DK1408968T3 - Receptoradapteret nikotinafvænning gennem en kombination af atropin, scopolamin, clonidin - Google Patents
Receptoradapteret nikotinafvænning gennem en kombination af atropin, scopolamin, clonidinInfo
- Publication number
- DK1408968T3 DK1408968T3 DK02753025T DK02753025T DK1408968T3 DK 1408968 T3 DK1408968 T3 DK 1408968T3 DK 02753025 T DK02753025 T DK 02753025T DK 02753025 T DK02753025 T DK 02753025T DK 1408968 T3 DK1408968 T3 DK 1408968T3
- Authority
- DK
- Denmark
- Prior art keywords
- atropine
- scopolamine
- clonidine
- combination
- patch
- Prior art date
Links
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 title abstract 5
- 229930003347 Atropine Natural products 0.000 title abstract 5
- RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 title abstract 5
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 title abstract 5
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 title abstract 5
- RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 title abstract 5
- 229960000396 atropine Drugs 0.000 title abstract 5
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 title abstract 5
- 229960002646 scopolamine Drugs 0.000 title abstract 5
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 title abstract 4
- 229960002896 clonidine Drugs 0.000 title abstract 4
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title 1
- 238000001784 detoxification Methods 0.000 title 1
- 229960002715 nicotine Drugs 0.000 title 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title 1
- 238000010255 intramuscular injection Methods 0.000 abstract 2
- 239000007927 intramuscular injection Substances 0.000 abstract 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 1
- 229940124133 Acetylcholine release inhibitor Drugs 0.000 abstract 1
- 206010057852 Nicotine dependence Diseases 0.000 abstract 1
- 208000025569 Tobacco Use disease Diseases 0.000 abstract 1
- 230000002738 anti-smoking effect Effects 0.000 abstract 1
- 238000009246 art therapy Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 229960002748 norepinephrine Drugs 0.000 abstract 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Addiction (AREA)
- Neurology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10136228A DE10136228A1 (de) | 2001-07-25 | 2001-07-25 | Rezeptoradaptierter Nikotinetzug durch anticholinerge und noradrenerge Blockade |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1408968T3 true DK1408968T3 (da) | 2006-03-27 |
Family
ID=7693048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02753025T DK1408968T3 (da) | 2001-07-25 | 2002-07-18 | Receptoradapteret nikotinafvænning gennem en kombination af atropin, scopolamin, clonidin |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1408968B1 (da) |
| AT (1) | ATE310520T1 (da) |
| CY (1) | CY1107651T1 (da) |
| DE (4) | DE10136228A1 (da) |
| DK (1) | DK1408968T3 (da) |
| ES (1) | ES2254709T3 (da) |
| WO (1) | WO2003015782A2 (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007145874A1 (en) * | 2006-06-08 | 2007-12-21 | Hythiam, Inc. | Anti-nicotine treatment comprising use of three anticholinergic agents |
| EP2095814A1 (de) | 2008-02-26 | 2009-09-02 | Wolfgang J. Kox | Medikamentengestützter Nikotinentzug |
| CN103494810A (zh) * | 2013-09-25 | 2014-01-08 | 青岛市市立医院 | 治疗网络成瘾的药物组合物 |
| KR102729111B1 (ko) * | 2021-09-28 | 2024-11-13 | 한국과학기술연구원 | 니코틴 중독 또는 금단 증상 예방 또는 치료용 약학 조성물 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4555397A (en) * | 1983-08-12 | 1985-11-26 | Nicholas Bachynsky | Method for anti-cholinergic blockage of withdrawal symptoms in smoking cessation |
| US4788189A (en) * | 1988-02-29 | 1988-11-29 | Glazer Howard I | Method to treat smoking withdrawal symptoms by potentiated central noradrenergic blocking |
| JPH11505547A (ja) * | 1996-03-13 | 1999-05-21 | エール ユニバーシティ | ナルトレキソン及び関連化合物を用いる禁煙処置 |
| US6132754A (en) * | 1999-02-23 | 2000-10-17 | Hudson; Paul J. | Method for helping a patient eliminate tobacco dependency |
| EP1185246A1 (de) * | 1999-06-02 | 2002-03-13 | Klöcker, Norbert, Dr.med. | Pharmazeutische zusammmensetzung zur nasalen anwendung von wasserunlöslichen und/oder schwer wasserlöslischen wirkstoffen |
| DE19934523A1 (de) * | 1999-07-22 | 2001-01-25 | Novosis Pharma Ag | Transdermalsysteme zur Abgabe von Muscarin-Rezeptor-Antagonisten und ihre Verwendung zur Behandlung von Spasmen der glatten Muskulatur im urologischen Bereich |
-
2001
- 2001-07-25 DE DE10136228A patent/DE10136228A1/de not_active Withdrawn
-
2002
- 2002-04-16 DE DE20205918U patent/DE20205918U1/de not_active Expired - Lifetime
- 2002-07-18 EP EP02753025A patent/EP1408968B1/de not_active Expired - Lifetime
- 2002-07-18 DE DE10293600T patent/DE10293600B4/de not_active Expired - Fee Related
- 2002-07-18 AT AT02753025T patent/ATE310520T1/de active
- 2002-07-18 DE DE50205046T patent/DE50205046D1/de not_active Expired - Lifetime
- 2002-07-18 WO PCT/DE2002/002626 patent/WO2003015782A2/de not_active Ceased
- 2002-07-18 ES ES02753025T patent/ES2254709T3/es not_active Expired - Lifetime
- 2002-07-18 DK DK02753025T patent/DK1408968T3/da active
-
2006
- 2006-02-01 CY CY20061100132T patent/CY1107651T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1408968B1 (de) | 2005-11-23 |
| ATE310520T1 (de) | 2005-12-15 |
| DE20205918U1 (de) | 2002-12-05 |
| WO2003015782A2 (de) | 2003-02-27 |
| CY1107651T1 (el) | 2012-05-23 |
| DE10136228A1 (de) | 2003-03-06 |
| EP1408968A2 (de) | 2004-04-21 |
| DE10293600D2 (de) | 2004-08-05 |
| DE50205046D1 (de) | 2005-12-29 |
| DE10293600B4 (de) | 2005-08-25 |
| ES2254709T3 (es) | 2006-06-16 |
| WO2003015782A3 (de) | 2003-08-07 |
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