増幅法 |
| US6037127A (en) | 1994-03-31 | 2000-03-14 | E. I. Du Pont De Nemours And Company | Method for detection of non-denatured nucleic acid fragments |
| GB9416002D0 (en) | 1994-08-08 | 1994-09-28 | Univ Cranfield | Fluid transport device |
| GB9502112D0 (en) | 1995-02-03 | 1995-03-22 | British Biocell Int | Assay device and method |
| US5989813A (en) | 1995-07-13 | 1999-11-23 | Molecular Innovations, Inc. | Detection of amplified nucleic acid sequences using bifunctional haptenization and dyed microparticles |
| US20040110167A1 (en) | 1995-07-13 | 2004-06-10 | Gerdes John C. | Lateral flow system for nucleic acid detection |
| US6130098A (en) | 1995-09-15 | 2000-10-10 | The Regents Of The University Of Michigan | Moving microdroplets |
| ES2212071T3 (es) | 1996-01-05 | 2004-07-16 | The Government Of The United States Of America, As Represented By The Secretary, Department Of | Antigeno de mesotelio y kits para marcarlo como diana. |
| US6750031B1 (en) | 1996-01-11 | 2004-06-15 | The United States Of America As Represented By The Secretary Of The Navy | Displacement assay on a porous membrane |
| EP0880598A4 (en) | 1996-01-23 | 2005-02-23 | Affymetrix Inc | RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM |
| US5741647A (en) | 1996-02-16 | 1998-04-21 | Tam; Joseph Wing On | Flow through nucleic acid hybridisation uses thereof and a device thereof |
| DE19609838A1 (de) | 1996-03-13 | 1997-09-18 | Boehringer Mannheim Gmbh | Verfahren und Teststreifen zur Bestimmung eines Analyten |
| US5824478A (en) | 1996-04-30 | 1998-10-20 | Vysis, Inc. | Diagnostic methods and probes |
| US6582921B2 (en) | 1996-07-29 | 2003-06-24 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses thereof |
| WO1998022625A1 (en) * | 1996-11-20 | 1998-05-28 | The Regents Of The University Of Michigan | Microfabricated isothermal nucleic acid amplification devices and methods |
| US5922617A (en) | 1997-11-12 | 1999-07-13 | Functional Genetics, Inc. | Rapid screening assay methods and devices |
| US6190612B1 (en) | 1998-01-21 | 2001-02-20 | Bayer Corporation | Oxygen sensing membranes and methods of making same |
| DK1086372T3 (da) | 1998-03-30 | 2006-09-18 | Orasure Technologies Inc | Opsamlingsindretning til enkelttrinsanalyse af mundvæsker |
| US7640083B2 (en) | 2002-11-22 | 2009-12-29 | Monroe David A | Record and playback system for aircraft |
| US6207379B1 (en) | 1998-09-11 | 2001-03-27 | One Lambda | Method for amplification of DNA |
| US6261779B1 (en) | 1998-11-10 | 2001-07-17 | Bio-Pixels Ltd. | Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system |
| EP1131159A1 (en) | 1998-11-18 | 2001-09-12 | Orchid BioSciences, Inc. | One-step nucleic acid dipstick device with movable membrane |
| WO2000031538A1 (en) | 1998-11-23 | 2000-06-02 | Praxsys Biosystems, Inc. | Improved lateral flow assays |
| US6416642B1 (en) | 1999-01-21 | 2002-07-09 | Caliper Technologies Corp. | Method and apparatus for continuous liquid flow in microscale channels using pressure injection, wicking, and electrokinetic injection |
| US20020177135A1 (en) | 1999-07-27 | 2002-11-28 | Doung Hau H. | Devices and methods for biochip multiplexing |
| US6300069B1 (en) | 1999-05-03 | 2001-10-09 | Qiagen Gmbh | Generation and amplification of nucleic acids from ribonucleic acids |
| WO2001026813A2 (en) | 1999-10-08 | 2001-04-19 | Micronics, Inc. | Microfluidics without electrically of mechanically operated pumps |
| US6471916B1 (en) | 1999-11-09 | 2002-10-29 | Packard Instrument Company | Apparatus and method for calibration of a microarray scanning system |
| US6875619B2 (en) | 1999-11-12 | 2005-04-05 | Motorola, Inc. | Microfluidic devices comprising biochannels |
| US20020058252A1 (en) | 1999-12-06 | 2002-05-16 | Ananiev Evgueni V. | Short shared nucleotide sequences |
| US6468749B1 (en) | 2000-03-30 | 2002-10-22 | Quark Biotech, Inc. | Sequence-dependent gene sorting techniques |
| GB0016814D0 (en) | 2000-07-07 | 2000-08-30 | Lee Helen | Improved dipstick assays (3) |
| GB0016813D0 (en) | 2000-07-07 | 2000-08-30 | Lee Helen | Improved dipstick assays (4) |
| EP1362122A2 (en) | 2000-09-12 | 2003-11-19 | TransGenetics Incorporated | Microarrayed organization of transcription factor target genes |
| US20020076825A1 (en) | 2000-10-10 | 2002-06-20 | Jing Cheng | Integrated biochip system for sample preparation and analysis |
| DE60117699T2 (de) | 2000-12-26 | 2006-10-19 | Matsushita Electric Industrial Co., Ltd., Kadoma | Analyseverfahren durch spezifisches binden und vorrichtung, die das verfahren einsetzt |
| WO2002072773A2 (en) | 2001-03-09 | 2002-09-19 | Nugen Technologies, Inc. | Methods and compositions for amplification of rna sequences |
| IL153504A0 (en) | 2001-03-09 | 2003-07-06 | Nugen Technologies Inc | Methods and compositions for amplification of rna sequences |
| US6960437B2 (en) | 2001-04-06 | 2005-11-01 | California Institute Of Technology | Nucleic acid amplification utilizing microfluidic devices |
| CA2446246A1 (en) | 2001-05-03 | 2002-11-14 | Immunetics, Inc. | Systems and methods for detection of analytes in biological fluids |
| EP1604688B1 (de) | 2001-06-05 | 2010-02-03 | CureVac GmbH | Stabilisierte Tumorantigen-mRNA mit erhöhtem G/C-Gehalt |
| US20030044862A1 (en) | 2001-06-22 | 2003-03-06 | The Board Of Trustees Of The Leland Stanford Jr. University | Diagnostic marker for tumor hypoxia and prognosis |
| CN1242270C (zh) | 2001-08-09 | 2006-02-15 | 松下电器产业株式会社 | 生物传感器及测定方法 |
| US6916541B2 (en) | 2001-09-07 | 2005-07-12 | Penn State Research Foundation | Modified substrates for the attachment of biomolecules |
| KR100488281B1 (ko) | 2001-09-15 | 2005-05-10 | 아람 바이오시스템 주식회사 | 열 대류를 이용한 염기서열 증폭 방법 및 장치 |
| EP1451584B1 (en) | 2001-11-09 | 2011-05-11 | 3dbiosurfaces Technologies, LLC | High surface area substrates for microarrays and methods to make same |
| WO2003049530A2 (en) | 2001-12-07 | 2003-06-19 | Dyax Corporation | Method and apparatus for washing magnetically responsive particles |
| US7772383B2 (en) | 2002-01-25 | 2010-08-10 | The Trustees Of Princeton University | Chemical PCR: Compositions for enhancing polynucleotide amplification reactions |
| US20030211488A1 (en) | 2002-05-07 | 2003-11-13 | Northwestern University | Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection |
| JP2005532827A (ja) | 2002-07-12 | 2005-11-04 | ブリティッシュ・バイオセル・インターナショナル・リミテッド | 側方フローアッセイ用のデバイスおよびその方法 |
| CA2491436C (en) | 2002-07-23 | 2015-01-06 | Microban Products Company | Antimicrobial melamine resin and products made therefrom |
| US20040064435A1 (en) | 2002-07-26 | 2004-04-01 | Ahmad-Maher Moubayed | Clinical assessment and diagnostic tool for use with peristaltic pump |
| US20040018577A1 (en) | 2002-07-29 | 2004-01-29 | Emerson Campbell John Lewis | Multiple hybrid immunoassay |
| US7662594B2 (en) | 2002-09-20 | 2010-02-16 | New England Biolabs, Inc. | Helicase-dependent amplification of RNA |
| CA2498764C (en) | 2002-09-20 | 2015-11-10 | New England Biolabs, Inc. | Helicase dependent amplification of nucleic acids |
| KR100463203B1 (ko) | 2002-12-10 | 2004-12-23 | 삼성전자주식회사 | 활성 영역을 구비하는 반도체 소자 |
| WO2004055159A2 (en) | 2002-12-12 | 2004-07-01 | Chiron Corporation | Identification of oligonucleotides for the capture, detection and quantitation of west nile virus |
| US20050221281A1 (en) | 2003-01-08 | 2005-10-06 | Ho Winston Z | Self-contained microfluidic biochip and apparatus |
| JP2004263708A (ja) | 2003-01-14 | 2004-09-24 | Kyowa Metal Work Co Ltd | ツインクラッチ式変速機 |
| JP2006520190A (ja) | 2003-01-21 | 2006-09-07 | マイクロニクス, インコーポレイテッド | 流体の微小流体的な操作、増幅、および分析(例えば、細菌アッセイおよびアンチグロブリン試験)のための方法およびシステム |
| WO2004076684A2 (en) | 2003-02-27 | 2004-09-10 | Strategic Diagnostics Inc. | Compositions and methods for the detection of mammalian muscle troponin i |
| TWI333545B (en) | 2003-04-02 | 2010-11-21 | Cholestech Corp | Adhered membranes retaining porosity and biological activity |
| FR2856046B1 (fr) | 2003-06-16 | 2005-07-29 | Biomerieux Sa | Microvanne fluidique a ouverture par commande electrique |
| US7722817B2 (en) | 2003-08-28 | 2010-05-25 | Epocal Inc. | Lateral flow diagnostic devices with instrument controlled fluidics |
| CN102018496A (zh) | 2003-09-03 | 2011-04-20 | 生命修复国际股份有限公司 | 个人诊断装置和相关方法 |
| US7354706B2 (en) | 2003-09-09 | 2008-04-08 | The Regents Of The University Of Colorado, A Body Corporate | Use of photopolymerization for amplification and detection of a molecular recognition event |
| EP1673595A2 (en) | 2003-09-15 | 2006-06-28 | DiagnoSwiss S.A. | Microfluidic flow monitoring device |
| JP2005110621A (ja) | 2003-10-10 | 2005-04-28 | Aisin Seiki Co Ltd | 核酸増幅方法及び核酸増幅用試薬キット |
| US20050116995A1 (en) | 2003-10-24 | 2005-06-02 | Toru Tanikawa | Head module, liquid jetting head, liquid jetting apparatus, method of manufacturing head module, and method of manufacturing liquid jetting head |
| US7754500B2 (en) | 2003-11-21 | 2010-07-13 | Anp Technologies, Inc. | Asymmetrically branched polymer conjugates and microarray assays |
| JP4250523B2 (ja) | 2003-12-25 | 2009-04-08 | 株式会社東芝 | マイクロリアクタ、分析システム、分析方法、反応システム、反応方法、分離システム、分離方法 |
| WO2005098439A2 (en) | 2004-03-30 | 2005-10-20 | Whatman, Inc. | Lateral flow format, materials and mehtods |
| US20050250141A1 (en) | 2004-03-30 | 2005-11-10 | Lambert James L | Diagnostic assays including multiplexed lateral flow immunoassays with quantum dots |
| JP2008500820A (ja) | 2004-04-07 | 2008-01-17 | アクセス バイオ, アイエヌシー. | 核酸検出システム |
| US8173078B2 (en) | 2004-04-28 | 2012-05-08 | Industrial Technology Research Institute | Gravity-driven micropump |
| US7273590B2 (en) | 2004-04-29 | 2007-09-25 | Industrial Technology Research Institute | gravity-driven apparatus and method for control of microfluidic devices |
| US7796266B2 (en) | 2004-04-30 | 2010-09-14 | Kimberly-Clark Worldwide, Inc. | Optical detection system using electromagnetic radiation to detect presence or quantity of analyte |
| JP2007538236A (ja) | 2004-05-21 | 2007-12-27 | アトノミックス アクティーゼルスカブ | ヒドロゲルを含む表面弾性波センサ |
| SE527036C2 (sv) | 2004-06-02 | 2005-12-13 | Aamic Ab | Analysanordning med reglerat flöde och motsvarande förfarande |
| CA2588820A1 (en) | 2004-11-30 | 2006-06-08 | Global Technologies (Nz) Ltd | Method of sample analysis and apparatus therefor |
| US20060127886A1 (en) | 2004-12-15 | 2006-06-15 | Kaylor Rosann M | Sample-efficient lateral flow immunoassay |
| JP2006185972A (ja) | 2004-12-27 | 2006-07-13 | Nikon Corp | マスク及び露光方法 |
| EP3028765B1 (en) | 2005-01-31 | 2020-01-08 | Realbio Technologies Ltd. | Method of sequentially transferring liquids through a lateral flow capillary device |
| US7396689B2 (en) | 2005-02-04 | 2008-07-08 | Decision Biomarkers Incorporated | Method of adjusting the working range of a multi-analyte assay |
| WO2006098804A2 (en) | 2005-03-11 | 2006-09-21 | Chembio Diagnostic Systems, Inc. | Dual path immunoassay device |
| WO2006104279A1 (en) | 2005-03-31 | 2006-10-05 | Fujifilm Corporation | Surface graft material and its manufacturing method, electrically conductive material and its manufacturing method, and electrically conductive pattern material |
| US7439079B2 (en) | 2005-04-29 | 2008-10-21 | Kimberly-Clark Worldwide, Inc. | Assay devices having detection capabilities within the hook effect region |
| WO2006122311A2 (en) | 2005-05-11 | 2006-11-16 | The Trustees Of The University Of Pennsylvania | Microfluidic chip |
| SI1891447T1 (sl) | 2005-05-23 | 2011-12-30 | Phadia Ab | Dvostopenjski postopki in naprave za teste lateralnega toka |
| US20070015166A1 (en) | 2005-07-14 | 2007-01-18 | Nilsen Thor W | Lateral flow methods and devices for detection of nucleic acid binding proteins |
| EP1929045B9 (en) | 2005-09-06 | 2012-06-20 | Gen-Probe Incorporated | Methods, compositions and kits for isothermal amplification of nucleic acids |
| CN101400993A (zh) | 2005-11-10 | 2009-04-01 | 阿普尔拉股份有限公司 | 包括多孔聚合物电极的微流体系统 |
| WO2008002462A2 (en) | 2006-06-23 | 2008-01-03 | Micronics, Inc. | Methods and devices for microfluidic point-of-care immunoassays |
| CN101360819A (zh) | 2006-01-20 | 2009-02-04 | 凸版印刷株式会社 | 反应容器及dna的扩增反应方法 |
| US7537917B2 (en) * | 2006-03-31 | 2009-05-26 | Collins Michael J | Microwave assisted PCR amplification of DNA |
| US8980561B1 (en) | 2006-08-22 | 2015-03-17 | Los Alamos National Security, Llc. | Nucleic acid detection system and method for detecting influenza |
| US20090047673A1 (en) | 2006-08-22 | 2009-02-19 | Cary Robert B | Miniaturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids |
| JP2008148690A (ja) | 2006-11-22 | 2008-07-03 | Fujifilm Corp | マイクロチップを用いた核酸増幅方法およびマイクロチップ、それを用いた核酸増幅システム |
| EP1972938B1 (de) | 2007-03-19 | 2014-05-14 | Ivoclar Vivadent | Teststreifen für die Bestimmung des Kariesrisikos |
| US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
| DK2183379T3 (da) | 2007-08-01 | 2015-07-27 | Dana Farber Cancer Inst Inc | Berigelse af en målsekvens |
| TW200909338A (en) | 2007-08-23 | 2009-03-01 | Ind Tech Res Inst | Autonomous microfluidic apparatus |
| US20090086357A1 (en) | 2007-09-28 | 2009-04-02 | Toshiba America Information Systems, Inc. | In drive written spirals for self servo writing |
| CN101409933B (zh) | 2007-10-11 | 2010-08-04 | 华为技术有限公司 | 一种释放资源的方法和设备 |
| US9409166B2 (en) | 2007-12-10 | 2016-08-09 | The Trustees Of The University Of Pennsylvania | Integrated PCR reactor for cell lysis, nucleic acid isolation and purification, and nucleic acid amplication related applications |
| DE102007062441A1 (de) | 2007-12-20 | 2009-06-25 | Aj Innuscreen Gmbh | Mobiles Schnelltestsystem für die Nukleinsäureanalytik |
| DK2252890T3 (da) | 2008-02-22 | 2014-10-13 | Orion Diagnostica Oy | Fremgangsmåde og anordning til påvisning af kulhydrater |
| US8187808B2 (en) * | 2008-02-29 | 2012-05-29 | Northwestern University | Barriers for facilitating biological reactions |
| US20110160090A1 (en) | 2008-05-05 | 2011-06-30 | Los Alamos National Laboratory | Nanocrystal-Based Lateral Flow Microarrays and Low-Voltage Signal Detection Systems |
| EP3067694A1 (en) | 2008-05-05 | 2016-09-14 | Los Alamos National Security, LLC | Lateral flow-based nucleic acid sample preparation device, integrated with passive fluid flow control |
| US7910309B2 (en) * | 2008-07-31 | 2011-03-22 | Los Alamos National Security, Llc | Multiplexed lateral flow microarray assay for detection of citrus pathogens Xylella fastidiosa and Xanthomonas axonopodis pv citri |
| EP2172260A1 (en) | 2008-09-29 | 2010-04-07 | Corning Incorporated | Multiple flow path microfluidic devices |
| AU2010224100B2 (en) * | 2009-03-12 | 2015-10-22 | Brandeis University | Reagents and methods for PCR |
| US8084272B2 (en) | 2009-03-25 | 2011-12-27 | Abbott Point Of Care Inc. | Amelioration of heterophile antibody immunosensor interference |
| FR2945097B1 (fr) | 2009-04-30 | 2011-06-03 | Commissariat Energie Atomique | Vanne microfluidique a usage unique. |
| WO2012083189A2 (en) | 2010-12-17 | 2012-06-21 | Life Technologies Corporation | Methods, compositions, systems, apparatuses and kits for nucleic acid amplification |
| JP5577681B2 (ja) | 2009-11-30 | 2014-08-27 | 住友電気工業株式会社 | 半導体装置 |
| WO2011087813A2 (en) | 2009-12-22 | 2011-07-21 | University Of Washington | Capillarity-based devices for performing chemical processes and associated systems and methods |
| EP4124856A1 (en) * | 2010-03-09 | 2023-02-01 | ANDE Corporation | Biochip with valve |
| EP2553473A4 (en) * | 2010-03-30 | 2016-08-10 | Advanced Liquid Logic Inc | DROPLET OPERATION PLATFORM |
| EP2661485A4 (en) | 2011-01-06 | 2018-11-21 | Meso Scale Technologies, LLC | Assay cartridges and methods of using the same |
| DK2699698T4 (da) | 2011-04-20 | 2020-04-14 | Mesa Biotech Inc | Oscillerende amplifikations-reaktion for nukleinsyrer |
| EP2943788B1 (en) * | 2013-01-11 | 2018-08-08 | Becton Dickinson and Company | Low-cost point-of-care assay device |
| TWI824991B (zh) | 2015-04-24 | 2023-12-11 | 美商梅薩生物科技股份有限公司 | 用於檢測目標核酸的卡匣及控制通過在用於檢測目標核酸的卡匣中之腔室的流體之垂直流的方法 |
| EP3612306A4 (en) | 2017-04-21 | 2021-01-13 | Mesa Biotech, Inc. | FLUID TEST CASSETTE |
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