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DK166620B1 - 4-amino-2,3-alkylen-quinolinderivater, en fremgangsmaade til deres fremstilling og anvendelse til fremstilling af et laegemiddel samt farmaceutisk praeparat indeholdende disse derivater - Google Patents

4-amino-2,3-alkylen-quinolinderivater, en fremgangsmaade til deres fremstilling og anvendelse til fremstilling af et laegemiddel samt farmaceutisk praeparat indeholdende disse derivater Download PDF

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Publication number
DK166620B1
DK166620B1 DK557189A DK557189A DK166620B1 DK 166620 B1 DK166620 B1 DK 166620B1 DK 557189 A DK557189 A DK 557189A DK 557189 A DK557189 A DK 557189A DK 166620 B1 DK166620 B1 DK 166620B1
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DK
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Prior art keywords
compound
tetrahydro
hydrogen
general formula
formula
Prior art date
Application number
DK557189A
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Danish (da)
English (en)
Other versions
DK557189D0 (da
DK557189A (da
Inventor
Gregory Michael Shutske
Kevin James Kapples
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Publication of DK557189D0 publication Critical patent/DK557189D0/da
Publication of DK557189A publication Critical patent/DK557189A/da
Application granted granted Critical
Publication of DK166620B1 publication Critical patent/DK166620B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
DK557189A 1988-11-09 1989-11-08 4-amino-2,3-alkylen-quinolinderivater, en fremgangsmaade til deres fremstilling og anvendelse til fremstilling af et laegemiddel samt farmaceutisk praeparat indeholdende disse derivater DK166620B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26903888 1988-11-09
US07/269,038 US4868177A (en) 1988-11-09 1988-11-09 1,2,3,4-tetrahydro-1,9-acridinediamines, pharmaceutical compositions and use

Publications (3)

Publication Number Publication Date
DK557189D0 DK557189D0 (da) 1989-11-08
DK557189A DK557189A (da) 1990-05-30
DK166620B1 true DK166620B1 (da) 1993-06-21

Family

ID=23025549

Family Applications (1)

Application Number Title Priority Date Filing Date
DK557189A DK166620B1 (da) 1988-11-09 1989-11-08 4-amino-2,3-alkylen-quinolinderivater, en fremgangsmaade til deres fremstilling og anvendelse til fremstilling af et laegemiddel samt farmaceutisk praeparat indeholdende disse derivater

Country Status (18)

Country Link
US (1) US4868177A (sv)
EP (1) EP0368188B1 (sv)
JP (1) JPH03153667A (sv)
KR (1) KR900007808A (sv)
AT (1) ATE111899T1 (sv)
AU (1) AU623701B2 (sv)
CA (1) CA2002531A1 (sv)
DE (1) DE68918402T2 (sv)
DK (1) DK166620B1 (sv)
ES (1) ES2059677T3 (sv)
FI (1) FI895288A7 (sv)
HU (1) HU208530B (sv)
IE (1) IE64499B1 (sv)
IL (1) IL92233A0 (sv)
NO (1) NO894445L (sv)
NZ (1) NZ231293A (sv)
PT (1) PT92234B (sv)
ZA (1) ZA898498B (sv)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL85741A (en) * 1987-03-17 1996-05-14 Hoechst Roussel Pharma Substituted tetrahydroacridines a process for their preparation and pharmaceutical compositions containing substituted alpha-amino-tetrahydroacridines
US6075144A (en) 1987-04-20 2000-06-13 Hoechst Marion Roussel, Inc. 9-hydroxyamino tetrahydroacridine and related compounds
US4970316A (en) * 1987-05-07 1990-11-13 American Home Products Corporation Pyrano-, thiopyrano- and cyclohexylquinolines as inhibitors of interleukin 1
US5053513A (en) * 1990-03-29 1991-10-01 Hoechst-Roussel Pharmaceuticals Incorporated Method of reducing a carbonyl containing acridine
US5783584A (en) * 1995-12-11 1998-07-21 Mayo Foundation For Medical Education And Research THA analogs useful as cholinesterase inhibitors
US5929093A (en) * 1996-06-13 1999-07-27 Mayo Foundation For Medical Education And Research Bifunctional acetylcholinesterase reactivators
KR100648869B1 (ko) 1998-09-30 2007-02-28 다케다 야쿠힌 고교 가부시키가이샤 방광 배출력 개선제
AR047759A1 (es) 2003-09-26 2006-02-22 Vertex Pharma Derivados de fenil - piperazina como moduladores de receptores muscarnicos
US20050222123A1 (en) 2004-01-27 2005-10-06 North Shore-Long Island Jewish Research Institute Cholinesterase inhibitors for treating inflammation
DE102021119724A1 (de) * 2021-07-29 2023-02-02 Brückner Maschinenbau GmbH & Co. KG Folienaufwickelsystem, Verbund aus einer Folienreckanlage und einem solchen Folienaufwickelsystem und Verwendung eines solchen Verbunds zur Herstellung von Dünnstfilmen und Membranen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695573A (en) * 1984-10-25 1987-09-22 Hoechst-Roussel Pharmaceuticals Inc. 9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
EP0268871A1 (en) * 1986-10-31 1988-06-01 Sumitomo Pharmaceuticals Company, Limited Quinoline derivatives
IL85741A (en) * 1987-03-17 1996-05-14 Hoechst Roussel Pharma Substituted tetrahydroacridines a process for their preparation and pharmaceutical compositions containing substituted alpha-amino-tetrahydroacridines
US5013741A (en) * 1987-09-08 1991-05-07 Hoechst-Roussel Pharmaceuticals Incorporated N-[substituted alkylidene]-1,2,3,4-tetrahydro-9-acridinamines useful for enhancing the cholinergic function in a mammal
IL87861A0 (en) * 1987-10-05 1989-03-31 Pfizer 4-aminopyridine derivatives

Also Published As

Publication number Publication date
KR900007808A (ko) 1990-06-02
HU895830D0 (en) 1990-01-28
AU4442389A (en) 1990-05-17
IE64499B1 (en) 1995-08-09
FI895288A0 (fi) 1989-11-07
PT92234A (pt) 1990-05-31
JPH03153667A (ja) 1991-07-01
FI895288A7 (sv) 1990-05-10
CA2002531A1 (en) 1990-05-09
EP0368188B1 (en) 1994-09-21
NZ231293A (en) 1991-09-25
NO894445L (no) 1990-05-10
ES2059677T3 (es) 1994-11-16
EP0368188A1 (en) 1990-05-16
DE68918402D1 (de) 1994-10-27
AU623701B2 (en) 1992-05-21
IL92233A0 (en) 1990-07-26
HU208530B (en) 1993-11-29
IE893592L (en) 1990-05-09
ATE111899T1 (de) 1994-10-15
ZA898498B (en) 1990-08-29
DE68918402T2 (de) 1995-03-09
DK557189D0 (da) 1989-11-08
DK557189A (da) 1990-05-30
PT92234B (pt) 1995-07-06
NO894445D0 (no) 1989-11-08
US4868177A (en) 1989-09-19

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed