DK1401432T3 - Natriumkanalmodulerende imidazolderivater - Google Patents

Natriumkanalmodulerende imidazolderivater

Info

Publication number: DK1401432T3
Authority: DK; Denmark
Prior art keywords: sodium channel; imidazole derivatives; channel modulating; disorders; neurodegenerating
Prior art date: 2001-06-14

Application number

DK02745529T

Other languages

English (en)

Inventor

Jacques Pommier

Dennis Bigg

Anne-Marie Liberatore

Original Assignee

Sod Conseils Rech Applic

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-14

Filing date

2002-06-14

Publication date

2006-02-06

2002-06-14 Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic

2006-02-06 Application granted granted Critical

2006-02-06 Publication of DK1401432T3 publication Critical patent/DK1401432T3/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Networks Using Active Elements (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Detergent Compositions (AREA)
Control Of Transmission Device (AREA)
Molds, Cores, And Manufacturing Methods Thereof (AREA)

DK02745529T 2001-06-14 2002-06-14 Natriumkanalmodulerende imidazolderivater DK1401432T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0107820A FR2825926A1 (fr)	2001-06-14	2001-06-14	Derives d'imidazoles modulant les canaux sodiques

Publications (1)

Publication Number	Publication Date
DK1401432T3 true DK1401432T3 (da)	2006-02-06

Family

ID=8864329

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02745529T DK1401432T3 (da)	2001-06-14	2002-06-14	Natriumkanalmodulerende imidazolderivater

Country Status (21)

Country	Link
US (3)	US7157483B2 (da)
EP (1)	EP1401432B1 (da)
JP (1)	JP2005500297A (da)
KR (1)	KR20040030672A (da)
CN (1)	CN1535148A (da)
AT (1)	ATE304354T1 (da)
BR (1)	BR0210285A (da)
CA (1)	CA2449916A1 (da)
CZ (1)	CZ297321B6 (da)
DE (1)	DE60206171T2 (da)
DK (1)	DK1401432T3 (da)
ES (1)	ES2249595T3 (da)
FR (1)	FR2825926A1 (da)
HU (1)	HUP0400195A3 (da)
IS (1)	IS2367B (da)
MX (1)	MXPA03011508A (da)
NO (1)	NO20035553D0 (da)
NZ (1)	NZ529741A (da)
PL (1)	PL366722A1 (da)
RU (1)	RU2296565C2 (da)
WO (1)	WO2002102375A2 (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2004210711B2 (en) *	2003-02-12	2010-07-08	Transtech Pharma, Inc.	Substituted azole derivatives as therapeutic agents
ZA200507752B (en) *	2003-03-28	2007-01-31	Threshold Pharmaceuticals Inc	Compositions and methods for treating cancer
BRPI0416639A (pt) *	2003-11-19	2007-01-16	Metabasis Therapeutics Inc	tiromiméticos contendo fósforo
AU2006249350B2 (en)	2003-11-19	2012-02-16	Metabasis Therapeutics, Inc.	Thyromimetics for the treatment of fatty liver diseases
CN102746336B (zh)	2005-06-29	2015-08-19	施瑞修德制药公司	氨基磷酸酯烷化剂前体药物
AU2006322844A1 (en) *	2005-12-07	2007-06-14	Ramot At Tel Aviv University Ltd.	Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof
US8247439B2 (en) *	2005-12-07	2012-08-21	Sepal Pharma Ltd.	Jasmonate derivatives, pharmaceutical compositions and methods of use thereof
US9284274B2 (en)	2005-12-07	2016-03-15	Ramot At Tel-Aviv University Ltd.	Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof
EP2114157B1 (en)	2006-12-26	2021-05-26	ImmunoGenesis, Inc.	Phosphoramidate alkylator prodrug for the treatment of cancer
US7883898B2 (en) *	2007-05-07	2011-02-08	General Electric Company	Method and apparatus for measuring pH of low alkalinity solutions
US8188080B2 (en) *	2007-10-17	2012-05-29	Sanford-Burnham Medical Research Institute	VHR protein tyrosine phosphatase inhibitors, compositions and methods of use
US8815892B2 (en)	2008-03-25	2014-08-26	Affectis Pharmaceuticals Ag	P2X7R antagonists and their use
EP2105164B1 (en) *	2008-03-25	2011-01-12	Affectis Pharmaceuticals AG	Novel P2X7R antagonists and their use
KR101602985B1 (ko) *	2008-10-06	2016-03-11	시코쿠가세이고교가부시키가이샤	2-벤질-4-(2,4-디클로로페닐)-5-메틸이미다졸 화합물
US9284252B2 (en)	2009-06-09	2016-03-15	Sepal Pharma Ltd.	Use of jasmonate ester derivatives for treating benign hyperproliferative skin disorders
JP5368244B2 (ja) *	2009-10-14	2013-12-18	四国化成工業株式会社	２−（２，４−ジクロロベンジル）−４−アリール−５−メチルイミダゾール化合物
JP5368263B2 (ja) *	2009-11-04	2013-12-18	四国化成工業株式会社	４−（２，４−ジクロロフェニル）−５−メチルイミダゾール化合物
JP5368271B2 (ja) *	2009-11-20	2013-12-18	四国化成工業株式会社	４−（４−ビフェニリル）−２−（２，４−ジクロロベンジル）イミダゾールおよび表面処理液
CN110198719A (zh)	2016-11-21	2019-09-03	维京治疗公司	治疗糖原贮积病的方法
KR102600115B1 (ko)	2017-06-05	2023-11-09	바이킹 테라퓨틱스 인코포레이티드	섬유증 치료를 위한 조성물
AU2019238090B2 (en)	2018-03-22	2024-08-01	Viking Therapeutics, Inc.	Crystalline forms and methods of producing crystalline forms of a compound
US12102646B2 (en)	2018-12-05	2024-10-01	Viking Therapeutics, Inc.	Compositions for the treatment of fibrosis and inflammation
CN120513089A (zh) *	2022-10-31	2025-08-19	Genep股份有限公司	作为钠通道抑制剂的咪唑化合物及其用途
WO2025231324A1 (en) *	2024-05-02	2025-11-06	Genep Inc.	Imidazole compounds and their use as sodium channel inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1046248A (en) *	1962-08-02	1966-10-19	Benger Lab Ltd	Substituted imidazoles
AU518569B2 (en) *	1979-08-07	1981-10-08	Farmos-Yhtyma Oy	4-benzyl- and 4-benzoyl imidazole derivatives
CN1093535C (zh) *	1994-09-26	2002-10-30	盐野义制药株式会社	咪唑衍生物
CN1284066A (zh) *	1997-12-04	2001-02-14	阿勒根销售公司	对α2B或2B/2C肾上腺素能受体具有激动剂样活性的取代咪唑衍生物
US6003118A (en) *	1997-12-16	1999-12-14	Acer Laboratories Inc.	Method and apparatus for synchronizing clock distribution of a data processing system
ATE467620T1 (de) *	1999-03-26	2010-05-15	Euro Celtique Sa	Arylsubstituierte pyrazole, imidazole, oxazole, thiazole und pyrrole, sowie deren verwendung
AR024077A1 (es) *	1999-05-25	2002-09-04	Smithkline Beecham Corp	Compuestos antibacterianos
TWI283577B (en) *	1999-10-11	2007-07-11	Sod Conseils Rech Applic	Pharmaceutical composition of imidazole derivatives acting as modulators of sodium channels and the use thereof
WO2001044201A1 (en) *	1999-12-16	2001-06-21	Schering Corporation	Substituted imidazole neuropeptide y y5 receptor antagonists

2001
- 2001-06-14 FR FR0107820A patent/FR2825926A1/fr not_active Withdrawn
2002
- 2002-06-14 KR KR10-2003-7016257A patent/KR20040030672A/ko not_active Abandoned
- 2002-06-14 CZ CZ20033550A patent/CZ297321B6/cs not_active IP Right Cessation
- 2002-06-14 CN CNA028111842A patent/CN1535148A/zh active Pending
- 2002-06-14 RU RU2004100843/15A patent/RU2296565C2/ru not_active IP Right Cessation
- 2002-06-14 WO PCT/FR2002/002039 patent/WO2002102375A2/fr not_active Ceased
- 2002-06-14 CA CA002449916A patent/CA2449916A1/fr not_active Abandoned
- 2002-06-14 US US10/480,977 patent/US7157483B2/en not_active Expired - Fee Related
- 2002-06-14 MX MXPA03011508A patent/MXPA03011508A/es active IP Right Grant
- 2002-06-14 HU HU0400195A patent/HUP0400195A3/hu unknown
- 2002-06-14 DK DK02745529T patent/DK1401432T3/da active
- 2002-06-14 NZ NZ529741A patent/NZ529741A/en unknown
- 2002-06-14 ES ES02745529T patent/ES2249595T3/es not_active Expired - Lifetime
- 2002-06-14 AT AT02745529T patent/ATE304354T1/de not_active IP Right Cessation
- 2002-06-14 PL PL02366722A patent/PL366722A1/xx not_active Application Discontinuation
- 2002-06-14 BR BR0210285-4A patent/BR0210285A/pt not_active IP Right Cessation
- 2002-06-14 JP JP2003504962A patent/JP2005500297A/ja active Pending
- 2002-06-14 EP EP02745529A patent/EP1401432B1/fr not_active Expired - Lifetime
- 2002-06-14 DE DE60206171T patent/DE60206171T2/de not_active Expired - Fee Related
2003
- 2003-12-08 IS IS7067A patent/IS2367B/is unknown
- 2003-12-12 NO NO20035553A patent/NO20035553D0/no not_active Application Discontinuation
2005
- 2005-11-17 US US11/281,864 patent/US7402602B2/en not_active Expired - Fee Related
2006
- 2006-11-27 US US11/604,522 patent/US20070099975A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US7157483B2 (en)	2007-01-02
HUP0400195A3 (en)	2004-10-28
ATE304354T1 (de)	2005-09-15
US20040198792A1 (en)	2004-10-07
CN1535148A (zh)	2004-10-06
MXPA03011508A (es)	2004-03-18
HUP0400195A2 (hu)	2004-07-28
US20060069146A1 (en)	2006-03-30
CA2449916A1 (fr)	2002-12-27
DE60206171D1 (de)	2005-10-20
NZ529741A (en)	2006-10-27
FR2825926A1 (fr)	2002-12-20
US7402602B2 (en)	2008-07-22
IS7067A (is)	2003-12-08
RU2004100843A (ru)	2005-04-10
CZ297321B6 (cs)	2006-11-15
EP1401432B1 (fr)	2005-09-14
US20070099975A1 (en)	2007-05-03
RU2296565C2 (ru)	2007-04-10
DE60206171T2 (de)	2006-06-22
NO20035553D0 (no)	2003-12-12
BR0210285A (pt)	2004-06-29
KR20040030672A (ko)	2004-04-09
JP2005500297A (ja)	2005-01-06
WO2002102375A2 (fr)	2002-12-27
IS2367B (is)	2008-06-15
WO2002102375A3 (fr)	2003-09-25
PL366722A1 (en)	2005-02-07
CZ20033550A3 (cs)	2005-05-18
EP1401432A2 (fr)	2004-03-31
ES2249595T3 (es)	2006-04-01

Publication	Publication Date	Title
DK1401432T3 (da)	2006-02-06	Natriumkanalmodulerende imidazolderivater
EA200501009A1 (ru)	2005-12-29	Замещённые пирролопиразольные производные в качестве ингибиторов киназы
NO20021358D0 (no)	2002-03-19	Alkylendiamin-substituerte heterocykler
MXPA05007513A (es)	2005-09-21	Compuestos, composiciones y metodos.
EA200300829A1 (ru)	2003-12-25	Производные 1-арил- или 1-алкилсульфонилбензазола в качестве лигандов 5-гидрокситриптамина-6
DE60045508D1 (de)	2011-02-24	Dalda-analoge und ihre verwendung
EA200500859A1 (ru)	2005-10-27	Хинолинилпирролопиразолы
ATE484508T1 (de)	2010-10-15	Furylverbindungen
BR0207278A (pt)	2004-02-10	Derivados de ftalazinona-piperidina como inibidores de pde4
MXPA05013905A (es)	2006-02-24	Compuestos de quinazolinona sustituidos por arilamina.
SE0203303D0 (sv)	2002-11-07	Novel Compounds
GB0229081D0 (en)	2003-01-15	Multifunctional cationic photoinitiators, their preparation and use
SE0203300D0 (sv)	2002-11-07	Novel Compounds
SE0400027D0 (sv)	2004-01-09	Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
ATE276259T1 (de)	2004-10-15	Dihydroporphyrinderivate und ihre verwendung
MXPA05006957A (es)	2005-09-30	Nuevos derivados de fosforamida.
SE0300103D0 (sv)	2003-01-16	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0301445D0 (sv)	2003-05-16	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0300104D0 (sv)	2003-01-16	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0203301D0 (sv)	2002-11-07	Novel Compounds
EA200401432A1 (ru)	2005-04-28	Сложноэфирные производные декагидроизохинолин-3-карбоновой кислоты в качестве анальгетиков
TW200512192A (en)	2005-04-01	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
MXPA05010428A (es)	2005-11-04	Derivados de diarilmetilidenpiperidina, preparaciones de los mismos y usos de los mismos.
SE0301441D0 (sv)	2003-05-16	Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
NO20063353L (no)	2006-09-06	1,2,3,4-tetrahydroisokinolinderivater, fremgangsmate for fremstilling derav og anvendelser derav