DK2010531T3 - Spirocykliske cyklohexanderivater med smertestillende virkning - Google Patents
Spirocykliske cyklohexanderivater med smertestillende virkningInfo
- Publication number
- DK2010531T3 DK2010531T3 DK07724560.3T DK07724560T DK2010531T3 DK 2010531 T3 DK2010531 T3 DK 2010531T3 DK 07724560 T DK07724560 T DK 07724560T DK 2010531 T3 DK2010531 T3 DK 2010531T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- heteroaryl
- aryl
- cycloalkyl
- saturated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006019597A DE102006019597A1 (de) | 2006-04-27 | 2006-04-27 | Spirocyclische Cyclohexan-Derivate |
| PCT/EP2007/003630 WO2007124903A1 (de) | 2006-04-27 | 2007-04-25 | Spirocycliche cyclohexanderivate mit analgesischer wirkung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2010531T3 true DK2010531T3 (da) | 2011-09-19 |
Family
ID=38293936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07724560.3T DK2010531T3 (da) | 2006-04-27 | 2007-04-25 | Spirocykliske cyklohexanderivater med smertestillende virkning |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8124788B2 (da) |
| EP (1) | EP2010531B1 (da) |
| JP (1) | JP2009534437A (da) |
| AT (1) | ATE520693T1 (da) |
| CA (1) | CA2649349A1 (da) |
| CY (1) | CY1111903T1 (da) |
| DE (1) | DE102006019597A1 (da) |
| DK (1) | DK2010531T3 (da) |
| ES (1) | ES2368266T3 (da) |
| PL (1) | PL2010531T3 (da) |
| PT (1) | PT2010531E (da) |
| SI (1) | SI2010531T1 (da) |
| WO (1) | WO2007124903A1 (da) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005016460A1 (de) * | 2005-04-11 | 2006-10-19 | Grünenthal GmbH | Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit |
| DE102006033114A1 (de) * | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische Azaindol-Derivate |
| JP5501251B2 (ja) | 2008-01-11 | 2014-05-21 | アルバニー モレキュラー リサーチ， インコーポレイテッド | Ｍｃｈ拮抗薬としての（１−アジノン）置換ピリドインドール類 |
| AU2009228642B2 (en) | 2008-03-27 | 2013-11-07 | Grunenthal Gmbh | Substituted 4-aminocyclohexane derivatives |
| CN102046596B (zh) | 2008-03-27 | 2013-12-25 | 格吕伦塔尔有限公司 | 取代的环己二胺 |
| RU2514192C2 (ru) | 2008-03-27 | 2014-04-27 | Грюненталь Гмбх | Гидроксиметилциклогексиламины |
| AU2009228647B2 (en) | 2008-03-27 | 2013-07-04 | Grunenthal Gmbh | Substituted spirocyclic cyclohexane derivatives |
| ES2375543T3 (es) | 2008-03-27 | 2012-03-01 | Grünenthal GmbH | Derivados de espiro(5.5)undecano. |
| JP5650637B2 (ja) | 2008-03-27 | 2015-01-07 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | （ヘテロ−）アリール−シクロヘキサン誘導体 |
| WO2011003012A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof |
| EP2448585B1 (en) | 2009-07-01 | 2014-01-01 | Albany Molecular Research, Inc. | Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof |
| WO2011003007A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof |
| WO2011003021A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof |
| TWI582092B (zh) * | 2010-07-28 | 2017-05-11 | 歌林達股份有限公司 | 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物 |
| WO2012088038A2 (en) | 2010-12-21 | 2012-06-28 | Albany Molecular Research, Inc. | Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof |
| US8993765B2 (en) | 2010-12-21 | 2015-03-31 | Albany Molecular Research, Inc. | Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof |
| CN102659662A (zh) * | 2012-03-28 | 2012-09-12 | 华东师范大学 | 3-r-3-羟基-2-氧化吲哚类化合物的合成方法 |
| PL3110797T3 (pl) | 2014-02-27 | 2019-11-29 | Gruenenthal Gmbh | Proces otrzymywania 5-fluorotryptofolu |
| US10214520B2 (en) | 2014-07-15 | 2019-02-26 | Gruenenthal Gmbh | Substituted azaspiro(4.5)decane derivatives |
| TW201607923A (zh) | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環（４．５）癸烷衍生物 |
| US20170197971A1 (en) | 2016-01-13 | 2017-07-13 | Gruenenthal Gmbh | 3-(Carboxymethyl)-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives |
| TWI635082B (zh) | 2016-01-13 | 2018-09-11 | 歌林達有限公司 | ３－（（雜－）芳基）－８－胺基－２－側氧－１,３－二氮雜－螺－［４.５］－癸烷衍生物 |
| CO2018008450A2 (es) | 2016-01-13 | 2018-09-20 | Gruenenthal Gmbh | Derivados de 8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2663935A1 (fr) * | 1990-06-27 | 1992-01-03 | Adir | Nouveaux 1,2,3,4,5,6-hexahydroazepino [4,5-b] indoles et 1,2,3,4-tetrahydrobethacarbolines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10360792A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10360793A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| US20050261327A1 (en) * | 2004-05-20 | 2005-11-24 | Bock Mark G | 2-(Bicyclo)alkylamino-derivatives as mediatores of chronic pain and inflammation |
| DE102004039382A1 (de) | 2004-08-13 | 2006-02-23 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102005016460A1 (de) * | 2005-04-11 | 2006-10-19 | Grünenthal GmbH | Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit |
-
2006
- 2006-04-27 DE DE102006019597A patent/DE102006019597A1/de not_active Withdrawn
-
2007
- 2007-04-25 CA CA002649349A patent/CA2649349A1/en not_active Abandoned
- 2007-04-25 SI SI200730703T patent/SI2010531T1/sl unknown
- 2007-04-25 WO PCT/EP2007/003630 patent/WO2007124903A1/de not_active Ceased
- 2007-04-25 AT AT07724560T patent/ATE520693T1/de active
- 2007-04-25 JP JP2009506976A patent/JP2009534437A/ja active Pending
- 2007-04-25 ES ES07724560T patent/ES2368266T3/es active Active
- 2007-04-25 EP EP07724560A patent/EP2010531B1/de not_active Not-in-force
- 2007-04-25 DK DK07724560.3T patent/DK2010531T3/da active
- 2007-04-25 PT PT07724560T patent/PT2010531E/pt unknown
- 2007-04-25 PL PL07724560T patent/PL2010531T3/pl unknown
-
2008
- 2008-10-27 US US12/258,936 patent/US8124788B2/en not_active Expired - Fee Related
-
2011
- 2011-10-06 CY CY20111100953T patent/CY1111903T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009534437A (ja) | 2009-09-24 |
| DE102006019597A1 (de) | 2007-10-31 |
| CA2649349A1 (en) | 2007-11-08 |
| PT2010531E (pt) | 2011-09-16 |
| CY1111903T1 (el) | 2015-11-04 |
| SI2010531T1 (sl) | 2011-10-28 |
| US8124788B2 (en) | 2012-02-28 |
| US20090111842A1 (en) | 2009-04-30 |
| ES2368266T3 (es) | 2011-11-15 |
| WO2007124903A1 (de) | 2007-11-08 |
| EP2010531B1 (de) | 2011-08-17 |
| ATE520693T1 (de) | 2011-09-15 |
| PL2010531T3 (pl) | 2011-12-30 |
| EP2010531A1 (de) | 2009-01-07 |
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