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DK1200095T3 - Lægemiddel med protektiv virkning mod oxidativ-toksiske og især mod cardiotoksiske - Google Patents

Lægemiddel med protektiv virkning mod oxidativ-toksiske og især mod cardiotoksiske

Info

Publication number
DK1200095T3
DK1200095T3 DK00947960T DK00947960T DK1200095T3 DK 1200095 T3 DK1200095 T3 DK 1200095T3 DK 00947960 T DK00947960 T DK 00947960T DK 00947960 T DK00947960 T DK 00947960T DK 1200095 T3 DK1200095 T3 DK 1200095T3
Authority
DK
Denmark
Prior art keywords
toxic
drug
protective effect
cardiotoxic
oxidative
Prior art date
Application number
DK00947960T
Other languages
English (en)
Inventor
Julius Gy Papp
Dirk Thormaehlen
Harald Waldeck
Zsuzsanna Rozsa
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Application granted granted Critical
Publication of DK1200095T3 publication Critical patent/DK1200095T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK00947960T 1999-07-13 2000-07-10 Lægemiddel med protektiv virkning mod oxidativ-toksiske og især mod cardiotoksiske DK1200095T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19932555A DE19932555A1 (de) 1999-07-13 1999-07-13 Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen

Publications (1)

Publication Number Publication Date
DK1200095T3 true DK1200095T3 (da) 2005-11-14

Family

ID=7914519

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00947960T DK1200095T3 (da) 1999-07-13 2000-07-10 Lægemiddel med protektiv virkning mod oxidativ-toksiske og især mod cardiotoksiske

Country Status (28)

Country Link
US (1) US6906059B2 (da)
EP (1) EP1200095B1 (da)
JP (1) JP4824235B2 (da)
KR (1) KR100738940B1 (da)
CN (1) CN1267099C (da)
AR (1) AR024476A1 (da)
AT (1) ATE306926T1 (da)
AU (1) AU782733B2 (da)
BR (1) BR0012442A (da)
CA (1) CA2377904C (da)
CZ (1) CZ299070B6 (da)
DE (2) DE19932555A1 (da)
DK (1) DK1200095T3 (da)
ES (1) ES2246874T3 (da)
HK (1) HK1049116B (da)
HU (1) HUP0202424A3 (da)
IL (2) IL147604A0 (da)
MX (1) MXPA02000411A (da)
NO (1) NO329558B1 (da)
NZ (1) NZ517130A (da)
PL (1) PL198723B1 (da)
RU (1) RU2268727C2 (da)
SK (1) SK286020B6 (da)
TR (1) TR200200053T2 (da)
TW (1) TWI280880B (da)
UA (1) UA73134C2 (da)
WO (1) WO2001003699A1 (da)
ZA (1) ZA200200265B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19932555A1 (de) * 1999-07-13 2001-01-18 Solvay Pharm Gmbh Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen
CA2447598A1 (en) * 2001-05-18 2002-11-28 Solvay Pharmaceuticals Gmbh Use of compounds with combined nep/mp-inhibitory activity in the preparation of medicaments
JP4521185B2 (ja) * 2001-09-10 2010-08-11 テイボテク・フアーマシユーチカルズ・リミテツド ヘキサヒドロ−フロ［２，３−ｂ］フラン−３−オールの製造法
IL162645A0 (en) 2002-01-16 2005-11-20 Solvay Pharm Bv solid salts benzazepine compounds and their use inthe preparation of pharmaceuticals compounds
AR038681A1 (es) * 2002-02-14 2005-01-26 Solvay Pharm Bv Formulacion oral de solucion solida de una sustancia activa pobremente soluble en agua
US7262184B2 (en) 2003-09-26 2007-08-28 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7427611B2 (en) 2003-09-26 2008-09-23 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl)-cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7452875B2 (en) 2003-09-26 2008-11-18 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
PL1687006T3 (pl) 2003-11-18 2008-01-31 Solvay Pharm Gmbh Kompozycje farmaceutyczne do leczenia zaburzeń czynności nerek
US20050267072A1 (en) * 2004-05-14 2005-12-01 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions containing dually acting inhibitors of neutral endopeptidase for the treatment of sexual dysfunction
US20050267124A1 (en) * 2004-05-14 2005-12-01 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous producing system and PDEV inhibiitors
US20050288272A1 (en) * 2004-06-23 2005-12-29 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and AT1 receptor antagonists
JP2008524159A (ja) 2004-12-15 2008-07-10 ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング ＮＥＰ阻害剤、内因性エンドセリン産生系の阻害剤およびＨＭＧＣｏＡレダクターゼ阻害剤を含有する医薬組成物
US20060205625A1 (en) * 2005-02-18 2006-09-14 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and diuretics
US8709738B2 (en) * 2006-02-27 2014-04-29 Quintiles Transnational Corporation Methods for predicting cardiac toxicity
WO2007102171A2 (en) * 2006-03-07 2007-09-13 Panacea Biotec Ltd Novel salts of 1h-1-benzazepine-1-acetic acid, their preparation and pharmaceutical composition
US20070292503A1 (en) * 2006-06-16 2007-12-20 Gorissen Henricus R Oral pharmaceutical composition of poorly water-soluble active substance
US20070299054A1 (en) * 2006-06-22 2007-12-27 Rajesh Jain Oral pharmaceutical composition of a poorly water-soluble active agent

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2850078A1 (de) * 1978-11-18 1980-05-29 Basf Ag Aminopropanolderivate des 6-hydroxy-2,3,4,5-tetrahydro-1h-1- benzazepin-2-ons
WO1995003305A1 (en) * 1993-07-21 1995-02-02 Yamanouchi Pharmaceutical Co., Ltd. Fused benzazepine derivative and pharmaceutical composition containing the same
DE19510566A1 (de) * 1995-03-23 1996-09-26 Kali Chemie Pharma Gmbh Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE19638020A1 (de) * 1996-09-18 1998-03-19 Solvay Pharm Gmbh Die gastrointestinale Durchblutung fördernde Arzneimittel
ATE233104T1 (de) * 1997-09-18 2003-03-15 Janssen Pharmaceutica Nv Kondensierte imidazolderivate zur erhöhung der oralen bioverfügbarkeit von pharmazeutika
DE19906310A1 (de) * 1999-02-16 2000-08-17 Solvay Pharm Gmbh Arzneimittel zur Behandlung von Bluthochdruck
DE19932555A1 (de) * 1999-07-13 2001-01-18 Solvay Pharm Gmbh Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen

Also Published As

Publication number Publication date
TR200200053T2 (tr) 2002-05-21
WO2001003699A1 (de) 2001-01-18
ATE306926T1 (de) 2005-11-15
RU2268727C2 (ru) 2006-01-27
KR20020019514A (ko) 2002-03-12
UA73134C2 (en) 2005-06-15
AU6157200A (en) 2001-01-30
PL198723B1 (pl) 2008-07-31
CN1267099C (zh) 2006-08-02
MXPA02000411A (es) 2002-07-02
NZ517130A (en) 2004-10-29
JP4824235B2 (ja) 2011-11-30
NO329558B1 (no) 2010-11-15
EP1200095A1 (de) 2002-05-02
HK1049116B (zh) 2006-12-08
SK142002A3 (en) 2002-06-04
CZ299070B6 (cs) 2008-04-16
CZ200252A3 (cs) 2002-08-14
JP2003504336A (ja) 2003-02-04
IL147604A (en) 2006-12-31
NO20020132D0 (no) 2002-01-11
PL353012A1 (en) 2003-10-06
DE50011388D1 (de) 2006-03-02
US6906059B2 (en) 2005-06-14
DE19932555A1 (de) 2001-01-18
AR024476A1 (es) 2002-10-02
KR100738940B1 (ko) 2007-07-12
HK1049116A1 (en) 2003-05-02
ZA200200265B (en) 2003-03-26
TWI280880B (en) 2007-05-11
NO20020132L (no) 2002-03-12
CA2377904C (en) 2009-03-24
SK286020B6 (sk) 2008-01-07
EP1200095B1 (de) 2005-10-19
CA2377904A1 (en) 2001-01-18
ES2246874T3 (es) 2006-03-01
BR0012442A (pt) 2002-04-02
AU782733B2 (en) 2005-08-25
HUP0202424A3 (en) 2003-03-28
CN1373666A (zh) 2002-10-09
US20030040512A1 (en) 2003-02-27
HUP0202424A2 (hu) 2002-11-28
IL147604A0 (en) 2002-08-14

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