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DK13189D0 - HIRUDIN DERIVATIVE, ITS MANUFACTURING AND USE - Google Patents

HIRUDIN DERIVATIVE, ITS MANUFACTURING AND USE

Info

Publication number
DK13189D0
DK13189D0 DK013189A DK13189A DK13189D0 DK 13189 D0 DK13189 D0 DK 13189D0 DK 013189 A DK013189 A DK 013189A DK 13189 A DK13189 A DK 13189A DK 13189 D0 DK13189 D0 DK 13189D0
Authority
DK
Denmark
Prior art keywords
hirudin derivative
manufacturing
thr
hirudin
derivative
Prior art date
Application number
DK013189A
Other languages
Danish (da)
Other versions
DK13189A (en
DK172350B1 (en
Inventor
Peter Crause
Paul Habermann
Dominique Tripier
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25865106&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK13189(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from HU851341A external-priority patent/HU198085B/en
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK13189D0 publication Critical patent/DK13189D0/en
Publication of DK13189A publication Critical patent/DK13189A/en
Application granted granted Critical
Publication of DK172350B1 publication Critical patent/DK172350B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A hirudin derivative which has the N-terminal amino-acid sequence Leu-Thr-Tyr-Thr-Asp has high biological activity. This hirudin derivative can be obtained very efficiently by production in genetically engineered yeasts.
DK013189A 1985-04-11 1989-01-12 Hirudin derivative, DNA encoding therefore, vectors containing such DNA, preparation of the hirudin derivative and drug containing this DK172350B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HU134185 1985-04-11
HU851341A HU198085B (en) 1984-04-18 1985-04-11 Process for producing new hirudine derivatives with anticoagulant effect and pharmaceutical compositions comprising same as active ingredient
DE3805540 1988-02-23
DE3805540 1988-02-23

Publications (3)

Publication Number Publication Date
DK13189D0 true DK13189D0 (en) 1989-01-12
DK13189A DK13189A (en) 1989-07-14
DK172350B1 DK172350B1 (en) 1998-04-06

Family

ID=25865106

Family Applications (1)

Application Number Title Priority Date Filing Date
DK013189A DK172350B1 (en) 1985-04-11 1989-01-12 Hirudin derivative, DNA encoding therefore, vectors containing such DNA, preparation of the hirudin derivative and drug containing this

Country Status (9)

Country Link
EP (1) EP0324712B1 (en)
AT (1) ATE87938T1 (en)
DE (2) DE58903988D1 (en)
DK (1) DK172350B1 (en)
ES (1) ES2055149T3 (en)
FI (1) FI96956C (en)
IL (1) IL88925A (en)
LU (1) LU90127I2 (en)
NL (1) NL970027I2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3835815A1 (en) * 1988-10-21 1990-04-26 Hoechst Ag NEW ISOHIRUDINE
JP3187044B2 (en) * 1989-12-01 2001-07-11 ビーエーエスエフ アクチェンゲゼルシャフト Hirudin mutein and hirudin polyalkylene glycol complex
DE4140381A1 (en) * 1991-12-07 1993-06-09 Hoechst Ag, 6230 Frankfurt, De NEW SYNTHETIC ISOHIRUDINE WITH IMPROVED STABILITY
DE4404168A1 (en) * 1994-02-10 1995-08-17 Hoechst Ag Hirudin derivatives and process for their preparation
DE19529997C1 (en) 1995-08-16 1997-04-10 Hoechst Ag A method for inactivating carboxypeptidase Y in hirudin-containing culture broths
DE19543737A1 (en) 1995-11-24 1997-05-28 Hoechst Ag Process for the ultrafiltration of biological matrices containing peptides or proteins
DE19544233A1 (en) * 1995-11-28 1997-06-05 Hoechst Ag Process for using the yeast ADH II promoter system for the biotechnological production of heterologous proteins in high yields
DE69624087T2 (en) 1996-01-31 2003-06-05 Sumitomo Bakelite Co. Ltd., Tokio/Tokyo Method of manufacturing semiconductor device encapsulated in epoxy resin
DE19607239A1 (en) 1996-02-27 1997-08-28 Behringwerke Ag Pharmaceutical composition containing hirudin and process for its preparation
DE19944870A1 (en) * 1999-09-18 2001-03-29 Aventis Pharma Gmbh Signal sequences for the production of Leu-hirudin via secretion by E. coli in the culture medium
DE10033195A1 (en) * 2000-07-07 2002-03-21 Aventis Pharma Gmbh Bifunctional fusion proteins from hirudin and TAP
US7202059B2 (en) 2001-02-20 2007-04-10 Sanofi-Aventis Deutschland Gmbh Fusion proteins capable of being secreted into a fermentation medium
US7638618B2 (en) 2001-02-20 2009-12-29 Sanofi-Aventis Deutschland Gmbh Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
JP2006096668A (en) * 2002-11-08 2006-04-13 Ono Pharmaceut Co Ltd A pharmaceutical comprising a combination of an elastase inhibitor and a blood coagulation system and / or fibrinolytic enzyme inhibitor
RU2435858C2 (en) * 2009-10-23 2011-12-10 Учреждение Российской академии наук Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН RECOMBINANT PLASMID DNA pER-Hir CODING HYBRID PROTEIN CAPABLE TO AUTOCATALYTIC BREAKDOWN TO FORM [LeuL, Thr2]-63-DESULPHATOHIRUDIN, Escherichia coli ER2566/pER-Hir STRAIN - PRODUCER OF SAID PROTEIN AND METHOD FOR PRODUCING GENETICALLY ENGINEERED [LeuL, Thr2]-63-DESULPHATOHIRUDIN

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3438296A1 (en) * 1984-04-18 1985-11-07 Hoechst Ag, 6230 Frankfurt NEW POLYPEPTIDES WITH A BLOOD-CLOTHING EFFECT, METHOD FOR THE PRODUCTION OR THEIR RECOVERY, THEIR USE AND THE CONTAINERS THEREOF
DE3689525D1 (en) * 1985-07-17 1994-02-24 Hoechst Ag New polypeptides with an anticoagulant effect, processes for their preparation or extraction, their use and agents containing them.

Also Published As

Publication number Publication date
EP0324712A2 (en) 1989-07-19
FI96956C (en) 1996-09-25
EP0324712B1 (en) 1993-04-07
ATE87938T1 (en) 1993-04-15
LU90127I2 (en) 1997-10-06
NL970027I1 (en) 1997-10-01
FI890127L (en) 1989-07-14
IL88925A (en) 1995-11-27
NL970027I2 (en) 1998-04-01
EP0324712A3 (en) 1990-07-04
DE19775033I2 (en) 2011-01-20
FI96956B (en) 1996-06-14
DK13189A (en) 1989-07-14
FI890127A0 (en) 1989-01-11
DK172350B1 (en) 1998-04-06
ES2055149T3 (en) 1994-08-16
DE58903988D1 (en) 1993-05-13

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
CTFF Application for supplementary protection certificate (spc) filed

Free format text: CA 1998 00017, 19980520, EXPIRES: 20120313

CTFG Supplementary protection certificate (spc) issued

Spc suppl protection certif: CA 1998 00017

PUP Patent expired