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DK217087A - PREPARATION OF LMW HEPARIN - Google Patents

PREPARATION OF LMW HEPARIN

Info

Publication number
DK217087A
DK217087A DK217087A DK217087A DK217087A DK 217087 A DK217087 A DK 217087A DK 217087 A DK217087 A DK 217087A DK 217087 A DK217087 A DK 217087A DK 217087 A DK217087 A DK 217087A
Authority
DK
Denmark
Prior art keywords
heparin
molecular weight
lmw
lmw heparin
polydispersity
Prior art date
Application number
DK217087A
Other languages
Danish (da)
Other versions
DK162108B (en
DK162108C (en
DK217087D0 (en
Inventor
Joergen Ilum Nielsen
Original Assignee
Novo Industri As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK196886A external-priority patent/DK196886D0/en
Application filed by Novo Industri As filed Critical Novo Industri As
Priority to DK217087A priority Critical patent/DK162108C/en
Publication of DK217087D0 publication Critical patent/DK217087D0/en
Publication of DK217087A publication Critical patent/DK217087A/en
Publication of DK162108B publication Critical patent/DK162108B/en
Application granted granted Critical
Publication of DK162108C publication Critical patent/DK162108C/en

Links

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Process for producing low molecular weight heparin (LMW heparin) by enzymically depolymerizing heparin with heparinase, with heparin being continuously added to a depolymerization zone, the depolymerized LMW heparin being subjected to ultrafiltration, the retentate being circulated to the depolymerization zone and the LMW heparin being recovered from the filtrate. The process makes it possible to produce LMW heparin of a desired molecular weight and low polydispersity within narrow limits by continuously or frequently measuring the molecular weight and polydispersity of the LMW heparin product and correcting the process parameters of the depolymerization reaction in order to counteract deviations in the molecular weight and the polydispersity from the desired values. <IMAGE>
DK217087A 1986-04-30 1987-04-29 METHOD FOR MANUFACTURING THE LMW HEPARIN DK162108C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK217087A DK162108C (en) 1986-04-30 1987-04-29 METHOD FOR MANUFACTURING THE LMW HEPARIN

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK196886A DK196886D0 (en) 1986-04-30 1986-04-30 PREPARATION OF POLYSACCHARIDES
DK196886 1986-04-30
DK217087 1987-04-29
DK217087A DK162108C (en) 1986-04-30 1987-04-29 METHOD FOR MANUFACTURING THE LMW HEPARIN

Publications (4)

Publication Number Publication Date
DK217087D0 DK217087D0 (en) 1987-04-29
DK217087A true DK217087A (en) 1987-10-31
DK162108B DK162108B (en) 1991-09-16
DK162108C DK162108C (en) 1992-02-24

Family

ID=26066235

Family Applications (1)

Application Number Title Priority Date Filing Date
DK217087A DK162108C (en) 1986-04-30 1987-04-29 METHOD FOR MANUFACTURING THE LMW HEPARIN

Country Status (1)

Country Link
DK (1) DK162108C (en)

Also Published As

Publication number Publication date
DK162108B (en) 1991-09-16
DK162108C (en) 1992-02-24
DK217087D0 (en) 1987-04-29

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