DK254488A - Azaindol- og indolizinderivater - Google Patents

Azaindol- og indolizinderivater

Info

Publication number: DK254488A
Authority: DK; Denmark
Prior art keywords: azaindol; indolizin; derivatives; indolizin derivatives
Prior art date: 1986-09-10

Application number

DK254488A

Other languages

English (en)

Other versions

DK254488D0 (da

Inventor

Paul Leroy Anderson

Faizulla Gulamhusein Kathawala

Nicholas Andrew Paolella

Sompong Wattanasin

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-09-10

Filing date

1988-05-09

Publication date

1988-06-24

1986-12-23 Priority claimed from US06/945,750 external-priority patent/US4751235A/en

1988-05-09 Application filed by Sandoz Ag filed Critical Sandoz Ag

1988-05-09 Publication of DK254488D0 publication Critical patent/DK254488D0/da

1988-06-24 Publication of DK254488A publication Critical patent/DK254488A/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK254488A 1986-09-10 1988-05-09 Azaindol- og indolizinderivater DK254488A (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US90589786A	1986-09-10	1986-09-10
US06/945,750 US4751235A (en)	1986-12-23	1986-12-23	Anti-atherosclerotic indolizine derivatives
PCT/EP1987/000511 WO1988001997A2 (en)	1986-09-10	1987-09-09	Azaindole and indolizine derivatives, processes for their production and their use as pharmaceuticals

Publications (2)

Publication Number	Publication Date
DK254488D0 DK254488D0 (da)	1988-05-09
DK254488A true DK254488A (da)	1988-06-24

Family

ID=27129444

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK254488A DK254488A (da)	1986-09-10	1988-05-09	Azaindol- og indolizinderivater

Country Status (12)

Country	Link
EP (1)	EP0265640A3 (da)
JP (1)	JPH01500834A (da)
KR (1)	KR880701719A (da)
AU (1)	AU606621B2 (da)
DK (1)	DK254488A (da)
FI (1)	FI882160A7 (da)
HU (1)	HU200769B (da)
IL (1)	IL83821A0 (da)
NZ (1)	NZ221717A (da)
PL (1)	PL267646A1 (da)
PT (1)	PT85662B (da)
WO (1)	WO1988001997A2 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0352575A3 (de) *	1988-07-28	1991-08-21	Bayer Ag	Substituierte anellierte Pyrrole
HU207993B (en) *	1988-10-13	1993-07-28	Sandoz Ag	Process for producing 7-substituted hept-6-enic acid derivatives
JPH04270285A (ja) *	1988-11-14	1992-09-25	Nissan Chem Ind Ltd	ピラゾロピリミジン系メバロノラクトン類
US5124453A (en) *	1990-03-02	1992-06-23	E. R. Squibb & Sons, Inc.	Process for preparing certain 5,6,7,8-tetrahydroindolizinyl (ethyl or ethynyl)-hydroxy or methoxy-phosphinyl-3-hydroxy-butanoates and derivatives thereof
US5025000A (en) *	1990-03-02	1991-06-18	E. R. Squibb & Sons, Inc.	Phosphorus-containing HMG-CoA reductase inhibitor compounds
WO1992019239A1 (en) *	1991-05-01	1992-11-12	University Of New Mexico	Treatment of aberrant cellular states with biomodulators
WO1992019240A1 (en) *	1991-05-01	1992-11-12	University Of New Mexico	Treatment of aberrant cellular states with biomodulators
FR2687402B1 (fr) *	1992-02-14	1995-06-30	Lipha	Nouveaux azaindoles, procedes de preparation et medicaments les contenant.
EP1535922A4 (en)	2002-07-11	2006-10-04	Takeda Pharmaceutical	PYRROLOPYRIDINE DERIVATIVE AND ITS USE
KR101298951B1 (ko)	2004-03-30	2013-09-30	버텍스 파마슈티칼스 인코포레이티드	Ｊａｋ 및 기타 단백질 키나제의 억제제로서 유용한아자인돌
TWI423976B (zh)	2006-01-17	2014-01-21	Vertex Pharma	適合作為傑納斯激酶（ｊａｎｕｓｋｉｎａｓｅ）抑制劑之氮雜吲哚
EP2815750A1 (en)	2006-12-21	2014-12-24	Vertex Pharmaceuticals Incorporated	5-cyano-4-(pyrrolo [2,3b] pyridine-3-yl)-pyrimidine derivatives useful as protein kinase inhibitors
PE20120508A1 (es)	2009-06-17	2012-05-09	Vertex Pharma	Inhibidores de la replicacion de los virus de la gripe
WO2012083117A1 (en)	2010-12-16	2012-06-21	Vertex Pharmaceuticals Incorporated	Inhibitors of influenza viruses replication
UA118010C2 (uk)	2011-08-01	2018-11-12	Вертекс Фармасьютікалз Інкорпорейтед	Інгібітори реплікації вірусів грипу
SI3421468T1 (sl)	2013-11-13	2021-03-31	Vertex Pharmaceuticals Incorporated	Postopki za pripravo inhibitorjev replikacije virusov influence
SG10201804026WA (en)	2013-11-13	2018-06-28	Vertex Pharma	Inhibitors of influenza viruses replication
WO2016183116A1 (en)	2015-05-13	2016-11-17	Vertex Pharmaceuticals Incorporated	Methods of preparing inhibitors of influenza viruses replication
EP3294735B8 (en)	2015-05-13	2022-01-05	Vertex Pharmaceuticals Incorporated	Inhibitors of influenza viruses replication

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI61030C (fi) *	1976-02-19	1982-05-10	Sanofi Sa	Foerfarande foer framstaellning av terapeutiskt verkande 2-substituerade-1- eller 3-benzoyl-indolizinderivat
JPS5559180A (en) *	1978-10-30	1980-05-02	Sankyo Co Ltd	4-hydroxy-2-pyrone ring compound, its preparation, and remedy for hyperlipemia comprising it as active constituent
US4474971A (en) *	1982-09-29	1984-10-02	Sandoz, Inc.	(Tetrahydropyran-2-yl)-aldehydes
WO1984002131A1 (fr) *	1982-11-22	1984-06-07	Sandoz Ag	Produits analogues de mevalolactone et leurs derives, leurs procedes de production, compositions pharmaceutiques les contenant ainsi que leur utilisation en tant que produits pharmaceutiques
CA1268473A (en) *	1983-01-24	1990-05-01	Paul L. Anderson	Analogs of mevalonolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
US4571428A (en) *	1983-07-08	1986-02-18	Sandoz, Inc.	6-Substituted-4-hydroxy-tetrahydropyran-2-ones
JPS61502467A (ja) *	1984-06-22	1986-10-30	サンド・アクチエンゲゼルシヤフト	メバロノラクトンのピラゾ−ル同族体およびその誘導体、それらの製造方法ならびに用途
US4677211A (en) *	1984-06-29	1987-06-30	Sandoz Pharmaceuticals Corp.	Preparation of lactones
US4668794A (en) *	1985-05-22	1987-05-26	Sandoz Pharm. Corp.	Intermediate imidazole acrolein analogs

1987
- 1987-09-08 NZ NZ221717A patent/NZ221717A/xx unknown
- 1987-09-08 PT PT85662A patent/PT85662B/pt not_active IP Right Cessation
- 1987-09-08 IL IL83821A patent/IL83821A0/xx unknown
- 1987-09-09 AU AU80221/87A patent/AU606621B2/en not_active Expired - Fee Related
- 1987-09-09 HU HU875259A patent/HU200769B/hu not_active IP Right Cessation
- 1987-09-09 EP EP87113159A patent/EP0265640A3/en not_active Withdrawn
- 1987-09-09 WO PCT/EP1987/000511 patent/WO1988001997A2/en not_active Ceased
- 1987-09-09 JP JP62505829A patent/JPH01500834A/ja active Pending
- 1987-09-09 PL PL1987267646A patent/PL267646A1/xx unknown
1988
- 1988-05-09 DK DK254488A patent/DK254488A/da not_active Application Discontinuation
- 1988-05-09 FI FI882160A patent/FI882160A7/fi not_active Application Discontinuation
- 1988-05-10 KR KR1019880700517A patent/KR880701719A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
WO1988001997A3 (en)	1988-04-07
EP0265640A2 (en)	1988-05-04
DK254488D0 (da)	1988-05-09
IL83821A0 (en)	1988-02-29
PT85662A (en)	1987-10-01
HU200769B (en)	1990-08-28
HUT46914A (en)	1988-12-28
PL267646A1 (en)	1988-07-21
AU8022187A (en)	1988-04-07
PT85662B (pt)	1990-06-29
JPH01500834A (ja)	1989-03-23
WO1988001997A2 (en)	1988-03-24
NZ221717A (en)	1990-08-28
FI882160A0 (fi)	1988-05-09
AU606621B2 (en)	1991-02-14
FI882160A7 (fi)	1988-05-09
EP0265640A3 (en)	1988-05-18
KR880701719A (ko)	1988-11-04

Publication	Publication Date	Title
IT1205010B (it)	1989-03-10	Tetraidronaftalin-derivati e indan-derivati
DK366787D0 (da)	1987-07-14	Tetrahydronaphthalen- og indanderivater
DK263587D0 (da)	1987-05-22	Imidazoquinolinyletherderivater
DK82087D0 (da)	1987-02-18	Pyrocatecholderivater
DK69887A (da)	1987-08-13	Dichloranilinderivater
ATA312487A (de)	1993-05-15	Tetrahydrocarbazolonderivate
DK254488D0 (da)	1988-05-09	Azaindol- og indolizinderivater
DK693587A (da)	1988-07-01	Alkansulfonanilidderivater
DK641587D0 (da)	1987-12-07	Benzofuran- og benzopyranderivater
DK139286A (da)	1986-10-03	Inden- og naphthalenderivater
DK81888D0 (da)	1988-02-17	Dibenzoxepinderivater
DK691287D0 (da)	1987-12-29	5-floururacilderivater
DE3680771D1 (de)	1991-09-12	Isoxazolopyridophenoxazin- und isothiazolopyridophenoxazinderivate.
DK444687A (da)	1988-02-28	Alfa-substituerede ketonitron-derivater
DE3680775D1 (de)	1991-09-12	Isoxazolopyridobenzoxazin- und isothiazolopyridobenzoxazinderivate.
DK440687D0 (da)	1987-08-24	Bicyclooctanderivater
DK619187A (da)	1988-05-28	Isoindolderivater
DK229887D0 (da)	1987-05-05	Alkenamidderivater
DK435087A (da)	1988-03-11	Isoprenderivater
DK440787D0 (da)	1987-08-24	Bicyclooctanderivater
DK289887D0 (da)	1987-06-04	Anvendelse af avaron- og avarolderivater
DK289987A (da)	1987-12-08	Anvendelse af avaron- og avarolderivater
DK691087D0 (da)	1987-12-29	Dioxazocinderivater
FI905165A7 (fi)	1991-04-21	Dibentsodioksatsesiini-ja dibentsodioksa-atsasykloundekiini-johdannaisia
BR8601118A (pt)	1987-09-08	Imantador e desimantador

Legal Events

Date	Code	Title	Description
1992-05-25	AHB	Application shelved due to non-payment