DK149194A - Thrombopoietin - Google Patents

Thrombopoietin

Info

Publication number: DK149194A
Authority: DK; Denmark
Prior art keywords: thrombopoietin
Prior art date: 1994-01-03

Application number

DK149194A

Other languages

English (en)

Inventor

Dan L Eaton

Frederic J De Sauvage

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-01-03

Filing date

1994-12-28

Publication date

1995-07-04

1994-02-15 Priority claimed from US08/196,689 external-priority patent/US8357513B1/en

1994-05-25 Priority claimed from US08/249,376 external-priority patent/US8192955B1/en

1994-12-02 Priority claimed from US08/348,657 external-priority patent/US6660256B1/en

1994-12-28 Application filed by Genentech Inc filed Critical Genentech Inc

1995-07-04 Publication of DK149194A publication Critical patent/DK149194A/da

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/524—Thrombopoietin, i.e. C-MPL ligand
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Diabetes (AREA)
Hematology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Toxicology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Saccharide Compounds (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Information Transfer Systems (AREA)
Vehicle Body Suspensions (AREA)

DK149194A 1994-01-03 1994-12-28 Thrombopoietin DK149194A (da)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
US17655394A	1994-01-03	1994-01-03
US18560794A	1994-01-21	1994-01-21
US08/196,689 US8357513B1 (en)	1994-01-03	1994-02-15	Nucleic acids encoding mpl ligand (thrombopoietin) and fragments thereof
US22326394A	1994-04-04	1994-04-04
US08/249,376 US8192955B1 (en)	1994-01-03	1994-05-25	Nucleic acids encoding MPL ligand (thrombopoietin), variants, and fragments thereof
US34865894A	1994-12-02	1994-12-02
US08/348,657 US6660256B1 (en)	1994-01-03	1994-12-02	Porcine mpl ligand

Publications (1)

Publication Number	Publication Date
DK149194A true DK149194A (da)	1995-07-04

Family

ID=27569151

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK149194A DK149194A (da)	1994-01-03	1994-12-28	Thrombopoietin

Country Status (28)

Country	Link
EP (1)	EP0738323A1 (da)
JP (2)	JPH09508262A (da)
CN (1)	CN1134539C (da)
AU (1)	AU704266B2 (da)
BG (1)	BG63639B1 (da)
CA (1)	CA2178482C (da)
CZ (1)	CZ296130B6 (da)
DK (1)	DK149194A (da)
ES (1)	ES2114786B1 (da)
FI (1)	FI121573B (da)
FR (1)	FR2714670B1 (da)
GB (1)	GB2285446B (da)
HR (1)	HRP941020A2 (da)
HU (1)	HUT75657A (da)
IE (1)	IE72517B1 (da)
IL (1)	IL112184A (da)
IT (1)	IT1283770B1 (da)
LU (1)	LU88573A1 (da)
LV (1)	LV11632B (da)
NL (1)	NL9500010A (da)
NO (1)	NO326903B1 (da)
NZ (1)	NZ278726A (da)
PT (1)	PT101627B (da)
RO (1)	RO117110B1 (da)
SG (1)	SG47030A1 (da)
SI (1)	SI9420079A (da)
SK (1)	SK282265B6 (da)
WO (1)	WO1995018858A1 (da)

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JPH09508797A (ja) *	1994-02-14	1997-09-09	ザイモジェネティクス，インコーポレイティド	造血タンパク質及びそれを製造するための材料及び方法
BR9506017A (pt) *	1994-03-31	1997-10-14	Amagen Inc	Polipeptide poninculeotídeo isolado sequência de Dna e Cdna vetor de Dna célula hospedeira anticorpo composição farmacêutica derivado de Mgdf produto polípeptídeo Mgdf com grupos peg e preparação do mesmo e processo para produzir um polipeptídeo Mgdf humano e uma condição trombocitopênica para aumentar o número de megacarióticos maduroas e de plaquetas em um paciente necessitado dos mesmos e para fixar um polímero solúvel em água a um polipeptídeo Mgdf uma molècula de polietileno glicol a um polipeptideo Mgdf e poipeptideo glicol solúvel em água a um polipeptideo mgdf
US5795569A (en) *	1994-03-31	1998-08-18	Amgen Inc.	Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation
US5986049A (en) *	1994-12-30	1999-11-16	Zymogenetics, Inc.	Purified thrombopoietin and method of making it
TW387940B (en) *	1995-01-17	2000-04-21	Kirin Brewery	Anti-tpo monodonal antibody
US6254870B1 (en)	1995-02-03	2001-07-03	G. D. Searle & Co.	Thrombopoietin: IL-3 fusion protein
US5696250A (en)	1995-02-15	1997-12-09	Amgen Inc.	DNA encoding megakaryocyte growth and development factor analogs
US5989538A (en) *	1995-02-15	1999-11-23	Amgen Inc.	Mpl ligand analogs
JP3836877B2 (ja) *	1995-02-15	2006-10-25	アムジエン・インコーポレーテツド	Ｍｐｌリガンド類似体
TW434021B (en) *	1995-03-15	2001-05-16	Kirin Brewery	Methods for preventing adsorption of thrombopoietin (TPO), and stable TPO-containing compositions
TW434020B (en) *	1995-03-15	2001-05-16	Kirin Brewery	Methods for preventing adsorption of thrombopoietin (TPO), and stable top-containing compositions
ZA964382B (en) *	1995-06-06	1997-12-01	Genentech Inc	Lymphotoxin and thrombopoietin for use in the treatment of cancer.
US5869451A (en) *	1995-06-07	1999-02-09	Glaxo Group Limited	Peptides and compounds that bind to a receptor
CN1315870C (zh) *	1995-06-07	2007-05-16	葛兰素集团有限公司	结合血小板生成素受体的肽和化合物
US6251864B1 (en)	1995-06-07	2001-06-26	Glaxo Group Limited	Peptides and compounds that bind to a receptor
TW497972B (en) *	1995-06-08	2002-08-11	Kirin Brewery	Stable thrombopoietin (TPO)-containing lyophilized compositions
US6066318A (en) *	1995-10-05	2000-05-23	G.D. Searle & Co.	Multi-functional hematopoietic fusion proteins between sequence rearranged C-MPL receptor agonists and other hematopoietic factors
US6031071A (en) *	1996-01-24	2000-02-29	Biophage, Inc.	Methods of generating novel peptides
US5879673A (en) *	1996-01-25	1999-03-09	Genentech, Inc.	Administration of thrombopoietin on a single day only
US7091311B2 (en)	1996-06-07	2006-08-15	Smithkline Beecham Corporation	Peptides and compounds that bind to a receptor
KR20000029998A (ko) *	1996-08-13	2000-05-25	리스 데브라 케이.	발현벡터,세포,그리고혈소판조혈인자를제조하는방법
CA2288964A1 (en) *	1997-05-21	1998-11-26	Genentech, Inc.	Novel administration of thrombopoietin
US5980893A (en) *	1997-07-17	1999-11-09	Beth Israel Deaconess Medical Center, Inc.	Agonist murine monoclonal antibody as a stimulant for megakaryocytopoiesis
US6342220B1 (en)	1997-08-25	2002-01-29	Genentech, Inc.	Agonist antibodies
KR20000006549A (ko) *	1998-06-30	2000-01-25	윤재승	생체내혈소판증식효능이향상된신규한트롬보포이에틴유도체
US20030228666A1 (en)	1998-06-30	2003-12-11	Daewoong Pharmaceutical Co., Ltd.	Novel human thrombopoietin mutein
DK2319928T3 (da)	1998-10-23	2013-06-24	Kirin Amgen Inc	Dimere trombopoietiske peptidomimetika, der binder til MPL-receptor og har trombopoietisk aktivitet
US6660843B1 (en)	1998-10-23	2003-12-09	Amgen Inc.	Modified peptides as therapeutic agents
CY2010012I2 (el) *	2000-05-25	2020-05-29	Novartis Ag	Μιμητικα θρομβοποιητινης
UY26317A1 (es) *	2000-08-30	2000-10-31	Alfonso Cayota Carlos Pritsch	Sistema de produccion de trombopoyetina humana por celulas de mamiferos en cultivo
US6673580B2 (en)	2000-10-27	2004-01-06	Genentech, Inc.	Identification and modification of immunodominant epitopes in polypeptides
US7332474B2 (en)	2001-10-11	2008-02-19	Amgen Inc.	Peptides and related compounds having thrombopoietic activity
US20050177884A1 (en)	2001-11-15	2005-08-11	Kirin Beer Kabushiki Kaisha	Chimeric nonhuman animal
KR100467750B1 (ko) *	2001-11-29	2005-01-24	씨제이 주식회사	생체내 에리스로포이에틴 활성이 증진된 융합단백질
US20030191056A1 (en)	2002-04-04	2003-10-09	Kenneth Walker	Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
ES2781475T3 (es)	2002-09-18	2020-09-02	Janssen Pharmaceuticals Inc	Métodos para aumentar la producción de células madre hematopoyéticas y plaquetas
JP4848277B2 (ja)	2003-08-28	2011-12-28	オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド	受容体に結合するペプチドおよび化合物
US7723295B2 (en)	2003-08-28	2010-05-25	Ortho-Mcneil Pharmaceutical, Inc.	Peptides and compounds that bind to a receptor
JP2007537755A (ja) *	2004-05-18	2007-12-27	イントレクソンコーポレイション	Ｄｎａクローニングベクタープラスミドのダイナミックなベクター構築のための方法
EP1773400A2 (en)	2004-07-08	2007-04-18	Amgen Inc.	Therapeutic peptides
CN101103045B (zh)	2004-09-24	2015-11-25	安姆根有限公司	修饰的Fc分子
US8008453B2 (en)	2005-08-12	2011-08-30	Amgen Inc.	Modified Fc molecules
US9012605B2 (en)	2006-01-23	2015-04-21	Amgen Inc.	Crystalline polypeptides
WO2007098547A1 (en) *	2006-03-01	2007-09-07	Apollo Life Sciences Limited	A molecule and chimeric molecules thereof
US7981425B2 (en)	2006-06-19	2011-07-19	Amgen Inc.	Thrombopoietic compounds
CA2658639C (en)	2006-07-24	2015-08-04	The University Of Queensland	Method of producing a population of cells of the neutrophil lineage
TW200902708A (en)	2007-04-23	2009-01-16	Wyeth Corp	Methods of protein production using anti-senescence compounds
AU2008262490B2 (en)	2007-05-22	2011-11-17	Amgen Inc.	Compositions and methods for producing bioactive fusion proteins
KR101040396B1 (ko)	2009-01-20	2011-06-09	한올바이오파마주식회사	변형된 인간 트롬보포이에틴 폴리펩타이드 절편 및 그의 제조방법
WO2014089478A1 (en) *	2012-12-07	2014-06-12	University Of Tennessee Research Foundation	Methods of numerical analysis for platelet disorders and computer-readable media and systems for performing the same
US9763984B2 (en)	2012-12-21	2017-09-19	Astellas Institute For Regenerative Medicine	Methods for production of platelets from pluripotent stem cells and compositions thereof
CN103555760B (zh) *	2013-10-18	2015-05-20	江苏康禾生物制药有限公司	一种重组人血小板生成素的制备方法及其制剂
RU2694064C1 (ru) *	2015-12-21	2019-07-09	Браинон Инк.	Композиция для улучшения памяти, способности к обучению и когнитивных способностей
GB201700621D0 (en)	2017-01-13	2017-03-01	Guest Ryan Dominic	Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue
CA3148158A1 (en) *	2019-09-20	2021-03-25	Longcheng Li	Nucleic acid molecule for treating thrombocytopenia and use thereof
CN115244173A (zh)	2019-12-20	2022-10-25	英研生物(英国)有限公司	用于分离肿瘤浸润淋巴细胞的装置及方法及其用途
CN118086536A (zh) *	2024-04-23	2024-05-28	佛山科学技术学院	一种通过snp标记改善黄牛血小板生成素分泌的方法及其应用

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US5260417A (en)	1989-04-03	1993-11-09	Genetics Institute, Inc.	Megakaryocyte growth promoting activity protein
WO1990012877A1 (en) *	1989-04-19	1990-11-01	Cetus Corporation	Multifunctional m-csf proteins and genes encoding therefor
US5223408A (en) *	1991-07-11	1993-06-29	Genentech, Inc.	Method for making variant secreted proteins with altered properties
CA2123430C (en) *	1991-12-06	2004-02-10	Cornelia M. Gorman	Prohormone convertase transformed cells
IL139335A (en)	1994-01-03	2005-08-31	Genentech Inc	Mpl ligand polypeptides, nucleic acids encoding them, vectors and host cells comprising such nucleic acids, processes for producing such polypeptides pharmaceutical compositions containing them and use thereof in the preparation of medicaments for treating thrombocytopenia

1994
- 1994-12-21 SG SG1996003050A patent/SG47030A1/en unknown
- 1994-12-21 GB GB9425831A patent/GB2285446B/en not_active Expired - Lifetime
- 1994-12-27 HR HR08/348,658A patent/HRP941020A2/hr not_active Application Discontinuation
- 1994-12-28 CN CNB941947513A patent/CN1134539C/zh not_active Expired - Lifetime
- 1994-12-28 HU HU9601805A patent/HUT75657A/hu not_active Application Discontinuation
- 1994-12-28 NZ NZ278726A patent/NZ278726A/en not_active IP Right Cessation
- 1994-12-28 RO RO96-01347A patent/RO117110B1/ro unknown
- 1994-12-28 CA CA2178482A patent/CA2178482C/en not_active Expired - Lifetime
- 1994-12-28 CZ CZ0192296A patent/CZ296130B6/cs not_active IP Right Cessation
- 1994-12-28 AU AU15146/95A patent/AU704266B2/en not_active Expired
- 1994-12-28 SK SK875-96A patent/SK282265B6/sk not_active IP Right Cessation
- 1994-12-28 EP EP95906653A patent/EP0738323A1/en not_active Withdrawn
- 1994-12-28 WO PCT/US1994/014553 patent/WO1995018858A1/en not_active Ceased
- 1994-12-28 DK DK149194A patent/DK149194A/da not_active Application Discontinuation
- 1994-12-28 SI SI9420079A patent/SI9420079A/sl unknown
- 1994-12-28 JP JP7518499A patent/JPH09508262A/ja active Pending
- 1994-12-29 IL IL11218494A patent/IL112184A/en not_active IP Right Cessation
- 1994-12-30 ES ES09402681A patent/ES2114786B1/es not_active Expired - Fee Related
- 1994-12-30 PT PT101627A patent/PT101627B/pt not_active IP Right Cessation
1995
- 1995-01-02 FR FR9500007A patent/FR2714670B1/fr not_active Expired - Lifetime
- 1995-01-02 IT IT95TO000002A patent/IT1283770B1/it active IP Right Grant
- 1995-01-03 NL NL9500010A patent/NL9500010A/nl active Search and Examination
- 1995-01-03 IE IE950002A patent/IE72517B1/en not_active IP Right Cessation
- 1995-01-03 LU LU88573A patent/LU88573A1/de unknown
1996
- 1996-07-02 FI FI962723A patent/FI121573B/fi not_active IP Right Cessation
- 1996-07-02 NO NO19962783A patent/NO326903B1/no not_active IP Right Cessation
- 1996-07-02 BG BG100693A patent/BG63639B1/bg unknown
- 1996-07-24 LV LVP-96-315A patent/LV11632B/xx unknown
1997
- 1997-03-27 JP JP9074906A patent/JPH10113186A/ja active Pending

Also Published As

Publication number	Publication date
BG100693A (en)	1998-01-30
FR2714670B1 (fr)	1997-01-10
IT1283770B1 (it)	1998-04-30
GB2285446B (en)	1999-07-28
CZ192296A3 (en)	1997-05-14
LV11632B (en)	1997-04-20
NO962783L (no)	1996-09-03
WO1995018858A1 (en)	1995-07-13
LV11632A (lv)	1996-12-20
HU9601805D0 (en)	1996-08-28
CA2178482C (en)	2012-01-03
AU704266B2 (en)	1999-04-15
SG47030A1 (en)	1998-03-20
ES2114786A1 (es)	1998-06-01
CA2178482A1 (en)	1995-07-13
EP0738323A1 (en)	1996-10-23
GB9425831D0 (en)	1995-02-22
BG63639B1 (bg)	2002-07-31
IE72517B1 (en)	1997-04-23
FI962723L (fi)	1996-09-03
NL9500010A (nl)	1995-08-01
CN1141061A (zh)	1997-01-22
JPH09508262A (ja)	1997-08-26
ES2114786B1 (es)	1999-01-01
CN1134539C (zh)	2004-01-14
JPH10113186A (ja)	1998-05-06
ITTO950002A1 (it)	1996-07-02
SK282265B6 (sk)	2001-12-03
IL112184A (en)	2004-07-25
FI962723A0 (fi)	1996-07-02
FI121573B (fi)	2011-01-14
LU88573A1 (de)	1995-06-01
FR2714670A1 (fr)	1995-07-07
PT101627B (pt)	1996-11-29
NO962783D0 (no)	1996-07-02
HUT75657A (en)	1997-05-28
NZ278726A (en)	1998-06-26
SI9420079A (en)	1997-02-28
IL112184A0 (en)	1995-03-15
PT101627A (pt)	1995-11-30
NO326903B1 (no)	2009-03-16
RO117110B1 (ro)	2001-10-30
GB2285446A (en)	1995-07-12
CZ296130B6 (cs)	2006-01-11
AU1514695A (en)	1995-08-01
HRP941020A2 (en)	1997-04-30
IE950002A1 (en)	1995-07-12
SK87596A3 (en)	1997-11-05
ITTO950002A0 (it)	1995-01-02

Publication	Publication Date	Title
DK149194A (da)	1995-07-04	Thrombopoietin
ATA166795A (de)	1999-07-15	Bis-resorcinyltriazine
ATA147195A (de)	1996-08-15	Alkoxyphenyl-substituierte bisbenzoylphosphinoxide
ATA163695A (de)	1999-01-15	2-hydroxyphenyltriazine
NO950651D0 (no)	1995-02-21	Antitranspirasjonsdeodorantpreparat
FI1608U1 (fi)	1994-11-14	Papperkniv
ATA108995A (de)	2005-07-15	Differenzdruckakkumulator
FI972411A0 (fi)	1997-06-06	Sekvestraatioaineet
ATA11894A (de)	1996-06-15	Stauförderbahn
FIU940246U0 (fi)	1994-04-22	Arkproduktfoerpackning
IS4247A (is)	1995-07-04	Thrombopoietin
GT199400093A (es)	1994-12-30	Trombopoietin
LV11241A (lv)	1996-04-20	Induktorgenerators
FI1526U1 (fi)	1994-09-23	Golv- och gaordstrall
FI1381U1 (fi)	1994-06-09	Baerrem foer dryckskorger
FI1478U1 (fi)	1994-08-31	Faestanordning foer en stoedstaong
FI1503U1 (fi)	1994-09-15	Tvaettmunstycke
FI1515U1 (fi)	1994-09-20	Staketelement
FI1527U1 (fi)	1994-09-23	Maskinkortspelare
ATE197372T1 (de)	2000-11-11	Vorteig
FI1707U1 (fi)	1995-01-16	Musunderlag
FI1254U1 (fi)	1994-03-16	Faestanordning
FI1459U1 (fi)	1994-08-15	Timringskutter
FI941612A0 (fi)	1994-04-08	Roerhaov
FI943075A0 (fi)	1994-06-27	Foerflyttare

Legal Events

Date	Code	Title	Description
1996-07-22	PBP	Patent lapsed
2014-09-22	PHB	Application deemed withdrawn due to non-payment or other reasons	Effective date: 20140916