DK204784D0 - Fremgangsmaade til fremstilling af et for gaer heterologt protein som produkt af gaerudtrykkelse,gaerudtrykkelsesmedium og gaerorganisme,som er i stand til at secernere modent heterologt protein til dyrkningsmediet - Google Patents
Fremgangsmaade til fremstilling af et for gaer heterologt protein som produkt af gaerudtrykkelse,gaerudtrykkelsesmedium og gaerorganisme,som er i stand til at secernere modent heterologt protein til dyrkningsmedietInfo
- Publication number
- DK204784D0 DK204784D0 DK2047/84A DK204784A DK204784D0 DK 204784 D0 DK204784 D0 DK 204784D0 DK 2047/84 A DK2047/84 A DK 2047/84A DK 204784 A DK204784 A DK 204784A DK 204784 D0 DK204784 D0 DK 204784D0
- Authority
- DK
- Denmark
- Prior art keywords
- year
- expression
- protein
- medium
- organism
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title 2
- 108090000623 proteins and genes Proteins 0.000 title 2
- 239000001963 growth medium Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002609 medium Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6478—Aspartic endopeptidases (3.4.23)
- C12N9/6481—Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
- C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48832383A | 1983-04-25 | 1983-04-25 | |
| US50135283A | 1983-06-06 | 1983-06-06 | |
| US50609883A | 1983-06-20 | 1983-06-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK204784D0 true DK204784D0 (da) | 1984-04-24 |
| DK204784A DK204784A (da) | 1984-10-26 |
Family
ID=27413799
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK204784A DK204784A (da) | 1983-04-25 | 1984-04-24 | Fremgangsmaade til fremstilling af et for gaer heterologt protein som produkt af gaerudtrykkelse, gaerudtrykkelsesmedium og gaerorganisme, som er i stand til at secernere modent heterologt protein til dyrkningsmediet |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0123544A3 (da) |
| KR (1) | KR840008695A (da) |
| DK (1) | DK204784A (da) |
| ES (1) | ES8603957A1 (da) |
| IL (1) | IL71621A0 (da) |
| NZ (1) | NZ207926A (da) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK172738B1 (da) * | 1983-04-07 | 1999-06-21 | Chiron Corp | Fremgangsmåde til at udtrykke modent insulin og DNA-struktur til anvendelse ved fremgangsmåden |
| NZ207842A (en) | 1983-04-25 | 1988-02-12 | Chiron Corp | Production of human insulin-like growth factor (igf) using cdna |
| IL71991A (en) | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
| US4870008A (en) * | 1983-08-12 | 1989-09-26 | Chiron Corporation | Secretory expression in eukaryotes |
| AU573883B2 (en) * | 1984-07-20 | 1988-06-23 | Celltech Limited | Vectors |
| GB2177095B (en) * | 1984-07-20 | 1988-05-25 | Celltech Ltd | Eucaryotic expression vectors |
| EP0170266B1 (en) * | 1984-07-30 | 1993-03-24 | Wakunaga Seiyaku Kabushiki Kaisha | Process for producing protein, and vector, recombinant dna and transformant used therefor |
| US5498600A (en) * | 1984-10-12 | 1996-03-12 | Zymogenetics, Inc. | Biologically active mosaic proteins |
| EP0487116B1 (en) * | 1984-10-12 | 1999-12-29 | ZymoGenetics, Inc. | Biologically active PDGF analogs in eucaryotic cells |
| US5187263A (en) * | 1984-10-12 | 1993-02-16 | Zymogenetics, Inc. | Expression of biologically active PDGE analogs in eucaryotic cells |
| US5045633A (en) * | 1985-02-25 | 1991-09-03 | Zymogenetics, Inc. | Expression of biologically active PDGF analogs in eucaryotic cells |
| US5821079A (en) * | 1985-05-02 | 1998-10-13 | Transgene S.A. | Vectors for the expression and secretion of hirudin by transformed yeasts |
| FR2593518B1 (fr) * | 1985-05-02 | 1989-09-08 | Transgene Sa | Vecteurs d'expression et de secretion de l'hirudine par les levures transformees |
| GB8521496D0 (en) * | 1985-08-29 | 1985-10-02 | Ciba Geigy Ag | Repressible yeast promoters |
| US4937189A (en) * | 1985-10-18 | 1990-06-26 | Pfizer Inc. | Expression and secretion of heterologous proteins by Yarrowia lipolytica transformants |
| DE3540075A1 (de) * | 1985-11-12 | 1987-05-14 | Boehringer Ingelheim Int | Human-lysozym |
| US5024941A (en) * | 1985-12-18 | 1991-06-18 | Biotechnica International, Inc. | Expression and secretion vector for yeast containing a glucoamylase signal sequence |
| ZA872534B (en) * | 1986-05-08 | 1987-11-25 | Phillips Petroleum Co | Yeast production of streptokinase |
| US5002876A (en) * | 1986-09-22 | 1991-03-26 | Phillips Petroleum Company | Yeast production of human tumor necrosis factor |
| US5013652A (en) * | 1986-10-14 | 1991-05-07 | Genex Corporation | Composite yeast vectors |
| US5420242A (en) * | 1986-10-22 | 1995-05-30 | Kaare M. Gautvik | Production of human parathyroid hormone from microorganisms |
| US5010010A (en) * | 1986-10-22 | 1991-04-23 | Selmer-Sande, A.S. | Production of human parathyroid hormone from microorganisms |
| AU627147B2 (en) | 1986-10-22 | 1992-08-20 | Peter Alestrom | Production of human parathyroid hormone from microorganisms |
| MY103358A (en) * | 1987-04-15 | 1993-06-30 | Novartis Ag | Process for the production of protiens. |
| US5266474A (en) * | 1987-06-24 | 1993-11-30 | Genentech, Inc. | Balanced inducible transcription system |
| US5063154A (en) * | 1987-06-24 | 1991-11-05 | Whitehead Institute For Biomedical Research | Pheromone - inducible yeast promoter |
| WO1988010308A1 (en) * | 1987-06-24 | 1988-12-29 | Whitehead Institute For Biomedical Research | Pheromone-inducible yeast promoter |
| US5010182A (en) * | 1987-07-28 | 1991-04-23 | Chiron Corporation | DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides |
| US5879907A (en) * | 1987-09-14 | 1999-03-09 | Skandigen Ab | Artificial gene coding for authentic human serum albumin, use thereof and method |
| SE459586B (sv) * | 1987-09-14 | 1989-07-17 | Mta Szegedi Biolog Koezponti | Strukturgen som kodar foer autentiskt humant serum albumin och foerfarande foer dess framstaellning |
| ZA889415B (en) * | 1987-12-18 | 1989-09-27 | Chiron Corp | Compositions and method for recombinant production of crotalidus venum fibrolase |
| CA1340772C (en) * | 1987-12-30 | 1999-09-28 | Patricia Tekamp-Olson | Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences |
| ATE135045T1 (de) * | 1988-07-23 | 1996-03-15 | Delta Biotechnology Ltd | Sekretorische leader-sequenzen |
| JPH0671434B2 (ja) * | 1989-09-18 | 1994-09-14 | 株式会社ミドリ十字 | ヒト血清アルブミンの製造方法 |
| DE69132546T2 (de) | 1990-09-13 | 2001-10-04 | Duke University, Durham | Expression von an g-protein gekoppelten rezeptoren in hefe |
| JP3366947B2 (ja) * | 1990-11-29 | 2003-01-14 | アンスティテュ ナシオナル ド ラ ルシェルシュ アグロノミクーイ.エン.エル.アー. | タイプ1 インターフェロン由来の新規変異体、それらの製造方法及びそれらの適用 |
| FR2669931B1 (fr) * | 1990-11-29 | 1995-03-31 | Transgene | Nouveaux variants derives des interferons-alpha et leur procede de production. |
| JPH0671432B2 (ja) * | 1991-03-20 | 1994-09-14 | 株式会社ミドリ十字 | ヒト血清アルブミンの製造方法 |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| US5538863A (en) * | 1993-07-01 | 1996-07-23 | Immunex Corporation | Expression system comprising mutant yeast strain and expression vector encoding synthetic signal peptide |
| JPH07308199A (ja) | 1994-05-18 | 1995-11-28 | Green Cross Corp:The | ヒト血清アルブミンの製造方法 |
| US6500645B1 (en) | 1994-06-17 | 2002-12-31 | Novo Nordisk A/S | N-terminally extended proteins expressed in yeast |
| CN1182451A (zh) | 1995-03-17 | 1998-05-20 | 诺沃挪第克公司 | 新的内切葡聚糖酶 |
| GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
| JP4064460B2 (ja) | 1996-03-01 | 2008-03-19 | ノボ ノルディスク アクティーゼルスカブ | 食欲抑制性ペプチドを含む医薬組成物の用途 |
| AU733007B2 (en) * | 1996-09-24 | 2001-05-03 | Cadus Pharmaceutical Corporation | Methods and compositions for identifying receptor effectors |
| US6265186B1 (en) | 1997-04-11 | 2001-07-24 | Dsm N.V. | Yeast cells comprising at least two copies of a desired gene integrated into the chromosomal genome at more than one non-ribosomal RNA encoding domain, particularly with Kluyveromyces |
| SE9702401D0 (sv) | 1997-06-19 | 1997-06-19 | Astra Ab | Pharmaceutical use |
| WO2001077137A1 (en) | 2000-04-12 | 2001-10-18 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US6946134B1 (en) | 2000-04-12 | 2005-09-20 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| EP1373493B1 (en) | 2001-03-22 | 2013-07-31 | Novo Nordisk Health Care AG | Coagulation factor vii derivative |
| US7507413B2 (en) | 2001-04-12 | 2009-03-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| EP1432794B1 (en) | 2001-09-27 | 2011-11-09 | Novo Nordisk Health Care AG | Human coagulation factor vii polypeptides |
| EP2277889B1 (en) | 2001-12-21 | 2014-07-09 | Human Genome Sciences, Inc. | Fusion proteins of albumin and interferon beta |
| GB0217033D0 (en) | 2002-07-23 | 2002-08-28 | Delta Biotechnology Ltd | Gene and polypeptide sequences |
| AU2003272410A1 (en) | 2002-09-13 | 2004-04-30 | Cornell Research Foundation, Inc. | Using mutations to improve aspergillus phytases |
| EP1594530A4 (en) | 2003-01-22 | 2006-10-11 | Human Genome Sciences Inc | HYBRID PROTEINS OF ALBUMIN |
| CN101870729A (zh) | 2003-09-09 | 2010-10-27 | 诺和诺德医疗保健公司 | 凝固因子ⅶ多肽 |
| WO2006111524A2 (en) | 2005-04-18 | 2006-10-26 | Novo Nordisk A/S | Il-21 variants |
| WO2007031559A2 (en) | 2005-09-14 | 2007-03-22 | Novo Nordisk Health Care Ag | Human coagulation factor vii polypeptides |
| CA2663083A1 (en) | 2006-09-08 | 2008-03-13 | Ambrx, Inc. | Modified human plasma polypeptide or fc scaffolds and their uses |
| KR20110020819A (ko) | 2008-05-15 | 2011-03-03 | 가부시키가이샤 아루떼꾸 우에노 | 안구건조증 및/또는 각막/결막 질환 치료용 약학 조성물 |
| US20120107267A1 (en) | 2009-03-11 | 2012-05-03 | Novo Nordisk A/S | Interleukin-21 variants having antagonistic binding to the il-21 receptor |
| CA2767755C (en) | 2009-07-17 | 2021-10-12 | Rigshospitalet | Inhibitors of complement activation |
| CN102666570B (zh) | 2009-12-01 | 2015-12-02 | 诺沃—诺迪斯克有限公司 | 新的肽基α-羟基甘氨酸α-酰胺化裂合酶 |
| US9815876B2 (en) | 2010-03-05 | 2017-11-14 | Omeros Corporation | Chimeric inhibitor molecules of complement activation |
| ES2676029T3 (es) | 2012-02-09 | 2018-07-16 | Var2 Pharmaceuticals Aps | Direccionamiento de glicanos de sulfato de condroitina |
| US20150307865A1 (en) | 2012-10-15 | 2015-10-29 | Novo Nordisk Health Care Ag | Coagulation factor vii polypeptides |
| WO2016127083A1 (en) * | 2015-02-06 | 2016-08-11 | Cargill, Incorporated | Modified glucoamylase enzymes and yeast strains having enhanced bioproduct production |
| EP3274461A1 (en) | 2015-03-27 | 2018-01-31 | Cargill, Incorporated | Glucoamylase-modified yeast strains and methods for bioproduct production |
| CN108431229A (zh) | 2015-12-17 | 2018-08-21 | 嘉吉公司 | 糖转运蛋白修饰的酵母菌株和用于生物制品生产的方法 |
| EA037848B1 (ru) | 2016-07-14 | 2021-05-27 | Общество С Ограниченной Ответственностью "Биохимический Агент" | Гибридный белок, полинуклеотид, генетическая конструкция, продуцент, препарат для регенерации хряща (варианты) |
| CN109661403A (zh) | 2016-08-05 | 2019-04-19 | 嘉吉公司 | 前导序列修饰的葡糖淀粉酶多肽和具有增强的生物产物产生的工程化的酵母菌株 |
| CN112789504A (zh) | 2018-07-13 | 2021-05-11 | 瓦克特诊断有限责任公司 | 使用重组疟疾蛋白var2csa分离胎儿来源的循环细胞 |
| WO2022049409A1 (en) | 2020-09-02 | 2022-03-10 | Sia Terragen | Express diagnosticum for sars-cov-2 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0116201B1 (en) * | 1983-01-12 | 1992-04-22 | Chiron Corporation | Secretory expression in eukaryotes |
| DK172738B1 (da) * | 1983-04-07 | 1999-06-21 | Chiron Corp | Fremgangsmåde til at udtrykke modent insulin og DNA-struktur til anvendelse ved fremgangsmåden |
| WO1984004330A1 (en) * | 1983-04-22 | 1984-11-08 | Amgen | Secretion of exogenous polypeptides from yeast |
| NZ207842A (en) * | 1983-04-25 | 1988-02-12 | Chiron Corp | Production of human insulin-like growth factor (igf) using cdna |
| US4588684A (en) * | 1983-04-26 | 1986-05-13 | Chiron Corporation | a-Factor and its processing signals |
| JPS59227899A (ja) * | 1983-05-25 | 1984-12-21 | チロン・コ−ポレイシヨン | 成長ホルモン放出因子の製造方法 |
| IL71991A (en) * | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
| JPS61500586A (ja) * | 1983-11-14 | 1986-04-03 | チロン コ−ポレイシヨン | インタ−ロイキン−2産生のための方法及び組成物 |
| EP0180615B1 (en) * | 1984-04-19 | 1995-04-05 | Scios Nova Inc. | Novel atrial natriuretic/vasodilator polypeptides |
-
1984
- 1984-04-19 NZ NZ207926A patent/NZ207926A/en unknown
- 1984-04-24 DK DK204784A patent/DK204784A/da not_active Application Discontinuation
- 1984-04-24 IL IL71621A patent/IL71621A0/xx unknown
- 1984-04-24 KR KR1019840002188A patent/KR840008695A/ko not_active Abandoned
- 1984-04-24 EP EP84302723A patent/EP0123544A3/en not_active Withdrawn
- 1984-04-25 ES ES531898A patent/ES8603957A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK204784A (da) | 1984-10-26 |
| EP0123544A2 (en) | 1984-10-31 |
| NZ207926A (en) | 1988-04-29 |
| ES531898A0 (es) | 1986-01-16 |
| KR840008695A (ko) | 1984-12-17 |
| EP0123544A3 (en) | 1986-07-16 |
| IL71621A0 (en) | 1984-07-31 |
| ES8603957A1 (es) | 1986-01-16 |
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