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DK131474B - Analogous process for the preparation of 9alpha-halogen-11beta, 17alpha, 21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione-21-adamantane-1'-carboxylates. - Google Patents

Analogous process for the preparation of 9alpha-halogen-11beta, 17alpha, 21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione-21-adamantane-1'-carboxylates.

Info

Publication number
DK131474B
DK131474B DK331372AA DK331372A DK131474B DK 131474 B DK131474 B DK 131474B DK 331372A A DK331372A A DK 331372AA DK 331372 A DK331372 A DK 331372A DK 131474 B DK131474 B DK 131474B
Authority
DK
Denmark
Prior art keywords
16beta
9alpha
methylpregna
11beta
17alpha
Prior art date
Application number
DK331372AA
Other languages
Danish (da)
Other versions
DK131474C (en
Inventor
G H Phillipps
A F English
Original Assignee
Glaxo Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Lab Ltd filed Critical Glaxo Lab Ltd
Publication of DK131474B publication Critical patent/DK131474B/en
Application granted granted Critical
Publication of DK131474C publication Critical patent/DK131474C/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK331372AA 1971-07-05 1972-07-04 Analogous process for the preparation of 9alpha-halogen-11beta, 17alpha, 21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione-21-adamantane-1'-carboxylates. DK131474B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3134971A GB1391443A (en) 1971-07-05 1971-07-05 Ester of betamethasone and its 9alpha-chloro analogue

Publications (2)

Publication Number Publication Date
DK131474B true DK131474B (en) 1975-07-21
DK131474C DK131474C (en) 1975-12-08

Family

ID=10321802

Family Applications (1)

Application Number Title Priority Date Filing Date
DK331372AA DK131474B (en) 1971-07-05 1972-07-04 Analogous process for the preparation of 9alpha-halogen-11beta, 17alpha, 21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione-21-adamantane-1'-carboxylates.

Country Status (17)

Country Link
JP (1) JPS5644079B1 (en)
AR (2) AR194120A1 (en)
AU (1) AU464251B2 (en)
BE (1) BE785812A (en)
CA (1) CA983919A (en)
CH (1) CH609065A5 (en)
DE (1) DE2232827A1 (en)
DK (1) DK131474B (en)
FR (1) FR2144761B1 (en)
GB (1) GB1391443A (en)
IE (1) IE36529B1 (en)
IL (1) IL39821A (en)
NL (1) NL169882C (en)
NO (1) NO137754C (en)
PH (1) PH13195A (en)
SE (1) SE385904B (en)
ZA (1) ZA724598B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5024427A (en) * 1973-01-03 1975-03-15
DE2512915A1 (en) * 1974-03-27 1975-10-09 Plurichemie Anstalt 16-METHYL-9 ALPHA-HALOGEN-STEROID ESTERS, ETHERS AND METHOD FOR THEIR PRODUCTION
JPS6163976U (en) * 1984-10-01 1986-05-01
US8207151B2 (en) 2008-05-28 2012-06-26 Validus Biopharma Inc. Non-hormonal steroid modulators of NF-κB for treatment of disease
EP2556083A4 (en) 2010-04-05 2013-12-04 Validus Biopharma Inc Non-hormonal steroid modulators of nf- kappa b for treatment of disease
WO2017004205A1 (en) 2015-06-29 2017-01-05 Reveragen Biopharma, Inc. NON-HORMONAL STEROID MODULATORS OF NF-κB FOR TREATMENT OF DISEASE
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Also Published As

Publication number Publication date
ZA724598B (en) 1973-03-28
AU4420572A (en) 1974-01-10
PH13195A (en) 1980-01-18
NO137754B (en) 1978-01-09
FR2144761B1 (en) 1976-03-05
NO137754C (en) 1978-04-19
AU464251B2 (en) 1975-08-21
GB1391443A (en) 1975-04-23
IL39821A (en) 1976-02-29
JPS5644079B1 (en) 1981-10-16
FR2144761A1 (en) 1973-02-16
AR194553A1 (en) 1973-07-23
IE36529L (en) 1973-01-05
NL7209345A (en) 1973-01-09
DK131474C (en) 1975-12-08
IE36529B1 (en) 1976-11-24
AR194120A1 (en) 1973-06-22
SE385904B (en) 1976-07-26
BE785812A (en) 1973-01-04
NL169882C (en) 1982-09-01
CA983919A (en) 1976-02-17
DE2232827A1 (en) 1973-01-18
IL39821A0 (en) 1972-09-28
CH609065A5 (en) 1979-02-15
NL169882B (en) 1982-04-01

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