DK0625912T3 - Behandling af inflammatorisk tarmsygdom - Google Patents
Behandling af inflammatorisk tarmsygdomInfo
- Publication number
- DK0625912T3 DK0625912T3 DK93904830.2T DK93904830T DK0625912T3 DK 0625912 T3 DK0625912 T3 DK 0625912T3 DK 93904830 T DK93904830 T DK 93904830T DK 0625912 T3 DK0625912 T3 DK 0625912T3
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- inflammatory bowel
- bowel disease
- tissus
- ibd
- Prior art date
Links
- 208000022559 Inflammatory bowel disease Diseases 0.000 title abstract 3
- 108010008212 Integrin alpha4beta1 Proteins 0.000 abstract 1
- 210000003038 endothelium Anatomy 0.000 abstract 1
- 210000000265 leukocyte Anatomy 0.000 abstract 1
- 230000023404 leukocyte cell-cell adhesion Effects 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70542—CD106
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83513992A | 1992-02-12 | 1992-02-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0625912T3 true DK0625912T3 (da) | 1997-10-27 |
Family
ID=25268692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK93904830.2T DK0625912T3 (da) | 1992-02-12 | 1993-02-02 | Behandling af inflammatorisk tarmsygdom |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0625912B1 (fr) |
| JP (3) | JPH07506566A (fr) |
| AT (1) | ATE151642T1 (fr) |
| AU (1) | AU674302B2 (fr) |
| CA (1) | CA2129637C (fr) |
| DE (1) | DE69309906T2 (fr) |
| DK (1) | DK0625912T3 (fr) |
| ES (1) | ES2103468T3 (fr) |
| GR (1) | GR3024041T3 (fr) |
| HK (1) | HK1007683A1 (fr) |
| WO (1) | WO1993015764A1 (fr) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5932214A (en) * | 1994-08-11 | 1999-08-03 | Biogen, Inc. | Treatment for inflammatory bowel disease with VLA-4 blockers |
| ATE150975T1 (de) | 1992-11-13 | 1997-04-15 | Univ Washington | Peripheralisierung hämatopoietischer stammzellen |
| NZ262615A (en) * | 1993-02-09 | 1996-02-27 | Biogen Inc | Treating insulin dependent diabetes (type i) with anti vla4 (very late antigen) antibodies |
| AU727187B2 (en) * | 1993-02-09 | 2000-12-07 | Biogen Idec Ma Inc. | Treatment for insulin dependent diabetes |
| ZA947006B (en) * | 1993-09-15 | 1995-05-02 | Univ Emory | Method of inhibiting binding of reticulocytes to endothelium by interfering with vla-4/vcam-1 interactions |
| DK1759709T3 (da) * | 1994-01-25 | 2013-06-10 | Elan Pharm Inc | Humaniserede antistoffer mod leukocytadhæsionsmolekyle VLA-4 |
| US5840299A (en) * | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
| US7435802B2 (en) | 1994-01-25 | 2008-10-14 | Elan Pharaceuticals, Inc. | Humanized anti-VLA4 immunoglobulins |
| US7803904B2 (en) | 1995-09-01 | 2010-09-28 | Millennium Pharmaceuticals, Inc. | Mucosal vascular addressing and uses thereof |
| US6551593B1 (en) | 1995-02-10 | 2003-04-22 | Millennium Pharmaceuticals, Inc. | Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through α 4 β 7 and its ligands and madcam |
| US7750137B2 (en) | 1995-09-01 | 2010-07-06 | Millennium Pharmaceuticals, Inc. | Mucosal vascular addressins |
| US7147851B1 (en) | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
| DE19741235A1 (de) | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE19741873A1 (de) * | 1997-09-23 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE19751251A1 (de) | 1997-11-19 | 1999-05-20 | Hoechst Marion Roussel De Gmbh | Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate |
| DE19821483A1 (de) | 1998-05-14 | 1999-11-18 | Hoechst Marion Roussel De Gmbh | Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE69940206D1 (de) | 1998-09-14 | 2009-02-12 | Univ Texas | Verfahren zur behandlung von multiplem myelom und von myelom- induzierter knochenresorption mit antagonisten der integrin-/rezeptorbindung |
| US7618630B2 (en) | 1998-09-14 | 2009-11-17 | Board Of Regents, The University Of Texas System | Methods of treating multiple myeloma and myeloma-induced bone resorption using integrin antagonists |
| DE19922462A1 (de) | 1999-05-17 | 2000-11-23 | Aventis Pharma Gmbh | Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE10111877A1 (de) | 2001-03-10 | 2002-09-12 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE10137595A1 (de) | 2001-08-01 | 2003-02-13 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung |
| DE60332093D1 (de) | 2002-02-20 | 2010-05-27 | Ajinomoto Kk | Neues phenylalaninderivat |
| DK2336184T3 (en) | 2002-02-25 | 2015-02-16 | Biogen Idec Inc | Administration of agents for the treatment of inflammation. |
| EP2803667A1 (fr) | 2003-12-22 | 2014-11-19 | Ajinomoto Co., Inc. | Dérivés de phenylalanine |
| CA2714335A1 (fr) | 2007-02-20 | 2008-08-28 | Merrimack Pharmaceuticals, Inc. | Methodes de traitement de la sclerose en plaques par administration d'une alpha-foetoproteine combinee a un antagoniste de l'integrine |
| JP4652356B2 (ja) | 2007-02-26 | 2011-03-16 | アルプス電気株式会社 | ターンシグナルスイッチ装置 |
| CA2721093A1 (fr) | 2008-04-11 | 2009-10-15 | Merrimack Pharmaceuticals, Inc. | Lieurs d'albumine de serum humain, et ses conjugues |
| PT2558499T (pt) | 2010-04-16 | 2017-07-14 | Biogen Ma Inc | Anticorpos anti-vla-4 |
| US10040855B2 (en) | 2011-05-02 | 2018-08-07 | Millennium Pharmaceuticals, Inc. | Formulation for anti-α4β7 antibody |
| UA116189C2 (uk) | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
| CN109884295B (zh) * | 2017-12-25 | 2022-03-08 | 苏州和锐生物科技有限公司 | 假单胞菌多肽、抗体捕获器件及试剂盒 |
| CN112867394B9 (zh) | 2018-06-04 | 2024-12-06 | 马萨诸塞州渤健公司 | 具有降低的效应功能的抗vla-4抗体 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3852374T2 (de) * | 1987-11-02 | 1995-05-04 | Baylor College Medicine | Verwendung von ICAM-1 oder ihre funktionelle Derivate zur Behandlung unspezifischer Entzündungen. |
| US5147637A (en) * | 1988-06-07 | 1992-09-15 | The Rockefeller University | Method of inhibiting the influx of leukocytes into organs during sepsis or other trauma |
| DK162890D0 (da) | 1990-07-06 | 1990-07-06 | Novo Nordisk As | Polypeptid |
| WO1993006864A1 (fr) * | 1991-10-01 | 1993-04-15 | The General Hospital Corporation | Prevention du rejet d'une allogreffe a l'aide d'anticorps contre des molecules d'adhesion |
-
1993
- 1993-02-02 WO PCT/US1993/000924 patent/WO1993015764A1/fr not_active Ceased
- 1993-02-02 EP EP93904830A patent/EP0625912B1/fr not_active Revoked
- 1993-02-02 ES ES93904830T patent/ES2103468T3/es not_active Expired - Lifetime
- 1993-02-02 DK DK93904830.2T patent/DK0625912T3/da active
- 1993-02-02 CA CA002129637A patent/CA2129637C/fr not_active Expired - Lifetime
- 1993-02-02 AU AU36059/93A patent/AU674302B2/en not_active Expired
- 1993-02-02 AT AT93904830T patent/ATE151642T1/de not_active IP Right Cessation
- 1993-02-02 HK HK98106928A patent/HK1007683A1/en not_active IP Right Cessation
- 1993-02-02 JP JP5514148A patent/JPH07506566A/ja not_active Withdrawn
- 1993-02-02 DE DE69309906T patent/DE69309906T2/de not_active Revoked
-
1997
- 1997-07-09 GR GR970401696T patent/GR3024041T3/el unknown
-
2003
- 2003-08-27 JP JP2003303345A patent/JP4108572B2/ja not_active Expired - Lifetime
-
2006
- 2006-11-10 JP JP2006306053A patent/JP2007045843A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU3605993A (en) | 1993-09-03 |
| ATE151642T1 (de) | 1997-05-15 |
| CA2129637A1 (fr) | 1993-08-19 |
| HK1007683A1 (en) | 1999-04-23 |
| DE69309906T2 (de) | 1997-11-06 |
| JP2004002472A (ja) | 2004-01-08 |
| EP0625912B1 (fr) | 1997-04-16 |
| JP2007045843A (ja) | 2007-02-22 |
| CA2129637C (fr) | 1999-05-04 |
| DE69309906D1 (de) | 1997-05-22 |
| JPH07506566A (ja) | 1995-07-20 |
| JP4108572B2 (ja) | 2008-06-25 |
| GR3024041T3 (en) | 1997-10-31 |
| ES2103468T3 (es) | 1997-09-16 |
| EP0625912A1 (fr) | 1994-11-30 |
| AU674302B2 (en) | 1996-12-19 |
| WO1993015764A1 (fr) | 1993-08-19 |
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