DK19286A - Cykliske imidderivater af 2-(4-butylpiperazin-1-yl)-pyridiner - Google Patents

Cykliske imidderivater af 2-(4-butylpiperazin-1-yl)-pyridiner Download PDF

Info

Publication number: DK19286A
Authority: DK; Denmark
Prior art keywords: imiderivatives; butylpiperazin; pyridines; cyclic; hydrogen
Prior art date: 1985-01-16

Application number

DK19286A

Other languages

English (en)

Other versions

DK19286D0 (da

Inventor

James Stewart New

Jr Walter G Lobeck

Joseph P Yevich

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-01-16

Filing date

1986-01-15

Publication date

1986-07-17

1986-01-15 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1986-01-15 Publication of DK19286D0 publication Critical patent/DK19286D0/da

1986-07-17 Publication of DK19286A publication Critical patent/DK19286A/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Pharmacology & Pharmacy (AREA)
Neurology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)

Description

og R2 ikke samtidig kan være hydrogen, Z er udvalgt fra gruppen bestående af

<*) (b) (c)

eller

(d) CO

hvor n er 3, 4, 5 eller 6, R3 og R4 hver især uafhængigt er lavere al kyl, R5 og R6 hver især uafhængigt er valgt fra gruppen bestående af hydrogen, lavere alkyl og phenyl, og A er oxygen eller svovl, fremstilles.

Forbindelserne har farmakologisk virkning.

DK19286A 1985-01-16 1986-01-15 Cykliske imidderivater af 2-(4-butylpiperazin-1-yl)-pyridiner DK19286A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/691,952 US4619930A (en)	1985-01-16	1985-01-16	Antipsychotic cyclic imide derivatives of 2-(4-butylpiperazin-1-yl)pyridines, compositions and use
US69195285		1985-01-16

Publications (2)

Publication Number	Publication Date
DK19286D0 DK19286D0 (da)	1986-01-15
DK19286A true DK19286A (da)	1986-07-17

Family

ID=24778661

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK19286A DK19286A (da)	1985-01-16	1986-01-15	Cykliske imidderivater af 2-(4-butylpiperazin-1-yl)-pyridiner

Country Status (29)

Country	Link
US (1)	US4619930A (da)
JP (1)	JPH0780873B2 (da)
KR (1)	KR900000366B1 (da)
CN (1)	CN1016691B (da)
AT (1)	AT391698B (da)
AU (1)	AU591473B2 (da)
BE (1)	BE904047A (da)
CA (1)	CA1284325C (da)
CH (1)	CH666269A5 (da)
DE (1)	DE3601143C2 (da)
DK (1)	DK19286A (da)
EG (1)	EG17759A (da)
ES (2)	ES8705869A1 (da)
FI (1)	FI90077C (da)
FR (1)	FR2580282B1 (da)
GB (1)	GB2191772B (da)
HU (1)	HU198202B (da)
IE (1)	IE58866B1 (da)
IL (1)	IL77577A (da)
IT (1)	IT1214497B (da)
LU (1)	LU86248A1 (da)
NL (1)	NL8600071A (da)
NZ (1)	NZ214790A (da)
OA (1)	OA08187A (da)
PT (1)	PT81843B (da)
SE (1)	SE466310B (da)
SU (1)	SU1521282A3 (da)
YU (1)	YU45757B (da)
ZA (1)	ZA859692B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4677104A (en) *	1985-05-06	1987-06-30	Bristol-Myers Company	Antipsychotic fused-ring pyridinylpiperazine derivatives
US4812567A (en) *	1985-10-16	1989-03-14	American Home Products Corporation	Polycyclic spiroimides with psychotropic activity
MX174210B (es) *	1987-02-17	1994-04-28	Pfizer	Procedimiento para la preparacion de compuestos arilpiperazinil-alquilenfenil-p-heterociclicos
US4748240A (en) *	1987-04-03	1988-05-31	American Home Products Corporation	Psychotropic bicyclic imides
EP0316723B1 (en) *	1987-11-20	1992-09-30	Hoechst-Roussel Pharmaceuticals Incorporated	3-[4(1-Substituted-4-piperazinyl)butyl]-4-thiazolidinones a process for their preparation and their use as medicaments
US4880930A (en) *	1987-11-30	1989-11-14	New James S	Psychotropic acyclic amide derivatives
US5116970A (en) *	1988-02-18	1992-05-26	New James S	Psychotropic heterobicycloalkylpiperazine derivatives: 2. fused pyridazinones
US5001130A (en) *	1988-02-18	1991-03-19	Bristol-Myers Company	Psychotropic heterobicycloalkylpiperazine derivatives
EP0482696B1 (en) *	1990-10-23	1996-01-10	Akzo Nobel N.V.	4-[4- or 6-(Trifluoromethyl-2-pyridinyl)]-1-piperazinyl-alkyl substituted lactams
DE4232175A1 (de)	1992-04-15	1993-10-21	Bayer Ag	Verfahren zur Herstellung von 2-Amino-5-methyl-pyridin
WO1996002503A1 (en) *	1994-07-15	1996-02-01	Meiji Seika Kabushiki Kaisha	Novel compound having platelet aggregation inhibitor effect
RU2126001C1 (ru) *	1995-01-10	1999-02-10	Самдзин Фармасьютикал Ко., Лтд	Производные пиперазина и фармацевтическая композиция на их основе
JP6440625B2 (ja)	2012-11-14	2018-12-19	ザ・ジョンズ・ホプキンス・ユニバーシティー	精神分裂病を処置するための方法および組成物
CN104230915B (zh) *	2014-08-29	2016-08-17	南京大学	含噻唑烷二酮的苯基哌嗪衍生物及其制备方法与用途
CN104513198A (zh) *	2014-11-29	2015-04-15	南京红太阳生物化学有限责任公司	一种2-氯烟酸的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE759371A (fr) *	1969-11-24	1971-05-24	Bristol Myers Co	Azaspirodecanediones heterocycliques et procedes pour leur preparation
US3976776A (en) *	1972-12-06	1976-08-24	Mead Johnson & Company	Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones
AT330777B (de) *	1973-09-08	1976-07-26	Thomae Gmbh Dr K	Verfahren zur herstellung von neuen isochinolinderivaten und deren salzen
US4305944A (en) *	1980-09-08	1981-12-15	Mead Johnson & Company	N-[(4-[3-cyano substituted pyridyl]piperazino)alkyl]-azaspirodecanediones
US4367335A (en) *	1981-08-03	1983-01-04	Mead Johnson & Company	Thiazolidinylalkylene piperazine derivatives
US4456756A (en) *	1981-08-03	1984-06-26	Mead Johnson & Company	Spirothiazolidinyl piperazine derivatives
DE3135532A1 (de) *	1981-09-08	1983-03-24	NPL po Dvigateli s Vatre&scaron;no Gorene, Varna	Brennkraftmaschine
US4361565A (en) *	1981-12-28	1982-11-30	Mead Johnson & Company	2-[4-[(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyridines
JPS5976059A (ja) *	1982-10-21	1984-04-28	Sumitomo Chem Co Ltd	環状イミド誘導体及びその酸付加塩
JPS61238784A (ja) *	1985-04-17	1986-10-24	Sumitomo Seiyaku Kk	コハク酸イミド誘導体及びその酸付加塩
DE3529872A1 (de) *	1985-08-21	1987-02-26	Kali Chemie Pharma Gmbh	Neue tetraoxoverbindungen

1985
- 1985-01-16 US US06/691,952 patent/US4619930A/en not_active Expired - Lifetime
- 1985-12-19 ZA ZA859692A patent/ZA859692B/xx unknown
- 1985-12-31 FR FR8519488A patent/FR2580282B1/fr not_active Expired - Lifetime
1986
- 1986-01-10 CA CA000499331A patent/CA1284325C/en not_active Expired - Fee Related
- 1986-01-10 NZ NZ214790A patent/NZ214790A/xx unknown
- 1986-01-13 IL IL77577A patent/IL77577A/xx not_active IP Right Cessation
- 1986-01-13 ES ES550829A patent/ES8705869A1/es not_active Expired
- 1986-01-13 YU YU4186A patent/YU45757B/sh unknown
- 1986-01-13 FI FI860136A patent/FI90077C/fi not_active IP Right Cessation
- 1986-01-14 JP JP61006146A patent/JPH0780873B2/ja not_active Expired - Lifetime
- 1986-01-15 KR KR1019860000203A patent/KR900000366B1/ko not_active Expired
- 1986-01-15 NL NL8600071A patent/NL8600071A/nl active Search and Examination
- 1986-01-15 CN CN86100224A patent/CN1016691B/zh not_active Expired
- 1986-01-15 PT PT81843A patent/PT81843B/pt unknown
- 1986-01-15 SU SU864011790A patent/SU1521282A3/ru active
- 1986-01-15 HU HU86207A patent/HU198202B/hu unknown
- 1986-01-15 BE BE0/216140A patent/BE904047A/fr not_active IP Right Cessation
- 1986-01-15 CH CH130/86A patent/CH666269A5/de not_active IP Right Cessation
- 1986-01-15 LU LU86248A patent/LU86248A1/fr unknown
- 1986-01-15 IE IE12586A patent/IE58866B1/en not_active IP Right Cessation
- 1986-01-15 IT IT8619081A patent/IT1214497B/it active
- 1986-01-15 OA OA58765A patent/OA08187A/xx unknown
- 1986-01-15 SE SE8600173A patent/SE466310B/sv not_active IP Right Cessation
- 1986-01-15 DK DK19286A patent/DK19286A/da not_active Application Discontinuation
- 1986-01-16 DE DE3601143A patent/DE3601143C2/de not_active Expired - Lifetime
- 1986-01-16 AU AU52294/86A patent/AU591473B2/en not_active Expired
- 1986-01-16 AT AT0010086A patent/AT391698B/de not_active IP Right Cessation
- 1986-01-16 EG EG20/86A patent/EG17759A/xx active
- 1986-06-17 GB GB8614686A patent/GB2191772B/en not_active Expired - Lifetime
1987
- 1987-02-13 ES ES557390A patent/ES8801822A1/es not_active Expired

Also Published As

Publication number	Publication date
JPH0780873B2 (ja)	1995-08-30
ES8705869A1 (es)	1987-05-16
BE904047A (fr)	1986-07-15
IE58866B1 (en)	1993-11-17
GB8614686D0 (en)	1986-07-23
CN1016691B (zh)	1992-05-20
KR860005808A (ko)	1986-08-13
GB2191772A (en)	1987-12-23
ES8801822A1 (es)	1988-02-16
ATA10086A (de)	1990-05-15
YU45757B (sh)	1992-07-20
GB2191772B (en)	1990-05-23
FI860136A7 (fi)	1986-07-17
IT8619081A0 (it)	1986-01-15
KR900000366B1 (ko)	1990-01-25
YU4186A (en)	1987-10-31
NZ214790A (en)	1989-04-26
FI860136A0 (fi)	1986-01-13
SE8600173L (sv)	1986-07-17
FI90077B (fi)	1993-09-15
NL8600071A (nl)	1986-08-18
CA1284325C (en)	1991-05-21
HU198202B (en)	1989-08-28
DE3601143A1 (de)	1986-07-17
FR2580282B1 (fr)	1992-10-16
HUT39743A (en)	1986-10-29
US4619930A (en)	1986-10-28
FI90077C (fi)	1993-12-27
IT1214497B (it)	1990-01-18
IE860125L (en)	1986-07-16
EG17759A (en)	1991-03-30
LU86248A1 (fr)	1986-08-04
JPS61167682A (ja)	1986-07-29
AU591473B2 (en)	1989-12-07
SU1521282A3 (ru)	1989-11-07
SE8600173D0 (sv)	1986-01-15
OA08187A (fr)	1987-10-30
IL77577A (en)	1990-02-09
ES550829A0 (es)	1987-05-16
DK19286D0 (da)	1986-01-15
PT81843B (pt)	1988-05-27
FR2580282A1 (fr)	1986-10-17
DE3601143C2 (de)	1994-05-11
ES557390A0 (es)	1988-02-16
PT81843A (en)	1986-02-01
AU5229486A (en)	1986-07-24
CH666269A5 (de)	1988-07-15
ZA859692B (en)	1986-07-14
CN86100224A (zh)	1986-11-19
SE466310B (sv)	1992-01-27
AT391698B (de)	1990-11-12

Publication	Publication Date	Title
DK19286A (da)	1986-07-17	Cykliske imidderivater af 2-(4-butylpiperazin-1-yl)-pyridiner
ATE21894T1 (de)	1986-09-15	Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln.
AU583694B2 (en)	1989-05-04	5-acylamido-1-aryl-pyrazoles
FI823687L (fi)	1983-05-01	Foerfarande foer extrahering och separering av uran, torium och saellsynta jordmetaller genom behandling av vattenloesningar av dessa grundaemnens klorider
FI872131A0 (fi)	1987-05-14	Menetelmä vähintään noin 40 paino-% polyesteriä sisältävän polyesteri/puuvillasekoitekankaan tekemiseksi tulenkestäväksi ja menetelmällä valmistettu tulenkestävä kangas
DK164857C (da)	1993-01-18	Fremgangsmaade til fremstilling af 2,5-bis(2,2,2-trifluorethoxy)-n-(2-piperidylmethyl)benzamid
SE8503415D0 (sv)	1985-07-09	Novel isoindolinyl-alkyl-piperazines
RO85070B (ro)	1984-09-30	Procedeu pentru prepararea unor derivati de n-fenilcarbamati
PT68743A (pt)	1978-12-01	Kondensierte isothiazol-3(2h)-on-1,1-dioxide deren herstellung und deren verwendung
EP0229630A3 (de)	1988-07-20	1,2-Disubstituierte Piperidine, Verfahren zu ihrer Herstellung sowie ihre Verwendung im Pflanzenschutz
DK159457C (da)	1991-03-18	Analogifremgangsmaade til fremstilling af 7alfa-acylthio-15,16-methylen-3-oxo-17alfa-pregna-1,4-dien-21,17-carbolactoner
DK156647C (da)	1990-02-05	Fremgangsmaade til fremstilling af 2-(2,2-dicyclohexylethyl)piperidin eller et salt deraf
FI862111A7 (fi)	1986-11-22	Foerfarande foer framstaellning av 2(n-bensyl-n-metylamino)-etylmetyl-2,6-dimetyl-4-(m-nitrofenyl) -1,4-dihydropyridin-3,5-dikarboxylat och dess hydrokloridsalt.
DK365879A (da)	1980-03-03	Fremgangsmaade til fremstilling af 4-hydroxy-2h (1) benzotheno(,3-)-1,2-thiazin-3-carboxamid-1,1-dioxider
ATE8046T1 (de)	1984-07-15	Dibenzofuranderivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung von pilzen.
KR870002113A (ko)	1987-03-30	제초제의 제조 방법
DK150517C (da)	1987-10-19	Analogifremgangsmaade til fremstilling af 2,5-dihydro-1,2-thiazino(5,6-b)indol-3-carboxamid-1,1-dioxider eller fysiologisk acceptable salte deraf
ES2106199T3 (es)	1997-11-01	Derivado de nitroxialquilamida.
TR22398A (tr)	1987-03-25	Yeni benzodisultamlar,hazirlanmalarina iliskin yoentem ve bunlarin herbisit olarak kullanimlari
FI890254A0 (fi)	1989-01-17	Automatiskt styrsystem foer ett snabbt fordon vars styrhjul aer foersedda med pneumatiska daeck.
DK164905C (da)	1993-01-18	Fremgangsmaade til afvanding af 2,6-dimethylmorpholin
DK163802C (da)	1992-09-07	Fremgangsmaade til toer-rensning af roeggas fra forbraending af affaldsmateriale, der er i hovedsagen ikke-metallisk shredderaffald
EP0113831A3 (de)	1984-11-07	Carbaminsäureester, Verfahren zu deren Herstellung und deren Verwendung
ATE5410T1 (de)	1983-12-15	N-methyl-n-silyl-carbamate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung von schaedlingen.
ATE37175T1 (de)	1988-09-15	Substituierte phenylether, verfahren zu ihrer herstellung und ihre verwendung bei der herstellung von substituierten phenolen.

Legal Events

Date	Code	Title	Description
1997-12-15	AHS	Application shelved for other reasons than non-payment