DK148586A - Fremgangsmaade til fremstilling af konjugater af metal-lothionein og biologisk aktive molekyler - Google Patents

Fremgangsmaade til fremstilling af konjugater af metal-lothionein og biologisk aktive molekyler Download PDF

Info

Publication number: DK148586A
Authority: DK; Denmark
Prior art keywords: metal; lothionein; conjugates; procedure; preparation
Prior art date: 1985-04-03

Application number

DK148586A

Other languages

English (en)

Other versions

DK148586D0 (da

Inventor

Richard Albert Hadjian

Cynthia Ann Drozynski

Original Assignee

Du Pont

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-04-03

Filing date

1986-04-02

Publication date

1986-10-04

1986-04-02 Application filed by Du Pont filed Critical Du Pont

1986-04-02 Publication of DK148586D0 publication Critical patent/DK148586D0/da

1986-10-04 Publication of DK148586A publication Critical patent/DK148586A/da

Links

DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 title abstract 4
102000003792 Metallothionein Human genes 0.000 title abstract 4
108090000157 Metallothionein Proteins 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 2
230000001268 conjugating effect Effects 0.000 abstract 2
239000002184 metal Substances 0.000 abstract 2
239000003431 cross linking reagent Substances 0.000 abstract 1
239000000700 radioactive tracer Substances 0.000 abstract 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Zoology (AREA)
Physics & Mathematics (AREA)
Animal Behavior & Ethology (AREA)
Biochemistry (AREA)
Immunology (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Hematology (AREA)
Biophysics (AREA)
Urology & Nephrology (AREA)
Bioinformatics & Cheminformatics (AREA)
Microbiology (AREA)
Radiology & Medical Imaging (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Engineering & Computer Science (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Gastroenterology & Hepatology (AREA)
Cell Biology (AREA)
Pharmacology & Pharmacy (AREA)
Plant Pathology (AREA)
Food Science & Technology (AREA)
Analytical Chemistry (AREA)
Toxicology (AREA)
Optics & Photonics (AREA)
Steroid Compounds (AREA)

DK148586A 1985-04-03 1986-04-02 Fremgangsmaade til fremstilling af konjugater af metal-lothionein og biologisk aktive molekyler DK148586A (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US71943685A	1985-04-03	1985-04-03

Publications (2)

Publication Number	Publication Date
DK148586D0 DK148586D0 (da)	1986-04-02
DK148586A true DK148586A (da)	1986-10-04

Family

ID=24890070

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK148586A DK148586A (da)	1985-04-03	1986-04-02	Fremgangsmaade til fremstilling af konjugater af metal-lothionein og biologisk aktive molekyler

Country Status (15)

Country	Link
EP (1)	EP0196669B1 (da)
JP (1)	JPS61236733A (da)
KR (1)	KR930003312B1 (da)
AT (1)	ATE72569T1 (da)
AU (1)	AU603981B2 (da)
DE (1)	DE3683861D1 (da)
DK (1)	DK148586A (da)
ES (1)	ES8800437A1 (da)
FI (1)	FI861424L (da)
GR (1)	GR860876B (da)
IE (1)	IE58425B1 (da)
IL (1)	IL78377A0 (da)
MX (1)	MX168179B (da)
NO (1)	NO167124C (da)
ZA (1)	ZA862417B (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4672028A (en) *	1984-05-23	1987-06-09	Icn Micromedic Systems, Inc.	Compositions and method for simultaneous multiple array of analytes using radioisotope chelate labels
US5177192A (en) *	1987-04-02	1993-01-05	Centocor, Incorporated	Method for labeling antibodies with a metal ion
US5053493A (en) *	1987-04-02	1991-10-01	Centocor Cardiovascular Imaging Partners, L.P.	Method for labeling antibodies with a metal ion
US5218128A (en) *	1988-06-15	1993-06-08	Centocor, Inc.	Bifunctional coupling agents and radionuclide labeled compositions prepared therefrom
US5985240A (en) *	1989-08-09	1999-11-16	Rhomed Incorporated	Peptide radiopharmaceutical applications
US5759515A (en) *	1989-08-09	1998-06-02	Rhomed Incorporated	Polyvalent peptide pharmaceutical applications
US5700444A (en) *	1992-02-20	1997-12-23	Rhomed Incorporated	Chemotactic peptide pharmaceutical applications
US5219556A (en) *	1990-07-09	1993-06-15	Mallinckrodt Medical, Inc.	Stabilized therapeutic radiopharmaceutical complexes
US5194594A (en) *	1990-09-07	1993-03-16	Techniclone, Inc.	Modified antibodies
CA2048078A1 (en) *	1990-11-15	1992-05-16	Wolfgang A. Wrasidlo	Chemical modification of antibodies for creation of immunoconjugates
US5556609A (en) *	1992-02-20	1996-09-17	Rhomed Incorporated	YIGSR peptide radiopharmaceutical applications
US5738838A (en) *	1992-02-20	1998-04-14	Rhomed Incorporated	IKVAV peptide radiopharmaceutical applications
WO1993012819A1 (en) *	1992-01-03	1993-07-08	Rhomed Incorporated	Protein- and peptide-metal ion pharmaceutical applications
CN1314966C (zh) *	2004-12-03	2007-05-09	湖南农业大学	一种猪金属硫蛋白的检测方法
JP5202443B2 (ja) *	2009-06-01	2013-06-05	興和株式会社	有害金属測定試薬及び測定方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4732864A (en) *	1983-10-06	1988-03-22	E. I. Du Pont De Nemours And Company	Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules
JP2871813B2 (ja) *	1990-07-03	1999-03-17	古河電気工業株式会社	クロスヘッドの角度調整装置

1986
- 1986-03-25 NO NO861200A patent/NO167124C/no unknown
- 1986-03-31 IL IL78377A patent/IL78377A0/xx not_active IP Right Cessation
- 1986-04-01 AU AU55524/86A patent/AU603981B2/en not_active Ceased
- 1986-04-02 FI FI861424A patent/FI861424L/fi not_active Application Discontinuation
- 1986-04-02 JP JP61074384A patent/JPS61236733A/ja active Pending
- 1986-04-02 AT AT86104523T patent/ATE72569T1/de not_active IP Right Cessation
- 1986-04-02 IE IE85386A patent/IE58425B1/en not_active IP Right Cessation
- 1986-04-02 KR KR1019860002489A patent/KR930003312B1/ko not_active Expired - Fee Related
- 1986-04-02 ZA ZA862417A patent/ZA862417B/xx unknown
- 1986-04-02 DE DE8686104523T patent/DE3683861D1/de not_active Expired - Fee Related
- 1986-04-02 EP EP86104523A patent/EP0196669B1/en not_active Expired - Lifetime
- 1986-04-02 DK DK148586A patent/DK148586A/da not_active Application Discontinuation
- 1986-04-02 GR GR860876A patent/GR860876B/el unknown
- 1986-04-03 MX MX002075A patent/MX168179B/es unknown
- 1986-04-03 ES ES553685A patent/ES8800437A1/es not_active Expired

Also Published As

Publication number	Publication date
NO861200L (no)	1986-10-06
EP0196669B1 (en)	1992-02-12
IL78377A0 (en)	1986-07-31
FI861424A0 (fi)	1986-04-02
FI861424A7 (fi)	1986-10-04
KR930003312B1 (ko)	1993-04-26
NO167124C (no)	1991-10-09
NO167124B (no)	1991-07-01
EP0196669A2 (en)	1986-10-08
GR860876B (en)	1986-07-29
DK148586D0 (da)	1986-04-02
ATE72569T1 (de)	1992-02-15
FI861424L (fi)	1986-10-04
DE3683861D1 (de)	1992-03-26
IE58425B1 (en)	1993-09-22
ZA862417B (en)	1987-12-30
ES8800437A1 (es)	1987-10-16
AU603981B2 (en)	1990-12-06
IE860853L (en)	1986-10-03
ES553685A0 (es)	1987-10-16
KR860008203A (ko)	1986-11-12
AU5552486A (en)	1986-10-09
EP0196669A3 (en)	1988-09-14
MX168179B (es)	1993-05-10
JPS61236733A (ja)	1986-10-22

Publication	Publication Date	Title
DK148586D0 (da)	1986-04-02	Fremgangsmaade til fremstilling af konjugater af metal-lothionein og biologisk aktive molekyler
NO166267C (no)	1991-06-26	Konjugat av et maalsoekende biologisk aktivt molekyl og en forbindelse inneholdende spormerkende metall, samt diagnostisk preparat inneholdende konjugatet.
ATE122679T1 (de)	1995-06-15	Amin-derivate von anthracyclin-antibiotika.
DE69128791D1 (de)	1998-02-26	Modifizierte antikörper mit kontrollierter clearance-zeit
BR9303469A (pt)	1994-03-22	Conjugado de interferon,composto,processo de preparacao de um conjugado de interferon,use e composicoes farmaceuticas
PT89062A (pt)	1989-11-30	Processo para a preparacao de conjugados de anticorpos monoclonais-farmacos com actividade antitumor
ES2065906T3 (es)	1995-03-01	Produccion de proteinas en formas activas.
IT1255449B (it)	1995-10-31	Uso di nor- e omo-derivati di acidi biliari come promotori di assorbimento di farmaci.
NO20005337D0 (no)	2000-10-23	Polyol-IFN-<BETA>-konjugater
ATE120091T1 (de)	1995-04-15	Vip-konjugate und deren aktive fragmente mit hydrophoben anteilen und topische zuberetungen zur verwendung in der behandlung männlicher impotenz.
DE3789788D1 (de)	1994-06-16	Aminderivate von Folsäure Analogen.
ATE135712T1 (de)	1996-04-15	Polypeptid, dessen verfahren zur herstellung und dieses enthaltende pharmazeutische zusammensetzung und deren benutzung
IT1143052B (it)	1986-10-22	Composizione a base di idrolisato di lattalbumina per il trattamento e la cura della pelle
RO82758A (ro)	1984-01-14	Procedeu de preparare a unor imunoglobulinei conjugate
ATE75487T1 (de)	1992-05-15	Langwirkende immunotoxine, die eine ribosominaktivierende, an ihren polysaccharidstellen modifizierte glycopeptidsubstanz umfassen.
DE3574707D1 (de)	1990-01-18	Konjugate von adenin-9-beta-arabinofuranosid-5'-monophosphat mit menschlichem lactosaminiertem albumin, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
DE69228869D1 (de)	1999-05-12	Stabilisierte antikörperfragmente
OA05887A (fr)	1981-05-31	Dérivés d'acides méthyl-2 phénoxy-2 propioniques, leur procédé de préparation et leurs applications en thérapeutique.
FR2698874B1 (fr)	1995-01-06	Procédé de préparation de dérivés d'acétoamides, d'acétothioamides et d'acétosélénoamides, en particulier de dérivés de carbamoylméthylphosphines et carbamoylméthylphosphines ainsi obtenues.
IT1230792B (it)	1991-10-29	Procedimento per aumentare la citotossicita' di antracicline mediante fotoattivazione.
ZA868404B (en)	1987-12-30	Pharmaceutical compositions for use in improving oxygenation of the brain and a process for their production

Legal Events

Date	Code	Title	Description
1989-12-11	PBP	Patent lapsed
1995-12-27	AHB	Application shelved due to non-payment