[go: up one dir, main page]

DK104390A - Vaevs-plasminogen aktivatorforbindelse, dna, der koder herfor, udtrykkelsesvektor indeholdende dette dna, vaertsceller transformeret med udtrykkelsesvektoren, fremgangsmaade til fremstilling af aktivatoren og farmaceutisk praeparat indeholdende denne - Google Patents

Vaevs-plasminogen aktivatorforbindelse, dna, der koder herfor, udtrykkelsesvektor indeholdende dette dna, vaertsceller transformeret med udtrykkelsesvektoren, fremgangsmaade til fremstilling af aktivatoren og farmaceutisk praeparat indeholdende denne Download PDF

Info

Publication number
DK104390A
DK104390A DK104390A DK104390A DK104390A DK 104390 A DK104390 A DK 104390A DK 104390 A DK104390 A DK 104390A DK 104390 A DK104390 A DK 104390A DK 104390 A DK104390 A DK 104390A
Authority
DK
Denmark
Prior art keywords
prepared
expression vector
dna
vaevs
processed
Prior art date
Application number
DK104390A
Other languages
Danish (da)
English (en)
Other versions
DK104390D0 (da
Inventor
Yasushi Kawauchi
Toshiyuki Takemoto
Makoto Takayama
Masami Yokota
Masao Kato
Kimio Katsuta
Hiroshi Gushima
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Publication of DK104390D0 publication Critical patent/DK104390D0/da
Publication of DK104390A publication Critical patent/DK104390A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Graft Or Block Polymers (AREA)
  • External Artificial Organs (AREA)
  • Pens And Brushes (AREA)
  • Fixed Capacitors And Capacitor Manufacturing Machines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK104390A 1987-10-29 1990-04-27 Vaevs-plasminogen aktivatorforbindelse, dna, der koder herfor, udtrykkelsesvektor indeholdende dette dna, vaertsceller transformeret med udtrykkelsesvektoren, fremgangsmaade til fremstilling af aktivatoren og farmaceutisk praeparat indeholdende denne DK104390A (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP27477087 1987-10-29
JP32078587 1987-12-18
JP7012688 1988-03-23
JP18935188 1988-07-27
PCT/JP1988/001098 WO1989003874A1 (fr) 1987-10-29 1988-10-28 Nouveaux composes polypeptidiques

Publications (2)

Publication Number Publication Date
DK104390D0 DK104390D0 (da) 1990-04-27
DK104390A true DK104390A (da) 1990-06-21

Family

ID=27465213

Family Applications (1)

Application Number Title Priority Date Filing Date
DK104390A DK104390A (da) 1987-10-29 1990-04-27 Vaevs-plasminogen aktivatorforbindelse, dna, der koder herfor, udtrykkelsesvektor indeholdende dette dna, vaertsceller transformeret med udtrykkelsesvektoren, fremgangsmaade til fremstilling af aktivatoren og farmaceutisk praeparat indeholdende denne

Country Status (10)

Country Link
US (2) US5556621A (fr)
JP (1) JP2534332B2 (fr)
KR (1) KR970005046B1 (fr)
AT (1) ATE125294T1 (fr)
DE (1) DE3854195T2 (fr)
DK (1) DK104390A (fr)
FI (1) FI102844B (fr)
HU (2) HU217100B (fr)
NO (1) NO301174B1 (fr)
WO (1) WO1989003874A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2007364A1 (fr) * 1989-01-17 1990-07-17 David J. Livingston Sequences de genes encodant des residus modifies situes dans le domaine protease du tpa
US6497877B1 (en) 1997-01-29 2002-12-24 University Technology Corporation Plasminogen activator as an anti-inflammatory agent
KR100613531B1 (ko) 1997-09-22 2006-08-16 도시오 미야타 멕신 단백질

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
US5073494A (en) * 1985-04-22 1991-12-17 Genentech, Inc. Human tissue plasminogen activator substituted at position 275 or at positions 275 and 277
GR861037B (en) * 1985-04-22 1986-07-16 Genentech Inc Novel human tissue plasminogen activator mutants
NZ217331A (en) * 1985-08-26 1989-05-29 Lilly Co Eli Tissue plasminogen activator derivatives and genetically engineered product
WO1987003906A1 (fr) * 1985-12-20 1987-07-02 The Upjohn Company Analogues d'un activateur de plasminogene tissulaire (tpa)
DK43387A (da) * 1986-01-29 1987-07-30 Beecham Group Plc Fibrinolytisk enzym
AU7090887A (en) * 1986-04-02 1987-10-08 Beecham Group Plc Plasminogen activators modified in first kringle domain
US4935237A (en) * 1988-03-21 1990-06-19 Genentech, Inc. Processes for the preparation of t-PA mutants
JPH02504102A (ja) * 1987-06-30 1990-11-29 ジェネンテク，インコーポレイテッド 血管障害治療のための改良法
US5094953A (en) * 1988-03-21 1992-03-10 Genentech, Inc. Human tissue plasminogen activator variants
US5037646A (en) * 1988-04-29 1991-08-06 Genentech, Inc. Processes for the treatment of vascular disease
JP2793462B2 (ja) * 1993-02-23 1998-09-03 山陽特殊製鋼株式会社 超耐食Ｎｉ基合金

Also Published As

Publication number Publication date
HU886304D0 (en) 1991-11-28
JPH02167076A (ja) 1990-06-27
DE3854195T2 (de) 1995-12-21
FI902066A0 (fi) 1990-04-25
KR970005046B1 (ko) 1997-04-11
HU211335A9 (en) 1995-11-28
DK104390D0 (da) 1990-04-27
KR890701732A (ko) 1989-12-21
FI102844B1 (fi) 1999-02-26
ATE125294T1 (de) 1995-08-15
FI102844B (fi) 1999-02-26
US5556621A (en) 1996-09-17
WO1989003874A1 (fr) 1989-05-05
NO901920L (no) 1990-04-27
US5739012A (en) 1998-04-14
NO301174B1 (no) 1997-09-22
JP2534332B2 (ja) 1996-09-11
DE3854195D1 (de) 1995-08-24
HUT58811A (en) 1992-03-30
NO901920D0 (no) 1990-04-27
HU217100B (hu) 1999-11-29

Similar Documents

Publication Publication Date Title
ATE74379T1 (de) Peptidplasminogenaktivatoren.
Matsuda et al. A simple, large scale method for preparation of plasminogen-free fibrinogen
ES2195993T3 (es) Metodo para inhibir la produccion de etileno en plantas.
DK36991D0 (da) Vaevsplasminoaktivator-(t-pa)-variant med zymogene eller fibrinspecifikke eller plasmakoagel-specifikke egenskaber, fremgangsmaade til fremstilling deraf, dna-sekvens, som koder for varianten, replicerbar udtrykkelsesvektor for denne og vaertsceller transformeret med vektoren
DK240088A (da) Fremgangsmaade til transformation af et plantecellematerale
DK198883A (da) Fremgangsmaade til fremstilling af menneskevaevs-plasminogen-aktivator, dna-sekvens der koder for denne aktivator, replicerbar udtrykkelsesvektor for dna-sekvensen og mikroorganisme eller cellekultur transformeret med udtrykkelsesvektoren
DE3680271D1 (de) Thrombolytische zusammensetzung und verfahren zu deren herstellung.
ES8800347A1 (es) Metodo para preparar uroquinasa de una sola cadena resistente a proteasas
KR890003952A (ko) 신규 조직 플라스미노겐 활성제
DE69912457D1 (de) Verlängerte lagerung roter blutzellen
GB1533205A (en) Plasmin fractions and complexes thereof
DK465986A (da) Fremgangsmaade til foroegelse af produktionen af t-pa (vaevsplasminogenaktivator) og scu-pa (enkeltkaede-urokinase-plasminogenaktivator)
DE69132889D1 (de) Überlegende thrombomodulinanaloga zur pharmazeutischen verwendung
DK104390D0 (da) Vaevs-plasminogen aktivatorforbindelse, dna, der koder herfor, udtrykkelsesvektor indeholdende dette dna, vaertsceller transformeret med udtrykkelsesvektoren, fremgangsmaade til fremstilling af aktivatoren og farmaceutisk praeparat indeholdende denne
ES8603951A1 (es) Un metodo de estabilizar el zimogeno de uroquinasa
Kaczmarek et al. Fibrinogen-Sepharose interaction with prothrombin, prethrombin 1, prethrombin 2 and thrombin
ES2033295T3 (es) Un metodo para preparar un activador de plasminogeno.
NO894362L (no) Fremgangsmaate for selektiv spaltning av fusjonsproteiner.
DK0819173T3 (da) Mutant af inhibitoren af Erythrina caffra-typen og anvendelse deraf til oprensning af serinproteaser

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment