DK182386A - Carbapenemmellemprodukter - Google Patents

Carbapenemmellemprodukter Download PDF

Info

Publication number: DK182386A
Authority: DK; Denmark
Prior art keywords: carbapenes; intermediate products; products; alkyl; useful
Prior art date: 1985-04-22

Application number

DK182386A

Other languages

English (en)

Other versions

DK182386D0 (da

Inventor

Yasutsugu Ueda

Guy Roberge

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-22

Filing date

1986-04-21

Publication date

1986-10-23

1986-04-21 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1986-04-21 Publication of DK182386D0 publication Critical patent/DK182386D0/da

1986-10-23 Publication of DK182386A publication Critical patent/DK182386A/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
- C07C205/42—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups or esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/12—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
- C07C245/14—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
- C07C245/18—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/12—Organo silicon halides
- C07F7/16—Preparation thereof from silicon and halogenated hydrocarbons direct synthesis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1896—Compounds having one or more Si-O-acyl linkages
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

Description

eller

og R1, R2 og R3 hver uafhængigt er C^alkyl eller alternativt

betegner

eller

forudsat, at når

kan R7 ikke være allyl eller C1_4alkyl, og under den forudsætning at når R5 og R6 er hydrogen, er R1, R2 og R3 ikke alkyl, og R7 ikke p-nitrobenzyl, fremstilles.

Carbapenemprodukterne er nyttige mellemprodukter ved fremstilling af thienamycin og andre nyttige carbapenemantibiotika.

DK182386A 1985-04-22 1986-04-21 Carbapenemmellemprodukter DK182386A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US72559485		1985-04-22
US06/725,594 US4683296A (en)	1983-03-07	1985-04-22	Carbapenem intermediates

Publications (2)

Publication Number	Publication Date
DK182386D0 DK182386D0 (da)	1986-04-21
DK182386A true DK182386A (da)	1986-10-23

Family

ID=24915191

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK182386A DK182386A (da)	1985-04-22	1986-04-21	Carbapenemmellemprodukter

Country Status (35)

Country	Link
US (1)	US4683296A (da)
JP (1)	JPS61275284A (da)
KR (1)	KR890004347B1 (da)
CN (1)	CN86102077A (da)
AR (1)	AR244236A1 (da)
AT (1)	AT386208B (da)
AU (1)	AU599022B2 (da)
BE (1)	BE904645A (da)
CA (1)	CA1302426C (da)
CH (1)	CH667273A5 (da)
CS (1)	CS266585B2 (da)
DD (1)	DD251352A5 (da)
DE (1)	DE3613366A1 (da)
DK (1)	DK182386A (da)
ES (1)	ES8708234A1 (da)
FI (1)	FI861633A7 (da)
FR (1)	FR2580653B1 (da)
GB (1)	GB2173801B (da)
GR (1)	GR861064B (da)
HU (1)	HU195824B (da)
IE (1)	IE59042B1 (da)
IL (1)	IL78533A (da)
IT (1)	IT1213061B (da)
LU (1)	LU86401A1 (da)
MY (1)	MY102926A (da)
NL (1)	NL8601010A (da)
NO (1)	NO861558L (da)
NZ (1)	NZ215263A (da)
OA (1)	OA08235A (da)
PT (1)	PT82435B (da)
SE (1)	SE8601824L (da)
YU (1)	YU43696B (da)
ZA (1)	ZA862987B (da)
ZM (1)	ZM6286A1 (da)
ZW (1)	ZW8986A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4772683A (en) *	1986-02-24	1988-09-20	Bristol-Myers Company	High percentage beta-yield synthesis of carbapenem intermediates
JP2675625B2 (ja) *	1989-01-12	1997-11-12	鐘淵化学工業株式会社	エノールシリルエーテル化合物の製造方法
NZ234411A (en) *	1989-07-18	1991-05-28	Merck & Co Inc	Preparation of 2-diazo-3-silyloxy-3-butenoate esters
US5340927A (en) *	1989-07-18	1994-08-23	Merck & Co., Inc.	Process for the preparation of 2-diazo-3-trisubstituted silyloxy 3-butenoates
DE4014649A1 (de) *	1990-05-08	1991-11-14	Hoechst Ag	Neue mehrfunktionelle verbindungen mit (alpha)-diazo-ss-ketoester- und sulfonsaeureester-einheiten, verfahren zu ihrer herstellung und deren verwendung
JP2000166962A (ja) *	1998-12-08	2000-06-20	Tatsu Ifukube	触覚刺激装置及び方法
ATE454388T1 (de)	2003-08-28	2010-01-15	Ranbaxy Lab Ltd	Verfahren zur herstellung von estern von 2-diazo- 3-trimethylsilyloxy-3-butensäure
US20070037971A1 (en) *	2005-07-29	2007-02-15	Meeran Hashim Nizar P N	Process for desilylation of carbapenem intermediates
CA2732619A1 (en) *	2008-07-30	2010-02-04	Ranbaxy Laboratories Limited	Process for the preparation of carbapenem compounds
WO2011048583A1 (en)	2009-10-23	2011-04-28	Ranbaxy Laboratories Limited	Process for the preparation of carbapenem compounds
CN102690282A (zh) *	2011-07-07	2012-09-26	深圳市海滨制药有限公司	晶体形式的1β甲基碳青霉烯类抗生素中间体及其制备方法
CN102643211A (zh) *	2012-04-10	2012-08-22	平顶山佳瑞高科实业有限公司	一种2-重氮乙酰乙酸对硝基苄酯的制备方法
WO2017132321A1 (en)	2016-01-29	2017-08-03	The Johns Hopkins University	Novel inhibitors of bacterial growth
CN106565535B (zh) *	2016-11-15	2018-07-17	山西师范大学	2-重氮-1-芳基酮类化合物的制备方法
CN107556212B (zh) *	2017-09-14	2020-03-24	台州昌霖化工科技有限公司	一种制备2-重氮乙酰乙酸对硝基苄酯的方法
CN114516820A (zh) *	2022-02-25	2022-05-20	山东艾孚特科技有限公司	一种制备2-重氮乙酰乙酸对硝基苄酯的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0075026B1 (en) *	1981-04-03	1986-12-17	Matsushita Electric Industrial Co., Ltd.	Method of cooking
US4444685A (en) *	1981-04-27	1984-04-24	Merck & Co., Inc.	Stereospecific synthesis of thienamycin from penicillin
CA1190236A (en) *	1981-10-23	1985-07-09	Edward J.J. Grabowski	Antibiotic synthesis
US4525582A (en) *	1982-06-22	1985-06-25	Merck & Co., Inc.	Silyl, benzyl, p-nitrobenyl, or methyl esters of diazoacetate, a synthon used in the conversion of penicillin to thienamycin
CA1269978A (en) *	1982-09-28	1990-06-05	Choung U. Kim	Carbapenem antibiotics
CA1220215A (en) *	1983-03-07	1987-04-07	Yasutsugu Ueda	Carbapenem intermediates

1985
- 1985-04-22 US US06/725,594 patent/US4683296A/en not_active Expired - Fee Related
1986
- 1986-02-21 NZ NZ215263A patent/NZ215263A/xx unknown
- 1986-03-28 CN CN198686102077A patent/CN86102077A/zh active Pending
- 1986-04-16 AU AU56167/86A patent/AU599022B2/en not_active Ceased
- 1986-04-17 FI FI861633A patent/FI861633A7/fi not_active Application Discontinuation
- 1986-04-18 FR FR868605640A patent/FR2580653B1/fr not_active Expired
- 1986-04-18 IL IL78533A patent/IL78533A/xx not_active IP Right Cessation
- 1986-04-18 OA OA58839A patent/OA08235A/xx unknown
- 1986-04-18 AR AR86303698A patent/AR244236A1/es active
- 1986-04-21 CS CS862873A patent/CS266585B2/cs unknown
- 1986-04-21 DK DK182386A patent/DK182386A/da not_active Application Discontinuation
- 1986-04-21 NL NL8601010A patent/NL8601010A/nl not_active Application Discontinuation
- 1986-04-21 CH CH1600/86A patent/CH667273A5/de not_active IP Right Cessation
- 1986-04-21 ZM ZM62/86A patent/ZM6286A1/xx unknown
- 1986-04-21 LU LU86401A patent/LU86401A1/fr unknown
- 1986-04-21 BE BE0/216571A patent/BE904645A/fr not_active IP Right Cessation
- 1986-04-21 ZW ZW89/86A patent/ZW8986A1/xx unknown
- 1986-04-21 ES ES554217A patent/ES8708234A1/es not_active Expired
- 1986-04-21 IT IT8620164A patent/IT1213061B/it active
- 1986-04-21 GB GB8609662A patent/GB2173801B/en not_active Expired
- 1986-04-21 SE SE8601824A patent/SE8601824L/ unknown
- 1986-04-21 IE IE104786A patent/IE59042B1/en not_active IP Right Cessation
- 1986-04-21 NO NO861558A patent/NO861558L/no unknown
- 1986-04-21 DD DD86289445A patent/DD251352A5/de not_active IP Right Cessation
- 1986-04-21 ZA ZA862987A patent/ZA862987B/xx unknown
- 1986-04-21 DE DE19863613366 patent/DE3613366A1/de not_active Ceased
- 1986-04-21 KR KR1019860003078A patent/KR890004347B1/ko not_active Expired
- 1986-04-21 PT PT82435A patent/PT82435B/pt not_active IP Right Cessation
- 1986-04-22 HU HU861677A patent/HU195824B/hu not_active IP Right Cessation
- 1986-04-22 YU YU658/86A patent/YU43696B/xx unknown
- 1986-04-22 AT AT0106886A patent/AT386208B/de not_active IP Right Cessation
- 1986-04-22 GR GR861064A patent/GR861064B/el unknown
- 1986-04-22 JP JP61091418A patent/JPS61275284A/ja active Granted
- 1986-04-22 CA CA000507256A patent/CA1302426C/en not_active Expired - Fee Related
1987
- 1987-09-29 MY MYPI87002268A patent/MY102926A/en unknown

Also Published As

Publication number	Publication date
AU599022B2 (en)	1990-07-12
US4683296A (en)	1987-07-28
OA08235A (fr)	1987-10-30
CH667273A5 (de)	1988-09-30
ES8708234A1 (es)	1987-10-01
GR861064B (en)	1986-09-01
MY102926A (en)	1993-03-31
NL8601010A (nl)	1986-11-17
GB2173801B (en)	1989-08-23
FI861633A0 (fi)	1986-04-17
ZW8986A1 (en)	1986-12-03
DK182386D0 (da)	1986-04-21
DD251352A5 (de)	1987-11-11
IE59042B1 (en)	1993-12-15
NO861558L (no)	1986-10-23
PT82435A (en)	1986-05-01
ZA862987B (en)	1987-12-30
IL78533A (en)	1992-05-25
KR860008191A (ko)	1986-11-12
CN86102077A (zh)	1987-01-28
IE861047L (en)	1986-10-22
AU5616786A (en)	1986-11-06
GB2173801A (en)	1986-10-22
KR890004347B1 (ko)	1989-10-31
JPS6358836B2 (da)	1988-11-17
HUT41040A (en)	1987-03-30
JPS61275284A (ja)	1986-12-05
FR2580653A1 (fr)	1986-10-24
IL78533A0 (en)	1986-08-31
CS287386A2 (en)	1989-04-14
PT82435B (pt)	1988-08-17
ZM6286A1 (en)	1987-04-30
IT8620164A0 (it)	1986-04-21
YU65886A (en)	1988-04-30
LU86401A1 (fr)	1986-11-05
ES554217A0 (es)	1987-10-01
CA1302426C (en)	1992-06-02
AR244236A1 (es)	1993-10-29
CS266585B2 (en)	1990-01-12
HU195824B (en)	1988-07-28
GB8609662D0 (en)	1986-05-29
SE8601824D0 (sv)	1986-04-21
FR2580653B1 (fr)	1989-06-16
YU43696B (en)	1989-10-31
DE3613366A1 (de)	1986-11-20
IT1213061B (it)	1989-12-07
ATA106886A (de)	1987-12-15
AT386208B (de)	1988-07-25
SE8601824L (sv)	1986-10-23
FI861633A7 (fi)	1986-10-23
NZ215263A (en)	1989-03-29
BE904645A (fr)	1986-10-21

Publication	Publication Date	Title
DK182386A (da)	1986-10-23	Carbapenemmellemprodukter
ZA857274B (en)	1986-05-28	Diarylacetylenes,their preparation and their use
FI880428A7 (fi)	1988-07-31	Hepatiitti B viruksen pinta-antigeenejä ja niitä sisältäviä hybridiantigeenejä.
DZ1712A1 (fr)	2002-02-17	Materiau composite pour le filtrage de rayonnementet sont utilisation.
AU5618880A (en)	1980-09-11	Vibrator having two imbalanced members
BG101105A (bg)	1998-04-30	Заместени бензамидини, тяхното получаване и използването им като лекарствени средства
TR200600582A1 (tr)	2006-08-21	N-(4-tiriflormetilfenil)-5-metil-[zoksazol-4-karboksamidin kristal formu
EP0533804A4 (en)	1993-04-21	Sigma binding site agents
FI853624L (fi)	1986-03-23	1-substituerade tetralinderivat, deras framstaellning och anvaendning.
IT1115787B (it)	1986-02-03	Perfezionamento nei preparari ant-acidita' in forma di compresse
IT8324147A0 (it)	1983-12-13	Perfezionamenti nella fabbricazione di tele per articoli di gomma rinforzati.
BG35042A3 (en)	1983-01-16	Method for preparing benzodiazepinic compounds
BG37838A3 (bg)	1985-08-15	Метод за получаване на цефалоспорини
GR930300084T1 (en)	1993-09-30	Intermediates for chelating agents with prefixed symmetry and process for their preparation.
DE59105224D1 (de)	1995-05-24	Verfahren zur Herstellung von N-substituierten Pyrrolidonen.
AU7515287A (en)	1988-01-11	Methods and compositions for treating viral infections
EP0739901A3 (en)	1996-11-13	Novel oligoribonucleotide derivatives and application thereof to antiviral agents
BR9102174A (pt)	1991-12-24	Processo de pos-tratamento de camadas de conversao e uso do processo
ES8501439A1 (es)	1984-12-01	Secuencia de adn y estructuras de adn y procedimiento que las utiliza para la preparacion de penicilin-acilasa
DE2967472D1 (en)	1985-07-25	Polymers of acrylyl or methacrylyl ureas containing quaternary groups, and their use as flocculation, sedimentation, dewatering and retention auxiliary agents
GB2063222B (en)	1984-03-28	Deskewing documents
PH23525A (en)	1989-08-25	2-(5-phenyl-2-furanyl) imidazoles useful as cardiotonic agents
DE59104649D1 (de)	1995-03-30	Verfahren zur Herstellung von N,N,N',N'-Tetraglycidyl-3,3'-dialkyl-4,4'-diaminodiphenylmethanen.
DE69104825D1 (de)	1994-12-01	Oberflächenbehandlung von verzinnten glatt- und tiefgezogenen dosen.
GB2023142A (en)	1979-12-28	Ureido Cephelosporins

Legal Events

Date	Code	Title	Description
1994-04-25	AHS	Application shelved for other reasons than non-payment