DK200201813A - Ekspression af gener i modificeret vaccinia virus ankara ved brug af ATI promotoren fra ko-kopper - Google Patents
Ekspression af gener i modificeret vaccinia virus ankara ved brug af ATI promotoren fra ko-kopper Download PDFInfo
- Publication number
- DK200201813A DK200201813A DK200201813A DKPA200201813A DK200201813A DK 200201813 A DK200201813 A DK 200201813A DK 200201813 A DK200201813 A DK 200201813A DK PA200201813 A DKPA200201813 A DK PA200201813A DK 200201813 A DK200201813 A DK 200201813A
- Authority
- DK
- Denmark
- Prior art keywords
- mva
- coding sequence
- virus
- expression cassette
- derivative
- Prior art date
Links
- 241001183012 Modified Vaccinia Ankara virus Species 0.000 title abstract description 19
- 108091026890 Coding region Proteins 0.000 title abstract description 7
- 230000003612 virological effect Effects 0.000 title abstract description 3
- 201000003740 cowpox Diseases 0.000 title abstract 2
- 208000036142 Viral infection Diseases 0.000 title 1
- 238000011321 prophylaxis Methods 0.000 title 1
- 238000011282 treatment Methods 0.000 title 1
- 230000009385 viral infection Effects 0.000 title 1
- 241000700605 Viruses Species 0.000 abstract description 6
- 229960005486 vaccine Drugs 0.000 abstract description 6
- 108090000765 processed proteins & peptides Proteins 0.000 abstract description 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract description 2
- 230000001105 regulatory effect Effects 0.000 abstract description 2
- 241001465754 Metazoa Species 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000012873 virucide Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 3
- 239000000427 antigen Substances 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Description
Krav: 1. Rekombinant Modificeret Vaccinia Virus Ankara (MVA) som i det virale genom omfatter en ekspressions kassette hvilket igen omfatter ko-koppe ATI promotoren eller en afledt deraf og en kodende sekvens, hvori ekspressionen af den kodende sekvens er reguleret af denne promotor. 2. Rekombinant MVA som ovenover, hvor ATI promotoren har samme sekvens som SEQ ID: No. 1. 3. Rekombinant MVA ifølge krav 1, hvor den afledte af ATI promotoren er udvalgt fra (i) subsekvenser af sekvensen ifølge SEQ ID: No. 1 og (ii) sekvenser der har en eller flere nukleotid substitutioner, deleteringer, og /eller indsættelser i forhold til sekvensen ifølge SEQ ID: No. I eller i forhold til en subsekvens deraf, hvori denne subsekvens og sekvenser respektivt stadig er aktive som promotorer i MVA. 4. Rekombinant MVA ifølge ethver af kravene 1-3, hvor MVA er udvalgt fra stammen MVA-BN deponeret hos European Collection of Cell Cultures (ECACC) under nummer V00083008 eller en afledt deraf og stamme MVA 575 deponeret hos ECACC under nummer V00120707. 5. Rekombinant MVA ifølge ethvert af kravene 1 -4, hvor den kodende sekvens koder for mindst et antigen, antigenisk peptid og/eller et terapeteutisk stof. 6. Rekombinant MVA ifolgc ethvert af kravene 1 til 5 som vaccine eller medikament. 7. Vaccine eller farmaceutisk komposition der omfatter en rekombinant MVA ifølge ethvert af kravene 1-5. 8. Brug af rekombinant MVA ifølge ethvert af kravene 1-5 til udarbejdelse af en vaccine eller et medikament. 9. En celle der indeholde virussen ifølge ethvert af kravene 1-5. 10. Brugen af ko-koppe ATI promotoren eller en afledt deraf som defineret ifølge ethvert af kravene 1-5 til ekspression af kodende sekvenser i MVA.
Priority Applications (22)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK200201813A DK200201813A (da) | 2002-11-25 | 2002-11-25 | Ekspression af gener i modificeret vaccinia virus ankara ved brug af ATI promotoren fra ko-kopper |
| EP03732369A EP1404852B1 (en) | 2002-05-16 | 2003-05-14 | Expression of genes in modified vaccinia virus ankara by using the cowpox ati promoter |
| NZ536500A NZ536500A (en) | 2002-05-16 | 2003-05-14 | Expression of genes in modified vaccinia virus ankara by using the cowpox ATI promoter |
| BR0310020-0A BR0310020A (pt) | 2002-05-16 | 2003-05-14 | Expressão de genes no vìrus da vacìnia modificado ancara por uso do promotor de ati de vacìnia |
| DE60302848T DE60302848T2 (de) | 2002-05-16 | 2003-05-14 | Expression von genen im modifizierten vaccinia virus ankara durch verwendung eines cowpox ati promoter |
| CNB038106523A CN1289682C (zh) | 2002-05-16 | 2003-05-14 | 通过使用牛痘ati启动子表达改良的安卡拉痘苗病毒中的基因 |
| EA200401505A EA009525B1 (ru) | 2002-05-16 | 2003-05-14 | Рекомбинантный модифицированный вирус осповакцины ankara, содержащий ati-промотор вируса коровьей оспы, и способы применения вируса и промотора |
| PCT/EP2003/005046 WO2003097844A1 (en) | 2002-05-16 | 2003-05-14 | Expression of genes in modified vaccinia virus ankara by using the cowpox ati promoter |
| CA002481783A CA2481783A1 (en) | 2002-05-16 | 2003-05-14 | Expression of genes in modified vaccinia virus ankara by using the cowpox ati promoter |
| AU2003240243A AU2003240243B2 (en) | 2002-05-16 | 2003-05-14 | Expression of genes in modified vaccinia virus Ankara by using the cowpox ATI promoter |
| JP2004506499A JP2005525821A (ja) | 2002-05-16 | 2003-05-14 | 牛痘ａｔｉプロモーターを用いた変異ワクシニアウイルスアンカラ中の遺伝子の発現 |
| ES03732369T ES2256747T3 (es) | 2002-05-16 | 2003-05-14 | Expresion de genes en el virus de la vacuna modificado, usando el promotor ati de la viruela de la vaca. |
| PL03372091A PL372091A1 (pl) | 2002-05-16 | 2003-05-14 | Ekspresja genów w zmodyfikowanym wirusie krowianki Ankara uzyskana w wyniku zastosowania promotora ATI wirusa ospy krów |
| MXPA04011034A MXPA04011034A (es) | 2002-05-16 | 2003-05-14 | Expresion de los genes en el virus de la vacuna de ankara modificada, usando el promotor ati de viruela. |
| DK03732369T DK1404852T3 (da) | 2002-05-16 | 2003-05-14 | Ekspression af gener i modificeret vacciniavirus Ankara ved anvendelse af kokoppe-ATI-promotoren |
| SI200330175T SI1404852T1 (sl) | 2002-05-16 | 2003-05-14 | Ekspresija genov v modularnem vakcinija virusa Ankara z uporabo ATI promotorja kravjih ospic |
| IL16417903A IL164179A0 (en) | 2002-05-16 | 2003-05-14 | Expression of genes in modified vaccinia virus ankara by using the cowpox ati promoter |
| HK05108709.0A HK1076835B (en) | 2002-05-16 | 2003-05-14 | Expression of genes in modified vaccinia virus ankara by using the cowpox ati promoter |
| AT03732369T ATE313641T1 (de) | 2002-05-16 | 2003-05-14 | Expression von genen im modifizierten vaccinia virus ankara durch verwendung eines cowpox ati promoter |
| US10/514,922 US20060029619A1 (en) | 2002-05-16 | 2003-05-14 | Expression of genes in modified vaccinia virus ankara by using the cowpox ati promoter |
| KR10-2004-7018205A KR20040108804A (ko) | 2002-05-16 | 2003-05-14 | 우두 ａｔｉ 프로모터를 사용하는 것에 의한 변형백시니아 바이러스 안카라에서 유전자의 발현 |
| NO20045315A NO20045315L (no) | 2002-05-16 | 2004-12-03 | Ekspresjon av gener i Modifisert Vacciniavirus Ankara ved a bruke kukoppe ATI-promoteren |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK200201813A DK200201813A (da) | 2002-11-25 | 2002-11-25 | Ekspression af gener i modificeret vaccinia virus ankara ved brug af ATI promotoren fra ko-kopper |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK200201813A true DK200201813A (da) | 2004-05-26 |
Family
ID=32479652
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK200201813A DK200201813A (da) | 2002-05-16 | 2002-11-25 | Ekspression af gener i modificeret vaccinia virus ankara ved brug af ATI promotoren fra ko-kopper |
Country Status (1)
| Country | Link |
|---|---|
| DK (1) | DK200201813A (da) |
-
2002
- 2002-11-25 DK DK200201813A patent/DK200201813A/da not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHS | Application shelved for other reasons than non-payment |