DK1962808T3 - HCV prodrug-formulering - Google Patents

HCV prodrug-formulering

Info

Publication number: DK1962808T3
Authority: DK; Denmark
Prior art keywords: prodrug formulation; hcv; hcv prodrug; formulation; prodrug
Prior art date: 2005-12-14

Application number

DK06830328.8T

Other languages

English (en)

Inventor

Kondamraj Birudaraj

Hashim A Ahmed

Thomas Vernon Alfredson

Michael Thomas Brandl

Wantanee Phuapradit

Navnit Hargovindas Shah

Dimitrios Stefanidis

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-12-14

Filing date

2006-12-04

Publication date

2010-11-08

2006-12-04 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2010-11-08 Application granted granted Critical

2010-11-08 Publication of DK1962808T3 publication Critical patent/DK1962808T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2893—Tablet coating processes

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK06830328.8T 2005-12-14 2006-12-04 HCV prodrug-formulering DK1962808T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US75014605P	2005-12-14	2005-12-14
US83059406P	2006-07-12	2006-07-12
PCT/EP2006/069262 WO2007068615A2 (en)	2005-12-14	2006-12-04	Hcv prodrug formulation

Publications (1)

Publication Number	Publication Date
DK1962808T3 true DK1962808T3 (da)	2010-11-08

Family

ID=37806115

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK06830328.8T DK1962808T3 (da)	2005-12-14	2006-12-04	HCV prodrug-formulering

Country Status (21)

Country	Link
US (1)	US7795237B2 (da)
EP (1)	EP1962808B1 (da)
JP (1)	JP5649783B2 (da)
KR (1)	KR20080089344A (da)
AR (1)	AR058313A1 (da)
AT (1)	ATE482690T1 (da)
AU (1)	AU2006326130B2 (da)
BR (1)	BRPI0619890A2 (da)
CA (1)	CA2631498A1 (da)
CR (1)	CR10026A (da)
DE (1)	DE602006017257D1 (da)
DK (1)	DK1962808T3 (da)
EC (1)	ECSP088528A (da)
IL (1)	IL191791A (da)
MA (1)	MA30056B1 (da)
NO (1)	NO20082563L (da)
PL (1)	PL1962808T3 (da)
PT (1)	PT1962808E (da)
RU (1)	RU2435592C2 (da)
TW (1)	TWI382840B (da)
WO (1)	WO2007068615A2 (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8957034B2 (en) *	2004-01-28	2015-02-17	Johns Hopkins University	Drugs and gene carrier particles that rapidly move through mucous barriers
RU2454220C2 (ru)	2006-08-16	2012-06-27	Новартис Аг	Способ получения твердых дисперсий высококристаллических терапевтических соединений
WO2008030557A2 (en) *	2006-09-08	2008-03-13	Johns Hopkins University	Compositions and methods for enhancing transport through mucus
ES2377760T3 (es)	2007-03-29	2012-03-30	F. Hoffmann-La Roche Ag	Composición farmacéutica y proceso
SI2389164T1 (sl) *	2009-01-21	2014-12-31	F. Hoffmann-La Roche Ag	Farmacevtski sestavki, obsegajoäśi predzdravilo inhibitorja hcv polimeraze
AR075180A1 (es) *	2009-01-29	2011-03-16	Novartis Ag	Formulaciones orales solidas de una pirido-pirimidinona
GB0909680D0 (en)	2009-06-05	2009-07-22	Euro Celtique Sa	Dosage form
PL2528930T3 (pl) *	2010-01-28	2014-03-31	Riboscience Llc	4`-azydonukleozydy jako związki przeciw hcv
MX344846B (es)	2010-05-10	2017-01-10	Euro-Celtique S A *	Combinacion de granulos cargados activos con activos adicionales.
US9993433B2 (en)	2010-05-10	2018-06-12	Euro-Celtique S.A.	Manufacturing of active-free granules and tablets comprising the same
ES2408343B2 (es)	2010-05-10	2014-07-17	Euro-Celtique, Sa	Composiciones farmacéuticas que comprenden hidromorfona y naloxona
CA3054532C (en) *	2010-11-05	2022-07-12	The Johns Hopkins University	Compositions and methods relating to reduced mucoadhesion
EP2455068A1 (en) *	2010-11-09	2012-05-23	F. Hoffmann-La Roche AG	Pharmaceutical composition for treating HCV infections
WO2012062691A1 (en) *	2010-11-09	2012-05-18	F. Hoffmann-La Roche Ag	Pharmaceutical compositions for treating hcv infections
JP5917964B2 (ja) *	2012-03-19	2016-05-18	富士ゼロックス株式会社	錠剤、錠剤の製造方法、錠剤管理装置、錠剤照合装置及びプログラム
US11596599B2 (en)	2012-05-03	2023-03-07	The Johns Hopkins University	Compositions and methods for ophthalmic and/or other applications
AU2013256130B2 (en) *	2012-05-03	2017-12-21	Alcon Inc.	Pharmaceutical nanoparticles showing improved mucosal transport
AU2013256064B2 (en)	2012-05-03	2018-01-04	Alcon Inc.	Pharmaceutical nanoparticles showing improved mucosal transport
US9827191B2 (en)	2012-05-03	2017-11-28	The Johns Hopkins University	Compositions and methods for ophthalmic and/or other applications
AU2014216178B2 (en)	2013-02-15	2018-06-28	KALA BIO, Inc.	Therapeutic compounds and uses thereof
US9688688B2 (en)	2013-02-20	2017-06-27	Kala Pharmaceuticals, Inc.	Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
CN105189462B (zh)	2013-02-20	2017-11-10	卡拉制药公司	治疗性化合物和其用途
AU2014342042B2 (en)	2013-11-01	2017-08-17	KALA BIO, Inc.	Crystalline forms of therapeutic compounds and uses thereof
US9890173B2 (en)	2013-11-01	2018-02-13	Kala Pharmaceuticals, Inc.	Crystalline forms of therapeutic compounds and uses thereof
EP3068397A1 (en)	2013-11-13	2016-09-21	Euro-Celtique S.A.	Hydromorphone and naloxone for treatment of pain and opioid bowel dysfunction syndrome
EP3509422A4 (en)	2016-09-08	2020-05-20	Kala Pharmaceuticals, Inc.	CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
CN109688818A (zh)	2016-09-08	2019-04-26	卡拉制药公司	治疗化合物的晶型及其用途
CA3036340A1 (en)	2016-09-08	2018-03-15	Kala Pharmaceuticals, Inc.	Crystalline forms of therapeutic compounds and uses thereof
EP3381479A1 (de) *	2017-03-29	2018-10-03	ARTOSS GmbH	Trägerzusammensetzung für knochenersatzmaterialien

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2260319B (en) *	1991-10-07	1995-12-06	Norsk Hydro As	Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
DK1014941T3 (da) *	1996-06-26	2009-07-27	Univ Texas	Ekstruderbar farmaceutisk hot-melt-formulering
AU754370B2 (en) *	1997-06-03	2002-11-14	Itochu Techo-Chemical Inc.	Natural antitumor or antiviral substances and use of the same
JP2001520984A (ja) *	1997-10-27	2001-11-06	メルクパテントゲゼルシャフトミットベシュレンクテルハフトング	水難溶性薬剤の固態溶剤及び固体分散体
RU2187509C1 (ru) *	2001-03-26	2002-08-20	Закрытое акционерное общество "Производственно-коммерческая Ассоциация АЗТ"	Производные 5'-h-фосфоната 3'-азидо-3'-дезокситимидина и фармацевтические композиции на их основе
EP1390063B1 (en) *	2001-05-03	2004-11-17	F. Hoffmann-La Roche Ag	Pharmaceutical dosage form of amorphous nelfinavir mesylate
DE10162593A1 (de) *	2001-12-19	2003-07-03	Menarini Ricerche Spa	Stabilisierte topische Brivudin-Formulierungen
DE10208344A1 (de) *	2002-02-27	2003-09-04	Roehm Gmbh	Schmelzextrusion von Wirkstoffsalzen
TWI332507B (en) *	2002-11-19	2010-11-01	Hoffmann La Roche	Antiviral nucleoside derivatives
US20050044529A1 (en) *	2003-08-20	2005-02-24	Microsoft Corporation	Task library of task data for a plurality of components on a computer system
US20050048112A1 (en) *	2003-08-28	2005-03-03	Jorg Breitenbach	Solid pharmaceutical dosage form

2006
- 2006-12-04 AT AT06830328T patent/ATE482690T1/de active
- 2006-12-04 BR BRPI0619890-2A patent/BRPI0619890A2/pt not_active IP Right Cessation
- 2006-12-04 JP JP2008544952A patent/JP5649783B2/ja not_active Expired - Fee Related
- 2006-12-04 PL PL06830328T patent/PL1962808T3/pl unknown
- 2006-12-04 DE DE602006017257T patent/DE602006017257D1/de active Active
- 2006-12-04 KR KR1020087014073A patent/KR20080089344A/ko not_active Ceased
- 2006-12-04 CA CA002631498A patent/CA2631498A1/en not_active Abandoned
- 2006-12-04 PT PT06830328T patent/PT1962808E/pt unknown
- 2006-12-04 AU AU2006326130A patent/AU2006326130B2/en not_active Ceased
- 2006-12-04 WO PCT/EP2006/069262 patent/WO2007068615A2/en not_active Ceased
- 2006-12-04 EP EP06830328A patent/EP1962808B1/en active Active
- 2006-12-04 DK DK06830328.8T patent/DK1962808T3/da active
- 2006-12-04 RU RU2008128361/15A patent/RU2435592C2/ru not_active IP Right Cessation
- 2006-12-12 AR ARP060105459A patent/AR058313A1/es not_active Application Discontinuation
- 2006-12-12 TW TW095146501A patent/TWI382840B/zh not_active IP Right Cessation
- 2006-12-13 US US11/637,999 patent/US7795237B2/en not_active Expired - Fee Related
2008
- 2008-05-28 CR CR10026A patent/CR10026A/es not_active Application Discontinuation
- 2008-05-28 IL IL191791A patent/IL191791A/en not_active IP Right Cessation
- 2008-06-02 NO NO20082563A patent/NO20082563L/no not_active Application Discontinuation
- 2008-06-12 EC EC2008008528A patent/ECSP088528A/es unknown
- 2008-06-16 MA MA31038A patent/MA30056B1/fr unknown

Also Published As

Publication number	Publication date
EP1962808A2 (en)	2008-09-03
AR058313A1 (es)	2008-01-30
PL1962808T3 (pl)	2011-03-31
IL191791A0 (en)	2008-12-29
RU2435592C2 (ru)	2011-12-10
PT1962808E (pt)	2010-10-29
ATE482690T1 (de)	2010-10-15
US7795237B2 (en)	2010-09-14
NO20082563L (no)	2008-07-03
TW200803873A (en)	2008-01-16
RU2008128361A (ru)	2010-01-20
WO2007068615A2 (en)	2007-06-21
ECSP088528A (es)	2008-07-30
AU2006326130A1 (en)	2007-06-21
JP5649783B2 (ja)	2015-01-07
CA2631498A1 (en)	2007-06-21
TWI382840B (zh)	2013-01-21
WO2007068615A3 (en)	2007-09-07
EP1962808B1 (en)	2010-09-29
US20070202175A1 (en)	2007-08-30
CR10026A (es)	2008-07-29
JP2009519289A (ja)	2009-05-14
BRPI0619890A2 (pt)	2011-10-25
KR20080089344A (ko)	2008-10-06
IL191791A (en)	2011-06-30
DE602006017257D1 (de)	2010-11-11
AU2006326130B2 (en)	2011-09-22
MA30056B1 (fr)	2008-12-01

Publication	Publication Date	Title
NO20082563L (no)	2008-07-03	HCV prodroge formulering
ITMI20050728A1 (it)	2006-10-23	Formulazione innovativa
DE602006020996D1 (de)	2011-05-12	Hreren eingängen
CY2013047I1 (el)	2015-11-04	Ενωσεις διαρυλυδαντοϊνης
ATE408603T1 (de)	2008-10-15	Pyrazolylcarboxanilide
CR9974A (es)	2008-09-19	Gavión
ITMI20041252A1 (it)	2004-09-22	Composizioni perfluoroelastomeriche
DE602006000913D1 (de)	2008-05-29	Tensidzusammensetzung
NO20055686D0 (no)	2005-12-01	Sammensetning
DE602006012066D1 (de)	2010-03-18	Daraus
DK1868586T3 (da)	2013-03-11	Antiinflammatorisk formulering
DE602005016978D1 (de)	2009-11-12	Quecksilberfreisetzende Zusammensetzungen
ATE549324T1 (de)	2012-03-15	Tetrahydrobenzoxazine
DE502006006590D1 (de)	2010-05-12	Biozide zusammensetzungen
DE112006002964A5 (de)	2008-09-11	Zweirichtungsreflektanzverteilungsmessgerät
DE502005005839D1 (de)	2008-12-11	Feldgeerät
DE502006001397D1 (de)	2008-10-02	Lagerbuchse
DE102005052834B8 (de)	2010-12-30	Punktschweißklebverbindung
DE502006001004D1 (de)	2008-08-14	Hydrolager
ATE485368T1 (de)	2010-11-15	Hiv - impfung
AT501523A3 (de)	2010-05-15	Estrich
DE112005003765A5 (de)	2008-08-28	Dreifachbild
DE502006000445D1 (de)	2008-04-24	Mulchmähdeck
DE102006033170A8 (de)	2007-06-06	Einfassnähmaschine
DE502006000489D1 (de)	2008-04-30	Induktionshärtungsanlage