[go: up one dir, main page]

DK100392D0 - 3- og 5-substituerede 1,2,3,4-oxatriazol-5-iminforbindelser og fremgangsmaade til fremstilling deraf, farmaceutisk praeparat indeholdende disse forbindelser samt forbindelsernes anvendelse til fremstilling af laegemidler - Google Patents

3- og 5-substituerede 1,2,3,4-oxatriazol-5-iminforbindelser og fremgangsmaade til fremstilling deraf, farmaceutisk praeparat indeholdende disse forbindelser samt forbindelsernes anvendelse til fremstilling af laegemidler

Info

Publication number
DK100392D0
DK100392D0 DK921003A DK100392A DK100392D0 DK 100392 D0 DK100392 D0 DK 100392D0 DK 921003 A DK921003 A DK 921003A DK 100392 A DK100392 A DK 100392A DK 100392 D0 DK100392 D0 DK 100392D0
Authority
DK
Denmark
Prior art keywords
compounds
oxatriazol
imin
procedures
substituted
Prior art date
Application number
DK921003A
Other languages
English (en)
Inventor
Gunnar Leo Karup
Herbert Fritz Preikschat
Soeren Bols Pedersen
Tim Niss Corell
Boerge Ingvar Frisch Alhede
Original Assignee
Gea Farmaceutisk Fabrik As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gea Farmaceutisk Fabrik As filed Critical Gea Farmaceutisk Fabrik As
Priority to DK921003A priority Critical patent/DK100392D0/da
Publication of DK100392D0 publication Critical patent/DK100392D0/da
Priority to JP6504904A priority patent/JPH07509703A/ja
Priority to SK182-95A priority patent/SK18295A3/sk
Priority to PL93307395A priority patent/PL307395A1/xx
Priority to ES93914656T priority patent/ES2085787T3/es
Priority to DK93914656.9T priority patent/DK0654028T3/da
Priority to CZ95339A priority patent/CZ33995A3/cs
Priority to DE69302279T priority patent/DE69302279T2/de
Priority to BR9306880A priority patent/BR9306880A/pt
Priority to RU95106464/04A priority patent/RU95106464A/ru
Priority to CA002140641A priority patent/CA2140641A1/en
Priority to AU44181/93A priority patent/AU4418193A/en
Priority to HU9500401A priority patent/HUT71230A/hu
Priority to NZ253681A priority patent/NZ253681A/en
Priority to AT93914656T priority patent/ATE136893T1/de
Priority to PCT/DK1993/000234 priority patent/WO1994003442A1/en
Priority to EP93914656A priority patent/EP0654028B1/en
Priority to IS4052A priority patent/IS4052A/is
Priority to ZA935199A priority patent/ZA935199B/xx
Priority to LTIP816A priority patent/LT3054B/lt
Priority to APAP/P/1993/000559A priority patent/AP455A/en
Priority to MX9304788A priority patent/MX9304788A/es
Priority to CN93109277A priority patent/CN1086813A/zh
Priority to SI9300425A priority patent/SI9300425A/sl
Priority to LVP-93-1027A priority patent/LV10263B/en
Priority to EE9400084A priority patent/EE9400084A/xx
Priority to BG99378A priority patent/BG99378A/bg
Priority to NO950484A priority patent/NO950484D0/no
Priority to FI950575A priority patent/FI950575A0/fi
Priority to OA60609A priority patent/OA10127A/en
Priority to GR960401060T priority patent/GR3019681T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK921003A 1992-08-10 1992-08-10 3- og 5-substituerede 1,2,3,4-oxatriazol-5-iminforbindelser og fremgangsmaade til fremstilling deraf, farmaceutisk praeparat indeholdende disse forbindelser samt forbindelsernes anvendelse til fremstilling af laegemidler DK100392D0 (da)

Priority Applications (31)

Application Number Priority Date Filing Date Title
DK921003A DK100392D0 (da) 1992-08-10 1992-08-10 3- og 5-substituerede 1,2,3,4-oxatriazol-5-iminforbindelser og fremgangsmaade til fremstilling deraf, farmaceutisk praeparat indeholdende disse forbindelser samt forbindelsernes anvendelse til fremstilling af laegemidler
EP93914656A EP0654028B1 (en) 1992-08-10 1993-07-08 3- and 5-substituted 1,2,3,4-oxatriazole-5-imine compounds, a process for the preparation thereof, a pharmaceutical preparation containing said compounds and the use of said compounds for the preparation of medicaments
AT93914656T ATE136893T1 (de) 1992-08-10 1993-07-08 3-und 5-substituierte 1,2,3,4,-oxatriazol-5-imin derivate, verfahren zu deren herstellung, diese enthaltende arzneimittel und verwendung dieser verbindungen zur herstellung von arzneimitteln
PCT/DK1993/000234 WO1994003442A1 (en) 1992-08-10 1993-07-08 3- and 5-substituted 1,2,3,4-oxatriazole-5-imine compounds, a process for the preparation thereof, a pharmaceutical preparation containing said compounds and the use of said compounds for the preparation of medicaments
PL93307395A PL307395A1 (en) 1992-08-10 1993-07-08 3- and 5-substituted 1,2,3,4-oxa-triazolo-5-imine compounds, method of obtaining them, pharmaceutic agent containinmg such compounds and their application in production of drugs
ES93914656T ES2085787T3 (es) 1992-08-10 1993-07-08 Compuestos de 1,2,3,4-oxatriazol-5-imina 3- y 5-sustituidos, un proceso para la preparacion de los mismos, un preparado farmaceutico que contiene tales compuestos y el uso de dichos compuestos en la preparacion de medicamentos.
DK93914656.9T DK0654028T3 (da) 1992-08-10 1993-07-08 3- og 5-substituerede 1,2,3,4-oxatriazol-5-iminforbindelser og fremgangsmåde til fremstilling deraf, farmaceutisk præparat indeholdende disse forbindelser samt forbindelsernes anvendelse til fremstilling af lægemidler
CZ95339A CZ33995A3 (en) 1992-08-10 1993-07-08 3- and 5-substituted 1,2,3,4-oxatriazol-5-imine compounds, process of their preparation, pharmaceutical composition containing thereof and use of said compounds for preparation of medicaments
DE69302279T DE69302279T2 (de) 1992-08-10 1993-07-08 3-und 5-substituierte 1,2,3,4,-oxatriazol-5-imin derivate, verfahren zu deren herstellung, diese enthaltende arzneimittel und verwendung dieser verbindungen zur herstellung von arzneimitteln
BR9306880A BR9306880A (pt) 1992-08-10 1993-07-08 Compostos de 1,2,3,4-oxatriazol-5-imina substituídos nas posições 3 e 5 um processo para preparação dos mesmos uma preparação farmacêutica contendo os referidos compostos e o uso dos referidos compostos para a preparação de medicamentos
RU95106464/04A RU95106464A (ru) 1992-08-10 1993-07-08 3- и 5-замещенные 1,2,3,4-оксатриазол-5-иминовые соединения, способ их получения, фармацевтическая композиция, содержащая названные соединения
SK182-95A SK18295A3 (en) 1992-08-10 1993-07-08 3- and 5-substituted 1,2,3,4-oxatriazole -5-imine compounds, method of their preparation, pharmaceutical agent containing these compounds and their use for prepare of medicine
AU44181/93A AU4418193A (en) 1992-08-10 1993-07-08 3- and 5-substituted 1,2,3,4-oxatriazole-5-imine compounds, a process for the preparation thereof, a pharmaceutical preparation containing said compounds and the use of said compounds for the preparation of medicaments
HU9500401A HUT71230A (en) 1992-08-10 1993-07-08 3-and 5-substituted 1,2,3,4-oxatriazole-5-iminined derivatives, a process for the preparation thereof, use of said compounds for the preparation of medicaments and pharmaceutical compositions containing said compounds
NZ253681A NZ253681A (en) 1992-08-10 1993-07-08 Substituted 1,2,3,4-oxatriazole-5-imine derivatives and medicaments
JP6504904A JPH07509703A (ja) 1992-08-10 1993-07-08 ３‐および５‐置換１，２，３，４‐オキサトリアゾール‐５‐イミン化合物，その製造方法，前記化合物を含む医薬組成物，および薬物製造用の前記化合物の使用
CA002140641A CA2140641A1 (en) 1992-08-10 1993-07-08 3- and 5-substituted 1,2,3,4-oxatriazole-5-imine compounds, a process for the preparation thereof, a pharmaceutical preparation containing said compounds and the use of said compounds for the preparation of medicaments
IS4052A IS4052A (is) 1992-08-10 1993-07-13 Aðferð til framleiðslu á 3- og 5- greinóttar (substituted) 1, 2, 3, 4-oxatriazole-5- imine efnasamböndum
ZA935199A ZA935199B (en) 1992-08-10 1993-07-19 3- And 5-substituted 1,2,3,4-oxatriazole-5-imine compounds a process for the preparation thereof a pharmaceutical preparation containing said compounds and the use of said compounds for the preparation of medicaments
LTIP816A LT3054B (en) 1992-08-10 1993-07-23 3- and 5-substituted 1,2,3,4-oxatriazole-5-imine compounds, a process for the preparation thereof, a pharmaceutical preparation containing said compounds and the use of said compounds for the preparation of medicaments
APAP/P/1993/000559A AP455A (en) 1992-08-10 1993-07-26 3-and 5-substituted 1,2,3,4-oxatriazole-5-imine compounds, a process for the preparation thereof, a pharmaceutical preparation containing said compounds and the use of said compounds for the preparation of medicaments.
MX9304788A MX9304788A (es) 1992-08-10 1993-08-06 Compuesto de 1, 2, 3, 4-oxatriazol-5-imina 3- y 5-sustituidos, procedimiento para su preparacion y composiciones farmaceticas que los contienen.
LVP-93-1027A LV10263B (en) 1992-08-10 1993-08-10 3- and 5-substituted 1,2,3,4-oxatriazole-5-imine compounds, a process for the preparation thereof, a pharmaceutical preparation containing said compounds and the use of said compounds for the preparation of medicaments
CN93109277A CN1086813A (zh) 1992-08-10 1993-08-10 取代的噁三唑-亚胺化合物，制备方法及药物应用
SI9300425A SI9300425A (en) 1992-08-10 1993-08-10 3-and 5- substituted 1,2,3,4-oxatriazol-5-imines compounds, process for their preparation, pharmaceutical preparation containing the same and use thereof for medicament preparing
EE9400084A EE9400084A (et) 1992-08-10 1994-08-09 3- ja 5- asendatud 1, 2, 3, 4- oksatriasool- 5- imiinühendid, nende saamise meetod, nimetatud ühendeid sisaldav farmatseutiline preparaat ja nimetatud ühendite kasutamine ravimite valmistamiseks
BG99378A BG99378A (bg) 1992-08-10 1995-01-27 3- и 5-заместени 1,2,3,4-оксатриазол-5-имини, метод за получаването им, фармацевтични състави, съдържащи посочените съединения и използването на посочените съединения за получаване на лекарства
NO950484A NO950484D0 (no) 1992-08-10 1995-02-09 3- og 5-substituerte 1,2,3,4-oksatriazol-5-iminforbindelser, fremgangsmåte for fremstilling derav, farmasöytisk preparat inneholdende forbindelsene samt anvendelse av slike for fremstilling av medikamenter
FI950575A FI950575A0 (fi) 1992-08-10 1995-02-09 3- ja 5-substituoidut 1,2,3,4-oksatriatsoli-5-imiiniyhdisteet, niiden valmistusmenetelmä, mainittuja yhdisteitä sisältävä farmaseuttinen valmiste ja mainittujen yhdisteiden käyttö lääkkeiden valmistukseen
OA60609A OA10127A (en) 1992-08-10 1995-02-10 3 - And 5-substituted 1,2,3,4-oxatriazole-5-imine compounds a process for the preparation thereof a pharmaceutical preparation containing said compounds and the use of said compounds for the preparation of medicaments
GR960401060T GR3019681T3 (en) 1992-08-10 1996-04-19 3- and 5-substituted 1,2,3,4-oxatriazole-5-imine compounds, a process for the preparation thereof, a pharmaceutical preparation containing said compounds and the use of said compounds for the preparation of medicaments.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK921003A DK100392D0 (da) 1992-08-10 1992-08-10 3- og 5-substituerede 1,2,3,4-oxatriazol-5-iminforbindelser og fremgangsmaade til fremstilling deraf, farmaceutisk praeparat indeholdende disse forbindelser samt forbindelsernes anvendelse til fremstilling af laegemidler

Publications (1)

Publication Number Publication Date
DK100392D0 true DK100392D0 (da) 1992-08-10

Family

ID=8099920

Family Applications (2)

Application Number Title Priority Date Filing Date
DK921003A DK100392D0 (da) 1992-08-10 1992-08-10 3- og 5-substituerede 1,2,3,4-oxatriazol-5-iminforbindelser og fremgangsmaade til fremstilling deraf, farmaceutisk praeparat indeholdende disse forbindelser samt forbindelsernes anvendelse til fremstilling af laegemidler
DK93914656.9T DK0654028T3 (da) 1992-08-10 1993-07-08 3- og 5-substituerede 1,2,3,4-oxatriazol-5-iminforbindelser og fremgangsmåde til fremstilling deraf, farmaceutisk præparat indeholdende disse forbindelser samt forbindelsernes anvendelse til fremstilling af lægemidler

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK93914656.9T DK0654028T3 (da) 1992-08-10 1993-07-08 3- og 5-substituerede 1,2,3,4-oxatriazol-5-iminforbindelser og fremgangsmåde til fremstilling deraf, farmaceutisk præparat indeholdende disse forbindelser samt forbindelsernes anvendelse til fremstilling af lægemidler

Country Status (29)

Country Link
EP (1) EP0654028B1 (da)
JP (1) JPH07509703A (da)
CN (1) CN1086813A (da)
AP (1) AP455A (da)
AT (1) ATE136893T1 (da)
AU (1) AU4418193A (da)
BG (1) BG99378A (da)
BR (1) BR9306880A (da)
CA (1) CA2140641A1 (da)
CZ (1) CZ33995A3 (da)
DE (1) DE69302279T2 (da)
DK (2) DK100392D0 (da)
EE (1) EE9400084A (da)
ES (1) ES2085787T3 (da)
FI (1) FI950575A0 (da)
GR (1) GR3019681T3 (da)
HU (1) HUT71230A (da)
IS (1) IS4052A (da)
LT (1) LT3054B (da)
LV (1) LV10263B (da)
MX (1) MX9304788A (da)
NZ (1) NZ253681A (da)
OA (1) OA10127A (da)
PL (1) PL307395A1 (da)
RU (1) RU95106464A (da)
SI (1) SI9300425A (da)
SK (1) SK18295A3 (da)
WO (1) WO1994003442A1 (da)
ZA (1) ZA935199B (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996011191A1 (en) * 1994-10-07 1996-04-18 A/S Gea Farmaceutisk Fabrik Substituted 3-phenyl-1,2,3,4-oxatriazole-5-imines useful for the treatment of asthma and thrombosis
US6399618B1 (en) 1997-07-09 2002-06-04 Cardiome Pharma Corp Compositions and methods for modulating sexual activity
FR2786699B1 (fr) * 1998-12-02 2002-10-04 Philippe Gorny Medicament destine notamment a prevenir ou traiter les dysfonctions sexuelles
CN111217817B (zh) * 2020-02-26 2022-06-10 山东潍坊润丰化工股份有限公司 一种三唑并嘧啶类除草剂的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2015878B (en) 1978-03-10 1982-05-26 Shell Int Research Biocidal compositions
US4329355A (en) * 1979-03-01 1982-05-11 Henry David W Mesoionic antitumor compositions and methods for using the same in the treatment of cancer

Also Published As

Publication number Publication date
LV10263A (lv) 1994-10-20
CZ33995A3 (en) 1995-09-13
WO1994003442A1 (en) 1994-02-17
HU9500401D0 (en) 1995-03-28
OA10127A (en) 1996-12-18
EP0654028B1 (en) 1996-04-17
HUT71230A (en) 1995-11-28
ES2085787T3 (es) 1996-06-01
NZ253681A (en) 1995-09-26
LT3054B (en) 1994-10-25
CA2140641A1 (en) 1994-02-17
FI950575A7 (fi) 1995-02-09
RU95106464A (ru) 1996-12-27
CN1086813A (zh) 1994-05-18
DE69302279D1 (de) 1996-05-23
EE9400084A (et) 1995-12-15
SI9300425A (en) 1994-03-31
JPH07509703A (ja) 1995-10-26
DE69302279T2 (de) 1996-09-19
FI950575A0 (fi) 1995-02-09
LV10263B (en) 1995-06-20
EP0654028A1 (en) 1995-05-24
AU4418193A (en) 1994-03-03
GR3019681T3 (en) 1996-07-31
ZA935199B (en) 1994-03-02
MX9304788A (es) 1994-02-28
AP9300559A0 (en) 1993-10-31
BR9306880A (pt) 1998-12-08
LTIP816A (en) 1994-05-15
PL307395A1 (en) 1995-05-15
SK18295A3 (en) 1995-07-11
IS4052A (is) 1994-02-11
BG99378A (bg) 1995-11-30
AP455A (en) 1996-01-19
DK0654028T3 (da) 1996-07-29
ATE136893T1 (de) 1996-05-15

Similar Documents

Publication Publication Date Title
DK343388D0 (da) 2,2-dimethylchroman-3-ol-derivater og fremgangsmaade til fremstilling deraf, farmaceutiske midler indeholdende derivaterne samt disse anvendelse til fremstilling af farmaceutiske midler
DK213085D0 (da) Aminotetralinderivater, laegemidler indeholdende disse og fremgangsmaade til forbindelsernes fremstilling
DK0622408T3 (da) Sammensætning og fremgangsmåde til fremstilling af gelatinfrie, bløde kapsler
DK356885D0 (da) 3-aminomethyl-imidazo(1,2-a)pyridinderivater samt fremgangsmaade til fremstilling af og laegemiddel indeholdende saadanne forbindelser
NO940261D0 (no) 5-Leddete heterocykler, fremgangsmaate ved fremstilling derav og legemidler som inneholder disse forbindelser
DK393482A (da) Urinstofderivater, fremgangsmaade til fremstilling heraf og medikamenter indeholdende disse forbindelser samt deres anvendelse
DK255086A (da) Heteroaromatiske aminderivater, laegemidler som indeholder disse forbindelser og fremgangsmaade til fremstilling af forbindelserne
DK0489647T3 (da) N,O-sulfaterede heparosaner, fremgangsmåde til fremstilling heraf og lægemidler indeholdende disse forbindelser.
DK514688D0 (da) Heterocykliske peptidylforbindelser, fremgangsmaade til fremstilling deraf samt anvendelse af disse
DK102990A (da) Thieno-triazolodiazepinderivater, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
NO930796D0 (no) Glykopeptidderivater, fremgangsmaate for deres fremstilling og farmasoeytiske midler inneholdende disse
DK635988A (da) 1,3-butandiolacetoacetat-derivater og anvendelse af 1,3-butandiolacetoacetat-forbindelser til fremstilling af farmaceutiske praeparater
DK100392D0 (da) 3- og 5-substituerede 1,2,3,4-oxatriazol-5-iminforbindelser og fremgangsmaade til fremstilling deraf, farmaceutisk praeparat indeholdende disse forbindelser samt forbindelsernes anvendelse til fremstilling af laegemidler
DK617684A (da) 1,3-dioxolanylderivater, fremgangsmaade til deres fremstilling, deres anvendelse og laegemidler indeholdende disse forbindelser
DK187989D0 (da) Substituerede propanaminer, fremgangsmaade til fremstilling heraf og laegemidler indeholdende saadanne forbindelser
DK291189A (da) Kondenserede diazepinoner, fremgangsmaade til fremstilling af saadanne forbindelser og laegemidler med indhold af forbindelserne
DK93385D0 (da) 3-amino-1-(4,5,6,7-tetrahydro-benzothiazolyl)-2-pyrazoliner, fremgangsmaade til fremstilling af disse forbindelser og farmaceutiske praeparater indeholdende disse forbindelser
DK449188A (da) 2'-deoxy-5-fluoruridinderivater og farmaceutiske praeparater med indhold af saadanne forbindelser
DK97388A (da) Mellemprodukt og fremgangsmaade til fremstilling af antihypercholestrolemiske tetrazolforbindelser
DK365087D0 (da) 1,3,5-trithianderivater, fremgangsmaade til fremstilling af saadanne forbindelser og laegemiddel indeholdende disse
NO905520D0 (no) Rifamycinderivater og fremgangsmaater for fremstilling av disse.
DK210787A (da) 4,5-dihydro-1h-1,2,4-triazol-3-caboxamidderivat, mellemprodukt til fremstilling af derivatet og herbicidt middel indeholdende derivatet
DK176888D0 (da) Thieno-imidazo(2,1-b)thiazolderivater, fremgangsmaade til fremstilling af saadanne derivater og laegemiddel indeholdende disse
FI955282A7 (fi) Menetelmä NG-monoalkyyli-L-arginiinin ja vastaavien yhdisteiden valmis tamiseksi
DK39584D0 (da) Anvendelse af nafazatrom til forebyggelse og behandling af diverse sygdomme, laegemidler indeholdende nafazatrom sa mt fremgangsmader til disses fremstilling

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment