DK0648503T3 - Pro-prodrugs, deres fremstilling og anvendelse - Google Patents

Pro-prodrugs, deres fremstilling og anvendelse

Info

Publication number: DK0648503T3
Authority: DK; Denmark
Prior art keywords: prodrugs; pro; manufacture; suited; drugs
Prior art date: 1993-09-22

Application number

DK94114195T

Other languages

English (en)

Inventor

Joerg Dr Czech

Dieter Dr Hoffmann

Francois Tillequin

Michel Azoulay

Claude Monneret

Michel Koch

Klaus Dr Bosslet

Jean-Claude Florent

Jean-Claude Jacquesy

Jean-Pierre Gesson

Original Assignee

Hoechst Ag

Hoechst Houde S A Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-22

Filing date

1994-09-09

Publication date

2000-10-02

1994-09-09 Application filed by Hoechst Ag, Hoechst Houde S A Lab filed Critical Hoechst Ag

2000-10-02 Application granted granted Critical

2000-10-02 Publication of DK0648503T3 publication Critical patent/DK0648503T3/da

Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/605—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the macromolecule containing phosphorus in the main chain, e.g. poly-phosphazene
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
- A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Nanotechnology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Crystallography & Structural Chemistry (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Medical Informatics (AREA)
Immunology (AREA)
Biophysics (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Dispersion Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)

DK94114195T 1993-09-22 1994-09-09 Pro-prodrugs, deres fremstilling og anvendelse DK0648503T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP93115234		1993-09-22

Publications (1)

Publication Number	Publication Date
DK0648503T3 true DK0648503T3 (da)	2000-10-02

Family

ID=8213288

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94114195T DK0648503T3 (da)	1993-09-22	1994-09-09	Pro-prodrugs, deres fremstilling og anvendelse

Country Status (14)

Country	Link
US (1)	US5877158A (da)
EP (1)	EP0648503B1 (da)
JP (1)	JPH07149666A (da)
KR (1)	KR950007875A (da)
AT (1)	ATE194920T1 (da)
AU (1)	AU681180B2 (da)
CA (1)	CA2132608A1 (da)
DE (1)	DE69425356T2 (da)
DK (1)	DK0648503T3 (da)
ES (1)	ES2148259T3 (da)
GR (1)	GR3034412T3 (da)
NZ (1)	NZ264487A (da)
PT (1)	PT648503E (da)
ZA (1)	ZA947332B (da)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5525606A (en)	1994-08-01	1996-06-11	The United States Of America As Represented By The Department Of Health And Human Services	Substituted 06-benzylguanines and 6(4)-benzyloxypyrimidines
GB9600471D0 (en) *	1996-01-10	1996-03-13	Univ London Pharmacy	Drug delivery system
US6180095B1 (en) *	1997-12-17	2001-01-30	Enzon, Inc.	Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
WO1999030727A1 (en) *	1997-12-17	1999-06-24	Enzon, Inc.	Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents
WO2003051113A1 (en) *	2001-12-14	2003-06-26	The University Of Wyoming	Methods and compositions for controlled release of drugs
JPWO2004000863A1 (ja) *	2002-06-20	2005-10-20	日本水産株式会社	プロドラッグ、その医薬としての使用、およびその製法
WO2004043493A1 (en) *	2002-11-14	2004-05-27	Syntarga B.V.	Prodrugs built as multiple self-elimination-release spacers
DE10256982A1 (de)	2002-12-05	2004-06-24	Schering Ag	Neue Effektor-Konjugate, Verfahren zu Ihrer Herstellung und Ihre Pharmazeutische Verwendung
EP1581218A1 (en) *	2002-12-05	2005-10-05	Schering AG	Epothilone analogs for site specific delivery in the treatment of proliferative diseases
ZA200507752B (en)	2003-03-28	2007-01-31	Threshold Pharmaceuticals Inc	Compositions and methods for treating cancer
WO2005082023A2 (en) *	2004-02-23	2005-09-09	Genentech, Inc.	Heterocyclic self-immolative linkers and conjugates
CN102746336B (zh)	2005-06-29	2015-08-19	施瑞修德制药公司	氨基磷酸酯烷化剂前体药物
WO2007149827A2 (en) *	2006-06-20	2007-12-27	Janssen Pharmaceutica, N.V.	Method for modulating the pharmacokinetics and metabolism of a therapeutic agent
US20080031866A1 (en) *	2006-06-20	2008-02-07	Eichenbaum Gary M	Method for modulating the pharmacokinetics and metabolism of a therapeutic agent
EP2114157B1 (en)	2006-12-26	2021-05-26	ImmunoGenesis, Inc.	Phosphoramidate alkylator prodrug for the treatment of cancer
US20090118031A1 (en) *	2007-11-01	2009-05-07	Qualizza Gregory K	Shaft Structure with Configurable Bending Profile
US9353150B2 (en)	2012-12-04	2016-05-31	Massachusetts Institute Of Technology	Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment
US11013690B2 (en)	2016-01-04	2021-05-25	Academia Sinica	Esterification/saponification-based method for liposomal encapsulation of hydrophilic glucuronides
US11730826B2 (en)	2016-05-02	2023-08-22	Massachusetts Institute Of Technology	Amphiphilic nanoparticles for delivery of CRISPR based therapy
US10918627B2 (en)	2016-05-11	2021-02-16	Massachusetts Institute Of Technology	Convergent and enantioselective total synthesis of Communesin analogs
WO2018209239A1 (en)	2017-05-11	2018-11-15	Massachusetts Institute Of Technology	Potent agelastatin derivatives as modulators for cancer invasion and metastasis
US10640508B2 (en)	2017-10-13	2020-05-05	Massachusetts Institute Of Technology	Diazene directed modular synthesis of compounds with quaternary carbon centers
KR102258299B1 (ko) *	2019-03-21	2021-05-28	고려대학교 산학협력단	대장암 선택적 항암 치료진단제
WO2020247054A1 (en)	2019-06-05	2020-12-10	Massachusetts Institute Of Technology	Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof
CN110590875B (zh) *	2019-08-30	2022-08-16	中国药科大学	一种多胺前体脂质及其应用
EP3909612A1 (en)	2020-05-12	2021-11-17	Life Science Inkubator Betriebs GmbH & Co. KG	Composition of nanoparticles
WO2022182415A1 (en)	2021-02-24	2022-09-01	Massachusetts Institute Of Technology	Himastatin derivatives, and processes of preparation thereof, and uses thereof
EP4673170A1 (en)	2023-03-02	2026-01-07	Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts	A therapeutic hpv vaccine based on validated target epitopes

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3803124A (en) *	1968-04-12	1974-04-09	Farmaceutici It Soc	Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
NL145536B (nl) *	1968-04-12	1975-04-15	Farmaceutici Italia	Werkwijze voor de bereiding van een nieuw antibioticum of zijn aglycon.
GB1541436A (en) *	1976-02-02	1979-02-28	Searle & Co	Immunological materials
US4337760A (en) *	1978-10-13	1982-07-06	Adolf Schwimmer	Method for the treatment of tumors with β-glucuronidase activity dependent pharmaceuticals
FR2439788A1 (fr) *	1978-10-27	1980-05-23	Rhone Poulenc Ind	Nouveaux derives de la daunorubicine, leur preparation et les medicaments qui les contiennent
PL124284B1 (en) *	1979-10-17	1983-01-31	Politechnika Gdanska	Process for preparing n-glycosyl derivatives of antibiotics from anthracyclines group
WO1981001145A1 (en) *	1979-10-18	1981-04-30	Univ Illinois	Hydrolytic enzyme-activatible pro-drugs
IN165717B (da) *	1986-08-07	1989-12-23	Battelle Memorial Institute
US4975278A (en) *	1988-02-26	1990-12-04	Bristol-Myers Company	Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
JPH03502327A (ja) *	1988-01-19	1991-05-30	ボード・オブ・リージェンツ，ザ・ユニバーシティ・オブ・テキサス・システム	３’‐デアミノドキソルビシンのエステル体、そのリポソーム組成物およびその使用方法
US5417970A (en) *	1988-10-21	1995-05-23	Sanofi	Drugs containing a glycosylated interleukin-2
DE4002888A1 (de) *	1990-02-01	1991-08-08	Behringwerke Ag	Anthracyclin-glycosyl-prodrugs, verfahren zu ihrer herstellung und ihre verwendung in kombination mit funktionalisierten tumorspezifischen enzymkonjugaten
FR2676058B1 (fr) *	1991-04-30	1994-02-25	Hoechst Lab	Prodrogues glycosylees, leur procede de preparation et leur utilisation dans le traitement des cancers.
EP0601417A3 (de) *	1992-12-11	1998-07-01	Hoechst Aktiengesellschaft	Physiologisch verträglicher und physiologisch abbaubarer, Kohlenhydratrezeptorblocker auf Polymerbasis, ein Verfahren zu seiner Herstellung und seine Verwendung
US5618528A (en) *	1994-02-28	1997-04-08	Sterling Winthrop Inc.	Biologically compatible linear block copolymers of polyalkylene oxide and peptide units

1994
- 1994-09-09 DK DK94114195T patent/DK0648503T3/da active
- 1994-09-09 DE DE69425356T patent/DE69425356T2/de not_active Expired - Fee Related
- 1994-09-09 PT PT94114195T patent/PT648503E/pt unknown
- 1994-09-09 ES ES94114195T patent/ES2148259T3/es not_active Expired - Lifetime
- 1994-09-09 AT AT94114195T patent/ATE194920T1/de not_active IP Right Cessation
- 1994-09-09 EP EP94114195A patent/EP0648503B1/en not_active Expired - Lifetime
- 1994-09-20 US US08/309,035 patent/US5877158A/en not_active Expired - Fee Related
- 1994-09-20 AU AU74109/94A patent/AU681180B2/en not_active Ceased
- 1994-09-20 NZ NZ264487A patent/NZ264487A/xx unknown
- 1994-09-21 ZA ZA947332A patent/ZA947332B/xx unknown
- 1994-09-21 CA CA002132608A patent/CA2132608A1/en not_active Abandoned
- 1994-09-21 JP JP6226323A patent/JPH07149666A/ja active Pending
- 1994-09-22 KR KR1019940023833A patent/KR950007875A/ko not_active Ceased
2000
- 2000-09-15 GR GR20000402100T patent/GR3034412T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
ZA947332B (en)	1995-05-10
EP0648503A1 (en)	1995-04-19
ES2148259T3 (es)	2000-10-16
PT648503E (pt)	2000-11-30
AU681180B2 (en)	1997-08-21
GR3034412T3 (en)	2000-12-29
CA2132608A1 (en)	1995-03-23
NZ264487A (en)	1998-12-23
EP0648503B1 (en)	2000-07-26
ATE194920T1 (de)	2000-08-15
DE69425356T2 (de)	2002-04-18
KR950007875A (ko)	1995-04-15
AU7410994A (en)	1995-04-06
US5877158A (en)	1999-03-02
JPH07149666A (ja)	1995-06-13
DE69425356D1 (de)	2000-08-31

Publication	Publication Date	Title
DK0648503T3 (da)	2000-10-02	Pro-prodrugs, deres fremstilling og anvendelse
NO933854D0 (no)	1993-10-26	Promedikamenter, deres fremstilling og anvendelse som legemiddel
SE9704546D0 (sv)	1997-12-05	Novel compounds
SE9704545D0 (sv)	1997-12-05	Novel compounds
SE9704544D0 (sv)	1997-12-05	Novel compounds
NO881164L (no)	1988-09-19	Substituerte 9-amino-tetrahydroakridiner og relaterte forbindelser, en fremgangsmaate for deres fremstilling og deres bruk som medikamenter.
DK15589D0 (da)	1989-01-13	Kemiske forbindelser
DK498988D0 (da)	1988-09-08	3,7-diazabicyclooe3,3,1aanonan-forbindelser, fremgangsmaade til deres fremstilling og hjertevirksomme laegemidler indeholdende disse
ATE220688T1 (de)	2002-08-15	Tumor-zerstörende effekte von enterotoxinen und verwandten verbindungen
DE69027472D1 (de)	1996-07-25	Arylsubstituierte Rhodaninderivate
DK0411733T3 (da)	1999-06-28	11-beta-aryl-gona-4,9-dien-3-oner
NO952205D0 (no)	1995-06-02	Heterocykliske karbamater, fremgangsmåte for fremstilling derav og medikamenter
GR1001597B (el)	1994-06-30	Νέα βιολογικώς δραστικά παράγωγα εμπουρναμενίνης, φαρμακευτικές συν?έσεις οι οποίες περιέχουν αυτά και μέ?οδος δια την παρασκευή αυτών.
CZ282732B6 (cs)	1997-09-17	Substituované 1,2,3,4-tetrahydrocyklopent/b/indoly, 1,2,3,3a,4,8a-hexahydrocyklopent/b/indoly a příbuzné sloučeniny, meziprodukty a způsob jejich přípravy a jejich použití jako léčiv
DK612788D0 (da)	1988-11-03	Alkoxyderivater af ginkolider, fremgangsmaade til fremstilling heraf og farmaceutiske praeparater indeholdende saadanne forbindelser
NO885231D0 (no)	1988-11-24	Peptidstrukturer, immunogener og anvendelse for fertilitetskontroll.
DK0403458T3 (da)	1994-01-10	Hidtil ukendte polypeptider og anvendelse deraf
NO306468B1 (no)	1999-11-08	Nye fosfolipid-derivater, deres fremstilling, legemiddel inneholdende derivatene og derivatenes anvendelse
NO20000199L (no)	2000-01-14	Medikamenter inneholdende polyhydroksybutylpyraziner, nye polyhydroksybutylpyraziner og deres fremstilling
FI890187A7 (fi)	1989-07-16	Menetelmä hydroksialkyloivien yhdisteiden valmistamiseksi, näin saadut uudet yhdisteet ja niiden käyttö.
DK291188A (da)	1988-11-30	5-methoxyalkylammonium-tetrahydrofuran- og -tetrahydrothiophen-derivater, fremgangsmaade til fremstilling deraf og laegemidler indeholdende saadanne derivater
NO902329D0 (no)	1990-05-25	Antiinflammatoriske og analgetiske forbindelser, beslektede preparater og fremgangsmaater for fremstilling og anvendelse derav.
DK0463139T3 (da)	1995-11-06	2,13-disubstituerede ergoliner, deres fremstilling og deres anvendelse i lægemidler
NO904667D0 (no)	1990-10-26	Nye benzopyridopiperidin-, benzopyridopiperidyliden- og benzopyridopiperazinforbindelser, -preparater, fremgangsmaater for fremstilling derav og anvendelser derav.
NO875144L (no)	1987-12-09	Plant, terapeutisk system, fremgangsmÿte for fremstilling og anvendelse derav.