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DK1692281T3 - Identifikation af en JAK2-mutation ved vaguez' polyglobuli - Google Patents

Identifikation af en JAK2-mutation ved vaguez' polyglobuli

Info

Publication number
DK1692281T3
DK1692281T3 DK05815749T DK05815749T DK1692281T3 DK 1692281 T3 DK1692281 T3 DK 1692281T3 DK 05815749 T DK05815749 T DK 05815749T DK 05815749 T DK05815749 T DK 05815749T DK 1692281 T3 DK1692281 T3 DK 1692281T3
Authority
DK
Denmark
Prior art keywords
mutation
vaguez
polyglobuli
identification
jak2
Prior art date
Application number
DK05815749T
Other languages
English (en)
Inventor
Chloe James
William Vainchenker
Valerie Ugo
Couedic Jean-Pierre Le
Nicole Casadevall
Original Assignee
Assist Publ Hopitaux De Paris
Inst Nat Sante Rech Med
Roussy Inst Gustave
Univ Versailles Saint Quentin En Yvelines
Univ Paris Sud
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34953071&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1692281(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Assist Publ Hopitaux De Paris, Inst Nat Sante Rech Med, Roussy Inst Gustave, Univ Versailles Saint Quentin En Yvelines, Univ Paris Sud filed Critical Assist Publ Hopitaux De Paris
Application granted granted Critical
Publication of DK1692281T3 publication Critical patent/DK1692281T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G01N33/57505—
    • G01N33/57595—
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
    • G01N2333/91215—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases with a definite EC number (2.7.1.-)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Plant Pathology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
DK05815749T 2004-10-27 2005-10-26 Identifikation af en JAK2-mutation ved vaguez' polyglobuli DK1692281T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0411480A FR2877013A1 (fr) 2004-10-27 2004-10-27 Indentification d'une mutation de jak2 impliquee dans la polyglobulie de vaquez
PCT/EP2005/055586 WO2006045827A1 (fr) 2004-10-27 2005-10-26 Identification d'une mutation de jak2 impliquée dans la polyglobulie de vaquez

Publications (1)

Publication Number Publication Date
DK1692281T3 true DK1692281T3 (da) 2008-05-13

Family

ID=34953071

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05815749T DK1692281T3 (da) 2004-10-27 2005-10-26 Identifikation af en JAK2-mutation ved vaguez' polyglobuli

Country Status (20)

Country Link
US (9) US7781199B2 (da)
EP (2) EP1692281B8 (da)
JP (3) JP5090171B2 (da)
KR (1) KR101203003B1 (da)
CN (1) CN101072870B (da)
AT (1) ATE382082T1 (da)
AU (1) AU2005298636B2 (da)
BR (1) BRPI0517398B8 (da)
CA (3) CA2754028A1 (da)
DE (1) DE602005004008T2 (da)
DK (1) DK1692281T3 (da)
ES (1) ES2296229T3 (da)
FR (1) FR2877013A1 (da)
IL (1) IL182761A0 (da)
MX (1) MX2007005174A (da)
PL (1) PL1692281T3 (da)
PT (1) PT1692281E (da)
SI (1) SI1692281T1 (da)
WO (1) WO2006045827A1 (da)
ZA (1) ZA200703433B (da)

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FR2877013A1 (fr) * 2004-10-27 2006-04-28 Assist Publ Hopitaux De Paris Indentification d'une mutation de jak2 impliquee dans la polyglobulie de vaquez
CN100497657C (zh) * 2006-09-27 2009-06-10 北京大学人民医院 检测JAK2V617F突变的方法及其专用引物与TaqMan-MGB探针
WO2008061196A2 (en) * 2006-11-15 2008-05-22 Eragen Biosciences, Inc. Methods and kits for detecting jak2 nucleic acid
US8367078B2 (en) * 2007-06-06 2013-02-05 University Of Florida Research Foundation, Inc. Kinase inhibitor compounds
WO2009011297A1 (ja) * 2007-07-13 2009-01-22 Arkray, Inc. Ｊａｋ２遺伝子の変異検出用プローブおよびその用途
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ATE554189T1 (de) 2009-07-10 2012-05-15 Biotrin Internat Ltd Hochsensibles schnelles isothermisches verfahren zur detektion von punktmutationen und snps
WO2011067373A1 (fr) * 2009-12-04 2011-06-09 Assistance Publique - Hopitaux De Paris Methode de detection d'une polyglobulie chez un chien
AU2011214254B2 (en) * 2010-02-10 2016-06-09 Genon Biotechnologies Oy Dual activity kinase domains and uses thereof
US20120021413A1 (en) * 2010-04-30 2012-01-26 Arkray, Inc. Method for Detecting Mutation in Exon 12 of JAK2 Gene, and Nucleic Acid Probe and Kit Therefor
AU2011277178B2 (en) * 2010-07-16 2016-10-20 Stichting Vumc A method of analysing a blood sample of a subject for the presence of a disease marker
BR112013023960B1 (pt) 2011-03-18 2020-12-01 Stichting Vumc método para analisar uma amostra de sangue de um indivíduo para a presença de um marcador de doença e métodos para determinar o estágio da doença ou a eficácia de um tratamento da doença em um indivíduo
JP2013017395A (ja) * 2011-07-07 2013-01-31 Toyobo Co Ltd 骨髄増殖性疾患に関する遺伝子変異を検出するためのプローブおよび該プローブを用いた遺伝子変異の検出方法
GB201116876D0 (en) * 2011-09-30 2011-11-16 Epistem Ltd Mutational analysis of JAK2
CN103243153B (zh) * 2012-02-10 2014-11-05 复旦大学附属华山医院 Jak2 v617f突变的检测应用
WO2014068072A1 (en) 2012-10-31 2014-05-08 Institut Gustave-Roussy Identification, assessment and therapy of essential thrombocythemia with resistance to jak2 inhibitors
WO2014072487A1 (en) 2012-11-08 2014-05-15 Centre National De La Recherche Scientifique (Cnrs) New phosphodeoxyribosyltransferase mutant enzymes and uses thereof
CA2890658A1 (en) 2012-11-09 2014-05-15 The Johns Hopkins University A genetic assay to determine prognosis in polycythemia vera patients
US9375485B2 (en) 2012-12-07 2016-06-28 Geron Corporation Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
SG11201504383TA (en) 2012-12-07 2015-07-30 Geron Corp Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
WO2014186764A1 (en) 2013-05-16 2014-11-20 Mobelisk Llc Modular tablet case
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AU2016248317A1 (en) * 2015-04-15 2017-11-09 Promedior, Inc. Methods for treating myeloproliferative disorders
US10519509B2 (en) 2015-04-23 2019-12-31 Quest Diagnostics Investments Incorporated Methods and compositions for the detection of CALR mutations in myeloproliferative diseases
CN108348578B (zh) 2015-08-04 2022-08-09 阿塞勒隆制药公司 用于治疗骨髓增生性病症的方法
CN105441573A (zh) * 2016-01-11 2016-03-30 武汉海吉力生物科技有限公司 用于检测人类jak2基因v617f突变的引物、探针及试剂盒
CA3026572A1 (en) * 2016-06-10 2017-12-14 Io Biotech Aps Calr and jak2 vaccine compositions
WO2019023667A1 (en) 2017-07-28 2019-01-31 Janssen Biotech, Inc. METHODS OF TREATING MYELODYSPLASTIC SYNDROME
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Also Published As

Publication number Publication date
US10364430B2 (en) 2019-07-30
KR20070104338A (ko) 2007-10-25
US20080076135A1 (en) 2008-03-27
SI1692281T1 (sl) 2008-04-30
US11162100B2 (en) 2021-11-02
US20200140863A1 (en) 2020-05-07
US20220042016A1 (en) 2022-02-10
EP1692281B8 (fr) 2008-02-13
US20150051263A2 (en) 2015-02-19
BRPI0517398A (pt) 2008-10-14
US8466338B2 (en) 2013-06-18
US20120066776A1 (en) 2012-03-15
US10563200B2 (en) 2020-02-18
PT1692281E (pt) 2008-02-06
BRPI0517398B8 (pt) 2021-05-25
KR101203003B1 (ko) 2012-11-21
EP1692281B1 (fr) 2007-12-26
FR2877013A1 (fr) 2006-04-28
US20090162849A1 (en) 2009-06-25
CN101072870B (zh) 2013-01-30
US7781199B2 (en) 2010-08-24
HK1094974A1 (en) 2007-04-20
AU2005298636B2 (en) 2009-11-26
MX2007005174A (es) 2007-10-10
US20190323007A1 (en) 2019-10-24
JP6103691B2 (ja) 2017-03-29
ES2296229T3 (es) 2008-04-16
CA2585062A1 (fr) 2006-05-04
PL1692281T3 (pl) 2008-06-30
CA2647086C (fr) 2012-09-18
WO2006045827A1 (fr) 2006-05-04
EP1692281A1 (fr) 2006-08-23
DE602005004008T2 (de) 2009-02-12
CA2585062C (fr) 2012-11-20
CA2754028A1 (fr) 2006-05-04
JP2008517613A (ja) 2008-05-29
EP1895000A1 (fr) 2008-03-05
JP5290884B2 (ja) 2013-09-18
DE602005004008D1 (de) 2008-02-07
BRPI0517398B1 (pt) 2021-03-02
CN101072870A (zh) 2007-11-14
JP5090171B2 (ja) 2012-12-05
AU2005298636A1 (en) 2006-05-04
US7429456B2 (en) 2008-09-30
IL182761A0 (en) 2007-07-24
US20140249204A1 (en) 2014-09-04
US8637235B2 (en) 2014-01-28
US20060288432A1 (en) 2006-12-21
JP2013135673A (ja) 2013-07-11
ZA200703433B (en) 2008-08-27
US20130189683A1 (en) 2013-07-25
ATE382082T1 (de) 2008-01-15
US8852931B2 (en) 2014-10-07
JP2009278982A (ja) 2009-12-03
CA2647086A1 (fr) 2006-05-04

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