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DK164684D0 - 4-substituerede-2-azetidinon-forbindelser,fremgangsmaade til fremstilling heraf og mellemprodukter til brug herved - Google Patents

4-substituerede-2-azetidinon-forbindelser,fremgangsmaade til fremstilling heraf og mellemprodukter til brug herved

Info

Publication number
DK164684D0
DK164684D0 DK1646/84A DK164684A DK164684D0 DK 164684 D0 DK164684 D0 DK 164684D0 DK 1646/84 A DK1646/84 A DK 1646/84A DK 164684 A DK164684 A DK 164684A DK 164684 D0 DK164684 D0 DK 164684D0
Authority
DK
Denmark
Prior art keywords
azetidinon
intermediates
substituted
compounds
producing
Prior art date
Application number
DK1646/84A
Other languages
English (en)
Other versions
DK164684A (da
Inventor
Toshinari Tamura
Hidenori Iwamoto
Makoto Yoshida
Minoru Yamamoto
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP58048989A external-priority patent/JPS59225182A/ja
Priority claimed from JP58221470A external-priority patent/JPS60115578A/ja
Priority claimed from JP58221469A external-priority patent/JPS60115577A/ja
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Publication of DK164684D0 publication Critical patent/DK164684D0/da
Publication of DK164684A publication Critical patent/DK164684A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK164684A 1983-03-25 1984-03-23 4-substituerede-2-azetidinon-forbindelser, fremgangsmaade til fremstilling heraf og mellemprodukter til brug herved DK164684A (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP58048989A JPS59225182A (ja) 1983-03-25 1983-03-25 ２−アゼチジノン−４−カルボン酸の誘導体
JP58221470A JPS60115578A (ja) 1983-11-25 1983-11-25 ２−アゼチジノン−４−置換化合物
JP58221469A JPS60115577A (ja) 1983-11-25 1983-11-25 ２−アゼチジノン−４−置換体

Publications (2)

Publication Number Publication Date
DK164684D0 true DK164684D0 (da) 1984-03-23
DK164684A DK164684A (da) 1984-09-26

Family

ID=27293483

Family Applications (1)

Application Number Title Priority Date Filing Date
DK164684A DK164684A (da) 1983-03-25 1984-03-23 4-substituerede-2-azetidinon-forbindelser, fremgangsmaade til fremstilling heraf og mellemprodukter til brug herved

Country Status (8)

Country Link
US (3) US4564609A (da)
EP (1) EP0123444B1 (da)
KR (3) KR870000357B1 (da)
CA (1) CA1256650A (da)
DE (1) DE3476399D1 (da)
DK (1) DK164684A (da)
ES (4) ES8600279A1 (da)
NO (1) NO158740C (da)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4719207A (en) * 1984-06-25 1988-01-12 Yamanouchi Pharmaceutical Co., Ltd. CNS active substituted azetidinone compounds
JPS6253994A (ja) 1985-05-09 1987-03-09 Yamanouchi Pharmaceut Co Ltd １−置換シリル−４−オキソ−２−アゼチジンカルボン酸低級アルキルエステル
ZA868957B (en) * 1985-12-06 1987-07-29 Yamanouchi Pharma Co Ltd Crystals of nalpha-(((s)-4-oxo-2-azetidinyl)carbonyl)-l-histidyl-l-prolinamide and process for producing the crystals
US5686420A (en) * 1987-06-05 1997-11-11 Georgetown University Thyrotropin-releasing hormone analogs and method of use
US5151497A (en) * 1989-02-21 1992-09-29 Japan Tobacco Inc. Histidyl peptide derivatives
DK437289D0 (da) * 1989-09-04 1989-09-04 Hans Bundgaard Prodrug derivatives of thyrotropin-releasing hormone (trh)
IT1249728B (it) * 1991-11-06 1995-03-09 Sigma Tau Ind Farmaceuti Derivati delle prolinammide quali attivatori della memoria e dei processi di apprendimento e composizioni farmaceutiche che li contengono
CA2288986A1 (en) * 1997-05-09 1998-11-12 Smithkline Beecham Corporation Beta-lactam inhibitors of coa-it
US20020151502A1 (en) * 1997-10-09 2002-10-17 Albert Sattin Tri-peptides for neurological and neurobehavior applications
US7202279B1 (en) * 1998-02-11 2007-04-10 Georgetown University Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders
JP4812225B2 (ja) * 2000-07-11 2011-11-09 塩野義製薬株式会社 生理活性ペプチド含有腸溶性製剤
CN1283314C (zh) 2000-08-31 2006-11-08 盐野义制药株式会社 抗帕金森氏病药
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
MEP27808A (en) * 2001-01-26 2010-10-10 Schering Corp Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications
JP2004517920A (ja) * 2001-01-26 2004-06-17 シェーリング　コーポレイション 血管状態を治療するためのステロール吸収阻害剤と血液調整剤との組合せ
MXPA03006727A (es) * 2001-01-26 2003-10-24 Schering Corp Combinaciones de acido nicotinico y derivados del mismo con inhibidor(es) de la absorcion de los esteroles, y tratamiento para indicaciones vasculares.
ATE331512T1 (de) * 2001-01-26 2006-07-15 Schering Corp Verwendung azetidinone-substituierter verbindungen zur behandlung der sitosterolhämie
US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
IL156585A0 (en) * 2001-01-26 2004-01-04 Schering Corp Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions
EP1363668B1 (en) * 2001-01-26 2007-08-15 Schering Corporation Combinations of bile acid sequestrant(s) and sterol absorption inhibitor(s) and treatments for vascular indications
US20060287254A1 (en) * 2001-01-26 2006-12-21 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
AR038956A1 (es) * 2001-05-25 2005-02-02 Schering Corp Uso de un compuesto que regula la produccion o niveles de peptidos beta amiloides para la manufactura de un medicamento para tratar la enfermedad de alzheimer y/o para regular dichos niveles de peptidos amiloides beta en un sujeto
JP2005504091A (ja) * 2001-09-21 2005-02-10 シェーリング　コーポレイション ステロール吸収阻害剤としてアゼチジノンを用いる黄色腫の処置
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US20030119808A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
US7056906B2 (en) * 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
ES2312624T3 (es) * 2001-09-21 2009-03-01 Schering Corporation Metodos para tratar o prevenir la inflamacion vascular usando un inhibidor (inhibidores) de la absorcion de esterol.
WO2004043457A1 (en) * 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
EP1606287B1 (en) * 2003-03-07 2013-10-02 Merck Sharp & Dohme Corp. Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
US7459442B2 (en) * 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
MXPA05009501A (es) * 2003-03-07 2005-10-18 Schering Corp Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
CA2517571C (en) * 2003-03-07 2011-07-05 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
WO2005046797A2 (en) * 2003-11-05 2005-05-26 Schering Corporation Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions
US7462595B2 (en) * 2004-09-17 2008-12-09 Prange Jr Arthur Jergen Methods for treating cancer-related fatigue
KR101137503B1 (ko) * 2009-07-14 2012-04-20 웰이앤씨 주식회사 고분자 고체 지지체를 이용한 히스티딜-프롤린아미드 유도체의 제조 방법
TWI648001B (zh) * 2013-08-16 2019-01-21 洛斯阿拉莫斯國家安全有限責任公司 用於改良植物性能之化合物及方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959248A (en) * 1974-04-03 1976-05-25 Merck & Co., Inc. Analogs of thyrotropin-releasing hormone
GB1523598A (en) * 1975-03-08 1978-09-06 Reckitt & Colmann Prod Ltd Tripeptides
US4271164A (en) * 1979-04-16 1981-06-02 Warner-Lambert Company 6-Substituted-arylpyrido[2,3-d]pyrimidin-7-amines and derivatives
HU180926B (en) * 1979-06-28 1983-05-30 Richter Gedeon Vegyeszet Process for preparing trh analogues,tripeptide amides infectives on the central nerve sysrhem
US4328134A (en) * 1980-05-06 1982-05-04 Schally Andrew Victor Anorexigenic peptides
US4426378A (en) * 1981-04-09 1984-01-17 The United States Of America As Represented By The Secretary Of The Army Thyrotropin releasing hormone in therapy of shock and as a central nervous system stimulant

Also Published As

Publication number Publication date
EP0123444A1 (en) 1984-10-31
ES8604209A1 (es) 1986-01-16
ES544236A0 (es) 1986-01-16
ES8604208A1 (es) 1986-01-16
ES530960A0 (es) 1985-10-01
KR870000357B1 (ko) 1987-03-05
EP0123444B1 (en) 1989-01-25
KR890002105B1 (ko) 1989-06-19
US4636567A (en) 1987-01-13
ES544235A0 (es) 1986-01-16
CA1256650A (en) 1989-06-27
ES544234A0 (es) 1986-01-16
ES8600279A1 (es) 1985-10-01
US4610821A (en) 1986-09-09
ES8604136A1 (es) 1986-01-16
KR880009550A (ko) 1988-09-15
NO158740B (no) 1988-07-18
KR880009549A (ko) 1988-09-15
DE3476399D1 (en) 1989-03-02
DK164684A (da) 1984-09-26
KR840008021A (ko) 1984-12-12
NO841158L (no) 1984-09-26
US4564609A (en) 1986-01-14
NO158740C (no) 1988-10-26
KR890002104B1 (ko) 1989-06-19

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