[go: up one dir, main page]

DK267489D0 - 1-deoxy-nojirimycin-derivater, deres fremstilling og anvendelse som laegemidler - Google Patents

1-deoxy-nojirimycin-derivater, deres fremstilling og anvendelse som laegemidler

Info

Publication number
DK267489D0
DK267489D0 DK267489A DK267489A DK267489D0 DK 267489 D0 DK267489 D0 DK 267489D0 DK 267489 A DK267489 A DK 267489A DK 267489 A DK267489 A DK 267489A DK 267489 D0 DK267489 D0 DK 267489D0
Authority
DK
Denmark
Prior art keywords
deoxy
preparation
medicinal products
nojirimycin derivatives
nojirimycin
Prior art date
Application number
DK267489A
Other languages
English (en)
Other versions
DK267489A (da
Inventor
Jean-Bernard Ducep
Charles Danzin
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of DK267489D0 publication Critical patent/DK267489D0/da
Publication of DK267489A publication Critical patent/DK267489A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/06—Heterocyclic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK267489A 1988-06-02 1989-06-01 1-deoxy-nojirimycin-derivater, deres fremstilling og anvendelse som laegemidler DK267489A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP88401340A EP0344383A1 (en) 1988-06-02 1988-06-02 Novel alpha-Glucosidase inhibitors

Publications (2)

Publication Number Publication Date
DK267489D0 true DK267489D0 (da) 1989-06-01
DK267489A DK267489A (da) 1989-12-03

Family

ID=8200392

Family Applications (1)

Application Number Title Priority Date Filing Date
DK267489A DK267489A (da) 1988-06-02 1989-06-01 1-deoxy-nojirimycin-derivater, deres fremstilling og anvendelse som laegemidler

Country Status (22)

Country Link
US (1) US5157116A (da)
EP (1) EP0344383A1 (da)
JP (1) JP2791419B2 (da)
KR (1) KR0155541B1 (da)
CN (1) CN1023803C (da)
AR (1) AR247890A1 (da)
AT (1) ATE129716T1 (da)
AU (1) AU608711B2 (da)
CA (1) CA1339740C (da)
DE (1) DE68924670T2 (da)
DK (1) DK267489A (da)
ES (1) ES2081857T3 (da)
FI (1) FI92934C (da)
GR (1) GR3018354T3 (da)
HU (1) HU203559B (da)
IE (1) IE68455B1 (da)
IL (1) IL90463A0 (da)
NO (1) NO170023C (da)
NZ (1) NZ229337A (da)
PH (1) PH25908A (da)
PT (1) PT90713B (da)
ZA (1) ZA894068B (da)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3936295A1 (de) * 1989-11-01 1991-05-02 Bayer Ag Verfahren zur herstellung von zwischenprodukten und zur synthese von n-(2-hydroxyethyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine
US5504078A (en) * 1990-06-08 1996-04-02 Merrell Dow Pharmaceuticals Inc. α-glucosidase inhibitors
US5844102A (en) * 1994-07-07 1998-12-01 University Of Maryland Baltimore County Glycohydrolase inhibitors, their preparation and use thereof
JP3580900B2 (ja) * 1995-04-20 2004-10-27 ホクレン農業協同組合連合会 α−グルコシダーゼ阻害剤を含む糖を主体とする組成物を有効成分とする食品及び飼料
AU4335997A (en) * 1996-09-09 1998-03-26 Wisconsin Alumni Research Foundation Human salivary proteins and fragments thereof having alpha-glucosidase inhibitory activity
KR100510614B1 (ko) * 1997-04-15 2005-08-30 씨에스아이알 식욕 억제 활성을 갖는 화합물의 제조를 위한 중간체 및이의 제조 방법
IL132170A0 (en) * 1997-05-06 2001-03-19 Novo Nordisk As Novel heterocyclic compounds
GB2396815B (en) * 1999-10-27 2004-09-08 Phytopharm Plc A composition comprising a pregnenone derivative and an NSAID
GB2363985B (en) * 2000-06-30 2004-09-29 Phytopharm Plc Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
JP4486792B2 (ja) * 2003-06-12 2010-06-23 学校法人近畿大学 環状オニウム化合物およびグルコシダーゼ阻害剤
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
WO2005092334A2 (en) * 2004-03-25 2005-10-06 David Priestman Use of n-substituted imino sugars for appetite suppression
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
CA2590533C (en) * 2004-11-23 2010-09-07 Warner-Lambert Company Llc 7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for the treatment of lipidemia
BRPI0613221A2 (pt) * 2005-06-08 2010-12-28 Amicus Therapeutics Inc furanose cristalina e método para produzir uma furanose cristalina
BRPI0613222A2 (pt) * 2005-06-08 2010-12-28 Amicus Therapeutic Inc método para purificação de um açúcar bruto contendo nitrogênio e método para purificar d-l-deoxigalactonojirimicina bruta (dgj)
BRPI0613224A2 (pt) * 2005-06-08 2010-12-28 Amicus Therapeutics Inc método para estabilizar um açúcar triflatado, método para aumentar o rendimento da reação de um produto de açúcar e composição de açúcar triflatado estabilizada
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
GB0614947D0 (en) * 2006-07-27 2006-09-06 Isis Innovation Epitope reduction therapy
ATE547394T1 (de) 2006-12-01 2012-03-15 Bristol Myers Squibb Co N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
EP2368560A1 (en) 2007-03-12 2011-09-28 Zadec ApS An anti-diabetic extract of rooibos
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
WO2009149279A2 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2571860A1 (en) 2010-05-21 2013-03-27 Pfizer Inc 2-phenyl benzoylamides
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US20130345392A1 (en) 2011-03-04 2013-12-26 Pfizer Inc Edn3-like peptides and uses thereof
WO2013133685A1 (en) 2012-03-09 2013-09-12 Biotropics Malaysia Berhad Extract formulations of rhodamnia cinerea and uses thereof
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
CA2909442A1 (en) 2013-04-17 2014-10-23 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
AU2014274812B2 (en) 2013-06-05 2018-09-27 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase C, method of making and using same
DK3186242T3 (da) 2014-08-29 2021-12-20 Tes Pharma S R L Alfa-amino-beta-carboxymuconsyre-semialdehyd-decarboxylasehæmmere
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
AR109950A1 (es) 2016-10-14 2019-02-06 Tes Pharma S R L INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA
BR112021009589A2 (pt) 2018-11-20 2021-08-17 Tes Pharma S.R.L. inibidores de semialdeído descarboxilase de ácido alfa-amino-beta-carboximucônico
HUE069590T2 (hu) 2019-01-18 2025-03-28 Astrazeneca Ab PCSK9-gátló 6'-[[(1s,3s)-3-[[5-(difluormetoxi)-2-pirimidinil]amino]ciklopentil]amino][1(2h ),3'-bipiridin]-2-on és alkalmazására szolgáló eljárások

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1555654A (en) * 1977-06-25 1979-11-14 Exxon Research Engineering Co Agricultural burner apparatus
NO154918C (no) * 1977-08-27 1987-01-14 Bayer Ag Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
DE2830469A1 (de) * 1978-07-11 1980-01-24 Bayer Ag Herstellung von l-desoxy-nojirimycin und n-substituierten derivaten
DE2922760A1 (de) * 1979-06-05 1980-12-11 Bayer Ag Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung
GB2064527B (en) * 1979-12-08 1984-05-02 Nippon Shinyaku Co Ltd Moranoline derivatives and process for preparation thereof
DE3038901A1 (de) * 1980-10-15 1982-05-06 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins
JPS61115093A (ja) * 1984-11-09 1986-06-02 Nippon Shinyaku Co Ltd モラノリン誘導体の製法
US4634765A (en) * 1984-12-18 1987-01-06 Merrell Dow Pharmaceuticals Inc. Homodisaccharide hypoglycemic agents
GB2181729B (en) * 1985-10-12 1990-04-04 Nippon Shinyaku Co Ltd Glucosylmoranoline derivatives and production thereof
DE3737523A1 (de) * 1987-11-05 1989-05-18 Bayer Ag Verwendung von substituierten hydroxypiperidinen als antivirale mittel

Also Published As

Publication number Publication date
AU608711B2 (en) 1991-04-11
JPH0225498A (ja) 1990-01-26
FI92934B (fi) 1994-10-14
NO170023C (no) 1992-09-02
FI892682L (fi) 1989-12-03
HU203559B (en) 1991-08-28
DK267489A (da) 1989-12-03
KR0155541B1 (ko) 1998-10-15
US5157116A (en) 1992-10-20
NO892230D0 (no) 1989-06-01
ES2081857T3 (es) 1996-03-16
IE68455B1 (en) 1996-06-26
FI892682A0 (fi) 1989-06-01
PT90713A (pt) 1989-12-29
NO892230L (no) 1989-12-04
DE68924670D1 (de) 1995-12-07
DE68924670T2 (de) 1996-05-23
FI92934C (fi) 1995-01-25
ATE129716T1 (de) 1995-11-15
EP0344383A1 (en) 1989-12-06
GR3018354T3 (en) 1996-03-31
JP2791419B2 (ja) 1998-08-27
PT90713B (pt) 1993-09-30
CN1040032A (zh) 1990-02-28
KR910000776A (ko) 1991-01-30
CN1023803C (zh) 1994-02-16
ZA894068B (en) 1990-09-26
NZ229337A (en) 1990-12-21
IE891798L (en) 1989-12-02
NO170023B (no) 1992-05-25
AU3580189A (en) 1990-02-01
CA1339740C (en) 1998-03-17
AR247890A1 (es) 1995-04-28
IL90463A0 (en) 1990-01-18
PH25908A (en) 1991-12-19
HUT50191A (en) 1989-12-28

Similar Documents

Publication Publication Date Title
DK267489A (da) 1-deoxy-nojirimycin-derivater, deres fremstilling og anvendelse som laegemidler
DK143588D0 (da) Substituerede 9-amino-tetrahydroacridiner, deres fremstilling og anvendelse som laegemidler
DK658688A (da) 1-aryl-3-quinolin- og 1-aryl-3-isoquinolin-carboxamider, deres fremstilling og anvendelse som laegemidler
DK609489A (da) Imidazolderivater, deres fremstilling og anvendelse
DK166590A (da) Substituerede allylaminderivater, deres fremstilling og anvendelse som laegemidler
DK55088D0 (da) 3,4-dihydro-2h-benzo(b)pyraner, deres fremstilling og anvendelse som laegemidler
DK219685A (da) Heterocycliske forbindelser, deres fremstilling og anvendelse som laegemidler
DK366888A (da) Castanosperminestre og -glykosider, deres fremstilling og anvendelse som laegemidler
DK581586A (da) N-(pyrrol-l-yl)-pyridinaminer, deres fremstilling og anvendelse som laegemidler
DK103987A (da) Substituerede 1,3,4,9-tetrahydropyranooe3,4-baaindol-l-eddikesyrer, deres fremstilling og anvendelse som laegemidler
DK284688A (da) Beta-lactam-forbindelser, deres fremstilling og anvendelse som laegemidler
DK144885A (da) Substituerede 4-hydroxybenzopyraner eller farmaceutisk acceptable additionssalte deraf, deres fremstilling og anvendelse som laegemidler
NO921908D0 (no) Aminosyreazetidinylsubstituerte pyridonderivater, deres fremstilling og anvendelse som medikamenter
DK648389D0 (da) Anthracylin-derivater, deres fremstilling og anvendelse som laegemidler
DK619989A (da) Dipeptidderivater, deres fremstilling og anvendelse som laegemidler
DK469389A (da) Piperidinyl-imidazol-derivater, deres fremstilling og anvendelse
DK501888D0 (da) 6-mercaptopurin-derivater, deres fremstilling og anvendelse som laegemidler
DK42888D0 (da) Arylthiadiazolylsulfonamider og derivater deraf, deres fremstilling og anvendelse som laegemiddel
DK568289A (da) 1-aminoalkyl-3-oxy-substituerede-4-aryl-1,3,4,5-tetrahydro-2h-1,3-benzodiazepin-2-oner, deres fremstilling og anvendelse som laegemidler
DK602184D0 (da) Imidazoquinoliner, deres fremstilling og anvendelse som laegemidler
DK37787A (da) 2,3-dioxabicyclooe3,3,0aaoctan-derivater og deres anvendelse som laegemidler
DK278290A (da) Substituerede 6h-pyridooe4,3-baacarbazoler og deres anvendelse som laegemidler
DK111887D0 (da) Aromatiske omega-alkylimino-tetrahydro-6h-1,3-thiazin-6-on-derivater, deres fremstilling og anvendelse som laegemidler
DK116787A (da) Diarylsulfidderivater, deres fremstilling og anvendelse som laegemidler
DK288989D0 (da) Cholestadienderivater, deres fremstilling og anvendelse som laegemidler

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment