DK215289D0 - N-(5,6,7,8-tetrahydropyrido(2,3-d)pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater - Google Patents
N-(5,6,7,8-tetrahydropyrido(2,3-d)pyrimidin-6-yl-alkanoyl)-glutaminsyrederivaterInfo
- Publication number
- DK215289D0 DK215289D0 DK215289A DK215289A DK215289D0 DK 215289 D0 DK215289 D0 DK 215289D0 DK 215289 A DK215289 A DK 215289A DK 215289 A DK215289 A DK 215289A DK 215289 D0 DK215289 D0 DK 215289D0
- Authority
- DK
- Denmark
- Prior art keywords
- hydrogen
- carbon
- glutaminsyrederivater
- pyrido
- alkanoyl
- Prior art date
Links
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000004956 cyclohexylene group Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 150000002306 glutamic acid derivatives Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrane Compounds (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19820188 | 1988-05-25 | ||
| US07/198,207 US4882334A (en) | 1988-05-25 | 1988-05-25 | N-(5,6,7,8-tetrahydropyrido]2,3-d]pyrimidin-6-ylethl-thineyl-and furylcarbonyl)-glutamic acid derivatives |
| US07/198,201 US4882333A (en) | 1988-05-25 | 1988-05-25 | N-(5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives |
| US19820788 | 1988-05-25 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK215289D0 true DK215289D0 (da) | 1989-05-02 |
| DK215289A DK215289A (da) | 1989-11-26 |
| DK172753B1 DK172753B1 (da) | 1999-06-28 |
Family
ID=26893557
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198902152A DK172753B1 (da) | 1988-05-25 | 1989-05-02 | N-(5,6,7,8-tetrahydropyrido[2,3--d]pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater, deres anvendelse, farmaceutiske præparat |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0343801B1 (da) |
| JP (1) | JP2818198B2 (da) |
| KR (1) | KR0131589B1 (da) |
| CN (1) | CN1025334C (da) |
| AT (1) | ATE109480T1 (da) |
| AU (1) | AU611027B2 (da) |
| CA (1) | CA1340631C (da) |
| CY (1) | CY2055B1 (da) |
| DE (1) | DE68917211T2 (da) |
| DK (1) | DK172753B1 (da) |
| ES (1) | ES2057116T3 (da) |
| HK (1) | HK1000284A1 (da) |
| HU (1) | HU205356B (da) |
| IE (1) | IE63620B1 (da) |
| IL (1) | IL90179A (da) |
| NZ (1) | NZ229242A (da) |
| PT (1) | PT90635B (da) |
| RU (1) | RU2002747C1 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03173890A (ja) * | 1989-09-21 | 1991-07-29 | Takeda Chem Ind Ltd | ピロロ［２，３―ｄ］ピリミジン誘導体，その製造法，用途及び中間体 |
| IL96531A (en) * | 1989-12-11 | 1995-08-31 | Univ Princeton | History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them) |
| CA2032695A1 (en) * | 1989-12-20 | 1991-06-21 | Hiroshi Akimoto | Condensed heterocyclic compounds, their production and use |
| ZA932731B (en) * | 1992-04-23 | 1994-10-19 | Lilly Co Eli | Method of treating gar-transformylase-dependent tumors |
| US5608082A (en) * | 1994-07-28 | 1997-03-04 | Agouron Pharmaceuticals, Inc. | Compounds useful as antiproliferative agents and GARFT inhibitors |
| SK281724B6 (sk) * | 1994-11-14 | 2001-07-10 | Warner-Lambert Company | 6-arylpyrido[2,3-d]pyrimidíny, ich použitie a farmaceutické prostriedky na ich báze |
| JPH09165387A (ja) * | 1995-09-08 | 1997-06-24 | Univ Princeton | 非古典的抗葉酸剤 |
| JP2001524927A (ja) * | 1996-05-01 | 2001-12-04 | ザ トラスティーズ オブ プリンストン ユニバーシティー | ５，６，７，８―テトラヒドロピリド［２，３―ｄ］ピリミジン類 |
| JP2002503648A (ja) | 1998-02-11 | 2002-02-05 | イーライ・リリー・アンド・カンパニー | 葉酸拮抗薬を製造するのに有用な方法および中間体 |
| RU2305677C2 (ru) * | 2001-12-27 | 2007-09-10 | Адзиномото Ко., Инк. | Способы получения производных глутаминовой кислоты, способы получения промежуточных соединений и новое промежуточное соединение для данных способов |
| RU2342360C2 (ru) * | 2003-01-09 | 2008-12-27 | Адзиномото Ко., Инк. | Способ получения производного глутаминовой кислоты и производного пироглутаминовой кислоты и новое промежуточное соединение для получения этих производных |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA861235B (en) * | 1985-03-08 | 1986-10-29 | Univ Princeton | Pyrido(2,3-d)pyrimidine derivatives |
| US4684653A (en) * | 1985-03-08 | 1987-08-04 | The Trustees Of Princeton University | Pyrido(2,3-d)pyrimidine derivatives |
| NZ219971A (en) * | 1986-06-06 | 1989-08-29 | Univ Princeton | Tetrahydropyrido (2,3-d pyrimidine derivatives and pharmaceutical compositions |
| IE60038B1 (en) * | 1986-06-30 | 1994-05-18 | Univ Princeton | 4(3H)-oxo-5, 6, 7, 8-tetrahydropyrido-[2, 3-d]pyrimidine derivatives |
-
1989
- 1989-05-02 DK DK198902152A patent/DK172753B1/da not_active IP Right Cessation
- 1989-05-03 IL IL9017989A patent/IL90179A/en not_active IP Right Cessation
- 1989-05-04 EP EP89304499A patent/EP0343801B1/en not_active Expired - Lifetime
- 1989-05-04 DE DE68917211T patent/DE68917211T2/de not_active Expired - Fee Related
- 1989-05-04 ES ES89304499T patent/ES2057116T3/es not_active Expired - Lifetime
- 1989-05-04 AT AT89304499T patent/ATE109480T1/de not_active IP Right Cessation
- 1989-05-17 CA CA000599937A patent/CA1340631C/en not_active Expired - Fee Related
- 1989-05-23 PT PT90635A patent/PT90635B/pt not_active IP Right Cessation
- 1989-05-23 NZ NZ229242A patent/NZ229242A/xx unknown
- 1989-05-24 AU AU35109/89A patent/AU611027B2/en not_active Ceased
- 1989-05-24 RU SU894614259A patent/RU2002747C1/ru active
- 1989-05-25 CN CN89103686A patent/CN1025334C/zh not_active Expired - Fee Related
- 1989-05-25 JP JP1132541A patent/JP2818198B2/ja not_active Expired - Lifetime
- 1989-05-25 KR KR1019890007041A patent/KR0131589B1/ko not_active Expired - Fee Related
- 1989-05-25 HU HU892684A patent/HU205356B/hu not_active IP Right Cessation
- 1989-06-12 IE IE176789A patent/IE63620B1/en not_active IP Right Cessation
-
1997
- 1997-09-24 HK HK97101830A patent/HK1000284A1/en not_active IP Right Cessation
-
1998
- 1998-06-12 CY CY9802055A patent/CY2055B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL90179A0 (en) | 1989-12-15 |
| DE68917211T2 (de) | 1994-11-24 |
| AU3510989A (en) | 1989-11-30 |
| PT90635B (pt) | 1994-10-31 |
| DE68917211D1 (de) | 1994-09-08 |
| IL90179A (en) | 1994-02-27 |
| KR900018100A (ko) | 1990-12-20 |
| HU205356B (en) | 1992-04-28 |
| RU2002747C1 (ru) | 1993-11-15 |
| CN1025334C (zh) | 1994-07-06 |
| CA1340631C (en) | 1999-07-06 |
| HUT50342A (en) | 1990-01-29 |
| EP0343801B1 (en) | 1994-08-03 |
| EP0343801A3 (en) | 1991-05-02 |
| ATE109480T1 (de) | 1994-08-15 |
| JPH0267281A (ja) | 1990-03-07 |
| NZ229242A (en) | 1990-10-26 |
| CN1038098A (zh) | 1989-12-20 |
| AU611027B2 (en) | 1991-05-30 |
| JP2818198B2 (ja) | 1998-10-30 |
| DK172753B1 (da) | 1999-06-28 |
| PT90635A (pt) | 1989-11-30 |
| ES2057116T3 (es) | 1994-10-16 |
| EP0343801A2 (en) | 1989-11-29 |
| IE63620B1 (en) | 1995-05-17 |
| KR0131589B1 (ko) | 1998-04-17 |
| IE891767L (en) | 1989-11-25 |
| CY2055B1 (en) | 1998-06-12 |
| HK1000284A1 (en) | 1998-02-20 |
| DK215289A (da) | 1989-11-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |