DK175716B1 - Anvendelse af en substitueret naphthoquinon eller et derivat deraf til fremstilling af et lægemiddel til behandling af toxoplasmose - Google Patents
Anvendelse af en substitueret naphthoquinon eller et derivat deraf til fremstilling af et lægemiddel til behandling af toxoplasmose Download PDFInfo
- Publication number
- DK175716B1 DK175716B1 DK199100930A DK93091A DK175716B1 DK 175716 B1 DK175716 B1 DK 175716B1 DK 199100930 A DK199100930 A DK 199100930A DK 93091 A DK93091 A DK 93091A DK 175716 B1 DK175716 B1 DK 175716B1
- Authority
- DK
- Denmark
- Prior art keywords
- compound
- toxoplasmosis
- formula
- treatment
- physiologically acceptable
- Prior art date
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- 239000007903 gelatin capsule Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- MNQZXJOMYWMBOU-UHFFFAOYSA-N glyceraldehyde Chemical compound OCC(O)C=O MNQZXJOMYWMBOU-UHFFFAOYSA-N 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000003979 granulating agent Substances 0.000 description 1
- MNWFXJYAOYHMED-UHFFFAOYSA-N heptanoic acid Chemical compound CCCCCCC(O)=O MNWFXJYAOYHMED-UHFFFAOYSA-N 0.000 description 1
- XXMIOPMDWAUFGU-UHFFFAOYSA-N hexane-1,6-diol Chemical compound OCCCCCCO XXMIOPMDWAUFGU-UHFFFAOYSA-N 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 230000008629 immune suppression Effects 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 229940124589 immunosuppressive drug Drugs 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 229940102213 injectable suspension Drugs 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- CSFWPUWCSPOLJW-UHFFFAOYSA-N lawsone Chemical class C1=CC=C2C(=O)C(O)=CC(=O)C2=C1 CSFWPUWCSPOLJW-UHFFFAOYSA-N 0.000 description 1
- 239000008297 liquid dosage form Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 208000018555 lymphatic system disease Diseases 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 229950008312 menoctone Drugs 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 239000007932 molded tablet Substances 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- AJFDBNQQDYLMJN-UHFFFAOYSA-N n,n-diethylacetamide Chemical compound CCN(CC)C(C)=O AJFDBNQQDYLMJN-UHFFFAOYSA-N 0.000 description 1
- HSZCJVZRHXPCIA-UHFFFAOYSA-N n-benzyl-n-ethylaniline Chemical compound C=1C=CC=CC=1N(CC)CC1=CC=CC=C1 HSZCJVZRHXPCIA-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 229940100692 oral suspension Drugs 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 125000004043 oxo group Chemical group O=* 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 235000015927 pasta Nutrition 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 210000004197 pelvis Anatomy 0.000 description 1
- 210000003200 peritoneal cavity Anatomy 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229940068965 polysorbates Drugs 0.000 description 1
- 150000003109 potassium Chemical class 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 229940069328 povidone Drugs 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 244000000040 protozoan parasite Species 0.000 description 1
- WKSAUQYGYAYLPV-UHFFFAOYSA-N pyrimethamine Chemical compound CCC1=NC(N)=NC(N)=C1C1=CC=C(Cl)C=C1 WKSAUQYGYAYLPV-UHFFFAOYSA-N 0.000 description 1
- 229960000611 pyrimethamine Drugs 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 229910001961 silver nitrate Inorganic materials 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 239000004296 sodium metabisulphite Substances 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- HSFQBFMEWSTNOW-UHFFFAOYSA-N sodium;carbanide Chemical group [CH3-].[Na+] HSFQBFMEWSTNOW-UHFFFAOYSA-N 0.000 description 1
- 239000002195 soluble material Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229960004016 sucrose syrup Drugs 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 210000003371 toe Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 210000003812 trophozoite Anatomy 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898921516A GB8921516D0 (en) | 1989-09-22 | 1989-09-22 | Medicaments |
| GB8921516 | 1989-09-22 | ||
| PCT/GB1989/001286 WO1991004021A1 (en) | 1989-09-22 | 1989-10-26 | Medicaments for the treatment of toxoplasmosis |
| GB8901286 | 1989-10-26 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK93091D0 DK93091D0 (da) | 1991-05-16 |
| DK93091A DK93091A (da) | 1991-06-28 |
| DK175716B1 true DK175716B1 (da) | 2005-01-31 |
Family
ID=10663513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK199100930A DK175716B1 (da) | 1989-09-22 | 1991-05-16 | Anvendelse af en substitueret naphthoquinon eller et derivat deraf til fremstilling af et lægemiddel til behandling af toxoplasmose |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0445141B1 (hu) |
| JP (1) | JP2810746B2 (hu) |
| KR (1) | KR920700626A (hu) |
| AT (1) | ATE108063T1 (hu) |
| AU (1) | AU628422B2 (hu) |
| CA (1) | CA2001568C (hu) |
| DE (1) | DE68916651T2 (hu) |
| DK (1) | DK175716B1 (hu) |
| GB (1) | GB8921516D0 (hu) |
| HU (1) | HU207942B (hu) |
| IE (1) | IE66153B1 (hu) |
| MC (1) | MC2142A1 (hu) |
| MW (1) | MW1291A1 (hu) |
| PH (1) | PH27250A (hu) |
| SG (1) | SG28346G (hu) |
| WO (1) | WO1991004021A1 (hu) |
| ZA (1) | ZA898146B (hu) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9126874D0 (en) * | 1991-12-18 | 1992-02-19 | Wellcome Found | Medicaments |
| GB9224739D0 (en) * | 1992-11-26 | 1993-01-13 | Wellcome Found | Medicaments |
| GB9226905D0 (en) * | 1992-12-24 | 1993-02-17 | Wellcome Found | Pharmaceutical preparation |
| WO2010023686A2 (en) * | 2008-08-29 | 2010-03-04 | Matrix Laboratories Limited | Crystalline form of 2-chloro-3-[4-(4-chlorophenyl) cyclohexyl] [1,4]naphthoquinone, process for the same and use for producing 2-[4-(4-chlorophenyl)cyclohexyl]-3- hydroxy- 1,4- naphthoquinone |
| WO2013093937A2 (en) * | 2011-09-16 | 2013-06-27 | Alkem Laboratories Ltd. | ''3-(5-methyl-2-oxo-l, 3-dioxol-4-yl) methyloxy-2- trans-[(4-chloro phenyl) cyclohexyl] [1,4]naphthaquinone"-atovaquone prodrug |
| CN104474416A (zh) * | 2014-11-03 | 2015-04-01 | 青岛绿曼生物工程有限公司 | 治疗猪弓形体病的复方蜂胶组合物及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8310140D0 (en) * | 1983-04-14 | 1983-05-18 | Wellcome Found | Antiprotozoal agents |
| GB8310141D0 (en) * | 1983-04-14 | 1983-05-18 | Wellcome Found | Naphthoquinone derivatives |
| IE65715B1 (en) * | 1988-08-16 | 1995-11-15 | Wellcome Found | Medicaments |
-
1989
- 1989-09-22 GB GB898921516A patent/GB8921516D0/en active Pending
- 1989-10-26 IE IE345189A patent/IE66153B1/en not_active IP Right Cessation
- 1989-10-26 DE DE68916651T patent/DE68916651T2/de not_active Expired - Lifetime
- 1989-10-26 CA CA002001568A patent/CA2001568C/en not_active Expired - Lifetime
- 1989-10-26 ZA ZA898146A patent/ZA898146B/xx unknown
- 1989-10-26 WO PCT/GB1989/001286 patent/WO1991004021A1/en not_active Ceased
- 1989-10-26 SG SG1995904215A patent/SG28346G/en unknown
- 1989-10-26 HU HU896916A patent/HU207942B/hu not_active IP Right Cessation
- 1989-10-26 MC MC@@@@D patent/MC2142A1/xx unknown
- 1989-10-26 AT AT89912648T patent/ATE108063T1/de not_active IP Right Cessation
- 1989-10-26 KR KR1019910700523A patent/KR920700626A/ko not_active Ceased
- 1989-10-26 EP EP89912648A patent/EP0445141B1/en not_active Expired - Lifetime
- 1989-10-26 JP JP1511680A patent/JP2810746B2/ja not_active Expired - Lifetime
- 1989-10-26 AU AU45191/89A patent/AU628422B2/en not_active Expired
-
1991
- 1991-05-16 DK DK199100930A patent/DK175716B1/da not_active IP Right Cessation
- 1991-05-20 MW MW12/91A patent/MW1291A1/xx unknown
- 1991-10-26 PH PH39415A patent/PH27250A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE68916651D1 (de) | 1994-08-11 |
| SG28346G (en) | 1995-09-18 |
| HUT57040A (en) | 1991-11-28 |
| KR920700626A (ko) | 1992-08-10 |
| CA2001568C (en) | 1998-05-12 |
| MW1291A1 (en) | 1991-11-13 |
| ATE108063T1 (de) | 1994-07-15 |
| JP2810746B2 (ja) | 1998-10-15 |
| EP0445141A1 (en) | 1991-09-11 |
| DE68916651T2 (de) | 1995-02-16 |
| EP0445141B1 (en) | 1994-07-06 |
| CA2001568A1 (en) | 1991-03-22 |
| PH27250A (en) | 1993-05-04 |
| MC2142A1 (fr) | 1992-02-18 |
| DK93091A (da) | 1991-06-28 |
| GB8921516D0 (en) | 1989-11-08 |
| DK93091D0 (da) | 1991-05-16 |
| AU628422B2 (en) | 1992-09-17 |
| HU896916D0 (en) | 1991-08-28 |
| ZA898146B (en) | 1991-06-26 |
| WO1991004021A1 (en) | 1991-04-04 |
| HU207942B (en) | 1993-07-28 |
| JPH04504107A (ja) | 1992-07-23 |
| IE893451A1 (en) | 1991-03-27 |
| AU4519189A (en) | 1991-04-18 |
| IE66153B1 (en) | 1995-12-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUP | Patent expired |