DK106586D0 - Cyklopenta(d)pyrimidinderivater samt deres fremstilling og anvendelse - Google Patents
Cyklopenta(d)pyrimidinderivater samt deres fremstilling og anvendelseInfo
- Publication number
- DK106586D0 DK106586D0 DK106586A DK106586A DK106586D0 DK 106586 D0 DK106586 D0 DK 106586D0 DK 106586 A DK106586 A DK 106586A DK 106586 A DK106586 A DK 106586A DK 106586 D0 DK106586 D0 DK 106586D0
- Authority
- DK
- Denmark
- Prior art keywords
- sup
- cyclopenta
- preparation
- pyrimidine derivatives
- hydrogen
- Prior art date
Links
- LTFBFZBWUKWXID-UHFFFAOYSA-N 1h-cyclopenta[d]pyrimidine Chemical class N1=CNC2=CC=CC2=C1 LTFBFZBWUKWXID-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 201000003102 mental depression Diseases 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Dental Preparations (AREA)
- Hydrogenated Pyridines (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Soil Working Implements (AREA)
- Luminescent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Eyeglasses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4362685 | 1985-03-07 | ||
| JP4362685 | 1985-03-07 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK106586D0 true DK106586D0 (da) | 1986-03-07 |
| DK106586A DK106586A (da) | 1986-09-08 |
| DK165109B DK165109B (da) | 1992-10-12 |
| DK165109C DK165109C (da) | 1993-03-01 |
Family
ID=12669058
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK106586A DK165109C (da) | 1985-03-07 | 1986-03-07 | 4-anilino-cyklopentaoedaapyrimidinderivater samt farmaceutiske midler indeholdende saadanne |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4749704A (da) |
| EP (1) | EP0194161B1 (da) |
| JP (1) | JPS6270A (da) |
| KR (1) | KR890003839B1 (da) |
| AT (1) | ATE106077T1 (da) |
| AU (1) | AU580391B2 (da) |
| CA (1) | CA1273632A (da) |
| DE (1) | DE3689848T2 (da) |
| DK (1) | DK165109C (da) |
| ES (3) | ES8704905A1 (da) |
| FI (1) | FI88717C (da) |
| HK (1) | HK1005450A1 (da) |
| IE (1) | IE64504B1 (da) |
| NO (1) | NO168767C (da) |
| ZA (1) | ZA861708B (da) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5037980A (en) * | 1988-04-18 | 1991-08-06 | American Cyanamid Company | Phenyl imidazo[1,2-a]pyrimidines |
| US5877178A (en) * | 1991-04-08 | 1999-03-02 | Duquesne University Of The Holy Ghost | Pyrimidine derivatives and methods of making and using these derivatives |
| US5234936A (en) * | 1991-10-24 | 1993-08-10 | American Home Products Corporation | Pyrimidocycloalkanes as a ii antagonists |
| CA2534785A1 (en) * | 2003-08-12 | 2005-02-17 | Robin Douglas Clark | Tetrahydroquinazoline derivatives as cfr antagonists |
| JPWO2007049342A1 (ja) | 2005-10-26 | 2009-04-30 | 三菱電機株式会社 | エレベーター群管理制御装置 |
| US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| US8329701B2 (en) | 2006-07-06 | 2012-12-11 | Array Biopharma Inc. | Dihydrofuro pyrimidines as AKT protein kinase inhibitors |
| ATE532789T1 (de) | 2006-07-06 | 2011-11-15 | Array Biopharma Inc | Dihydrothienopyrimidine als akt-proteinkinase- inhibitoren |
| KR20150041164A (ko) | 2006-07-06 | 2015-04-15 | 어레이 바이오파마 인크. | Ａｋｔ 단백질 키나제 억제제로서의 시클로펜타〔ｄ〕피리미딘 |
| WO2008021456A2 (en) * | 2006-08-16 | 2008-02-21 | Cytovia, Inc. | N-aryl-5,7-dihydrofuro[3,4-d]pyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| KR101624361B1 (ko) | 2007-07-05 | 2016-05-25 | 어레이 바이오파마 인크. | Ａｋｔ 단백질 키나제 억제제로서의 피리미딜 시클로펜탄 |
| AR067413A1 (es) | 2007-07-05 | 2009-10-07 | Genentech Inc | Compuestos heterociclicos que contienen ciclopenta[d]pirimidina inhibidores de proteinquinasas akt, composiciones farmaceuticas que los contienen, metodo de preparacion y uso de las mismas para el tratamiento de enfermedades hiperproliferativas, tales como cancer |
| US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
| AU2009204025B2 (en) | 2008-01-09 | 2014-02-20 | Array Biopharma Inc. | Hydroxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| US8853216B2 (en) | 2008-01-09 | 2014-10-07 | Array Biopharma, Inc. | Hydroxylated pyrimidyl cyclopentane as AKT protein kinase inhibitor |
| WO2010047201A1 (ja) | 2008-10-20 | 2010-04-29 | 三菱電機株式会社 | エレベーター群管理装置 |
| CN103841976A (zh) | 2011-04-01 | 2014-06-04 | 基因泰克公司 | Akt和mek抑制剂化合物的组合及其使用方法 |
| EP2694072B2 (en) | 2011-04-01 | 2024-08-07 | Genentech, Inc. | Combination of akt inhibitor compound and abiraterone for use in therapeutic treatments |
| GB201121127D0 (en) | 2011-12-08 | 2012-01-18 | Dow Corning | Treatment of filler with silane |
| CN111303053B (zh) * | 2020-03-16 | 2023-01-17 | 中国海洋大学 | 环戊并[d]嘧啶类化合物及其药学上可接受的盐、溶剂合物或者前药以及应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3470182A (en) * | 1967-02-09 | 1969-09-30 | Sandoz Ag | 4-amino-substituted quinazolines |
| US3980650A (en) * | 1972-05-05 | 1976-09-14 | N.V. Koninklijke Pharmaceutische Fabrieken V/H Brocades-Stheeman En Pharmacia | 4-Amino-pyrimidine derivatives |
| US3915976A (en) * | 1972-09-01 | 1975-10-28 | Sandoz Ag | Substituted-4-phenyl-5h-cycloalkano(d)pyrimidines |
| PH20344A (en) * | 1981-01-29 | 1986-12-04 | Sankyo Co | Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them |
| JPS57203072A (en) * | 1981-06-05 | 1982-12-13 | Sankyo Co Ltd | 4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient |
-
1986
- 1986-03-06 JP JP61049238A patent/JPS6270A/ja not_active Withdrawn
- 1986-03-06 US US06/837,079 patent/US4749704A/en not_active Expired - Lifetime
- 1986-03-07 ES ES552796A patent/ES8704905A1/es not_active Expired
- 1986-03-07 ZA ZA861708A patent/ZA861708B/xx unknown
- 1986-03-07 NO NO860852A patent/NO168767C/no unknown
- 1986-03-07 DK DK106586A patent/DK165109C/da not_active IP Right Cessation
- 1986-03-07 CA CA000503571A patent/CA1273632A/en not_active Expired - Lifetime
- 1986-03-07 FI FI860969A patent/FI88717C/fi not_active IP Right Cessation
- 1986-03-07 AT AT86301660T patent/ATE106077T1/de not_active IP Right Cessation
- 1986-03-07 IE IE59786A patent/IE64504B1/en not_active IP Right Cessation
- 1986-03-07 EP EP86301660A patent/EP0194161B1/en not_active Expired - Lifetime
- 1986-03-07 DE DE3689848T patent/DE3689848T2/de not_active Expired - Fee Related
- 1986-03-07 AU AU54481/86A patent/AU580391B2/en not_active Ceased
- 1986-03-07 KR KR1019860001624A patent/KR890003839B1/ko not_active Expired
- 1986-11-14 ES ES557198A patent/ES8801221A1/es not_active Expired
- 1986-11-14 ES ES557199A patent/ES8801222A1/es not_active Expired
-
1998
- 1998-05-27 HK HK98104569A patent/HK1005450A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA1273632A (en) | 1990-09-04 |
| US4749704A (en) | 1988-06-07 |
| EP0194161A3 (en) | 1987-09-02 |
| ES8801222A1 (es) | 1988-01-01 |
| DK165109C (da) | 1993-03-01 |
| DK165109B (da) | 1992-10-12 |
| JPS6270A (ja) | 1987-01-06 |
| DK106586A (da) | 1986-09-08 |
| DE3689848T2 (de) | 1995-01-12 |
| NO860852L (no) | 1986-09-08 |
| AU580391B2 (en) | 1989-01-12 |
| ZA861708B (en) | 1986-11-26 |
| KR890003839B1 (ko) | 1989-10-05 |
| NO168767C (no) | 1992-04-01 |
| IE860597L (en) | 1986-09-07 |
| FI88717C (fi) | 1993-06-28 |
| HK1005450A1 (en) | 1999-01-08 |
| EP0194161A2 (en) | 1986-09-10 |
| EP0194161B1 (en) | 1994-05-25 |
| ATE106077T1 (de) | 1994-06-15 |
| FI860969A0 (fi) | 1986-03-07 |
| ES557198A0 (es) | 1988-01-01 |
| FI860969L (fi) | 1986-09-08 |
| NO168767B (no) | 1991-12-23 |
| IE64504B1 (en) | 1995-08-09 |
| ES8704905A1 (es) | 1987-04-16 |
| KR860007221A (ko) | 1986-10-08 |
| ES8801221A1 (es) | 1988-01-01 |
| DE3689848D1 (de) | 1994-06-30 |
| AU5448186A (en) | 1986-09-11 |
| ES552796A0 (es) | 1987-04-16 |
| ES557199A0 (es) | 1988-01-01 |
| FI88717B (fi) | 1993-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |