[go: up one dir, main page]

DK0846693T3 - N-benzyldioxothiazolidylbenzamidderivater og fremgangsmåder til fremstilling deraf - Google Patents

N-benzyldioxothiazolidylbenzamidderivater og fremgangsmåder til fremstilling deraf

Info

Publication number
DK0846693T3
DK0846693T3 DK96920002T DK96920002T DK0846693T3 DK 0846693 T3 DK0846693 T3 DK 0846693T3 DK 96920002 T DK96920002 T DK 96920002T DK 96920002 T DK96920002 T DK 96920002T DK 0846693 T3 DK0846693 T3 DK 0846693T3
Authority
DK
Denmark
Prior art keywords
carbon atoms
groups
processes
group
atoms
Prior art date
Application number
DK96920002T
Other languages
Danish (da)
English (en)
Inventor
Koji Murakami
Toshio Maeda
Masahiro Nomura
Katsuya Awano
Susumu Kinoshita
Hiroya Satoh
Masaki Tsunoda
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Application granted granted Critical
Publication of DK0846693T3 publication Critical patent/DK0846693T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
DK96920002T 1995-06-02 1996-05-30 N-benzyldioxothiazolidylbenzamidderivater og fremgangsmåder til fremstilling deraf DK0846693T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP15978195 1995-06-02
JP15313996A JP3144624B2 (ja) 1995-06-02 1996-05-24 Ｎ−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法
PCT/JP1996/001459 WO1996038428A1 (fr) 1995-06-02 1996-05-30 Derives de n-benzyldioxothiazolidylbenzamide et leur procede de production

Publications (1)

Publication Number Publication Date
DK0846693T3 true DK0846693T3 (da) 2002-05-06

Family

ID=26481850

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96920002T DK0846693T3 (da) 1995-06-02 1996-05-30 N-benzyldioxothiazolidylbenzamidderivater og fremgangsmåder til fremstilling deraf

Country Status (15)

Country Link
US (1) US6030990A (fr)
EP (1) EP0846693B1 (fr)
JP (1) JP3144624B2 (fr)
KR (1) KR100456177B1 (fr)
CN (2) CN1069901C (fr)
AT (1) ATE212341T1 (fr)
AU (1) AU698896B2 (fr)
CA (1) CA2220698C (fr)
DE (1) DE69618792T2 (fr)
DK (1) DK0846693T3 (fr)
ES (1) ES2170858T3 (fr)
HU (1) HU225039B1 (fr)
PT (1) PT846693E (fr)
TW (1) TW400328B (fr)
WO (1) WO1996038428A1 (fr)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2159938A1 (fr) * 1994-10-07 1996-04-08 Hiroaki Yanagisawa Derives d'oximes; methode de preparation et applications therapeutiques
CZ293016B6 (cs) * 1995-06-01 2004-01-14 Sankyo Company Limited Benzimidazolové deriváty a farmaceutické prostředky s jejich obsahem
WO1997032863A1 (fr) * 1996-03-08 1997-09-12 Torii Pharmaceutical Co., Ltd. Derives de thiazolidine-2,4-dione
HUP0104240A2 (hu) 1998-09-17 2002-03-28 Bristol-Myers Squibb Company Eljárás ateroszklerozis kezelésére egy aP2 inhibítor vagy kombinációja alkalmazásával
US6756360B1 (en) 1998-12-24 2004-06-29 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
CN1152025C (zh) 1999-08-23 2004-06-02 杏林制药株式会社 取代的苄基噻唑烷-2,4-二酮衍生物
CA2382573C (fr) 1999-08-23 2007-05-22 Kyorin Pharmaceutical Co., Ltd. Derives de benzylthiazolidine-2,4-dione substitues
DE60020375T2 (de) * 1999-08-23 2006-11-23 Kyorin Pharmaceutical Co., Ltd. Substituierte benzylthiazolidin-2,4-dion derivate
EP1213287B1 (fr) 1999-08-23 2005-05-25 Kyorin Pharmaceutical Co., Ltd. Derives de benzylthiazolidine-2,4-dione substitues
CA2385083C (fr) * 1999-09-17 2007-06-05 Kyorin Pharmaceutical Co., Ltd. Derives d'o-anisamide
TWI262185B (en) 1999-10-01 2006-09-21 Eisai Co Ltd Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives
TWI271192B (en) 1999-11-11 2007-01-21 Kyorin Pharmaceutical Co Ltd Solid formulation for oral administration
AU784370B2 (en) * 1999-12-22 2006-03-23 Metabasis Therapeutics, Inc. Novel bisamidate phosphonate prodrugs
WO2001057007A1 (fr) * 2000-02-01 2001-08-09 Kyorin Pharmaceutical Co., Ltd. Sel de metal alcalin de derive de thiazolidine-4,4-dione
AU2001236079A1 (en) * 2000-03-07 2001-09-17 Kyorin Pharmaceutical Co. Ltd. Intermediate compounds
CN1426402A (zh) * 2000-04-25 2003-06-25 杏林制药株式会社 噻唑烷二酮衍生物的新颖的稳定晶体及其制法
AU2001274502A1 (en) * 2000-06-14 2001-12-24 Kyorin Pharmaceutical Co. Ltd. Process for the preparation of thiazolidinedione derivatives
US7563774B2 (en) * 2000-06-29 2009-07-21 Metabasis Therapeutics, Inc. Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
US6982251B2 (en) * 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
EP1354602B1 (fr) * 2000-12-26 2006-10-04 Sankyo Company, Limited Compositions medicinales contenant un diuretique et un agent renforcant la resistance a l'insuline
PT1353694E (pt) * 2001-01-26 2008-03-12 Schering Corp Combinações de ezetimiba com aspirina para o tratamento de doenças vasculares
CZ305202B6 (cs) * 2001-01-26 2015-06-10 Merck Sharp & Dohme Corp. Farmaceutický prostředek
DK1363668T3 (da) * 2001-01-26 2007-11-05 Schering Corp Kombinationer af galdesyrekompleksdanner(e) og sterolabsorptionsinhibitor(er) og behandling af vaskulære indikationer
JP2004517919A (ja) * 2001-01-26 2004-06-17 シェーリング　コーポレイション 血管状態の処置のための心臓血管薬剤とステロール吸収インヒビターとの組み合わせ
RU2356550C2 (ru) * 2001-01-26 2009-05-27 Шеринг Корпорейшн Комбинации активатора (активаторов) рецептора, активируемого пролифератором пероксисом (рапп), и ингибитора (ингибиторов) всасывания стерина и лечение заболеваний сосудов
AR034204A1 (es) * 2001-01-26 2004-02-04 Schering Corp Composiciones y combinaciones de acido nicotinico y derivados del mismo con inhibidor(es) de la absorcion de los esteroles, y el uso de los mismos para preparar medicamentos para el tratamiento para indicaciones vasculares
US20060287254A1 (en) * 2001-01-26 2006-12-21 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
US7071181B2 (en) * 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
WO2002079162A1 (fr) 2001-03-28 2002-10-10 Eisai Co., Ltd. Acides carboxyliques
US7244861B2 (en) 2001-03-30 2007-07-17 Eisai Co., Ltd. Benzene compound and salt thereof
TWI311133B (en) 2001-04-20 2009-06-21 Eisai R&D Man Co Ltd Carboxylic acid derivativeand the salt thereof
AR038956A1 (es) * 2001-05-25 2005-02-02 Schering Corp Uso de un compuesto que regula la produccion o niveles de peptidos beta amiloides para la manufactura de un medicamento para tratar la enfermedad de alzheimer y/o para regular dichos niveles de peptidos amiloides beta en un sujeto
WO2002098840A1 (fr) 2001-06-04 2002-12-12 Eisai Co., Ltd. Derive de l'acide carboxylique et medicament comprenant un sel ou un ester dudit derive
WO2003016265A1 (fr) 2001-08-17 2003-02-27 Eisai Co., Ltd. Compose cyclique et agoniste du recepteur ppar
US7056906B2 (en) * 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
US20030119808A1 (en) * 2001-09-21 2003-06-26 Schering Corporation Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects
US7053080B2 (en) * 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
AU2002336609B2 (en) * 2001-09-21 2006-08-24 Merck Sharp & Dohme Corp. Treatment of xanthoma with azetidinone derivatives as sterol absorption inhibitors
PA8557501A1 (es) 2001-11-12 2003-06-30 Pfizer Prod Inc Benzamida, heteroarilamida y amidas inversas
WO2003042190A1 (fr) 2001-11-12 2003-05-22 Pfizer Products Inc. Derives de n-adamantylalkyle benzamide en tant qu'antagonistes du recepteur p2x7
ITRM20020016A1 (it) * 2002-01-15 2003-07-15 Sigma Tau Ind Farmaceuti Derivati di acidi fenil(alchil)carbossilici e derivati fenilalchileterociclici dionici, loro uso come medicamenti ad attivita' ipoglicemizza
WO2003088962A1 (fr) * 2002-04-16 2003-10-30 Merck & Co., Inc. Therapie combinatoire faisant appel a un agoniste de ppar alpha/gamma
US6821524B2 (en) * 2002-06-03 2004-11-23 Jan Marini Skin Research, Inc. Cosmetic skin care compositions
US7220880B2 (en) 2002-06-19 2007-05-22 Eli Lilly And Company Amide linker peroxisome proliferator activated receptor modulators
US7560449B2 (en) 2002-11-06 2009-07-14 Schering Corporation Methods and therapeutic combinations for the treatment of demyelination
PA8591801A1 (es) 2002-12-31 2004-07-26 Pfizer Prod Inc Inhibidores benzamidicos del receptor p2x7.
US7071223B1 (en) * 2002-12-31 2006-07-04 Pfizer, Inc. Benzamide inhibitors of the P2X7 receptor
DE10308352A1 (de) 2003-02-27 2004-09-09 Aventis Pharma Deutschland Gmbh Arylcycloalkylderivate mit verzweigten Seitenketten, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
DE10308355A1 (de) 2003-02-27 2004-12-23 Aventis Pharma Deutschland Gmbh Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
DE10308351A1 (de) 2003-02-27 2004-11-25 Aventis Pharma Deutschland Gmbh 1,3-substituierte Cycloalkylderivate mit sauren, meist heterocyclischen Gruppen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10308353A1 (de) 2003-02-27 2004-12-02 Aventis Pharma Deutschland Gmbh Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US7148246B2 (en) 2003-02-27 2006-12-12 Sanofi-Aventis Deutschland Gmbh Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals
CA2517571C (fr) 2003-03-07 2011-07-05 Schering Corporation Azetidinones substituees , procedes pour leur preparation, formulations et utilisations de celles-ci
US7459442B2 (en) * 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
MXPA05009502A (es) 2003-03-07 2005-10-18 Schering Corp Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
JP4589919B2 (ja) * 2003-03-07 2010-12-01 シェーリング コーポレイション 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用
DE602004005033T2 (de) * 2003-05-12 2007-08-09 Pfizer Products Inc., Groton Benzamidinhibitoren des p2x7-rezeptors
KR20060109926A (ko) 2003-11-19 2006-10-23 메타베이시스 테라퓨틱스, 인크. 새로운 인-함유 갑상선 호르몬 모방약들
DE602004004631D1 (de) 2004-04-01 2007-03-22 Sanofi Aventis Deutschland Oxadiazolone, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Pharmazeutika
EP1763353A1 (fr) * 2004-06-29 2007-03-21 Warner-Lambert Company LLC THERAPIES COMBINATOIRES DANS LESQUELLES SONT UTILISES DES INHIBITEURS DE BENZAMIDE DU RECEPTEUR P2X<SB>7</SB>
CA2571124A1 (fr) * 2004-06-29 2006-01-12 Pfizer Products Inc. Procedes permettant de preparer des derives de 5-[4-(2-hydroxy-propyl)-3,5-dioxo-4,5-dihydro-3h-[1,2,4]triazin-2-yl]-benzamides par deprotection des precurseurs proteges par hydroxyle
AU2005258924A1 (en) * 2004-06-29 2006-01-12 Pfizer Products Inc. Method for preparing 5-`4-(2-hydroxy-ethyl)-3,5-dioxo-4,5-dihydro-3H-`1,2,4!-triazin-2-YK!benzamide derivatives with P2x7 inhibiting activity by reaction of the derivative unsubstituted in 4-position of the triazine with an oxiran in the presence of a lewis acid
BRPI0514372A (pt) * 2004-08-18 2008-06-10 Metabasis Therapeutics Inc inibidores de tiazol de frutose 1, 6-bisfosfatase
DE102005026762A1 (de) 2005-06-09 2006-12-21 Sanofi-Aventis Deutschland Gmbh Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
KR100958831B1 (ko) * 2006-09-19 2010-05-24 주식회사유한양행 헤테로아릴피리미딘 유도체, 이들의 제조방법, 및 이들을포함하는 조성물
US20120046364A1 (en) 2009-02-10 2012-02-23 Metabasis Therapeutics, Inc. Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5061717A (en) * 1988-03-08 1991-10-29 Pfizer Inc. Thiazolidinedione hypoglycemic agents
FR2680512B1 (fr) * 1991-08-20 1995-01-20 Adir Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
NO302519B1 (no) * 1991-12-26 1998-03-16 Sankyo Co Tiazolidinforbindelser som inneholder en kinongruppe, og farmasöytisk preparat

Also Published As

Publication number Publication date
HUP9802565A3 (en) 2000-01-28
HUP9802565A2 (hu) 1999-04-28
JP3144624B2 (ja) 2001-03-12
KR19990022435A (ko) 1999-03-25
DE69618792T2 (de) 2002-10-10
CN1186489A (zh) 1998-07-01
US6030990A (en) 2000-02-29
CN1133627C (zh) 2004-01-07
CN1336366A (zh) 2002-02-20
DE69618792D1 (de) 2002-03-14
WO1996038428A1 (fr) 1996-12-05
HU225039B1 (en) 2006-05-29
AU698896B2 (en) 1998-11-12
CA2220698A1 (fr) 1996-12-05
PT846693E (pt) 2002-05-31
EP0846693B1 (fr) 2002-01-23
ES2170858T3 (es) 2002-08-16
AU5844696A (en) 1996-12-18
KR100456177B1 (ko) 2004-12-30
CA2220698C (fr) 2003-06-17
JPH0948771A (ja) 1997-02-18
CN1069901C (zh) 2001-08-22
EP0846693A4 (fr) 1999-03-03
ATE212341T1 (de) 2002-02-15
TW400328B (en) 2000-08-01
EP0846693A1 (fr) 1998-06-10

Similar Documents

Publication Publication Date Title
DK0846693T3 (da) N-benzyldioxothiazolidylbenzamidderivater og fremgangsmåder til fremstilling deraf
ATE263759T1 (de) N-substituierte dioxothiazolidyl-benzamid- derivate und verfahren zu ihrer herstellung
ES2056962T3 (es) Un procedimiento para la preparacion de nuevos derivados de camptotecina.
MXPA02012875A (es) Derivado de benzoilpiridina o su sal, fungicida que lo contiene como un ingrediente activo, su procedimiento de produccion e intermediario para producirlo.
SG44794A1 (en) Novel peptide derivatives
ATE239708T1 (de) Huperzin-derivate, ihre herstellung und ihre verwendung
ATE232528T1 (de) Pyrimidinylpyrazolderivate
ES2169220T3 (es) Derivados de vitamina d3 con sustituyentes en la posicion 2.
ATE134376T1 (de) Mono- und bis-alkylaminoanthracycline
NO20025053L (no) Benzo[b]tiofen-derivat og fremgangsmÕte for fremstilling derav
DE59305415D1 (de) Neue benzopyranone, verfahren zu ihrer herstellung und verwendung
ES8602712A1 (es) Un procedimiento para preparar un derivado de rodanina
HUP0104045A2 (hu) Eljárás 4-[(2',5'-diamino-6'-halogén-pirimidin-4'-il)-amino]-ciklopent-2-enilmetanol-származékok előállítására
DK1138679T3 (da) Hydronaphto[2,3-c]-furanderivater og fremgangsmåder til deres fremstilling
DK0916674T3 (da) Cyclopropanringholdige purinderivater
TW429249B (en) Process for production a novel N-substituted pyrrolidine derivatives