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DK1709065T3 - Modion-bytningsfremgangsmåde til peptider - Google Patents

Modion-bytningsfremgangsmåde til peptider

Info

Publication number
DK1709065T3
DK1709065T3 DK05811089.1T DK05811089T DK1709065T3 DK 1709065 T3 DK1709065 T3 DK 1709065T3 DK 05811089 T DK05811089 T DK 05811089T DK 1709065 T3 DK1709065 T3 DK 1709065T3
Authority
DK
Denmark
Prior art keywords
modion
peptides
exchange method
peptide
column
Prior art date
Application number
DK05811089.1T
Other languages
English (en)
Inventor
Avi Tovi
Chaim Eidelman
Shimon Shushan
Shai Elster
Hagi Alon
Alexander Ivchenko
Gabriel-Marcus Butilca
Gil Zaoui
Original Assignee
Novetide Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novetide Ltd filed Critical Novetide Ltd
Application granted granted Critical
Publication of DK1709065T3 publication Critical patent/DK1709065T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK05811089.1T 2004-10-04 2005-10-04 Modion-bytningsfremgangsmåde til peptider DK1709065T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61601004P 2004-10-04 2004-10-04
US63052804P 2004-11-22 2004-11-22
PCT/US2005/035868 WO2006041945A2 (en) 2004-10-04 2005-10-04 A counterion exchange process for peptides

Publications (1)

Publication Number Publication Date
DK1709065T3 true DK1709065T3 (da) 2010-08-23

Family

ID=36096369

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05811089.1T DK1709065T3 (da) 2004-10-04 2005-10-04 Modion-bytningsfremgangsmåde til peptider

Country Status (10)

Country Link
US (1) US20060148699A1 (da)
EP (2) EP1709065B1 (da)
JP (1) JP2007513192A (da)
AT (1) ATE469912T1 (da)
CA (1) CA2582083A1 (da)
DE (1) DE602005021614D1 (da)
DK (1) DK1709065T3 (da)
ES (1) ES2344657T3 (da)
IL (1) IL182157A0 (da)
WO (1) WO2006041945A2 (da)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL2000126C2 (nl) * 2005-07-15 2008-01-29 Solvay Werkwijze voor de vervaardiging van eptifibatide.
WO2008109079A2 (en) * 2007-03-01 2008-09-12 Novetide, Ltd. High purity peptides
AU2008271608A1 (en) * 2007-06-29 2009-01-08 Lonza Ag Process for the production of pramlintide
EP2062909A1 (en) * 2007-11-21 2009-05-27 SOLVAY (Société Anonyme) Peptide production and purification process
US9051349B2 (en) 2007-11-21 2015-06-09 Alba Therapeutics Corporation Larazotide acetate compositions
EP2245043A4 (en) * 2008-02-06 2011-05-11 Biocon Ltd PROCESS FOR CLEANING A PEPTIDE
CN101314613B (zh) * 2008-05-08 2012-04-25 吉尔生化（上海）有限公司 一种阿托西班的固相合成方法
WO2009150657A1 (en) * 2008-06-09 2009-12-17 Natco Pharma Limited Improved process for preparation of eptifibatide by fmoc solid phase synthesis
CN101463080B (zh) * 2009-01-09 2011-09-14 深圳翰宇药业股份有限公司 一种纯化奈西利肽的方法
CN101696236B (zh) * 2009-02-11 2012-02-15 海南中和药业有限公司 一种固相合成阿托西班方法
EP2417150A2 (en) 2009-04-06 2012-02-15 Matrix Laboratories Ltd An improved process for the preparation of desmopressin or its pharmaceutically acceptable salts
WO2011011342A1 (en) * 2009-07-20 2011-01-27 Mallinckrodt Inc. Synthesis of desmopressin
SG178306A1 (en) * 2009-08-11 2012-03-29 Biocon Ltd Chromatographic processes and purified compounds thereof
CN101787071B (zh) * 2010-02-26 2012-11-07 深圳翰宇药业股份有限公司 一种伐普肽的纯化方法
CN101780267A (zh) * 2010-03-12 2010-07-21 深圳翰宇药业股份有限公司 一种抗血小板凝集的制剂及其制备方法
RU2441018C1 (ru) * 2010-09-28 2012-01-27 Закрытое Акционерное Общество "Фарм-Синтез" Способ хроматографической очистки октреотида
CN102146121A (zh) * 2010-11-19 2011-08-10 深圳市健元医药科技有限公司 一种含有oxt拮抗剂药物的生产工艺
RU2494105C2 (ru) * 2010-12-29 2013-09-27 Общество с ограниченной ответственностью "Химфармресурс" Способ получения циклического пептида
US9388212B2 (en) 2013-02-21 2016-07-12 Chemical & Biopharmaceutical Laboratories Of Patras S.A. Solid phase peptide synthesis via side chain attachment
CN102875663B (zh) * 2012-09-26 2014-06-11 深圳翰宇药业股份有限公司 利西拉来的纯化方法
JP6382488B2 (ja) * 2013-02-21 2018-08-29 ケミカル アンド バイオファーマシューティカル ラボラトリーズ オブ パトラ エス．エー． 側鎖結合を介する固相ペプチド合成
CN103965291B (zh) * 2014-05-27 2016-09-21 上海第一生化药业有限公司 奥曲肽、奥曲肽醋酸盐的制备方法
CN106699847B (zh) * 2017-01-04 2020-08-14 陕西慧康生物科技有限责任公司 一种低成本纯化六胜肽的方法
JP6707576B2 (ja) * 2018-04-03 2020-06-10 ケミカル アンド バイオファーマシューティカル ラボラトリーズ オブ パトラ エス．エー． 側鎖結合を介する固相ペプチド合成
BR112020020369A2 (pt) 2018-04-06 2021-01-19 The Trustees Of The University Of Pennsylvania Análogos de compstatina com aumento de solubilidade e propriedades farmacocinéticas melhoradas
WO2020170185A1 (en) * 2019-02-21 2020-08-27 Dr. Reddy’S Laboratories Limited Substantially pure lanreotide or its salt & process thereof
CN109929011B (zh) * 2019-05-06 2021-04-06 上海上药第一生化药业有限公司 一种加压素[5-Asp]杂质的精制方法
CN109942686B (zh) * 2019-05-06 2021-06-25 上海上药第一生化药业有限公司 一种加压素乙酰化杂质的精制方法
MX2022001062A (es) * 2019-07-26 2022-02-14 Allegro Pharmaceuticals Llc Peptidos para el tratamiento de degeneracion macular no exudativa y otros trastornos del ojo.
WO2024112250A1 (en) * 2022-11-23 2024-05-30 Polypeptide Laboratories Holding (Ppl) Ab Method of preparing vasopressin

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4310518A (en) * 1979-10-31 1982-01-12 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4235886A (en) * 1979-10-31 1980-11-25 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
ATE2512T1 (de) * 1979-11-27 1983-03-15 Sandoz Ag Polypeptide, verfahren zu ihrer herstellung, pharmazeutische zusammensetzungen, die diese polypeptide enthalten, und ihre verwendung.
GB8813160D0 (en) * 1988-06-03 1988-07-06 Soc D Etudes Prod Chimique Therapeutic methods
PT710243E (pt) * 1993-06-29 2000-11-30 Ferring Bv Sintese melhorada de peptidos ciclicos.
EP0763061B1 (de) * 1994-06-02 2002-10-30 Forssmann, Wolf-Georg, Prof. Dr. med. Verfahren zur herstellung von cardiodilatin-fragmenten, hochgereinigte cardiodilatin-fragmente und zwischenprodukte zu deren herstellung
US5889146A (en) * 1997-11-26 1999-03-30 Institute Of Nuclear Energy Research Method for synthesis of bifunctional chelating agents-peptides
JP4741076B2 (ja) * 1998-07-10 2011-08-03 サイオス インコーポレイテッド ８より上または５未満のｐＩを有するペプチドを産生するための方法
MXPA02007867A (es) * 2000-02-22 2003-02-10 Applied Research Systems Hormona luteinizante (lh) purificada.
ME00296B (me) * 2000-02-22 2011-05-10 Applied Res Systems Ars Holding N V PROCES PREČIŠĆAVANJA hCG I REKOMBINANTNOG hCG PREČIŠĆENOG TOM METODOM
DE602004001727T2 (de) * 2003-04-07 2007-08-02 Novetide Ltd. Verfahren zur herstellung cyclischer peptide
KR101238133B1 (ko) * 2004-04-08 2013-03-04 밀레니엄 파머슈티컬스 인코퍼레이티드 엡티피바타이드 및 관련 중간체 화합물의 제조 방법

Also Published As

Publication number Publication date
EP1709065A2 (en) 2006-10-11
ATE469912T1 (de) 2010-06-15
DE602005021614D1 (de) 2010-07-15
US20060148699A1 (en) 2006-07-06
IL182157A0 (en) 2007-07-24
EP2163558A3 (en) 2010-10-27
ES2344657T3 (es) 2010-09-02
WO2006041945A3 (en) 2006-08-24
EP2163558A2 (en) 2010-03-17
CA2582083A1 (en) 2006-04-20
EP1709065B1 (en) 2010-06-02
WO2006041945A2 (en) 2006-04-20
JP2007513192A (ja) 2007-05-24

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