DK0682524T3 - Farmaceutiske præparater indeholdende et baktericid/permeabilitetsforøgende protein og et afspændingsmiddel - Google Patents
Farmaceutiske præparater indeholdende et baktericid/permeabilitetsforøgende protein og et afspændingsmiddelInfo
- Publication number
- DK0682524T3 DK0682524T3 DK94907963T DK94907963T DK0682524T3 DK 0682524 T3 DK0682524 T3 DK 0682524T3 DK 94907963 T DK94907963 T DK 94907963T DK 94907963 T DK94907963 T DK 94907963T DK 0682524 T3 DK0682524 T3 DK 0682524T3
- Authority
- DK
- Denmark
- Prior art keywords
- bpi
- pharmaceutical compositions
- relaxant
- bactericide
- compositions containing
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 3
- 230000035699 permeability Effects 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 239000002249 anxiolytic agent Substances 0.000 title 1
- 239000003899 bactericide agent Substances 0.000 title 1
- 230000002708 enhancing effect Effects 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 229960000502 poloxamer Drugs 0.000 abstract 1
- 229920001983 poloxamer Polymers 0.000 abstract 1
- 229950008882 polysorbate Drugs 0.000 abstract 1
- 229920000136 polysorbate Polymers 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1751—Bactericidal/permeability-increasing protein [BPI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Marine Sciences & Fisheries (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1236093A | 1993-02-02 | 1993-02-02 | |
| PCT/US1994/001239 WO1994017819A1 (en) | 1993-02-02 | 1994-02-02 | Pharmaceutical compositions containing bactericidal permeability increasing protein and a surfactant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0682524T3 true DK0682524T3 (da) | 2002-01-28 |
Family
ID=21754603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94907963T DK0682524T3 (da) | 1993-02-02 | 1994-02-02 | Farmaceutiske præparater indeholdende et baktericid/permeabilitetsforøgende protein og et afspændingsmiddel |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US5488034A (da) |
| EP (1) | EP0682524B1 (da) |
| JP (2) | JP3946246B2 (da) |
| CN (1) | CN1163264C (da) |
| AT (1) | ATE206308T1 (da) |
| AU (1) | AU695125B2 (da) |
| CA (1) | CA2155005C (da) |
| DE (1) | DE69428521T2 (da) |
| DK (1) | DK0682524T3 (da) |
| ES (1) | ES2164098T3 (da) |
| PT (1) | PT682524E (da) |
| WO (1) | WO1994017819A1 (da) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6153193A (en) * | 1993-04-28 | 2000-11-28 | Supratek Pharma Inc. | Compositions for targeting biological agents |
| US6277410B1 (en) | 1992-10-08 | 2001-08-21 | Supratek Pharma Inc. | Copolymer compositions for oral delivery |
| US6093391A (en) * | 1992-10-08 | 2000-07-25 | Supratek Pharma, Inc. | Peptide copolymer compositions |
| DK0682524T3 (da) * | 1993-02-02 | 2002-01-28 | Xoma Technology Ltd | Farmaceutiske præparater indeholdende et baktericid/permeabilitetsforøgende protein og et afspændingsmiddel |
| US5420019A (en) * | 1993-02-02 | 1995-05-30 | Xoma Corporation | Stable bactericidal/permeability-increasing protein muteins |
| US6214789B1 (en) | 1993-03-12 | 2001-04-10 | Xoma Corporation | Treatment of mycobacterial diseases by administration of bactericidal/permeability-increasing protein products |
| US5652332A (en) * | 1993-03-12 | 1997-07-29 | Xoma | Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof |
| AU7175694A (en) | 1993-06-17 | 1995-01-17 | Xoma Corporation | Lipopolysaccharide binding protein derivatives |
| AU7330994A (en) * | 1993-07-14 | 1995-02-13 | Xoma Corporation | Method for potentiating bpi protein product bactericidal activity by administration of lbp protein products |
| US5770561A (en) * | 1993-07-14 | 1998-06-23 | Xoma Corporation | Method for potentiating BPI protein product bactericidal activity by administration of LBP protein products |
| CN1133634A (zh) * | 1993-09-22 | 1996-10-16 | 爱克斯欧玛公司 | 定量体液中的bpi的方法 |
| WO1995008344A1 (en) * | 1993-09-22 | 1995-03-30 | Xoma Corporation | Method of treating gram-negative bacterial infection by administration of bactericidal/permeability-increasing (bpi) protein product and antibiotic |
| US6759203B1 (en) | 1993-09-22 | 2004-07-06 | Xoma Corporation | Method for quantifying BPI in body fluids |
| US5578572A (en) * | 1994-01-14 | 1996-11-26 | Xoma Corporation | Anti-gram-positive bacterial methods and materials |
| WO1995019179A1 (en) * | 1994-01-14 | 1995-07-20 | Xoma Corporation | Anti-fungal methods and materials |
| US5447913A (en) | 1994-03-11 | 1995-09-05 | Xoma Corporation | Therapeutic uses of bactericidal/permeability-increasing protein dimer products |
| US5830860A (en) * | 1994-03-24 | 1998-11-03 | Regents Of The University Of Minnesota | Peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use |
| US5786324A (en) * | 1994-03-24 | 1998-07-28 | Regents Of The University Of Minnesota | Synthetic peptides with bactericidal activity and endotoxin neutralizing activity for gram negative bacteria and methods for their use |
| US5932544A (en) * | 1994-05-31 | 1999-08-03 | Xoma Corporation | Bactericidal/permeability-increasing protein (BPI) compositions |
| US5646114A (en) * | 1994-07-11 | 1997-07-08 | Xoma Corporation | Anti-protozoan methods |
| US6271203B1 (en) | 1994-07-07 | 2001-08-07 | Xoma Corporation | Anti-protozoan methods and materials |
| US6353055B1 (en) | 1994-11-18 | 2002-03-05 | Supratek Pharma Inc. | Polynucleotide compositions |
| US6221959B1 (en) | 1994-11-18 | 2001-04-24 | Supratek Pharma, Inc. | Polynucleotide compositions |
| US5912228A (en) | 1995-01-13 | 1999-06-15 | Xoma Corporation | Therapeutic compositions comprising bactericidal/permeability-increasing (BPI) protein products |
| US5494896A (en) * | 1995-03-31 | 1996-02-27 | Xoma Corporation | Method of treating conditions associated with burn injuries |
| JP2001520631A (ja) * | 1995-07-20 | 2001-10-30 | ゾーマ コーポレイション | 抗真菌性ペプチド |
| WO1997017990A1 (en) * | 1995-11-14 | 1997-05-22 | Xoma Corporation | Bactericidal permeability increasing protein (bpi) for treating conditions associated with corneal injury |
| US5686414A (en) * | 1995-11-14 | 1997-11-11 | Xoma Corporation | Methods of treating conditions associated with corneal transplantation |
| US5741779A (en) * | 1996-05-10 | 1998-04-21 | Xoma Corporation | Antithrombotic materials and methods |
| CA2253837C (en) * | 1996-05-10 | 2002-07-02 | Xoma Corporation | Therapeutic uses of bpi protein products for human meningococcemia |
| WO1997044056A1 (en) * | 1996-05-23 | 1997-11-27 | Xoma Corporation | Therapeutic uses of bpi protein products in humans with hemorrhage due to trauma |
| CA2255865C (en) | 1996-05-24 | 2008-10-14 | The Regents Of The University Of Minnesota | Synthesis of soluble beta-sheet forming peptides |
| US5888973A (en) | 1996-08-09 | 1999-03-30 | Xoma Corporation | Anti-chlamydial uses of BPI protein products |
| WO1998013069A2 (en) | 1996-09-09 | 1998-04-02 | Supratek Pharma, Inc. | Fluorinated copolymeric pharmaceutical adjuncts |
| AU744918B2 (en) * | 1996-11-01 | 2002-03-07 | Xoma Corporation | Therapeutic uses of BPI protein products in cystic fibrosis patients |
| US6482796B2 (en) | 1996-11-01 | 2002-11-19 | Xoma Corporation | Therapeutic uses of N-terminal BPI protein products in ANCA-positive patients |
| US20030190307A1 (en) * | 1996-12-24 | 2003-10-09 | Biogen, Inc. | Stable liquid interferon formulations |
| US6093573A (en) * | 1997-06-20 | 2000-07-25 | Xoma | Three-dimensional structure of bactericidal/permeability-increasing protein (BPI) |
| FR2764800B1 (fr) * | 1997-06-23 | 1999-09-10 | Sanofi Sa | Composition pharmaceutique solide contenant des derives de benzofuranne |
| US5990082A (en) | 1997-10-22 | 1999-11-23 | Xoma Corporation | Uses of lipopolysaccharide binding protein |
| US6013631A (en) | 1998-06-19 | 2000-01-11 | Xoma Corporation | Bactericidal/permeability-increasing protein (BPI) deletion analogs |
| US20030166525A1 (en) | 1998-07-23 | 2003-09-04 | Hoffmann James Arthur | FSH Formulation |
| WO2000062795A2 (en) * | 1999-04-21 | 2000-10-26 | The Government Of The United States Of America, Represented By The Secretary, Department Of Healt H And Human Services The National Institutes Of Health | UTEROGLOBIN IN THE TREATMENT OF IgA MEDIATED AUTOIMMUNE DISORDERS |
| US6413537B1 (en) | 2000-03-10 | 2002-07-02 | Wisconsin Alumni Research Foundation | Nystatin formulation having reduced toxicity |
| US7256180B2 (en) | 2000-04-28 | 2007-08-14 | Supratek Pharma Inc. | Compositions and methods for inducing activation of dendritic cells |
| AU2002335815A1 (en) * | 2001-10-16 | 2003-04-28 | Rxkinetix, Inc. | High-concentration protein formulations and method of manufacture |
| JP2005536453A (ja) | 2002-02-20 | 2005-12-02 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 部分的なペプチド擬似物及び方法 |
| EP1539212A4 (en) * | 2002-07-12 | 2007-05-02 | Medarex Inc | METHOD AND COMPOSITIONS FOR PREVENTING OXIDATIVE DEGRADATION OF PROTEINS |
| DE60317822D1 (de) * | 2002-10-29 | 2008-01-10 | Alza Corp | Stabilisierte feste polypeptidpartikel |
| WO2004047862A1 (en) * | 2002-11-26 | 2004-06-10 | Eurocine Ab | Novel amine-based adjuvant |
| AU2004216298B2 (en) * | 2003-02-28 | 2009-04-23 | Chugai Seiyaku Kabushiki Kaisha | Stabilized protein-containing formulations |
| US7741268B2 (en) * | 2003-04-02 | 2010-06-22 | Ares Trading S.A. | Liquid pharmaceutical formulations of FSH and LH together with a non-ionic surfactant |
| US7838721B2 (en) * | 2003-04-09 | 2010-11-23 | Paragon Trade Brands, Llc | Disposable articles using high column AUL superabsorbents |
| WO2004112826A1 (en) * | 2003-06-20 | 2004-12-29 | Ares Trading Sa | Freeze-dried fsh / lh formulations |
| US8377459B2 (en) * | 2003-07-09 | 2013-02-19 | The Procter & Gamble Company | Composition for wet wipes that enhances the efficacy of cleansing while being gentle to the skin |
| WO2005034999A2 (en) * | 2003-10-10 | 2005-04-21 | Bvm Holding Co. | Composition comprising association complex of a pharmaceutical and a poloxamer |
| US7150995B2 (en) * | 2004-01-16 | 2006-12-19 | Metrika, Inc. | Methods and systems for point of care bodily fluid analysis |
| ES2526913T3 (es) * | 2004-08-04 | 2015-01-16 | Ipsen Biopharm Limited | Composición farmacéutica que contiene neurotoxina 2 botulínica |
| TR201708749T4 (tr) * | 2004-08-04 | 2018-03-21 | Ipsen Biopharm Ltd | Botuli̇num nörotoksi̇n a2 i̇çeren farmasöti̇k bi̇leşi̇m |
| US20060173428A1 (en) * | 2005-02-02 | 2006-08-03 | Acors Deanna M | Absorbent article with logically correlated image and textual graphics |
| CA2609038A1 (en) | 2005-05-18 | 2006-11-23 | Trinity Biosystems, Inc. | Methods and compositions for immunizing against chlamydia infection |
| CU23432B6 (es) * | 2005-11-02 | 2009-10-16 | Ct Ingenieria Genetica Biotech | Formulaciones estabilizadas que contienen a los interferones gamma y alfa en proporciones potenciadoras |
| US20110303542A1 (en) * | 2007-08-08 | 2011-12-15 | Advanced Liquid Logic, Inc. | Use of Additives for Enhancing Droplet Operations |
| WO2009034958A1 (ja) * | 2007-09-12 | 2009-03-19 | Jsr Corporation | タンパク安定化剤およびその製造方法、タンパク安定化剤の使用方法、ならびにタンパク安定化方法 |
| KR101784231B1 (ko) | 2008-06-20 | 2017-11-08 | 노파르티스 아게 | 응집이 감소된 면역글로불린 |
| PL2896404T3 (pl) | 2009-06-04 | 2017-12-29 | Novartis Ag | Sposoby identyfikacji miejsc koniugacji IgG |
| EP3075386B1 (en) * | 2009-06-17 | 2019-10-16 | BioMarin Pharmaceutical Inc. | Formulations for lysosomal enzymes |
| SI3626258T1 (sl) | 2010-06-25 | 2021-11-30 | Shire Human Genetic Therapies, Inc. | Postopki in sestavki za dovajanje idunorat-2-sulfataze v cžs |
| US11246915B2 (en) | 2010-09-15 | 2022-02-15 | Applied Molecular Transport Inc. | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo |
| US9090691B2 (en) | 2010-09-15 | 2015-07-28 | Applied Molecular Transport Llc | Systems and methods of delivery of bioactive agents using bacterial toxin-derived transport sequences |
| GB201116271D0 (en) * | 2011-09-21 | 2011-11-02 | Univ Cardiff | Dispersion anaesthetic device |
| MX385898B (es) | 2014-05-07 | 2025-03-18 | Applied Molecular Transp Llc | Moleculas de fusion derivadas de la toxina colix para suministro oral de una carga biologicamente activa. |
| HUE059330T2 (hu) | 2018-03-08 | 2022-11-28 | Applied Molecular Transport Inc | Toxinból származó bejuttatási konstrukciók orális beadásra |
| CA3093386A1 (en) | 2018-03-08 | 2019-09-12 | Applied Molecular Transport Inc. | Toxin-derived delivery constructs for oral delivery |
| PH12022550330A1 (en) | 2019-08-16 | 2023-02-06 | Applied Molecular Transport Inc | Compositions, formulations, and interleukin production and purification |
| CN115666522B (zh) * | 2020-03-18 | 2025-05-27 | Gi医诺微新 | 包含il-2蛋白和cd80蛋白的融合蛋白制剂 |
| MX2023011087A (es) * | 2021-03-24 | 2023-10-02 | Japan Chem Res | Composicion farmaceutica acuosa o composicion farmaceutica liofilizada estable. |
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| WO1988006038A1 (en) * | 1987-02-20 | 1988-08-25 | Emory University | Antiinfective compounds and method of use |
| US5198541A (en) * | 1987-08-11 | 1993-03-30 | New York University | Dna encoding bactericidal/permeability-increasing proteins |
| EP1659132A1 (en) * | 1987-08-11 | 2006-05-24 | New York University | Biologically active bactericidal/permeability-increasing protein fragments |
| FR2630115B1 (fr) * | 1988-04-14 | 1994-10-28 | Merieux Inst | Procede de stabilisation des solutions d'albumine humaine et solution obtenue |
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| DK0682524T3 (da) * | 1993-02-02 | 2002-01-28 | Xoma Technology Ltd | Farmaceutiske præparater indeholdende et baktericid/permeabilitetsforøgende protein og et afspændingsmiddel |
| US5348942A (en) * | 1993-03-12 | 1994-09-20 | Xoma Corporation | Therapeutic uses of bactericidal/permeability increasing protein products |
-
1994
- 1994-02-02 DK DK94907963T patent/DK0682524T3/da active
- 1994-02-02 AU AU61330/94A patent/AU695125B2/en not_active Ceased
- 1994-02-02 CN CNB941913554A patent/CN1163264C/zh not_active Expired - Fee Related
- 1994-02-02 CA CA002155005A patent/CA2155005C/en not_active Expired - Fee Related
- 1994-02-02 US US08/190,869 patent/US5488034A/en not_active Expired - Lifetime
- 1994-02-02 ES ES94907963T patent/ES2164098T3/es not_active Expired - Lifetime
- 1994-02-02 AT AT94907963T patent/ATE206308T1/de not_active IP Right Cessation
- 1994-02-02 PT PT94907963T patent/PT682524E/pt unknown
- 1994-02-02 EP EP94907963A patent/EP0682524B1/en not_active Expired - Lifetime
- 1994-02-02 JP JP51821394A patent/JP3946246B2/ja not_active Expired - Fee Related
- 1994-02-02 DE DE69428521T patent/DE69428521T2/de not_active Expired - Fee Related
- 1994-02-02 WO PCT/US1994/001239 patent/WO1994017819A1/en not_active Ceased
-
1995
- 1995-06-07 US US08/472,995 patent/US5696090A/en not_active Expired - Fee Related
-
1997
- 1997-12-08 US US08/986,413 patent/US5955427A/en not_active Expired - Fee Related
-
1999
- 1999-05-17 US US09/313,525 patent/US6066620A/en not_active Expired - Lifetime
-
2000
- 2000-02-11 US US09/502,356 patent/US6255284B1/en not_active Expired - Fee Related
-
2005
- 2005-02-25 JP JP2005052149A patent/JP2005145986A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CN1127992A (zh) | 1996-07-31 |
| DE69428521T2 (de) | 2002-05-23 |
| HK1014156A1 (en) | 1999-09-24 |
| EP0682524B1 (en) | 2001-10-04 |
| JP3946246B2 (ja) | 2007-07-18 |
| US5696090A (en) | 1997-12-09 |
| ATE206308T1 (de) | 2001-10-15 |
| US5488034A (en) | 1996-01-30 |
| WO1994017819A1 (en) | 1994-08-18 |
| CN1163264C (zh) | 2004-08-25 |
| EP0682524A1 (en) | 1995-11-22 |
| US6255284B1 (en) | 2001-07-03 |
| AU6133094A (en) | 1994-08-29 |
| US6066620A (en) | 2000-05-23 |
| JP2005145986A (ja) | 2005-06-09 |
| CA2155005C (en) | 1999-04-06 |
| CA2155005A1 (en) | 1994-08-18 |
| JPH10513433A (ja) | 1998-12-22 |
| PT682524E (pt) | 2002-03-28 |
| AU695125B2 (en) | 1998-08-06 |
| DE69428521D1 (de) | 2001-11-08 |
| ES2164098T3 (es) | 2002-02-16 |
| US5955427A (en) | 1999-09-21 |
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