DK0427680T3 - Heteroatom-holdige cykliske forbindelser - Google Patents
Heteroatom-holdige cykliske forbindelserInfo
- Publication number
- DK0427680T3 DK0427680T3 DK90810854.1T DK90810854T DK0427680T3 DK 0427680 T3 DK0427680 T3 DK 0427680T3 DK 90810854 T DK90810854 T DK 90810854T DK 0427680 T3 DK0427680 T3 DK 0427680T3
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- heteroatom
- containing cyclic
- cyclic compounds
- compounds
- Prior art date
Links
- 150000001923 cyclic compounds Chemical class 0.000 title 1
- 125000005842 heteroatom Chemical group 0.000 title 1
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- 206010059866 Drug resistance Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229940044683 chemotherapy drug Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 abstract 1
- 238000010511 deprotection reaction Methods 0.000 abstract 1
- 229960003444 immunosuppressant agent Drugs 0.000 abstract 1
- 230000001861 immunosuppressant effect Effects 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000011987 methylation Effects 0.000 abstract 1
- 238000007069 methylation reaction Methods 0.000 abstract 1
- 230000000269 nucleophilic effect Effects 0.000 abstract 1
- 125000003431 oxalo group Chemical group 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- ZWZVWGITAAIFPS-UHFFFAOYSA-N thiophosgene Chemical compound ClC(Cl)=S ZWZVWGITAAIFPS-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyrane Compounds (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3937336 | 1989-11-09 | ||
| DE3938132 | 1989-11-16 | ||
| DE3942831 | 1989-12-23 | ||
| DE3942833 | 1989-12-23 | ||
| DE4006819 | 1990-03-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0427680T3 true DK0427680T3 (da) | 1995-12-18 |
Family
ID=27511355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90810854.1T DK0427680T3 (da) | 1989-11-09 | 1990-11-07 | Heteroatom-holdige cykliske forbindelser |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0427680B1 (da) |
| JP (1) | JP2750302B2 (da) |
| KR (1) | KR0166074B1 (da) |
| AT (1) | ATE126803T1 (da) |
| AU (1) | AU640963B2 (da) |
| CA (1) | CA2029694C (da) |
| DE (2) | DE10299040I2 (da) |
| DK (1) | DK0427680T3 (da) |
| ES (1) | ES2077663T3 (da) |
| GR (1) | GR3017858T3 (da) |
| HK (1) | HK30096A (da) |
| HU (1) | HU210900A9 (da) |
| IE (1) | IE69974B1 (da) |
| LU (1) | LU91021I2 (da) |
| LV (1) | LV11621B (da) |
| MY (1) | MY111430A (da) |
| NL (1) | NL300134I2 (da) |
| NZ (1) | NZ235991A (da) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0356399A3 (en) * | 1988-08-26 | 1991-03-20 | Sandoz Ag | Substituted 4-azatricyclo (22.3.1.04.9) octacos-18-ene derivatives, their preparation and pharmaceutical compositions containing them |
| CA2032159A1 (en) * | 1989-06-14 | 1990-12-15 | Andrew J. F. Edmunds | Heteroatoms-containing tricyclic compounds |
| US5208228A (en) * | 1989-11-13 | 1993-05-04 | Merck & Co., Inc. | Aminomacrolides and derivatives having immunosuppressive activity |
| MY110418A (en) * | 1990-07-02 | 1998-05-30 | Novartis Ag | Heteroatoms-containing tricyclic compounds. |
| EP0480623A1 (en) * | 1990-10-11 | 1992-04-15 | Merck & Co. Inc. | New halomacrolides and derivatives having immunosuppressive activity |
| US5143918A (en) * | 1990-10-11 | 1992-09-01 | Merck & Co., Inc. | Halomacrolides and derivatives having immunosuppressive activity |
| WO1992020688A1 (en) * | 1991-05-13 | 1992-11-26 | Merck & Co., Inc. | Amino o-aryl, o-alkyl, o-alkenyl and o-alkynyl macrolides |
| US5162334A (en) * | 1991-05-13 | 1992-11-10 | Merck & Co., Inc. | Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity |
| US5250678A (en) * | 1991-05-13 | 1993-10-05 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity |
| US5565560A (en) * | 1991-05-13 | 1996-10-15 | Merck & Co., Inc. | O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity |
| US5189042A (en) * | 1991-08-22 | 1993-02-23 | Merck & Co. Inc. | Fluoromacrolides having immunosuppressive activity |
| US5708002A (en) * | 1991-09-05 | 1998-01-13 | Abbott Laboratories | Macrocyclic immunomodulators |
| JP3644957B2 (ja) * | 1991-09-05 | 2005-05-11 | アボット・ラボラトリーズ | 大環式イムノモジュレーター |
| US5208241A (en) * | 1991-09-09 | 1993-05-04 | Merck & Co., Inc. | N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity |
| ATE159725T1 (de) * | 1992-03-02 | 1997-11-15 | Pfizer | 2-aminozuckermakrolid-derivate |
| CA2091194A1 (en) * | 1992-04-08 | 1993-10-09 | Richard D. Connell | 2-oxo-ethyl derivatives as immunosuppressants |
| US5284877A (en) * | 1992-06-12 | 1994-02-08 | Merck & Co., Inc. | Alkyl and alkenyl macrolides having immunosuppressive activity |
| US5284840A (en) * | 1992-06-12 | 1994-02-08 | Merck & Co., Inc. | Alkylidene macrolides having immunosuppressive activity |
| CH686761A5 (de) | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
| US5612350A (en) * | 1993-11-30 | 1997-03-18 | Abbott Laboratories | Macrocyclic immunomodulators with novel cyclohexyl ring replacements |
| WO1995015328A1 (en) * | 1993-11-30 | 1995-06-08 | Abbott Laboratories | Macrocyclic immunomodulators with novel cyclohexyl ring replacements |
| US5880280A (en) * | 1994-06-15 | 1999-03-09 | Merck & Co., Inc. | Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity |
| US5550233A (en) * | 1994-06-21 | 1996-08-27 | Merck & Co., Inc. | Aryl, alkyl, alkenyl and alkynylmacrolides having immunosuppressive activity |
| US5693648A (en) * | 1994-09-30 | 1997-12-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity |
| US5545734A (en) * | 1994-10-25 | 1996-08-13 | Merck & Co., Inc. | Aryl and heteroaryl macrolides having immunosuppressive activity |
| PT786986E (pt) | 1994-10-26 | 2002-07-31 | Novartis Ag | Formulacoes farmaceuticas |
| IL115742A (en) | 1994-10-26 | 2000-06-01 | Novartis Ag | Pharmaceutical compositions comprising a difficultly soluble active agent a hydrophilic phase a lipophilic phase and a surfactant |
| GB9618952D0 (en) * | 1996-09-11 | 1996-10-23 | Sandoz Ltd | Process |
| AR004480A1 (es) * | 1995-04-06 | 1998-12-16 | Amico Derin C D | Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen |
| JP3282945B2 (ja) * | 1995-06-07 | 2002-05-20 | 松下電器産業株式会社 | スピンドルモータ |
| BE1009856A5 (fr) * | 1995-07-14 | 1997-10-07 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule. |
| GB9601120D0 (en) * | 1996-01-19 | 1996-03-20 | Sandoz Ltd | Organic compounds |
| GB9713730D0 (en) * | 1997-06-30 | 1997-09-03 | Ciba Geigy Ag | Organic compounds |
| JP3714970B2 (ja) | 1998-03-26 | 2005-11-09 | アステラス製薬株式会社 | 徐放性製剤 |
| AR018330A1 (es) * | 1998-04-27 | 2001-11-14 | Fujisawa Pharmaceutical Co | Composiciones farmaceuticas que comprenden macrolidos como agentes activos para la terapia y profilaxis de las enfermedades de la piel |
| GB9826656D0 (en) | 1998-12-03 | 1999-01-27 | Novartis Ag | Organic compounds |
| US7063857B1 (en) | 1999-04-30 | 2006-06-20 | Sucampo Ag | Use of macrolide compounds for the treatment of dry eye |
| GB0003932D0 (en) * | 2000-02-18 | 2000-04-12 | Novartis Ag | Pharmaceutical compositions |
| GB0008785D0 (en) | 2000-04-10 | 2000-05-31 | Novartis Ag | Organic compounds |
| GB0012383D0 (en) * | 2000-05-22 | 2000-07-12 | Novartis Ag | Organic compounds |
| AR033151A1 (es) * | 2001-04-12 | 2003-12-03 | Sucampo Pharmaceuticals Inc | Agente para el tratamiento oftalmico topico de las enfermedades inflamatorias oculares |
| GB0125443D0 (en) * | 2001-10-23 | 2001-12-12 | Novartis Ag | Organic Compounds |
| WO2004009056A1 (en) | 2002-07-23 | 2004-01-29 | Novartis Ag | Ophtalmic ointment composition comprising a drug, an ointment base and a solubiling/dispersing agent |
| CN1714085A (zh) * | 2002-11-15 | 2005-12-28 | 诺瓦提斯公司 | 药物递送系统 |
| BRPI0407350A (pt) * | 2003-02-10 | 2006-01-10 | Novartis Ag | Combinações farmacêuticas compreendendo corticóides e imunosupressores para tratamento de doenças resistentes aos corticóides e/ou inibidores de calcineurina |
| AR043504A1 (es) * | 2003-03-17 | 2005-08-03 | Novartis Ag | Composiciones farmaceuticas que comprenden rapamicina para el tratamiento de enfermedades inflamatorias |
| EP1729729B1 (en) | 2004-03-23 | 2014-04-23 | Novartis AG | Pharmaceutical compositions |
| GT200500282A (es) * | 2004-10-12 | 2006-05-04 | Heteroatomos conteniendo compuestos triciclicos. | |
| JP2007523069A (ja) * | 2004-12-01 | 2007-08-16 | テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ | 非吸湿性及び粉末性非晶質ピメクロリマス |
| CA2668134A1 (en) * | 2006-11-06 | 2008-05-15 | Teva Gyogyszergyar Zartkoerueen Muekoedoe Reszvenytarsasag | Ascomycin and pimecrolimus having reduced levels of des-methylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof |
| US20100087550A1 (en) | 2008-10-06 | 2010-04-08 | Zora Marlowe | Formulations with a Tertiary Amine Oxide |
| US20100106128A1 (en) | 2008-10-23 | 2010-04-29 | Shane Mao | Contact lens cases for delivery of ophthalmic agents |
| IT1394309B1 (it) * | 2009-05-22 | 2012-06-06 | Poli Ind Chimica Spa | Nuovo approccio chimico-enzimatico alla sintesi del pimecrolimus |
| GB0914589D0 (en) * | 2009-08-20 | 2009-09-30 | Biotica Tech Ltd | Novel compounds and methods for their production |
| CN107106588B (zh) | 2014-10-28 | 2020-08-11 | 山口晃史 | 用于改善妊娠状态的药剂及其使用 |
| EP3178824A1 (en) | 2015-12-08 | 2017-06-14 | Medichem, S.A. | Process for preparing pimecrolimus |
| CN106074367A (zh) * | 2016-07-20 | 2016-11-09 | 中山大学中山眼科中心 | 含fk506类化合物/fkbp蛋白二聚体的药物组合物及其制备方法 |
| SI3619215T1 (sl) | 2017-05-01 | 2022-05-31 | Meda Pharma Gmbh & Co. Kg | Postopek za pretvorbo surovega askomicina v prečiščen pimekrolimus |
| WO2020032252A1 (ja) | 2018-08-10 | 2020-02-13 | 晃史 山口 | 母体と胎児との関係における液性免疫関連疾患の治療薬 |
| CN120053439A (zh) | 2018-12-18 | 2025-05-30 | 山口晃史 | 用于改善不孕不育症或妊娠状态的药物 |
| EP3741367A1 (en) | 2019-05-21 | 2020-11-25 | Premark Pharma GmbH | Treatment of ocular disease |
| EP4687895A1 (en) | 2023-04-06 | 2026-02-11 | Premark Pharma GmbH | Use of pimecrolimus for the treatment of dry eye in patients characterized by a corneal staining score of 4 or 5 on the oxford grading scale |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4894366A (en) * | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| US4650803A (en) * | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
| JP2799208B2 (ja) * | 1987-12-09 | 1998-09-17 | フアイソンズ・ピーエルシー | マクロ環状化合物 |
| CA2032159A1 (en) * | 1989-06-14 | 1990-12-15 | Andrew J. F. Edmunds | Heteroatoms-containing tricyclic compounds |
| PT98990A (pt) * | 1990-09-19 | 1992-08-31 | American Home Prod | Processo para a preparacao de esteres de acidos carboxilicos de rapamicina |
-
1990
- 1990-11-07 DE DE2002199040 patent/DE10299040I2/de active Active
- 1990-11-07 AU AU65843/90A patent/AU640963B2/en not_active Expired
- 1990-11-07 NZ NZ235991A patent/NZ235991A/xx unknown
- 1990-11-07 EP EP90810854A patent/EP0427680B1/en not_active Expired - Lifetime
- 1990-11-07 DK DK90810854.1T patent/DK0427680T3/da active
- 1990-11-07 ES ES90810854T patent/ES2077663T3/es not_active Expired - Lifetime
- 1990-11-07 AT AT90810854T patent/ATE126803T1/de active
- 1990-11-07 DE DE69021833T patent/DE69021833T2/de not_active Expired - Lifetime
- 1990-11-08 KR KR1019900018016A patent/KR0166074B1/ko not_active Expired - Lifetime
- 1990-11-08 MY MYPI90001975A patent/MY111430A/en unknown
- 1990-11-08 JP JP2305894A patent/JP2750302B2/ja not_active Expired - Lifetime
- 1990-11-08 IE IE402390A patent/IE69974B1/en not_active IP Right Cessation
- 1990-11-09 CA CA002029694A patent/CA2029694C/en not_active Expired - Lifetime
-
1995
- 1995-06-02 HU HU95P/P00161P patent/HU210900A9/hu active Protection Beyond IP Right Term
- 1995-10-25 GR GR950402962T patent/GR3017858T3/el unknown
-
1996
- 1996-02-15 HK HK30096A patent/HK30096A/en not_active IP Right Cessation
- 1996-07-17 LV LVP-96-253A patent/LV11621B/lv unknown
-
2003
- 2003-04-23 LU LU91021C patent/LU91021I2/fr unknown
- 2003-09-05 NL NL300134C patent/NL300134I2/nl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU640963B2 (en) | 1993-09-09 |
| GR3017858T3 (en) | 1996-01-31 |
| LU91021I2 (fr) | 2003-06-24 |
| MY111430A (en) | 2000-05-31 |
| KR0166074B1 (ko) | 1999-01-15 |
| DE69021833D1 (de) | 1995-09-28 |
| ATE126803T1 (de) | 1995-09-15 |
| IE69974B1 (en) | 1996-10-16 |
| LV11621B (en) | 1997-04-20 |
| HU210900A9 (en) | 1995-09-28 |
| AU6584390A (en) | 1991-05-23 |
| HK30096A (en) | 1996-02-23 |
| NL300134I1 (nl) | 2003-11-03 |
| JP2750302B2 (ja) | 1998-05-13 |
| IE904023A1 (en) | 1991-05-22 |
| DE10299040I1 (de) | 2003-02-20 |
| EP0427680B1 (en) | 1995-08-23 |
| EP0427680A1 (en) | 1991-05-15 |
| CA2029694C (en) | 2001-05-08 |
| LV11621A (lv) | 1996-12-20 |
| KR910009711A (ko) | 1991-06-28 |
| NL300134I2 (nl) | 2004-05-03 |
| CA2029694A1 (en) | 1991-05-10 |
| DE10299040I2 (de) | 2006-08-24 |
| JPH03223291A (ja) | 1991-10-02 |
| DE69021833T2 (de) | 1996-03-21 |
| NZ235991A (en) | 1993-05-26 |
| ES2077663T3 (es) | 1995-12-01 |
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